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The map label for this gene is dxr

Identifier: 167624889

GI number: 167624889

Start: 3619685

End: 3620875

Strand: Reverse

Name: dxr

Synonym: Shal_2975

Alternate gene names: 167624889

Gene position: 3620875-3619685 (Counterclockwise)

Preceding gene: 167624890

Following gene: 167624888

Centisome position: 69.27

GC content: 45.51

Gene sequence:

>1191_bases
ATGCAAAACATGGTGATTTTAGGCGCGACGGGCTCTATCGGTGCCAGCACCTTGAGTGTTGTAGCGTGTAATCCAGAGCA
ATACAAGGTATATGCTCTAGTGGCGAATACCAATGTCGCAAAGATGCTGGAGATCTGTATTGCGCATCAGCCTAAAATTG
CCCATATGGTCGATGCACAAGCAGCCCAATCGCTTAAGCAACAACTTCCAAGTCATTTAGATATCGAAGTGACGACGGGT
GAAGATGAACTTTTATCACTCGTAAGTAGCAGTGATGTTGATACGGTTATGGCGGCCATTGTTGGCGCAGCGGGCTTACC
TTCGACACTCGCCGCCGTTAACGCGGGTAAGCGCGTGTTGTTAGCCAATAAAGAATCGCTGGTTATGTCGGGGCAGCTGT
TTATTGAAGCTATGCAAAAATCGGGCGCACAAGTGCTACCCGTCGATAGTGAGCATAACGCTATTTTCCAGTGTTTATCT
GAACGCTCTCAACTTGAGATTGGTCGCTGCGATCTAGCTGGTGCAGGGGTTTCTCATATCTTGCTGACAGGTTCTGGTGG
CCCATTTTTAACTTCTGATTTGGCAACGCTATCGGCAATGACCCCGGAGCAGGCTTGTAAGCACCCTAATTGGTCAATGG
GGCGCAAGATCTCTGTTGATTCGGCGACCATGATGAATAAAGGCCTTGAGTATATTGAGGCGCGTTGGCTGTTTAACGCT
AGCTCCGAACAGTTAAAAGTGGTTATTCATCCTCAAAGTGTCATTCACTCCATGGTACAGTATCGCGATGGTTCGGTATT
GGCGCAGTTAGGTAATCCTGATATGCGTACACCTATTGCTCATTGTATGGCTTTTCCACAGAGAATTAACTCAGGAGTTG
AACCTTTAGACTTTTTTAAAGTCGGACAGTTAAGCTTCTTAGAACCTGATTTTACTCGTTTCCCTTGTTTAGCGTTGGCA
ATAGAGGCTTGTAAACAAGGGCAAGAAGCGACAACCGTATTAAATGCTGCCAACGAGATCTCCGTACAGGCATTTTTAGA
TGGCAAGATTCGATTTACCGATATAGCAAGAATAAACGAACAGAGCTTAATGAATACGGCGACGCATCCATTAAACAGTA
TTGATGATATCTTGGCGTTAGATTTTCAAAGCCGTCAATCTACATTAGACGCCATCACTAAGCTGAATTAG

Upstream 100 bases:

>100_bases
ATCCTACCGGGTCACGGTGGCGTATTAGATAGAATCGATAGCCTAACGGCTGCTCTACCTGTATTCACATTAATCTATAT
AGCTTTTTGGATGTAACTAA

Downstream 100 bases:

>100_bases
TTCAGAGGAAAGGAATGATCGATTTTTTATGGAACCTAGGTTCCTTTATTGTTGCCTTAGGGATCTTAATTGCAGCCCAT
GAATACGGGCACTTTTGGGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQNMVILGATGSIGASTLSVVACNPEQYKVYALVANTNVAKMLEICIAHQPKIAHMVDAQAAQSLKQQLPSHLDIEVTTG
EDELLSLVSSSDVDTVMAAIVGAAGLPSTLAAVNAGKRVLLANKESLVMSGQLFIEAMQKSGAQVLPVDSEHNAIFQCLS
ERSQLEIGRCDLAGAGVSHILLTGSGGPFLTSDLATLSAMTPEQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
SSEQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMAFPQRINSGVEPLDFFKVGQLSFLEPDFTRFPCLALA
IEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIARINEQSLMNTATHPLNSIDDILALDFQSRQSTLDAITKLN

