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The map label for this gene is pgcA [H]

Identifier: 167624727

GI number: 167624727

Start: 3418187

End: 3419920

Strand: Reverse

Name: pgcA [H]

Synonym: Shal_2810

Alternate gene names: 167624727

Gene position: 3419920-3418187 (Counterclockwise)

Preceding gene: 167624729

Following gene: 167624720

Centisome position: 65.43

GC content: 51.44

Gene sequence:

>1734_bases
ATGGATACCCAATTAGCATTGAGAGTCAAACACTGGATGGCAACCGATCCCGACTCTTCGAGGCGTCAGGAGCTACAAGC
CCTAATAGACTCAGATGATGGCGCTGAGCTTGAAGCGCGTTTTGCGGGGCGACTCGCATTTGGTACCGCGGGATTACGTG
GCGTCGTGGGCGCGGGGCCGACTCGAATGAATCGATTAGTGATCCAGCAAACTTCTGCGGGTTTAGCATCATACCTAAAA
GCACAAATTAGTGACGTATCAAGCCGCGGCGTAGTGATTGGTTATGACGGTCGCCATGACTCGAAGCAATTCGCCCATGA
CGCCGCCTGCGTATTAACGGCGATGGGAATTAAAGTCTATCTCACAGCAAATGTTGCTGCGACGCCGCTGTTGGCCTTTG
GTGTGCTTCACCTTGGCTGCGCAGCGGGTGTTGTGGTCACCGCGAGTCATAATCCGCCGCAATATAACGGCTACAAGGTC
TATTGGGGCAATGGCGCGCAGATCATTCCTCCCCACGACTCGGGTATCGCGGCTTGTATCGATAAAGCTGCGACCGAGGC
TATTCCATTGTTGGAGATCCAGCAGGCCAAGGCCTCAGGCCTGCTGGTCATGCTAGAGGATGATTTTTATGATGCTTATC
GCCAAGGTGTAAAGCAGGCGGCAGTATTGCAAAATCATACTCAGCCAGAGTCTGTCAGTTTGGCTTACACGGCCATGCAT
GGCGTGGGTAACGCGATGGCGCTTAATGTGCTGAAAGATGCCGGATTCACAAAAGTTTATTCAGTTGCCGAGCAGGCGTT
GCCCGATGGTGATTTCCCAACGGTGAACTTTCCTAACCCCGAAGAGAAAGGGGCGATGGATAGGGTGATAGCCGAGGCCA
AAAAGCATAACGCTATGCTTGCCTGCGCTAACGATCCCGATGCCGACCGTTTCGCCGTTGCGGTGCGAACCTATGATGGT
GAGTATCAGATGCTTACTGGCGACCAAGTTGGTGTGTTATTTGGCCATTACCTATTAACCCATGCCAGTGATGATCAGCG
CTTAACTTGCACCACGATTGTGTCATCGAGTTTATTGTCAAGGGTCGCACAGAGCCTCAATGCGACTTGCCTAACAACTT
TAACCGGTTTTAAGTGGCTGACTAATGTCGGCATGAGTGAAGAGACAGACGATAACCGCTTCCTATTTGCCTACGAAGAG
GCGCTCGGTTACACCGTTGGCTCTATGGTGTGGGATAAAGATGGTTTATCGGCACTGGTCGCATTTGCTCAGTTAACCGC
TGAGCTTACCAGCCAAGGGCAAACTATTTGGGACCGTCTTGAAGCCATCTATCGTGAACATGGTTTTCATCTCAACGCCC
AGGTAAGTATTGCCCTTAAACCGACGACGCCAAATATCGGCGCCTATTTACGTGAGCATCCCCCCGTTGAGATAGCAGGA
CATAAGGTGGTCTCGACTGATGATATCAGTATTGGTAAGCGCTTCTTTTCTGGTGGGAGTGCCGATGGCACAGAAGAAGA
GATCGCGCTACCCGCTAGTGATGTGCTGATTTATCGTCTTGAAAATGGTGCTCGAGTGATCGTCAGACCGTCGGGCACTG
AACCTAAGATTAAGTGTTACTACGAGGTGGTAGAAGCGATGTCGTCAGAAGACACATTAGTCAGCGCGCAGCAAAGAGCT
CAATCGACTATGGATGATTTTATCGCTGCGCATCAGGCGGCGCTACCGAAGTAG

