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The map label for this gene is folP [H]

Identifier: 167625065

GI number: 167625065

Start: 3849355

End: 3850143

Strand: Reverse

Name: folP [H]

Synonym: Shal_3153

Alternate gene names: 167625065

Gene position: 3850143-3849355 (Counterclockwise)

Preceding gene: 167625066

Following gene: 167625064

Centisome position: 73.66

GC content: 48.54

Gene sequence:

>789_bases
ATGGGGATCCTCAATGTCACGCCTGACTCATTTTCTGATGGCGGTGAGTACTCATCGTTCGAAACCGCCTGCCGACAAGC
CGATCTAATGGTGGCTCAAGGGGCAAAGATTATCGATATCGGTGGCGAGTCGACCCGTCCAGGCGCGAAAGAGGTGTCTG
TTGAAGATGAGCTGGCTCGAGTGCTTCCGTTAATCGATTACGTTAGCCGCACCCATAAGGTGTGGATCTCGATAGATACC
AGTAAGGCGACCGTGATGAAGGCGGCTGTTGAGGCAGGGGCACATCTAATTAATGACGTTAGAGCACTGCAAGAGGCTGG
AGCATTAGACGTTGCCGCCCAATTGGGTGTGCCAGTTTGCCTGATGCATATGCAGGGGCAGCCAAGAACGATGCAAGATG
CCCCTCATTATGAAGATATTATCAGTGACATTAGCCAGTTTTTTTGTGAACGCATCGATGCTTGTCTTGCGGCAGGTATA
AGGCGTGAGCAAATCGTGCTCGATCCAGGCTTTGGTTTTGGTAAATCTCTCGCTCACAATTATGAGCTGCTTAATCGAAT
GCCTGAGCTATTGCAATTGGGCTTACCTGTTCTTGCGGGTTTATCGCGTAAGAGCATGTTTGGACAGTTACTCGGACGTG
AGGTATCACAAAGACTCAGTGCCACACTTACTGGTAATATGTTGGCAATACAAGCAGGTGCAAAAATATTGCGAGTGCAT
GATGTGCAAGAAACCAGCGATATGCTCGCGGTTTTAAGTGCAACAAGGAATTATAACGCTTTAAGCTAA

Upstream 100 bases:

>100_bases
TAAAGAAAACCCCGTCTAGGGGTTTTCTTGTTTACGGAACTTTATTTTGTCTATATTAACCAGTGGTCATACATCTCTTG
AATTGAACTCTCCCGTCATT

Downstream 100 bases:

>100_bases
CATTAAGTGTTCAGCTAAAGTCAGTGTTTTTACGGTAGGATTGAAGGATTCAAACTACCGAGTGATAAGTCTGGAGTTAA
AGTGAAGCAAAGACAATTTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MGILNVTPDSFSDGGEYSSFETACRQADLMVAQGAKIIDIGGESTRPGAKEVSVEDELARVLPLIDYVSRTHKVWISIDT
SKATVMKAAVEAGAHLINDVRALQEAGALDVAAQLGVPVCLMHMQGQPRTMQDAPHYEDIISDISQFFCERIDACLAAGI
RREQIVLDPGFGFGKSLAHNYELLNRMPELLQLGLPVLAGLSRKSMFGQLLGREVSQRLSATLTGNMLAIQAGAKILRVH
DVQETSDMLAVLSATRNYNALS

Sequences:

>Translated_262_residues
MGILNVTPDSFSDGGEYSSFETACRQADLMVAQGAKIIDIGGESTRPGAKEVSVEDELARVLPLIDYVSRTHKVWISIDT
SKATVMKAAVEAGAHLINDVRALQEAGALDVAAQLGVPVCLMHMQGQPRTMQDAPHYEDIISDISQFFCERIDACLAAGI
RREQIVLDPGFGFGKSLAHNYELLNRMPELLQLGLPVLAGLSRKSMFGQLLGREVSQRLSATLTGNMLAIQAGAKILRVH
DVQETSDMLAVLSATRNYNALS
>Mature_261_residues
GILNVTPDSFSDGGEYSSFETACRQADLMVAQGAKIIDIGGESTRPGAKEVSVEDELARVLPLIDYVSRTHKVWISIDTS
KATVMKAAVEAGAHLINDVRALQEAGALDVAAQLGVPVCLMHMQGQPRTMQDAPHYEDIISDISQFFCERIDACLAAGIR
REQIVLDPGFGFGKSLAHNYELLNRMPELLQLGLPVLAGLSRKSMFGQLLGREVSQRLSATLTGNMLAIQAGAKILRVHD
VQETSDMLAVLSATRNYNALS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=255, Percent_Identity=55.6862745098039, Blast_Score=314, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6324073, Length=314, Percent_Identity=29.9363057324841, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28326; Mature: 28195

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILNVTPDSFSDGGEYSSFETACRQADLMVAQGAKIIDIGGESTRPGAKEVSVEDELAR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHH
VLPLIDYVSRTHKVWISIDTSKATVMKAAVEAGAHLINDVRALQEAGALDVAAQLGVPVC
HHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEE
LMHMQGQPRTMQDAPHYEDIISDISQFFCERIDACLAAGIRREQIVLDPGFGFGKSLAHN
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
YELLNRMPELLQLGLPVLAGLSRKSMFGQLLGREVSQRLSATLTGNMLAIQAGAKILRVH
HHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
DVQETSDMLAVLSATRNYNALS
CHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GILNVTPDSFSDGGEYSSFETACRQADLMVAQGAKIIDIGGESTRPGAKEVSVEDELAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHH
VLPLIDYVSRTHKVWISIDTSKATVMKAAVEAGAHLINDVRALQEAGALDVAAQLGVPVC
HHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEE
LMHMQGQPRTMQDAPHYEDIISDISQFFCERIDACLAAGIRREQIVLDPGFGFGKSLAHN
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
YELLNRMPELLQLGLPVLAGLSRKSMFGQLLGREVSQRLSATLTGNMLAIQAGAKILRVH
HHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
DVQETSDMLAVLSATRNYNALS
CHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]