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The map label for this gene is prpC [H]

Identifier: 167623891

GI number: 167623891

Start: 2358371

End: 2359510

Strand: Direct

Name: prpC [H]

Synonym: Shal_1962

Alternate gene names: 167623891

Gene position: 2358371-2359510 (Clockwise)

Preceding gene: 167623890

Following gene: 167623892

Centisome position: 45.12

GC content: 48.77

Gene sequence:

>1140_bases
ATGGTTGATAAAACTGAGGTTTCTAAGAAAATTGGTGGTGCAGGCCTACGTGGTCAAAGCGCAGGTGAAACAGCCCTTTG
TACCGTGGGGAAATCAGGTTCGGGTCTAACGTACTGTGGTTACGACGTGTCAGACTTGGCCGATAACGCCACGTTTGAAG
AGGTAGCCTACCTACTGTTTAACGGCGAGCTACCTAATCAAACTCAGCTCGACCACTATAAAACTGAACTCTTCGCTCAC
CGCGATCTTCCACAAGCGCTAAAAGAGGTGCTGCAGCGTATTCCTGCCGAGGCGCATCCAATGGATGTGATGCGTACCGG
TTGCTCATTCTTAGGAAATCTTGAGCCTGAAAATGACTTTAGTGAGCAAAACCGTGCAGCAAACCGCTTACTCGCAGCGT
TCCCAGCCATCATGTGCTACTGGTATAAGTTCTCTCACGAAGGTGTAGAGATTGATTGCGTGACCGATGAAGATTCAATC
GGTGGTCACTTCCTACATCTACTCAATGGCAAGGCGCCATCAGAGCAACATCGCCGCGTAATGGATGTGTCGCTTATTTT
GTATGCCGAGCATGAGTTTAATGCATCAACCTTTACTGCGCGTGTGTGTGCATCAACCTTGTCAGATATGTACTCTTGTA
TTACAGGTGCTATCGGTACACTTCGTGGCCCACTGCATGGCGGCGCGAATGAAGCGGCTATGGATATGATCCAAAAGTTT
AGCTCGCCTGAAGATGCCAAAGAGCAGATGGCAGGTATGCTTGAGCGTAAAGAGAAGATTATGGGTTTTGGCCATGCGAT
TTATCGCACTTCAGATCCACGTAACGTAATCATCAAAGCCTGGTCTAAAAAACTCGGAGCAGAGTTTGGTGACAGCTCAC
TATATGACATCTCAGTAGCCTGTGAAGAGTTTATGTGGGACACCAAGAAGCTTTTCTGTAACGCCGACTTCTTCCACGCA
TCGGCTTATCACTTTATGGGCATTCCGACTAAGTTGTTTACGCCTATCTTTGTCTGCTCACGCTTAACGGGCTGGGCTGC
ACACGTGATGGAGCAGCGCTCTAACAACCGTATCATCCGCCCAAGTGCCGACTACACCGGCAGCGAGCCACGTACGGTTA
CACCAATCAGTGAAAGATAG

Upstream 100 bases:

>100_bases
AGTTTACAAGTGGAAGCGTTAAGGATTAGCGCGCCAATATAAATATAAAAATTATCTGCAGCCTTAAGGCTGACGGCAAA
CAAATAGAAGGAAGACAGTA

Downstream 100 bases:

>100_bases
AAGCTAGAACTTAGAGTCTAGAACTCAGGACCTAGGACTTAGAATTTAGGACCTAGGACTTAGAATTTAGGACCTAGGAC
CTAGGACCTAAAAGCGAAGC

Product: 2-methylcitrate synthase/citrate synthase II

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MVDKTEVSKKIGGAGLRGQSAGETALCTVGKSGSGLTYCGYDVSDLADNATFEEVAYLLFNGELPNQTQLDHYKTELFAH
RDLPQALKEVLQRIPAEAHPMDVMRTGCSFLGNLEPENDFSEQNRAANRLLAAFPAIMCYWYKFSHEGVEIDCVTDEDSI
GGHFLHLLNGKAPSEQHRRVMDVSLILYAEHEFNASTFTARVCASTLSDMYSCITGAIGTLRGPLHGGANEAAMDMIQKF
SSPEDAKEQMAGMLERKEKIMGFGHAIYRTSDPRNVIIKAWSKKLGAEFGDSSLYDISVACEEFMWDTKKLFCNADFFHA
SAYHFMGIPTKLFTPIFVCSRLTGWAAHVMEQRSNNRIIRPSADYTGSEPRTVTPISER

Sequences:

>Translated_379_residues
MVDKTEVSKKIGGAGLRGQSAGETALCTVGKSGSGLTYCGYDVSDLADNATFEEVAYLLFNGELPNQTQLDHYKTELFAH
RDLPQALKEVLQRIPAEAHPMDVMRTGCSFLGNLEPENDFSEQNRAANRLLAAFPAIMCYWYKFSHEGVEIDCVTDEDSI
GGHFLHLLNGKAPSEQHRRVMDVSLILYAEHEFNASTFTARVCASTLSDMYSCITGAIGTLRGPLHGGANEAAMDMIQKF
SSPEDAKEQMAGMLERKEKIMGFGHAIYRTSDPRNVIIKAWSKKLGAEFGDSSLYDISVACEEFMWDTKKLFCNADFFHA
SAYHFMGIPTKLFTPIFVCSRLTGWAAHVMEQRSNNRIIRPSADYTGSEPRTVTPISER
>Mature_379_residues
MVDKTEVSKKIGGAGLRGQSAGETALCTVGKSGSGLTYCGYDVSDLADNATFEEVAYLLFNGELPNQTQLDHYKTELFAH
RDLPQALKEVLQRIPAEAHPMDVMRTGCSFLGNLEPENDFSEQNRAANRLLAAFPAIMCYWYKFSHEGVEIDCVTDEDSI
GGHFLHLLNGKAPSEQHRRVMDVSLILYAEHEFNASTFTARVCASTLSDMYSCITGAIGTLRGPLHGGANEAAMDMIQKF
SSPEDAKEQMAGMLERKEKIMGFGHAIYRTSDPRNVIIKAWSKKLGAEFGDSSLYDISVACEEFMWDTKKLFCNADFFHA
SAYHFMGIPTKLFTPIFVCSRLTGWAAHVMEQRSNNRIIRPSADYTGSEPRTVTPISER

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=245, Percent_Identity=24.0816326530612, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1786527, Length=382, Percent_Identity=51.0471204188482, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1786939, Length=381, Percent_Identity=32.2834645669291, Blast_Score=187, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17555174, Length=245, Percent_Identity=26.1224489795918, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319850, Length=342, Percent_Identity=23.6842105263158, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324328, Length=332, Percent_Identity=22.5903614457831, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325257, Length=357, Percent_Identity=25.2100840336134, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640126, Length=378, Percent_Identity=24.0740740740741, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640124, Length=379, Percent_Identity=24.0105540897098, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356863, Length=265, Percent_Identity=24.5283018867925, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42064; Mature: 42064

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDKTEVSKKIGGAGLRGQSAGETALCTVGKSGSGLTYCGYDVSDLADNATFEEVAYLLF
CCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEECCCHHHHHCCCCHHHHHHHHC
NGELPNQTQLDHYKTELFAHRDLPQALKEVLQRIPAEAHPMDVMRTGCSFLGNLEPENDF
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCH
SEQNRAANRLLAAFPAIMCYWYKFSHEGVEIDCVTDEDSIGGHFLHLLNGKAPSEQHRRV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHH
MDVSLILYAEHEFNASTFTARVCASTLSDMYSCITGAIGTLRGPLHGGANEAAMDMIQKF
HEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SSPEDAKEQMAGMLERKEKIMGFGHAIYRTSDPRNVIIKAWSKKLGAEFGDSSLYDISVA
CCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHCCCCCCCCEEEHHHH
CEEFMWDTKKLFCNADFFHASAYHFMGIPTKLFTPIFVCSRLTGWAAHVMEQRSNNRIIR
HHHHHHHHHHHHCCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
PSADYTGSEPRTVTPISER
CCCCCCCCCCCEECCCCCC
>Mature Secondary Structure
MVDKTEVSKKIGGAGLRGQSAGETALCTVGKSGSGLTYCGYDVSDLADNATFEEVAYLLF
CCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEECCCHHHHHCCCCHHHHHHHHC
NGELPNQTQLDHYKTELFAHRDLPQALKEVLQRIPAEAHPMDVMRTGCSFLGNLEPENDF
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCH
SEQNRAANRLLAAFPAIMCYWYKFSHEGVEIDCVTDEDSIGGHFLHLLNGKAPSEQHRRV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHH
MDVSLILYAEHEFNASTFTARVCASTLSDMYSCITGAIGTLRGPLHGGANEAAMDMIQKF
HEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SSPEDAKEQMAGMLERKEKIMGFGHAIYRTSDPRNVIIKAWSKKLGAEFGDSSLYDISVA
CCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHCCCCCCCCEEEHHHH
CEEFMWDTKKLFCNADFFHASAYHFMGIPTKLFTPIFVCSRLTGWAAHVMEQRSNNRIIR
HHHHHHHHHHHHCCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
PSADYTGSEPRTVTPISER
CCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]