Upstream 100 bases:

>100_bases
CTAGGCTTAGTGTTTAGTAATGTTTTACAGTCGTAATGTGCTGCGCTTGGTTCAATATTCTTTAGCGGCCATTACCCATC
GATAGTAAATGGAGCGAGTT

Downstream 100 bases:

>100_bases
GATCTATTAGATATGCAGGACTAGTCGGCTTTGTTGACTGACTGGCGAGTCGCTCACATGGGGAGGGGCGGCAAATAGGG
ACTTTCTGTCACGGTAGGTG

Product: phosphoglucomutase/phosphomannomutase subunit alpha/beta

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MDTQLALRVKHWMATDPDSSRRQELQALIDSDDGAELEARFAGRLAFGTAGLRGVVGAGPTRMNRLVIQQTSAGLASYLK
AQISDVSSRGVVIGYDGRHDSKQFAHDAACVLTAMGIKVYLTANVAATPLLAFGVLHLGCAAGVVVTASHNPPQYNGYKV
YWGNGAQIIPPHDSGIAACIDKAATEAIPLLEIQQAKASGLLVMLEDDFYDAYRQGVKQAAVLQNHTQPESVSLAYTAMH
GVGNAMALNVLKDAGFTKVYSVAEQALPDGDFPTVNFPNPEEKGAMDRVIAEAKKHNAMLACANDPDADRFAVAVRTYDG
EYQMLTGDQVGVLFGHYLLTHASDDQRLTCTTIVSSSLLSRVAQSLNATCLTTLTGFKWLTNVGMSEETDDNRFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELTSQGQTIWDRLEAIYREHGFHLNAQVSIALKPTTPNIGAYLREHPPVEIAG
HKVVSTDDISIGKRFFSGGSADGTEEEIALPASDVLIYRLENGARVIVRPSGTEPKIKCYYEVVEAMSSEDTLVSAQQRA
QSTMDDFIAAHQAALPK

Sequences:

>Translated_577_residues
MDTQLALRVKHWMATDPDSSRRQELQALIDSDDGAELEARFAGRLAFGTAGLRGVVGAGPTRMNRLVIQQTSAGLASYLK
AQISDVSSRGVVIGYDGRHDSKQFAHDAACVLTAMGIKVYLTANVAATPLLAFGVLHLGCAAGVVVTASHNPPQYNGYKV
YWGNGAQIIPPHDSGIAACIDKAATEAIPLLEIQQAKASGLLVMLEDDFYDAYRQGVKQAAVLQNHTQPESVSLAYTAMH
GVGNAMALNVLKDAGFTKVYSVAEQALPDGDFPTVNFPNPEEKGAMDRVIAEAKKHNAMLACANDPDADRFAVAVRTYDG
EYQMLTGDQVGVLFGHYLLTHASDDQRLTCTTIVSSSLLSRVAQSLNATCLTTLTGFKWLTNVGMSEETDDNRFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELTSQGQTIWDRLEAIYREHGFHLNAQVSIALKPTTPNIGAYLREHPPVEIAG
HKVVSTDDISIGKRFFSGGSADGTEEEIALPASDVLIYRLENGARVIVRPSGTEPKIKCYYEVVEAMSSEDTLVSAQQRA
QSTMDDFIAAHQAALPK
>Mature_577_residues
MDTQLALRVKHWMATDPDSSRRQELQALIDSDDGAELEARFAGRLAFGTAGLRGVVGAGPTRMNRLVIQQTSAGLASYLK
AQISDVSSRGVVIGYDGRHDSKQFAHDAACVLTAMGIKVYLTANVAATPLLAFGVLHLGCAAGVVVTASHNPPQYNGYKV
YWGNGAQIIPPHDSGIAACIDKAATEAIPLLEIQQAKASGLLVMLEDDFYDAYRQGVKQAAVLQNHTQPESVSLAYTAMH
GVGNAMALNVLKDAGFTKVYSVAEQALPDGDFPTVNFPNPEEKGAMDRVIAEAKKHNAMLACANDPDADRFAVAVRTYDG
EYQMLTGDQVGVLFGHYLLTHASDDQRLTCTTIVSSSLLSRVAQSLNATCLTTLTGFKWLTNVGMSEETDDNRFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELTSQGQTIWDRLEAIYREHGFHLNAQVSIALKPTTPNIGAYLREHPPVEIAG
HKVVSTDDISIGKRFFSGGSADGTEEEIALPASDVLIYRLENGARVIVRPSGTEPKIKCYYEVVEAMSSEDTLVSAQQRA
QSTMDDFIAAHQAALPK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=575, Percent_Identity=34.0869565217391, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI31377548, Length=573, Percent_Identity=32.2862129144852, Blast_Score=285, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71993870, Length=557, Percent_Identity=34.4703770197487, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI71993878, Length=314, Percent_Identity=37.2611464968153, Blast_Score=210, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323934, Length=582, Percent_Identity=35.3951890034364, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI20129809, Length=573, Percent_Identity=36.3001745200698, Blast_Score=328, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24651977, Length=557, Percent_Identity=35.7271095152603, Blast_Score=310, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24653722, Length=606, Percent_Identity=30.5280528052805, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 62169; Mature: 62169

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQLALRVKHWMATDPDSSRRQELQALIDSDDGAELEARFAGRLAFGTAGLRGVVGAGP
CCCCEEEEEEHHCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHCEEEECCCCCCCCCCCCH
TRMNRLVIQQTSAGLASYLKAQISDVSSRGVVIGYDGRHDSKQFAHDAACVLTAMGIKVY
HHHHEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEE
LTANVAATPLLAFGVLHLGCAAGVVVTASHNPPQYNGYKVYWGNGAQIIPPHDSGIAACI
EEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCCHHHHH
DKAATEAIPLLEIQQAKASGLLVMLEDDFYDAYRQGVKQAAVLQNHTQPESVSLAYTAMH
HHHHHHCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHH
GVGNAMALNVLKDAGFTKVYSVAEQALPDGDFPTVNFPNPEEKGAMDRVIAEAKKHNAML
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEE
ACANDPDADRFAVAVRTYDGEYQMLTGDQVGVLFGHYLLTHASDDQRLTCTTIVSSSLLS
EECCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHEECCCCCEEEHHHHHHHHHHH
RVAQSLNATCLTTLTGFKWLTNVGMSEETDDNRFLFAYEEALGYTVGSMVWDKDGLSALV
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCHHHHHEECCCCHHHHH
AFAQLTAELTSQGQTIWDRLEAIYREHGFHLNAQVSIALKPTTPNIGAYLREHPPVEIAG
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHCCCCEEECC
HKVVSTDDISIGKRFFSGGSADGTEEEIALPASDVLIYRLENGARVIVRPSGTEPKIKCY
CEEEECCCHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCEEEEECCCCCCHHHHH
YEVVEAMSSEDTLVSAQQRAQSTMDDFIAAHQAALPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDTQLALRVKHWMATDPDSSRRQELQALIDSDDGAELEARFAGRLAFGTAGLRGVVGAGP
CCCCEEEEEEHHCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHCEEEECCCCCCCCCCCCH
TRMNRLVIQQTSAGLASYLKAQISDVSSRGVVIGYDGRHDSKQFAHDAACVLTAMGIKVY
HHHHEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEE
LTANVAATPLLAFGVLHLGCAAGVVVTASHNPPQYNGYKVYWGNGAQIIPPHDSGIAACI
EEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCCHHHHH
DKAATEAIPLLEIQQAKASGLLVMLEDDFYDAYRQGVKQAAVLQNHTQPESVSLAYTAMH
HHHHHHCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHH
GVGNAMALNVLKDAGFTKVYSVAEQALPDGDFPTVNFPNPEEKGAMDRVIAEAKKHNAML
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEE
ACANDPDADRFAVAVRTYDGEYQMLTGDQVGVLFGHYLLTHASDDQRLTCTTIVSSSLLS
EECCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHEECCCCCEEEHHHHHHHHHHH
RVAQSLNATCLTTLTGFKWLTNVGMSEETDDNRFLFAYEEALGYTVGSMVWDKDGLSALV
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCHHHHHEECCCCHHHHH
AFAQLTAELTSQGQTIWDRLEAIYREHGFHLNAQVSIALKPTTPNIGAYLREHPPVEIAG
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHCCCCEEECC
HKVVSTDDISIGKRFFSGGSADGTEEEIALPASDVLIYRLENGARVIVRPSGTEPKIKCY
CEEEECCCHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCEEEEECCCCCCHHHHH
YEVVEAMSSEDTLVSAQQRAQSTMDDFIAAHQAALPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]