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The map label for this gene is 167623920

Identifier: 167623920

GI number: 167623920

Start: 2399933

End: 2401618

Strand: Reverse

Name: 167623920

Synonym: Shal_1991

Alternate gene names: NA

Gene position: 2401618-2399933 (Counterclockwise)

Preceding gene: 167623922

Following gene: 167623914

Centisome position: 45.95

GC content: 45.61

Gene sequence:

>1686_bases
ATGATTAACAATACGACAAAACAAGCTTCACAAGACGCTATTGAATGGGCGATAACCCATGGAATGGTTATCAAGGCAAC
GGCTTATTCAGCTTCTCATACCGCATTTAGTTTTACACCTACACCCATTAGCCGCGAGCGCTTTCACAACTTGGTCGCTT
CGGTAAATCTGCTTGGTAAGCTAGTACACTATGCATCAGAAGATCATCAATTCTTAAGCCAAGCAATTGCCCCAGTCACC
TCAGGAGAGCCTTTCTTTAAAGCCTTATTAGAGATGCATAATGCAATCTATGACCCATCTAACGCTGACAACTGTTGTAA
TCGCGGCATTAGTCATCGCGGCGATAGCTATCTTGATGTTAAAAACATCGATACCAAGATGAATGACTCCAACCAAAGCG
ACGCTAAACGATTGCCCCTATTAATCATGCGCAGTGACTTTATGGATGATACCGCTTTAGGGCCGAAGCTCATTGAGTTC
AACGGCATCGCCGCAGGTATGGGGCCATTTGGCCAAAGAGTGCATGAATTACATCAATACCTACAGCAGCAATGGCCAGA
AGAATTTAAACAGTGGTCAAGCCAGCAAGAGACTGAACTTGTAGCAAACCAAGCCATTGAAAGGTTATCTCAGGGCATTG
CCAACGCGACATTTAAGATAAAAAATGAATTTGCAGATAGTTTTTCAAGTAAGGCTATTAATAACAGTGCAACGACATAC
AGCGAGAATAACCCGCCTGTTTTTTTGATGGTAGTGCAAGCTGACGAAGACAACGTGTTTGATCAACACCTACTTGAAGG
TGCGTTACAGGCCAAAGGAATTAGGACGGTTAGACGTACCTTTCGCGAACTGCACAACAAACTCTCAACCGGCGCAAATC
ACAGATTATTGTTAGAAGGTGTCGGGCCAATCGATACCGTATACCTACGCGCGGGTTATCAATACAGCGATTATCACGCC
AATGACATCATCAGCCGCGTATGCTGCGAAGCATTAATGCAAACTCGTATTTTTATTGAAAGACACCGAGTCGCCGTTAA
CGCAACCGTGAGTCAGCAACTGGCCACCAGCAAACGGGTGCAGATGTTACTGTCTTCTATGGAGCCCGATGCCCTCACCC
GCTTTGGTTTAACCCTAGATGAGGCAAAAACCGTTAAAGGATTACTCGGCGAGATGCGAGCGGTCACTAAAGGCAGCGCA
GCCTCAATCACCCAAACTGGCAGCGAGCAATGGGTACTTAAAAACCAAGGCGAAGGTGGCGGCCACTGCATATTTGGCGA
CGATATTCTGTCAAAGCTTGCCGAGCTCAAACCCTGCGAGTATCAAGCCTGGTCGCTTATGCGAAGACTTCATCCTACAC
CAAGACCCATTCCCGCATTAACCGTACGCAAAGGTGAGTTACTACAAGTCGATGATTTGATCAGCGAGATCGGCATGTTC
ACCGTGCATATCGACGGCGAAGCTGCTATAGACGTTAAAAAAATAGGAGTGAAACAGTTAGACGTGCAAGGCTTACTTAA
GCAAAACATAGATAATAAAGAGATAGATATTAAAGACATAAACGTGCAAGCCACAGATAAAAAGGCCTATGCAGGATATT
TAATCCGAAGTAAGTCAGCCCGCACCACAGAAGGCGGCGTTCACAGTGGTATGGGCGTATTGGATTCGCTAATTTTTGGC
GATTGA

Upstream 100 bases:

>100_bases
GCCAAAGTTAATGCACGCACCTATTGCACGCACCTATTGCACGCACTCATGTCGCAATTCGCGTTCTAATTGCTAGAGTC
TTACTTTTACGGTGGCAACC

Downstream 100 bases:

>100_bases
GTTTAGTGCTTATGATTACTGTTCGAATTGTAATCCTAGAAAGTATGAGTCCCGACTCAAACCGACACATCAACTCGACT
CGCTGAACGTTACCATGTAA

Product: glutathione synthase

Products: ADP; phosphate; glutathione

Alternate protein names: Glutathione Synthetase

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MINNTTKQASQDAIEWAITHGMVIKATAYSASHTAFSFTPTPISRERFHNLVASVNLLGKLVHYASEDHQFLSQAIAPVT
SGEPFFKALLEMHNAIYDPSNADNCCNRGISHRGDSYLDVKNIDTKMNDSNQSDAKRLPLLIMRSDFMDDTALGPKLIEF
NGIAAGMGPFGQRVHELHQYLQQQWPEEFKQWSSQQETELVANQAIERLSQGIANATFKIKNEFADSFSSKAINNSATTY
SENNPPVFLMVVQADEDNVFDQHLLEGALQAKGIRTVRRTFRELHNKLSTGANHRLLLEGVGPIDTVYLRAGYQYSDYHA
NDIISRVCCEALMQTRIFIERHRVAVNATVSQQLATSKRVQMLLSSMEPDALTRFGLTLDEAKTVKGLLGEMRAVTKGSA
ASITQTGSEQWVLKNQGEGGGHCIFGDDILSKLAELKPCEYQAWSLMRRLHPTPRPIPALTVRKGELLQVDDLISEIGMF
TVHIDGEAAIDVKKIGVKQLDVQGLLKQNIDNKEIDIKDINVQATDKKAYAGYLIRSKSARTTEGGVHSGMGVLDSLIFG
D

Sequences:

>Translated_561_residues
MINNTTKQASQDAIEWAITHGMVIKATAYSASHTAFSFTPTPISRERFHNLVASVNLLGKLVHYASEDHQFLSQAIAPVT
SGEPFFKALLEMHNAIYDPSNADNCCNRGISHRGDSYLDVKNIDTKMNDSNQSDAKRLPLLIMRSDFMDDTALGPKLIEF
NGIAAGMGPFGQRVHELHQYLQQQWPEEFKQWSSQQETELVANQAIERLSQGIANATFKIKNEFADSFSSKAINNSATTY
SENNPPVFLMVVQADEDNVFDQHLLEGALQAKGIRTVRRTFRELHNKLSTGANHRLLLEGVGPIDTVYLRAGYQYSDYHA
NDIISRVCCEALMQTRIFIERHRVAVNATVSQQLATSKRVQMLLSSMEPDALTRFGLTLDEAKTVKGLLGEMRAVTKGSA
ASITQTGSEQWVLKNQGEGGGHCIFGDDILSKLAELKPCEYQAWSLMRRLHPTPRPIPALTVRKGELLQVDDLISEIGMF
TVHIDGEAAIDVKKIGVKQLDVQGLLKQNIDNKEIDIKDINVQATDKKAYAGYLIRSKSARTTEGGVHSGMGVLDSLIFG
D
>Mature_561_residues
MINNTTKQASQDAIEWAITHGMVIKATAYSASHTAFSFTPTPISRERFHNLVASVNLLGKLVHYASEDHQFLSQAIAPVT
SGEPFFKALLEMHNAIYDPSNADNCCNRGISHRGDSYLDVKNIDTKMNDSNQSDAKRLPLLIMRSDFMDDTALGPKLIEF
NGIAAGMGPFGQRVHELHQYLQQQWPEEFKQWSSQQETELVANQAIERLSQGIANATFKIKNEFADSFSSKAINNSATTY
SENNPPVFLMVVQADEDNVFDQHLLEGALQAKGIRTVRRTFRELHNKLSTGANHRLLLEGVGPIDTVYLRAGYQYSDYHA
NDIISRVCCEALMQTRIFIERHRVAVNATVSQQLATSKRVQMLLSSMEPDALTRFGLTLDEAKTVKGLLGEMRAVTKGSA
ASITQTGSEQWVLKNQGEGGGHCIFGDDILSKLAELKPCEYQAWSLMRRLHPTPRPIPALTVRKGELLQVDDLISEIGMF
TVHIDGEAAIDVKKIGVKQLDVQGLLKQNIDNKEIDIKDINVQATDKKAYAGYLIRSKSARTTEGGVHSGMGVLDSLIFG
D

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4504169, Length=575, Percent_Identity=23.4782608695652, Blast_Score=120, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324524, Length=580, Percent_Identity=21.8965517241379, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281361051, Length=566, Percent_Identity=24.2049469964664, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642900, Length=566, Percent_Identity=24.2049469964664, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281361044, Length=566, Percent_Identity=24.2049469964664, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281361034, Length=566, Percent_Identity=24.2049469964664, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281361053, Length=321, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281376915, Length=321, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281361042, Length=321, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281361040, Length=321, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.2.3

Molecular weight: Translated: 62209; Mature: 62209

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNTTKQASQDAIEWAITHGMVIKATAYSASHTAFSFTPTPISRERFHNLVASVNLLGK
CCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
LVHYASEDHQFLSQAIAPVTSGEPFFKALLEMHNAIYDPSNADNCCNRGISHRGDSYLDV
HHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEE
KNIDTKMNDSNQSDAKRLPLLIMRSDFMDDTALGPKLIEFNGIAAGMGPFGQRVHELHQY
ECCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
LQQQWPEEFKQWSSQQETELVANQAIERLSQGIANATFKIKNEFADSFSSKAINNSATTY
HHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHCCCCCCCC
SENNPPVFLMVVQADEDNVFDQHLLEGALQAKGIRTVRRTFRELHNKLSTGANHRLLLEG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
VGPIDTVYLRAGYQYSDYHANDIISRVCCEALMQTRIFIERHRVAVNATVSQQLATSKRV
CCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHH
QMLLSSMEPDALTRFGLTLDEAKTVKGLLGEMRAVTKGSAASITQTGSEQWVLKNQGEGG
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCC
GHCIFGDDILSKLAELKPCEYQAWSLMRRLHPTPRPIPALTVRKGELLQVDDLISEIGMF
CEEEECHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEEHHHHHHHCCEE
TVHIDGEAAIDVKKIGVKQLDVQGLLKQNIDNKEIDIKDINVQATDKKAYAGYLIRSKSA
EEEECCCCEEEHHHHCCHHHHHHHHHHCCCCCCCCEEEECCEEECCCHHHHHHEEECCCC
RTTEGGVHSGMGVLDSLIFGD
CCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MINNTTKQASQDAIEWAITHGMVIKATAYSASHTAFSFTPTPISRERFHNLVASVNLLGK
CCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
LVHYASEDHQFLSQAIAPVTSGEPFFKALLEMHNAIYDPSNADNCCNRGISHRGDSYLDV
HHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEE
KNIDTKMNDSNQSDAKRLPLLIMRSDFMDDTALGPKLIEFNGIAAGMGPFGQRVHELHQY
ECCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
LQQQWPEEFKQWSSQQETELVANQAIERLSQGIANATFKIKNEFADSFSSKAINNSATTY
HHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHCCCCCCCC
SENNPPVFLMVVQADEDNVFDQHLLEGALQAKGIRTVRRTFRELHNKLSTGANHRLLLEG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
VGPIDTVYLRAGYQYSDYHANDIISRVCCEALMQTRIFIERHRVAVNATVSQQLATSKRV
CCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHH
QMLLSSMEPDALTRFGLTLDEAKTVKGLLGEMRAVTKGSAASITQTGSEQWVLKNQGEGG
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCC
GHCIFGDDILSKLAELKPCEYQAWSLMRRLHPTPRPIPALTVRKGELLQVDDLISEIGMF
CEEEECHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEEHHHHHHHCCEE
TVHIDGEAAIDVKKIGVKQLDVQGLLKQNIDNKEIDIKDINVQATDKKAYAGYLIRSKSA
EEEECCCCEEEHHHHCCHHHHHHHHHHCCCCCCCCEEEECCEEECCCHHHHHHEEECCCC
RTTEGGVHSGMGVLDSLIFGD
CCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; gamma-L-glutamyl-L-cysteine; glycine

Specific reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA