Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 167625124

GI number: 167625124

Start: 3916185

End: 3917435

Strand: Reverse

Name: hemA

Synonym: Shal_3212

Alternate gene names: 167625124

Gene position: 3917435-3916185 (Counterclockwise)

Preceding gene: 167625128

Following gene: 167625123

Centisome position: 74.95

GC content: 46.04

Gene sequence:

>1251_bases
ATGAGCCTTGTAGCAATCGGAATTAACCATAAAACGGCCACGGTCGACCTGCGTGAGAAAGTCGCATTTGCACCAGACAG
AATTCATGATGCCATGAAGAGTCTAGCGTCTTGTACTCAATCGGGCGAAGCCGTCATCATTTCCACCTGTAACCGCACAG
AACTCTACTGTAATAACAGTGAAGCCGCTGATGTCGTCGCTTGGCTGGAAGATTATCATCAACTATCCCATGAAGATGTT
GAACCTTGCTTGTACCAATATAAAGGTCAGGAAGCGGTTAAACATTTAATGCGTGTATCTGCAGGACTCGATTCACTCAT
TTTGGGTGAACCGCAAATTTTAGGTCAAGTGAAGCAATCTTTTGTGAAAGCAAAAGAAGCGGGTACTGTTGCTGCGACAA
TGGATCGCATGTTTCAAAATACCTTTTCAGTCGCCAAAAAAATTCGTACCGAGACTGAAATTGGTGCCGCGGCTGTTTCG
GTAGCCTTTGCCGCGGTGAGCATGGCGAAACATATTTTCTCGTCGCTAAGCACGACTCAAGTATTATTGGTCGGAGCAGG
TGAGACAATAGAGTTAGTTGCGCGTCACTTAAAAGACAATGGTGTTAAAGCCATGGTCGTGGCAAACAGAACGATTTCAC
GTGCAGAAGCCATGTGTGACGAGTTCGGTGCAACAGCAATTACACTCGAACAGATCCCAGATTTTCTCCCTAAGGCCGAT
ATCGTGATATCCTCTACGGCTAGCCCATTACCAATACTTGGTAAAGGCATGGTAGAAAAAGCGCTAAAGCAGCGTCGTCA
TCAACCTATGTTGTTGGTTGATATAGCAGTTCCTCGAGATATCGAGGCTGAAGTTGCGGATCTAGATGATGCATTCCTCT
ATACCGTAGATGATCTGCAAAGCATTATTGAACAGAATATGGCGTCTCGAAGAGAGGCCGCCGAGCAAGCAGAATTAATT
GCAGAAGATCAAGCTTATCAATTTATGGAATGGATCCGCTCACTAGAGTCGGTAGACAGTATCCGTGAATATCGCACTCA
GAGTATGGCGATTAAAGATGAGCTGGTAGAGCGAGCGGTCAACAAGTTGGCCCAAGGTGGTAACAGTGAGCAAGTTTTAC
TGGAGCTAGCCAACAAGCTTACCAACAAACTGATCCATGCGCCGACACAAGCGCTTACCGCTGCGAGTCGACAAGGGGAC
CTGAATTCTCTTGGACAATTAAGAGCTGTGCTTGGACTAGATAAAGACTAA

Upstream 100 bases:

>100_bases
ATTATTATTCGGTTTTGTTAAGCGTATTCTGTTTTTAACAATACCAATTCAGTAGAATGGCACCAATAAATGAGATGCCC
AAGAGTCCAGAACGAGTCAA

Downstream 100 bases:

>100_bases
GGTTAGCGTTTTAATGAAGGACAGTGTGATTCGTAAGCTTGAAGGCTTACTTGAACGTAATGAAGAAGTGTTGGCGCTAC
TGAGCGATGCAAGCATTATT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSLVAIGINHKTATVDLREKVAFAPDRIHDAMKSLASCTQSGEAVIISTCNRTELYCNNSEAADVVAWLEDYHQLSHEDV
EPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQSFVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVS
VAFAAVSMAKHIFSSLSTTQVLLVGAGETIELVARHLKDNGVKAMVVANRTISRAEAMCDEFGATAITLEQIPDFLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQSIIEQNMASRREAAEQAELI
AEDQAYQFMEWIRSLESVDSIREYRTQSMAIKDELVERAVNKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGD
LNSLGQLRAVLGLDKD

Sequences:

>Translated_416_residues
MSLVAIGINHKTATVDLREKVAFAPDRIHDAMKSLASCTQSGEAVIISTCNRTELYCNNSEAADVVAWLEDYHQLSHEDV
EPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQSFVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVS
VAFAAVSMAKHIFSSLSTTQVLLVGAGETIELVARHLKDNGVKAMVVANRTISRAEAMCDEFGATAITLEQIPDFLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQSIIEQNMASRREAAEQAELI
AEDQAYQFMEWIRSLESVDSIREYRTQSMAIKDELVERAVNKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGD
LNSLGQLRAVLGLDKD
>Mature_415_residues
SLVAIGINHKTATVDLREKVAFAPDRIHDAMKSLASCTQSGEAVIISTCNRTELYCNNSEAADVVAWLEDYHQLSHEDVE
PCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQSFVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVSV
AFAAVSMAKHIFSSLSTTQVLLVGAGETIELVARHLKDNGVKAMVVANRTISRAEAMCDEFGATAITLEQIPDFLPKADI
VISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQSIIEQNMASRREAAEQAELIA
EDQAYQFMEWIRSLESVDSIREYRTQSMAIKDELVERAVNKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGDL
NSLGQLRAVLGLDKD

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=55.5023923444976, Blast_Score=460, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SHEHH (B0TR28)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675418.1
- ProteinModelPortal:   B0TR28
- SMR:   B0TR28
- GeneID:   5905574
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_3212
- HOGENOM:   HBG732626
- OMA:   IVANRTY
- ProtClustDB:   PRK00045
- BioCyc:   SHAL458817:SHAL_3212-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45452; Mature: 45321

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 105-105 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVAIGINHKTATVDLREKVAFAPDRIHDAMKSLASCTQSGEAVIISTCNRTELYCNNS
CCEEEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCC
EAADVVAWLEDYHQLSHEDVEPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQS
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHH
FVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVSVAFAAVSMAKHIFSSLSTTQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VLLVGAGETIELVARHLKDNGVKAMVVANRTISRAEAMCDEFGATAITLEQIPDFLPKAD
EEEEECCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCHHEEEHHHHH
SIIEQNMASRREAAEQAELIAEDQAYQFMEWIRSLESVDSIREYRTQSMAIKDELVERAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGDLNSLGQLRAVLGLDKD
HHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLVAIGINHKTATVDLREKVAFAPDRIHDAMKSLASCTQSGEAVIISTCNRTELYCNNS
CEEEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCC
EAADVVAWLEDYHQLSHEDVEPCLYQYKGQEAVKHLMRVSAGLDSLILGEPQILGQVKQS
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHH
FVKAKEAGTVAATMDRMFQNTFSVAKKIRTETEIGAAAVSVAFAAVSMAKHIFSSLSTTQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VLLVGAGETIELVARHLKDNGVKAMVVANRTISRAEAMCDEFGATAITLEQIPDFLPKAD
EEEEECCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVADLDDAFLYTVDDLQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCHHEEEHHHHH
SIIEQNMASRREAAEQAELIAEDQAYQFMEWIRSLESVDSIREYRTQSMAIKDELVERAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGGNSEQVLLELANKLTNKLIHAPTQALTAASRQGDLNSLGQLRAVLGLDKD
HHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA