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The map label for this gene is lon [H]

Identifier: 167624684

GI number: 167624684

Start: 3355788

End: 3358145

Strand: Reverse

Name: lon [H]

Synonym: Shal_2766

Alternate gene names: 167624684

Gene position: 3358145-3355788 (Counterclockwise)

Preceding gene: 167624685

Following gene: 167624683

Centisome position: 64.25

GC content: 45.8

Gene sequence:

>2358_bases
ATGACCCTAGAGCGTGATGCGCGAATCGAACTACCCGTACTACCACTAAGAGATGTGGTGGTTTATCCCCACATGGTAAT
TCCGTTATTCGTCGGTCGAGAGAAATCAATTCGTTGCTTAGAGAAAGCAATGGAGCAAGGTAAACAAATCATTTTAGTCG
CCCAGCGTGATGCTGAGTTAGACGACCCAACAAGTGATGATATTTTTGATGTCGGTACAGTCGCATCGATATTACAGCTA
CTTAAGTTGCCAGATGGCACGGTAAAGGTATTAGTTGAAGGCGGACAGCGTGCTCGCATCGATAACTATTCAGAGCAAGA
AGAGATCTTCCAAGCTACTGCCCACTATCTTGAATCTGAGCCATTGTCAGAGAAAGAAGAGGAAGTCCTTGTTCGTTCTG
CTGTTGGACAATTTGAAGGCTATATCAAGCTTAATAAGAAGATCCCACCAGAGGTCTTGACCTCGCTATCGGGTATTGAC
GAAGCTGCAAGACTTGCCGACACTATGGCCGCGCATATGCCACTTAAGCTAGAAGACAAACAGTCTGTGCTTGAGATGGT
CAATGTTAGCGAGCGTATCGAATATTTGATGGCGATGATGGAATCGGAGATTGACCTACTTCAGGTTGAGAAGCGTATTC
GTAGCCGTGTTAAAAAGCAGATGGAGAAGAGTCAGCGCGAGTACTATTTGAATGAGCAAATGAAAGCGATTCAAAAAGAG
CTGGGTGATATTGACGAATCTCACGATGAATTTGAAAGCTTAGCGAAAAAGATTGAAGAGGCGCAGATGCCTACTGAGGC
GAAAGAAAAAGCCTCTGCTGAGTTAAATAAGCTAAAAATGATGTCACCTATGTCCGCTGAAGCGACCGTGGTGAGAAGTT
ATGTTGAATGGATGGTGTCAGTGCCTTGGCACAAGCGCTCGAAAATCAAGCGTGACTTAGCTAAAGCACAAGATGTCTTA
GATACCGACCACTTTGGTCTTGAAAAAGTCAAAGAACGCATTTTAGAGTATCTAGCGGTACAAAGCCGAGTTAAACAGCT
TAAAGGTCCGATTCTGTGTTTAGTTGGACCACCAGGTGTGGGTAAAACCTCACTGGGTCAGTCAATTGCAAAAGCAACGG
GTCGTAAGTATGTGCGTGTTGCGTTAGGCGGCGTGCGTGATGAAGCGGAGATCCGTGGTCACCGTCGTACTTATATTGGT
TCTATGCCAGGTAAAGTCATTCAAAAAATGTCTAAAGTGGGCGTTAAAAACCCACTGTTCTTGCTCGATGAAATCGACAA
GATGAGTAGTGATATGCGTGGCGACCCGGCTTCAGCCCTGCTTGAGGTGTTAGACCCTGAGCAAAACTCAGCGTTTAGCG
ATCACTACATGGAAGTCGATTATGACTTGTCTGATGTGATGTTCGTGGCAACGTCAAACTCGATGAATATTCCAGGTCCT
CTATTAGACCGTATGGAAGTGATCCGTTTATCGGGTTACACCGAAGATGAGAAGCTTAATATCGCAAAGCAGCATCTGCT
GCCGAAGCAGATTGAGCGCAATGGTTTAAAAGCCAAAGAAGTGACGGTTGATGATAGTGCCATTATCGGTATTATTCGTT
ACTACACTCGTGAAGCGGGCGTACGTGCACTTGAGCGTGAGCTATCAAAAATCTGTCGTAAAGTGGTTAAACAAATTCTG
CTTGATAAGAGTATTAAGCATGTTGAAGTTAACCAAGACAACCTTAAGTCATTCCTAGGCGTACAACGCTGTGACTACGG
TAAAGCTGAGTCTAATAACCAGATTGGTCAAGTTACCGGTTTGGCGTGGACCGAAGTGGGTGGCGATCTGCTTACCATCG
AAGCCACCTCAGTGCCTGGTAAGGGTAAGCTGACGTATACCGGCTCACTTGGCGATGTGATGCAAGAATCGATTCAAGCG
GCAATGACGGTTGTGCGTGCTCGTGCAGAGCAATTGGGTATTAACCCCGACTTTTACGAGAAGCGTGATATTCACGTCCA
CGTACCAGAGGGCGCGACACCGAAAGATGGTCCATCAGCAGGTGCGGCTATGTGTACTGCGCTAGTATCTAGCCTAACGG
GCAACCCTGTTCGTGCTGACGTGGCAATGACAGGTGAAATAACCCTTCGTGGTGAAGTATTACCGATTGGTGGATTGAAA
GAAAAACTATTGGCCGCACATCGTGGCGGTACGAAAGTTGTTCTAATTCCAAAGGAAAATGAACGTGATTTGGAAGAAAT
TCCACAAAATGTCATTGCCGATCTAAAGATTTATCCCGTGAAATGGGTCGATGAAGTACTTAAGTTGGCGCTAGAGCGAC
CAGTTGAAGGCTTCGAAGTAGTAGAAAACGTGGACTAA

Upstream 100 bases:

>100_bases
CCTTTTTTGTACACTTATTTAATTAATTGTTTTTCGGCATTGAATCCTATCTAATCACCCCAATATACTCATAAGTAATC
ATAAAAAACGGAATCGAGCT

Downstream 100 bases:

>100_bases
CGCAATAAATTGTAGGATTGCTTTAAAAAAACAGTAAAAAGGGGCTTACCTAAGTATCAAGCTGTGGTAGCCTAAGTCTG
TGGAGAGTCAGTCGCTCCAG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MTLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMEQGKQIILVAQRDAELDDPTSDDIFDVGTVASILQL
LKLPDGTVKVLVEGGQRARIDNYSEQEEIFQATAHYLESEPLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
LGDIDESHDEFESLAKKIEEAQMPTEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVSVPWHKRSKIKRDLAKAQDVL
DTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAGVRALERELSKICRKVVKQIL
LDKSIKHVEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEVVENVD

Sequences:

>Translated_785_residues
MTLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMEQGKQIILVAQRDAELDDPTSDDIFDVGTVASILQL
LKLPDGTVKVLVEGGQRARIDNYSEQEEIFQATAHYLESEPLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
LGDIDESHDEFESLAKKIEEAQMPTEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVSVPWHKRSKIKRDLAKAQDVL
DTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAGVRALERELSKICRKVVKQIL
LDKSIKHVEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEVVENVD
>Mature_784_residues
TLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMEQGKQIILVAQRDAELDDPTSDDIFDVGTVASILQLL
KLPDGTVKVLVEGGQRARIDNYSEQEEIFQATAHYLESEPLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGIDE
AARLADTMAAHMPLKLEDKQSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKEL
GDIDESHDEFESLAKKIEEAQMPTEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVSVPWHKRSKIKRDLAKAQDVLD
TDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGS
MPGKVIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAGVRALERELSKICRKVVKQILL
DKSIKHVEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAA
MTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEVVENVD

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=666, Percent_Identity=42.042042042042, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI21396489, Length=624, Percent_Identity=41.1858974358974, Blast_Score=495, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=81.6901408450704, Blast_Score=1300, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=40.5819295558959, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=789, Percent_Identity=33.5868187579214, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=723, Percent_Identity=37.7593360995851, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=43.5483870967742, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=43.5483870967742, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87543; Mature: 87412

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMEQGKQIILVAQRDAEL
CCCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DDPTSDDIFDVGTVASILQLLKLPDGTVKVLVEGGQRARIDNYSEQEEIFQATAHYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
PLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIDESHDEFESLAKKIEEAQMPTEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVS
HCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWHKRSKIKRDLAKAQDVLDTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMSKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
VRALERELSKICRKVVKQILLDKSIKHVEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHEEC
LAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINPDFYE
EEHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEV
HHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHHCCCCHHHH
VENVD
HHCCC
>Mature Secondary Structure 
TLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMEQGKQIILVAQRDAEL
CCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DDPTSDDIFDVGTVASILQLLKLPDGTVKVLVEGGQRARIDNYSEQEEIFQATAHYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
PLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIDESHDEFESLAKKIEEAQMPTEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVS
HCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWHKRSKIKRDLAKAQDVLDTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMSKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
VRALERELSKICRKVVKQILLDKSIKHVEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHEEC
LAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINPDFYE
EEHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEV
HHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHHCCCCHHHH
VENVD
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]