Sequences:

>Translated_396_residues
MQNMVILGATGSIGASTLSVVACNPEQYKVYALVANTNVAKMLEICIAHQPKIAHMVDAQAAQSLKQQLPSHLDIEVTTG
EDELLSLVSSSDVDTVMAAIVGAAGLPSTLAAVNAGKRVLLANKESLVMSGQLFIEAMQKSGAQVLPVDSEHNAIFQCLS
ERSQLEIGRCDLAGAGVSHILLTGSGGPFLTSDLATLSAMTPEQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
SSEQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMAFPQRINSGVEPLDFFKVGQLSFLEPDFTRFPCLALA
IEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIARINEQSLMNTATHPLNSIDDILALDFQSRQSTLDAITKLN
>Mature_396_residues
MQNMVILGATGSIGASTLSVVACNPEQYKVYALVANTNVAKMLEICIAHQPKIAHMVDAQAAQSLKQQLPSHLDIEVTTG
EDELLSLVSSSDVDTVMAAIVGAAGLPSTLAAVNAGKRVLLANKESLVMSGQLFIEAMQKSGAQVLPVDSEHNAIFQCLS
ERSQLEIGRCDLAGAGVSHILLTGSGGPFLTSDLATLSAMTPEQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
SSEQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMAFPQRINSGVEPLDFFKVGQLSFLEPDFTRFPCLALA
IEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIARINEQSLMNTATHPLNSIDDILALDFQSRQSTLDAITKLN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=59.3434343434343, Blast_Score=454, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_SHEHH (B0TP77)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675183.1
- ProteinModelPortal:   B0TP77
- SMR:   B0TP77
- GeneID:   5906658
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2975
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   SHAL458817:SHAL_2975-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42579; Mature: 42579

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: BINDING 124-124 BINDING 151-151 BINDING 185-185 BINDING 208-208 BINDING 230-230

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNMVILGATGSIGASTLSVVACNPEQYKVYALVANTNVAKMLEICIAHQPKIAHMVDAQ
CCCEEEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHH
AAQSLKQQLPSHLDIEVTTGEDELLSLVSSSDVDTVMAAIVGAAGLPSTLAAVNAGKRVL
HHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHCCCCEEE
LANKESLVMSGQLFIEAMQKSGAQVLPVDSEHNAIFQCLSERSQLEIGRCDLAGAGVSHI
EECCCCCEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LLTGSGGPFLTSDLATLSAMTPEQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
EEECCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHEEECC
SSEQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMAFPQRINSGVEPLDFFK
CCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHC
VGQLSFLEPDFTRFPCLALAIEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIARINE
CCCEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCEEEEEHHHCCH
QSLMNTATHPLNSIDDILALDFQSRQSTLDAITKLN
HHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNMVILGATGSIGASTLSVVACNPEQYKVYALVANTNVAKMLEICIAHQPKIAHMVDAQ
CCCEEEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHH
AAQSLKQQLPSHLDIEVTTGEDELLSLVSSSDVDTVMAAIVGAAGLPSTLAAVNAGKRVL
HHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHCCCCEEE
LANKESLVMSGQLFIEAMQKSGAQVLPVDSEHNAIFQCLSERSQLEIGRCDLAGAGVSHI
EECCCCCEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LLTGSGGPFLTSDLATLSAMTPEQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
EEECCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHEEECC
SSEQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMAFPQRINSGVEPLDFFK
CCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHC
VGQLSFLEPDFTRFPCLALAIEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIARINE
CCCEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCEEEEEHHHCCH
QSLMNTATHPLNSIDDILALDFQSRQSTLDAITKLN
HHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA