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The map label for this gene is pth

Identifier: 167625131

GI number: 167625131

Start: 3924503

End: 3925087

Strand: Reverse

Name: pth

Synonym: Shal_3219

Alternate gene names: 167625131

Gene position: 3925087-3924503 (Counterclockwise)

Preceding gene: 167625132

Following gene: 167625130

Centisome position: 75.09

GC content: 45.98

Gene sequence:

>585_bases
ATGAGCAATATTAAACTGATAGTTGGGCTTGCAAACCCCGGCGCGCAGTACGAACGGACTCGTCATAATGCTGGCGCGTG
GTACGTTGAAGAACTCGCTAGAGTCTGTGGCGCCACATTAACATTAGACAGTAAATACTTTGGCATGACGGCGAGAGTCA
CCCTGCATGGCAAAGATGTACGTCTGTTAATTCCGACTACCTTTATGAATTTAAGTGGTAAGTCAGTGGGGGCGTTAGCG
AACTTTTTTCGTATCGCGCCTGAAGAGATATTAGTTGCACACGATGAGCTGGATATGCCACCGGGTGTAGCGAAGTTTAA
GTTGGGTGGTGGTCACGGTGGACATAATGGCCTTAAAGATATCATTGCGAAATTAGCTAATGATAAAGGCTTCTACCGCT
TACGTATTGGCATTGGTCATCCTGGTGATAAGAGTCAGGTGAGTAATTATGTGCTGAGTAAGGCCTCTCCAACGGATCAA
GAGCTAATGGACGCTGCAGTTGATGAAGCTGTCCGTTCAACAGAGGTCTTGTTCAATCAAGATATGGCAAAGGCGATGCA
TAGACTGCATTCTTTTAAGGCATAA

Upstream 100 bases:

>100_bases
GGCAGGCTATTTGAGTGCTAAAATGCCGCGTTTTTAATTTTGTTGTTAGTGTGTTTTATCGACGACAAAACATAAATTAG
GCAAATACAGACTGGGTACT

Downstream 100 bases:

>100_bases
ACAAGTACTTGGAGCATGGCTTCAAGTCATTCATTGATATTAAAGGTAACAATATGGGTTTCAAATGTGGCATCGTAGGC
CTGCCAAACGTTGGTAAATC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDVRLLIPTTFMNLSGKSVGALA
NFFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQVSNYVLSKASPTDQ
ELMDAAVDEAVRSTEVLFNQDMAKAMHRLHSFKA

Sequences:

>Translated_194_residues
MSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDVRLLIPTTFMNLSGKSVGALA
NFFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQVSNYVLSKASPTDQ
ELMDAAVDEAVRSTEVLFNQDMAKAMHRLHSFKA
>Mature_193_residues
SNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDVRLLIPTTFMNLSGKSVGALAN
FFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQVSNYVLSKASPTDQE
LMDAAVDEAVRSTEVLFNQDMAKAMHRLHSFKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=176, Percent_Identity=36.9318181818182, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=67.7083333333333, Blast_Score=249, Evalue=6e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_SHEHH (B0TR35)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675425.1
- ProteinModelPortal:   B0TR35
- SMR:   B0TR35
- GeneID:   5907004
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_3219
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   SHAL458817:SHAL_3219-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21120; Mature: 20988

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDV
CCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCEEEEEEEECCCE
RLLIPTTFMNLSGKSVGALANFFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKD
EEEECEEEECCCCCHHHHHHHHHHCCCHHHEEECCCCCCCCCCEEEEECCCCCCCCCHHH
IIAKLANDKGFYRLRIGIGHPGDKSQVSNYVLSKASPTDQELMDAAVDEAVRSTEVLFNQ
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DMAKAMHRLHSFKA
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDV
CCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCEEEEEEEECCCE
RLLIPTTFMNLSGKSVGALANFFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKD
EEEECEEEECCCCCHHHHHHHHHHCCCHHHEEECCCCCCCCCCEEEEECCCCCCCCCHHH
IIAKLANDKGFYRLRIGIGHPGDKSQVSNYVLSKASPTDQELMDAAVDEAVRSTEVLFNQ
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DMAKAMHRLHSFKA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA