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The map label for this gene is 167625216

Identifier: 167625216

GI number: 167625216

Start: 4029786

End: 4031255

Strand: Reverse

Name: 167625216

Synonym: Shal_3304

Alternate gene names: NA

Gene position: 4031255-4029786 (Counterclockwise)

Preceding gene: 167625217

Following gene: 167625215

Centisome position: 77.12

GC content: 47.41

Gene sequence:

>1470_bases
ATGCAGATGACTCTCTCTTTTTTAGGTGCGACTCAAGAAGTGACGGGCTCTTGTCACTTACTCAATATTGATGGACAGCA
AGTATTACTCGACTGTGGATTAATCCAAGGGAGTAAGGCTGATGTGTTGCGTAATCACGAGCCCTTTGCCTTCAGCCCAT
CGCAGATCCATGCAGTGGTCTTAAGTCATGCTCATATCGATCATTCGGGACGATTACCTTTGTTGGTTCGTTCGGGGTTT
ACAGGACCTATATATAGCCATAAGGCTACGGTAGAGCTTTGTGCGGTGATGCTAAAAGATGCCGCCATGCTCCAAGCTAG
AGATATAGATCGACTCAATAAGAAGCGAGTAAAGAATGATTTACCCTTGCTAGAGCCGCTATTCGATGATGCCGATGTCG
ACCGTGTTATGCAGCAATTTGTGGCGCTCGATTATGGCGAGAGCACACAAGTGATCCCCCATCTTAATGTGTGTTTGTCT
GATGCGGGGCATATTTTAGGTTCAGCAGTGGTTGAGCTTTGGTTAGGAGAGGGGACTTCAACTAAAAAGCTGGTCTTTAG
TGGCGATCTTGGTCGTGAAGGCATGCCGATATTAGACGATCCAAGCTTAATCGATACGGCGGATCTGGTATTGATGGAAA
GTACCTATGGCAACAGGTTACATCGCTCATGGAACGATACGCTAGAAGAGCTCAAATCAATCTTTGCGCGTACCATAGAT
CAGAGTCGTGGCAATATTCTACTGCCAGCGTTTTCGGTTGGTCGAGCACAGGAGCTGCTTTATCTGTTTCATCTCTACGC
CAAAGAGTGGGATCTATCTCGTTGGCGGGTCTGTCTCGATAGCCCGATGGCGATTAGGGCAACACAGATCTATGTCGAAA
ATTACGCCTTAATGGATGAGGATTTTAAGCGTTTTACCCGTTTATCCCCGGGAAAGCATCCACTATTGTCGAATGTGGAC
TTTATCGATACCACAGAGGAGTCGATGGAGCTGAATCATATTCACCAAGGGCTGATTATTATCGCAGGCAGTGGTATGTG
TAACGGTGGCCGTATTCGCTGCCATTTAGAACACAATCTAGCGAACAGTCTATCTGATGTGATTATTTGTGGCTATCAGG
CGCAGGGCACGCCTGGTCGACTCTTGGTCGATGGCGCGACAAGCTTAACTATCAGTGGTCAAAGTATCGATGTTGCGGCG
AGGCTACATACCGTTGGCGGACTATCGGCTCATGCCGATCAGGCTGAGCTGCTGCACTGGTATCGCCATTTTAACGACTC
TCCACCAATTGTATTGGTGCATGGTGAGAGTGAGGCGCAGCAGGTCTTATTGGCTGCGCTTAATGAAGACGCCACTAATG
CCCCTGCTCATAGTGTGATAGCCGAGCAAGGTGACTGTTTAGATCTGACGCAACTACCTAAGTTTGTTTGGTTAGCTAAC
GCTATAAATAGCGAATCACAAGATGATTGA

Upstream 100 bases:

>100_bases
CTTCATTAAGGGTTTATCTTTTAAGCATAAGCACCAGAGATGACCACTCTATGTTGAAGTGGTTTAAAGGGAATAACGGT
GCCTTTTGAGGAAGAATGCT

Downstream 100 bases:

>100_bases
CTGTTATGTGTTCATGAGCCGCAGGCGCAATTAGCGGGTGATATAGTTACGCAGGTGATATGCCATTATCCTCATGATAG
CTCTTAATCGCTTATCATTA

Product: RNA-metabolising metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MQMTLSFLGATQEVTGSCHLLNIDGQQVLLDCGLIQGSKADVLRNHEPFAFSPSQIHAVVLSHAHIDHSGRLPLLVRSGF
TGPIYSHKATVELCAVMLKDAAMLQARDIDRLNKKRVKNDLPLLEPLFDDADVDRVMQQFVALDYGESTQVIPHLNVCLS
DAGHILGSAVVELWLGEGTSTKKLVFSGDLGREGMPILDDPSLIDTADLVLMESTYGNRLHRSWNDTLEELKSIFARTID
QSRGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRVCLDSPMAIRATQIYVENYALMDEDFKRFTRLSPGKHPLLSNVD
FIDTTEESMELNHIHQGLIIIAGSGMCNGGRIRCHLEHNLANSLSDVIICGYQAQGTPGRLLVDGATSLTISGQSIDVAA
RLHTVGGLSAHADQAELLHWYRHFNDSPPIVLVHGESEAQQVLLAALNEDATNAPAHSVIAEQGDCLDLTQLPKFVWLAN
AINSESQDD

Sequences:

>Translated_489_residues
MQMTLSFLGATQEVTGSCHLLNIDGQQVLLDCGLIQGSKADVLRNHEPFAFSPSQIHAVVLSHAHIDHSGRLPLLVRSGF
TGPIYSHKATVELCAVMLKDAAMLQARDIDRLNKKRVKNDLPLLEPLFDDADVDRVMQQFVALDYGESTQVIPHLNVCLS
DAGHILGSAVVELWLGEGTSTKKLVFSGDLGREGMPILDDPSLIDTADLVLMESTYGNRLHRSWNDTLEELKSIFARTID
QSRGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRVCLDSPMAIRATQIYVENYALMDEDFKRFTRLSPGKHPLLSNVD
FIDTTEESMELNHIHQGLIIIAGSGMCNGGRIRCHLEHNLANSLSDVIICGYQAQGTPGRLLVDGATSLTISGQSIDVAA
RLHTVGGLSAHADQAELLHWYRHFNDSPPIVLVHGESEAQQVLLAALNEDATNAPAHSVIAEQGDCLDLTQLPKFVWLAN
AINSESQDD
>Mature_489_residues
MQMTLSFLGATQEVTGSCHLLNIDGQQVLLDCGLIQGSKADVLRNHEPFAFSPSQIHAVVLSHAHIDHSGRLPLLVRSGF
TGPIYSHKATVELCAVMLKDAAMLQARDIDRLNKKRVKNDLPLLEPLFDDADVDRVMQQFVALDYGESTQVIPHLNVCLS
DAGHILGSAVVELWLGEGTSTKKLVFSGDLGREGMPILDDPSLIDTADLVLMESTYGNRLHRSWNDTLEELKSIFARTID
QSRGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRVCLDSPMAIRATQIYVENYALMDEDFKRFTRLSPGKHPLLSNVD
FIDTTEESMELNHIHQGLIIIAGSGMCNGGRIRCHLEHNLANSLSDVIICGYQAQGTPGRLLVDGATSLTISGQSIDVAA
RLHTVGGLSAHADQAELLHWYRHFNDSPPIVLVHGESEAQQVLLAALNEDATNAPAHSVIAEQGDCLDLTQLPKFVWLAN
AINSESQDD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=460, Percent_Identity=26.5217391304348, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI33300633, Length=462, Percent_Identity=24.8917748917749, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32564696, Length=493, Percent_Identity=24.5436105476673, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32566029, Length=452, Percent_Identity=25.2212389380531, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323307, Length=455, Percent_Identity=25.7142857142857, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24648013, Length=453, Percent_Identity=26.4900662251656, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21358523, Length=475, Percent_Identity=24.8421052631579, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 53861; Mature: 53861

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMTLSFLGATQEVTGSCHLLNIDGQQVLLDCGLIQGSKADVLRNHEPFAFSPSQIHAVV
CCEEEEHHCCCHHCCCCEEEEECCCCEEEEEECCCCCCCHHHHCCCCCCCCCHHHHEEEE
LSHAHIDHSGRLPLLVRSGFTGPIYSHKATVELCAVMLKDAAMLQARDIDRLNKKRVKND
EEHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPLLEPLFDDADVDRVMQQFVALDYGESTQVIPHLNVCLSDAGHILGSAVVELWLGEGTS
CCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
TKKLVFSGDLGREGMPILDDPSLIDTADLVLMESTYGNRLHRSWNDTLEELKSIFARTID
CCEEEEECCCCCCCCCCCCCCCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
QSRGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRVCLDSPMAIRATQIYVENYALMDE
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEEEEEEEHHHHH
DFKRFTRLSPGKHPLLSNVDFIDTTEESMELNHIHQGLIIIAGSGMCNGGRIRCHLEHNL
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCH
ANSLSDVIICGYQAQGTPGRLLVDGATSLTISGQSIDVAARLHTVGGLSAHADQAELLHW
HCCCCCEEEEEEECCCCCCEEEEECCCEEEECCCCEEEEEEHHHHCCCCCCCCHHHHHHH
YRHFNDSPPIVLVHGESEAQQVLLAALNEDATNAPAHSVIAEQGDCLDLTQLPKFVWLAN
HHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCEECHHHCCHHHHHHH
AINSESQDD
HHCCCCCCC
>Mature Secondary Structure
MQMTLSFLGATQEVTGSCHLLNIDGQQVLLDCGLIQGSKADVLRNHEPFAFSPSQIHAVV
CCEEEEHHCCCHHCCCCEEEEECCCCEEEEEECCCCCCCHHHHCCCCCCCCCHHHHEEEE
LSHAHIDHSGRLPLLVRSGFTGPIYSHKATVELCAVMLKDAAMLQARDIDRLNKKRVKND
EEHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPLLEPLFDDADVDRVMQQFVALDYGESTQVIPHLNVCLSDAGHILGSAVVELWLGEGTS
CCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
TKKLVFSGDLGREGMPILDDPSLIDTADLVLMESTYGNRLHRSWNDTLEELKSIFARTID
CCEEEEECCCCCCCCCCCCCCCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
QSRGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRVCLDSPMAIRATQIYVENYALMDE
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEEEEEEEHHHHH
DFKRFTRLSPGKHPLLSNVDFIDTTEESMELNHIHQGLIIIAGSGMCNGGRIRCHLEHNL
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCH
ANSLSDVIICGYQAQGTPGRLLVDGATSLTISGQSIDVAARLHTVGGLSAHADQAELLHW
HCCCCCEEEEEEECCCCCCEEEEECCCEEEECCCCEEEEEEHHHHCCCCCCCCHHHHHHH
YRHFNDSPPIVLVHGESEAQQVLLAALNEDATNAPAHSVIAEQGDCLDLTQLPKFVWLAN
HHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCEECHHHCCHHHHHHH
AINSESQDD
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA