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The map label for this gene is caiC [H]

Identifier: 167624045

GI number: 167624045

Start: 2555045

End: 2556910

Strand: Direct

Name: caiC [H]

Synonym: Shal_2121

Alternate gene names: 167624045

Gene position: 2555045-2556910 (Clockwise)

Preceding gene: 167624044

Following gene: 167624046

Centisome position: 48.88

GC content: 41.8

Gene sequence:

>1866_bases
GTGAAAATTAAAAACCACAGTGGAGTGCCCTTGGCTTCCATGGAAGAGACTCAGACAAAGAGTGATAAACGCTCTGCTGC
TGCGCAACTTATTAAACCTTATGCAAATTATACAATAGCAGATAGGTTGGAACAGCAAGCGCTGTCGCAAACAGATAAGA
CGTTTCTTGTTTATAATGGCAAGCACTACAGTTACGCTGAAGTCGATCAACGTGCAAACCAAGTCGCTAACCTGGCTGCA
TCTCGCGGGTTAAATAGCGGTGATGTGTGCGCCATGGTGCTTGAAAATAGACCCGAGTTCTTCTTTATTTGGTTTGGATT
GACCAAAATAGGGGTCATCGTTGCGTTTATTAATTCACAGGTTCATGGAGCTCCTTTATCCCATGCGATTAAAGAAACTG
AAGCGAGTGCAGTGATTGTTGGTGAAGAATGTGCTCACTTAGTCAGTAAAACAATGAGTGAAGTTGCAGATTGCTCATTG
TTACAGGTACCTCTTTGGTTAGCATCTGATGTTGAAAAAACTGCATCCAAAGATGACCTCGAGTACTTCGATACAAACTT
ATCCTTAAATTACGGTGACTACAGTCATGAATTTAATTCAAAGGAAAGTCGAAAAGGTATAACGGCCGAAACACCGAGCT
TACTTATTTTTACCTCTGGTACGACCGGACTACCTAAAGCTGCCATATATAGTCATATGCGCTGGTTATGTTCAGGTGAT
GTCATGTCGGTGACAATTGATGCTTCCGCATCTGATGTGTTTTACGTTTGTTTGCCTATGTATCATGGTGCAGCGGCTAC
CTCTGTAACATCAACAGCTTTAGCCGCCGGAGCAAGTATTGTTGTTAGACGTAAATTTAGTGTCCGAGAGTTTTGGTTAG
ATGTACAACAAAACGGCATCACCGTATGTCAGTACATTGGTGAGATCTGTCGTTATTTACTTAATGATGATGACACAAGA
AATCAAGGCAAAGGCCTGAAAGATCATTCATTACGTTGCATGCTTGGTGCAGGGTTTAGTGGAGACTCTTGGCAAAGCTG
GATCAATAAATTCGGTGAGATGGATATTTTTGAAGGCTGGGGCTCTACAGAGGCTAATACAAATTTAATCAACTTAGACA
ATTATATCGGTTCATGTGGAAGGGTCGCTGATTGGAATAAAACTAATTTTCGTCTAGTTAAATTTAATACTGATTCAGAG
AGTCATGAAAAAGACGCTAATGGCCACTATATACCATGTAAAAGTGGCGAGGTAGGCGAGGCTATAGGCATGATTATTAA
TCATCCTGAATTTGGTGGCGGACGCTTTGAAGGCTACACCTCGAGTAATGCAACAGAGCAAAAAATACTCACAGATGTAT
TTACCAAGGGCGACGCATATTGGCGCTCCGGTGACTTATTGCGTTTTGATGACAATGGATATTTCTATTTTGTCGATAGG
ATCGGTGACACCTATCGTTGGAAGAGCGAGAACGTGTCAACTCAAGAAGTCGCAAATGAATTAAGCGGGTTAGCAGGTCT
TGAACTTATCAATATTTATGGTGTTCAAGTGCCAGAACATGAAGGGCGAGCAGGGATGGCCGCGGTAGTCATGCAACAAG
GGATTGATTTCGACCCAAATGCATTTTATGCGTTTACCGAGGCTAAATTACCTCGTTACGCTGCGCCACAATTTATAAGA
GTTAGCAGCGTTGCAGACATGACTTCAACCTATAAGTTACGCAAGATTGATTTGCAAAAACAAGGATATAGCCCGATAGG
TTGTGAGGATCCAATTTTTATCCGCAATGATAAATCGGGAACTTATGAATGTTACTCTGAAGAAGCGTTAACAGCTGTCG
GTTTTCAGCCGTTTAAACATGTGTAA

Upstream 100 bases:

>100_bases
AAGATACTCCTGCACCCAAGATCCGGGTCAAATAGTATTTTCTGGCTTATATGAGCAGCTATTACATGCAAATTAGCCTC
ACCATTAATAAGGACATGAT

Downstream 100 bases:

>100_bases
TCAGGAGGATAAATGGGATTATTAGGAAACGCAGCCATTGTAGGGGCTGCTCAGTATAAACCTGAAAAATATCAAACGGC
ACCACAGATGTTTCACTTGG

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MKIKNHSGVPLASMEETQTKSDKRSAAAQLIKPYANYTIADRLEQQALSQTDKTFLVYNGKHYSYAEVDQRANQVANLAA
SRGLNSGDVCAMVLENRPEFFFIWFGLTKIGVIVAFINSQVHGAPLSHAIKETEASAVIVGEECAHLVSKTMSEVADCSL
LQVPLWLASDVEKTASKDDLEYFDTNLSLNYGDYSHEFNSKESRKGITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
VMSVTIDASASDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWLDVQQNGITVCQYIGEICRYLLNDDDTR
NQGKGLKDHSLRCMLGAGFSGDSWQSWINKFGEMDIFEGWGSTEANTNLINLDNYIGSCGRVADWNKTNFRLVKFNTDSE
SHEKDANGHYIPCKSGEVGEAIGMIINHPEFGGGRFEGYTSSNATEQKILTDVFTKGDAYWRSGDLLRFDDNGYFYFVDR
IGDTYRWKSENVSTQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAVVMQQGIDFDPNAFYAFTEAKLPRYAAPQFIR
VSSVADMTSTYKLRKIDLQKQGYSPIGCEDPIFIRNDKSGTYECYSEEALTAVGFQPFKHV

Sequences:

>Translated_621_residues
MKIKNHSGVPLASMEETQTKSDKRSAAAQLIKPYANYTIADRLEQQALSQTDKTFLVYNGKHYSYAEVDQRANQVANLAA
SRGLNSGDVCAMVLENRPEFFFIWFGLTKIGVIVAFINSQVHGAPLSHAIKETEASAVIVGEECAHLVSKTMSEVADCSL
LQVPLWLASDVEKTASKDDLEYFDTNLSLNYGDYSHEFNSKESRKGITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
VMSVTIDASASDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWLDVQQNGITVCQYIGEICRYLLNDDDTR
NQGKGLKDHSLRCMLGAGFSGDSWQSWINKFGEMDIFEGWGSTEANTNLINLDNYIGSCGRVADWNKTNFRLVKFNTDSE
SHEKDANGHYIPCKSGEVGEAIGMIINHPEFGGGRFEGYTSSNATEQKILTDVFTKGDAYWRSGDLLRFDDNGYFYFVDR
IGDTYRWKSENVSTQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAVVMQQGIDFDPNAFYAFTEAKLPRYAAPQFIR
VSSVADMTSTYKLRKIDLQKQGYSPIGCEDPIFIRNDKSGTYECYSEEALTAVGFQPFKHV
>Mature_621_residues
MKIKNHSGVPLASMEETQTKSDKRSAAAQLIKPYANYTIADRLEQQALSQTDKTFLVYNGKHYSYAEVDQRANQVANLAA
SRGLNSGDVCAMVLENRPEFFFIWFGLTKIGVIVAFINSQVHGAPLSHAIKETEASAVIVGEECAHLVSKTMSEVADCSL
LQVPLWLASDVEKTASKDDLEYFDTNLSLNYGDYSHEFNSKESRKGITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
VMSVTIDASASDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWLDVQQNGITVCQYIGEICRYLLNDDDTR
NQGKGLKDHSLRCMLGAGFSGDSWQSWINKFGEMDIFEGWGSTEANTNLINLDNYIGSCGRVADWNKTNFRLVKFNTDSE
SHEKDANGHYIPCKSGEVGEAIGMIINHPEFGGGRFEGYTSSNATEQKILTDVFTKGDAYWRSGDLLRFDDNGYFYFVDR
IGDTYRWKSENVSTQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAVVMQQGIDFDPNAFYAFTEAKLPRYAAPQFIR
VSSVADMTSTYKLRKIDLQKQGYSPIGCEDPIFIRNDKSGTYECYSEEALTAVGFQPFKHV

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=608, Percent_Identity=34.046052631579, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI40807357, Length=569, Percent_Identity=37.0826010544815, Blast_Score=360, Evalue=3e-99,
Organism=Homo sapiens, GI38524616, Length=591, Percent_Identity=36.7174280879865, Blast_Score=352, Evalue=6e-97,
Organism=Homo sapiens, GI62865631, Length=576, Percent_Identity=32.4652777777778, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI13325055, Length=576, Percent_Identity=32.4652777777778, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI13325057, Length=596, Percent_Identity=34.0604026845638, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI13236579, Length=524, Percent_Identity=34.3511450381679, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI227499621, Length=607, Percent_Identity=30.4777594728171, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=24.8106060606061, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1788107, Length=576, Percent_Identity=19.0972222222222, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693145, Length=577, Percent_Identity=22.3570190641248, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17551278, Length=569, Percent_Identity=39.0158172231986, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI115534440, Length=568, Percent_Identity=35.0352112676056, Blast_Score=313, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6319515, Length=504, Percent_Identity=31.9444444444444, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6319264, Length=355, Percent_Identity=22.5352112676056, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573631, Length=591, Percent_Identity=37.3942470389171, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI20130353, Length=591, Percent_Identity=37.3942470389171, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24583465, Length=582, Percent_Identity=35.3951890034364, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24583463, Length=582, Percent_Identity=35.3951890034364, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI281364798, Length=582, Percent_Identity=35.3951890034364, Blast_Score=355, Evalue=8e-98,
Organism=Drosophila melanogaster, GI45552801, Length=574, Percent_Identity=35.5400696864112, Blast_Score=331, Evalue=7e-91,
Organism=Drosophila melanogaster, GI45550496, Length=574, Percent_Identity=35.5400696864112, Blast_Score=331, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 68822; Mature: 68822

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKNHSGVPLASMEETQTKSDKRSAAAQLIKPYANYTIADRLEQQALSQTDKTFLVYNG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECC
KHYSYAEVDQRANQVANLAASRGLNSGDVCAMVLENRPEFFFIWFGLTKIGVIVAFINSQ
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECHHHHHHHHHHHCCC
VHGAPLSHAIKETEASAVIVGEECAHLVSKTMSEVADCSLLQVPLWLASDVEKTASKDDL
CCCCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCH
EYFDTNLSLNYGDYSHEFNSKESRKGITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
HHHCCCEEEECCCCCCCCCCHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
VMSVTIDASASDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWLDVQQNGI
EEEEEEECCCCCEEEEEEEHHCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCC
TVCQYIGEICRYLLNDDDTRNQGKGLKDHSLRCMLGAGFSGDSWQSWINKFGEMDIFEGW
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEECCC
GSTEANTNLINLDNYIGSCGRVADWNKTNFRLVKFNTDSESHEKDANGHYIPCKSGEVGE
CCCCCCCCEEEEHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCHHH
AIGMIINHPEFGGGRFEGYTSSNATEQKILTDVFTKGDAYWRSGDLLRFDDNGYFYFVDR
HHHHEECCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEC
IGDTYRWKSENVSTQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAVVMQQGIDFDPN
CCCCEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
AFYAFTEAKLPRYAAPQFIRVSSVADMTSTYKLRKIDLQKQGYSPIGCEDPIFIRNDKSG
CEEEEECCCCCCCCCCCEEEEHHHHHHHHHEEEEEEEHHHCCCCCCCCCCCEEEECCCCC
TYECYSEEALTAVGFQPFKHV
CEEEECCCHHHHCCCCHHCCC
>Mature Secondary Structure
MKIKNHSGVPLASMEETQTKSDKRSAAAQLIKPYANYTIADRLEQQALSQTDKTFLVYNG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECC
KHYSYAEVDQRANQVANLAASRGLNSGDVCAMVLENRPEFFFIWFGLTKIGVIVAFINSQ
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECHHHHHHHHHHHCCC
VHGAPLSHAIKETEASAVIVGEECAHLVSKTMSEVADCSLLQVPLWLASDVEKTASKDDL
CCCCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCH
EYFDTNLSLNYGDYSHEFNSKESRKGITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
HHHCCCEEEECCCCCCCCCCHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
VMSVTIDASASDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWLDVQQNGI
EEEEEEECCCCCEEEEEEEHHCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCC
TVCQYIGEICRYLLNDDDTRNQGKGLKDHSLRCMLGAGFSGDSWQSWINKFGEMDIFEGW
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEECCC
GSTEANTNLINLDNYIGSCGRVADWNKTNFRLVKFNTDSESHEKDANGHYIPCKSGEVGE
CCCCCCCCEEEEHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCHHH
AIGMIINHPEFGGGRFEGYTSSNATEQKILTDVFTKGDAYWRSGDLLRFDDNGYFYFVDR
HHHHEECCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEC
IGDTYRWKSENVSTQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAVVMQQGIDFDPN
CCCCEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
AFYAFTEAKLPRYAAPQFIRVSSVADMTSTYKLRKIDLQKQGYSPIGCEDPIFIRNDKSG
CEEEEECCCCCCCCCCCEEEEHHHHHHHHHEEEEEEEHHHCCCCCCCCCCCEEEECCCCC
TYECYSEEALTAVGFQPFKHV
CEEEECCCHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA