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The map label for this gene is mdtA [H]

Identifier: 167624243

GI number: 167624243

Start: 2805061

End: 2806140

Strand: Reverse

Name: mdtA [H]

Synonym: Shal_2319

Alternate gene names: 167624243

Gene position: 2806140-2805061 (Counterclockwise)

Preceding gene: 167624244

Following gene: 167624242

Centisome position: 53.69

GC content: 44.81

Gene sequence:

>1080_bases
ATGAAAAAAATAATAATAATCCTTACATTGCTAGTAGTCGGCGCATATTTGTATTTTCAGCAACCTCCAGCAGAACAAGT
AAAAAAATCTCGACCTATACCTAATGTGGTTGTTACTAAGGCTGAGATACAGCCGATACGTGACGAAGTAGAAGCGCTGG
GAACGAGTAAGGCTAACGAGTCAATTACTGTTACGCCAAAAGTCACTGAGGTGGTGACAGAAGTCAATTTTAATGATGGC
GAGTTGGTCCAGAAAGGTCGTTTACTGGTTCAACTTCAAGACAGTGAGCAGCTTGCGCGTGTTACCGTCGCAAAAGTAAA
AGTCAAAGATCACCAACGAGAACTTGAACGCATTCGCACCTTAGTCACCAGCCAAACAATTGCAGAGCTTGAGCGCGATA
GGTTACAAACCTTAATCGATACCGCCAAAGCAGAGCTTGCACAGGCACAATCGGCTTTGAAGGATCGCCGTATTAGTGCC
CCGTTTTCAGGTGCGTTAGGATTACGTCAAGTCAGTGTCGGCGCGCTCGTTTCTCCTGGTAACGCCATTACTACTTTAGA
TGACATCTCTGTTATCAAATTGGATTTTTCAGTGCCTGAGCGCTTTTTACAAGCCTTAGCGCTAGGTAAACAAGTTGAAG
CTACTGCAGTAGCATTTGACGGTGAAGTGTTTGAAGGAAAGGTGGTGTCAATTGATAGTCGCATTAACCCTAAGACACGC
GCGGTAATCGTTCGCGCCAAGATCCCCAATCCAAAGCAAAGGCTCCTTCCAGGCATGTTGATGAAAGTAAAACTGATTAA
GACGAGCCGCGATGCACTCATATTGCCAGAATCTGCCATTATTCCCATTCAAGATAGGCATTATGTCTATGTGGTCAATG
ACGAAGGCGTTATTGAACAAAAACAAGTGTCTTTAGGCCTGCGTAAGCGTGGTTGGGTCGAAATTATTGACGGCGTAGTA
CTTAACGAACATGTCGTGATCCGGGGGCTTTTAAAAGTACGTCCTGGCGATAAAGTCAAAGTGACCTTTAGCGAACGTTT
TAGTTTTCTTAAGCAGGCGAGTGTGGAGCCTGTCGTATGA

Upstream 100 bases:

>100_bases
TAACTCAGTTGTATAATTTGTAAGAAAAGGTAAAACGTATTGAAGCAAATCTGTGTCTCGGTAAACTAACGATAATAAAA
AGTAGTTTGTTAAGGCAATC

Downstream 100 bases:

>100_bases
TCTTAACTGATATCTCGGTTAAGCGACCGGTTTTCGCTTCTGTTATTAGTATTTTATTGATTGTTTTTGGATTAGTGGCG
TTTGAGAAGCTGCCGTTAAG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKKIIIILTLLVVGAYLYFQQPPAEQVKKSRPIPNVVVTKAEIQPIRDEVEALGTSKANESITVTPKVTEVVTEVNFNDG
ELVQKGRLLVQLQDSEQLARVTVAKVKVKDHQRELERIRTLVTSQTIAELERDRLQTLIDTAKAELAQAQSALKDRRISA
PFSGALGLRQVSVGALVSPGNAITTLDDISVIKLDFSVPERFLQALALGKQVEATAVAFDGEVFEGKVVSIDSRINPKTR
AVIVRAKIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYVVNDEGVIEQKQVSLGLRKRGWVEIIDGVV
LNEHVVIRGLLKVRPGDKVKVTFSERFSFLKQASVEPVV

Sequences:

>Translated_359_residues
MKKIIIILTLLVVGAYLYFQQPPAEQVKKSRPIPNVVVTKAEIQPIRDEVEALGTSKANESITVTPKVTEVVTEVNFNDG
ELVQKGRLLVQLQDSEQLARVTVAKVKVKDHQRELERIRTLVTSQTIAELERDRLQTLIDTAKAELAQAQSALKDRRISA
PFSGALGLRQVSVGALVSPGNAITTLDDISVIKLDFSVPERFLQALALGKQVEATAVAFDGEVFEGKVVSIDSRINPKTR
AVIVRAKIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYVVNDEGVIEQKQVSLGLRKRGWVEIIDGVV
LNEHVVIRGLLKVRPGDKVKVTFSERFSFLKQASVEPVV
>Mature_359_residues
MKKIIIILTLLVVGAYLYFQQPPAEQVKKSRPIPNVVVTKAEIQPIRDEVEALGTSKANESITVTPKVTEVVTEVNFNDG
ELVQKGRLLVQLQDSEQLARVTVAKVKVKDHQRELERIRTLVTSQTIAELERDRLQTLIDTAKAELAQAQSALKDRRISA
PFSGALGLRQVSVGALVSPGNAITTLDDISVIKLDFSVPERFLQALALGKQVEATAVAFDGEVFEGKVVSIDSRINPKTR
AVIVRAKIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYVVNDEGVIEQKQVSLGLRKRGWVEIIDGVV
LNEHVVIRGLLKVRPGDKVKVTFSERFSFLKQASVEPVV

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=356, Percent_Identity=28.6516853932584, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789665, Length=346, Percent_Identity=26.3005780346821, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786668, Length=351, Percent_Identity=27.6353276353276, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789929, Length=317, Percent_Identity=24.9211356466877, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39747; Mature: 39747

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIIILTLLVVGAYLYFQQPPAEQVKKSRPIPNVVVTKAEIQPIRDEVEALGTSKANE
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCC
SITVTPKVTEVVTEVNFNDGELVQKGRLLVQLQDSEQLARVTVAKVKVKDHQRELERIRT
EEEECCHHHHHHHHCCCCCCHHEECCEEEEEECCCHHHHHHHHEEEEEHHHHHHHHHHHH
LVTSQTIAELERDRLQTLIDTAKAELAQAQSALKDRRISAPFSGALGLRQVSVGALVSPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEECCC
NAITTLDDISVIKLDFSVPERFLQALALGKQVEATAVAFDGEVFEGKVVSIDSRINPKTR
CCEEEECCCEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCEECCEEEEECCCCCCCEE
AVIVRAKIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYVVNDEGVIEQ
EEEEEEECCCCHHHHCCHHHHEEEEEECCCCEEECCCCCEEEECCCEEEEEECCCCCCCH
KQVSLGLRKRGWVEIIDGVVLNEHVVIRGLLKVRPGDKVKVTFSERFSFLKQASVEPVV
HHHHHCCCCCCHHHHHCCCCCCCCEEEEEHEEECCCCEEEEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKIIIILTLLVVGAYLYFQQPPAEQVKKSRPIPNVVVTKAEIQPIRDEVEALGTSKANE
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCC
SITVTPKVTEVVTEVNFNDGELVQKGRLLVQLQDSEQLARVTVAKVKVKDHQRELERIRT
EEEECCHHHHHHHHCCCCCCHHEECCEEEEEECCCHHHHHHHHEEEEEHHHHHHHHHHHH
LVTSQTIAELERDRLQTLIDTAKAELAQAQSALKDRRISAPFSGALGLRQVSVGALVSPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEECCC
NAITTLDDISVIKLDFSVPERFLQALALGKQVEATAVAFDGEVFEGKVVSIDSRINPKTR
CCEEEECCCEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCEECCEEEEECCCCCCCEE
AVIVRAKIPNPKQRLLPGMLMKVKLIKTSRDALILPESAIIPIQDRHYVYVVNDEGVIEQ
EEEEEEECCCCHHHHCCHHHHEEEEEECCCCEEECCCCCEEEECCCEEEEEECCCCCCCH
KQVSLGLRKRGWVEIIDGVVLNEHVVIRGLLKVRPGDKVKVTFSERFSFLKQASVEPVV
HHHHHCCCCCCHHHHHCCCCCCCCEEEEEHEEECCCCEEEEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA