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The map label for this gene is cysM [C]

Identifier: 167623867

GI number: 167623867

Start: 2328866

End: 2329942

Strand: Reverse

Name: cysM [C]

Synonym: Shal_1937

Alternate gene names: 167623867

Gene position: 2329942-2328866 (Counterclockwise)

Preceding gene: 167623871

Following gene: 167623865

Centisome position: 44.58

GC content: 44.66

Gene sequence:

>1077_bases
GTGACTAATTCTTGGGTAAATCAAGCAATCGAAAAGATTGAAGCTGACTTTCAACGAAGTGCAGACACTCATTTAATTAA
GCTAGAGACTCCAAGCCTAACTGGTATTGATATTTATCTTAAAGATGAAAGTACCCACCCTACTGGAAGTTTAAAGCACC
GCCTCGCTCGCTCTTTATTTCTGTATGCGCTTTGTAATGGCTGGATTAAGGAAGGTACCACCGTTATTGAGTCTTCTTCT
GGCAGCACTGCAGTATCTGAAGCCTATTTTGCAAGATTACTTGGATTACCATTTATCGCTGTCATGCCAAGCACCACGGC
AAAAAAGAAAGTTCAGCAAATTGAGTTTTATGGCGGTCAATGCCATTTTGTCGACCATTCCTGTAAAATTTATGCTGAAT
CAGAACGCTTAGCACAAGAGTTAGATGGTCACTATATGGATCAGTTTACCTATGCCGAGCGTGCTACAGATTGGCGCGGT
AACAACAATATCGCCAACTCTATCTTTAACCAGATGGAAAAAGAGCAACATTCAATCCCTACTTGGATTGTTATGAGCCC
TGGTACTGGCGGCACTTCGGCTACGATTGGTCGTTATATTCGCTATCAACGACTGACGACTAAGCTTTGTGTTGTCGATC
CTGAAAACTCTGTTTTCTTCGATTATTTCAATACCGGCGATAAGAACGTGACTTGCAGCAATGGCAGTAAGATAGAGGGC
ATTGGCAGACCTCGCGCCGAACCGTCCTTTATTCCTGGTGTTGTGGATGAGATGCGTAAGATCCCAGATCCCGCCTCTGT
CGCAACAATTAATTGGTTAGAGAAGATTATTGGCCGCAAGACGGGCGCCTCTACAGGTACAAACCTGTATGGTGCGTTGC
AGTTAGCCAGCGAAATGGCCGCTAGAGGCGAAACAGGCTCGATTGTGACCCTCATTTGCGACTCGGGTGAGCGCTACCTA
GACACCTATTACAACGCGGATTGGATTAAAGATAATATCGGCGATCTAACACCTTATACTGAAGCGTTAAGCCAATTTAG
CGAGACGAGTGTATTACATTGCCCAAGAGCCAAGTGA

Upstream 100 bases:

>100_bases
TTTACAGCTAATGAACAAACTATTCTTATACGCTTGTCACTACCAATCTAGCTCACTTTTCTCTATGATTTAGGCTTATT
GTTTAATCAGAGGCAAACAA

Downstream 100 bases:

>100_bases
GTATAACGATAAGTAACTAGCTCATCAGTAGTGATACAGAAAAGCCCTTGAGATAATTAAATCCAAGGGCTTTTTCATAA
AACATTGTCGATTTTGTTAA

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTNSWVNQAIEKIEADFQRSADTHLIKLETPSLTGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTTVIESSS
GSTAVSEAYFARLLGLPFIAVMPSTTAKKKVQQIEFYGGQCHFVDHSCKIYAESERLAQELDGHYMDQFTYAERATDWRG
NNNIANSIFNQMEKEQHSIPTWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVTCSNGSKIEG
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLEKIIGRKTGASTGTNLYGALQLASEMAARGETGSIVTLICDSGERYL
DTYYNADWIKDNIGDLTPYTEALSQFSETSVLHCPRAK

Sequences:

>Translated_358_residues
MTNSWVNQAIEKIEADFQRSADTHLIKLETPSLTGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTTVIESSS
GSTAVSEAYFARLLGLPFIAVMPSTTAKKKVQQIEFYGGQCHFVDHSCKIYAESERLAQELDGHYMDQFTYAERATDWRG
NNNIANSIFNQMEKEQHSIPTWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVTCSNGSKIEG
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLEKIIGRKTGASTGTNLYGALQLASEMAARGETGSIVTLICDSGERYL
DTYYNADWIKDNIGDLTPYTEALSQFSETSVLHCPRAK
>Mature_357_residues
TNSWVNQAIEKIEADFQRSADTHLIKLETPSLTGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTTVIESSSG
STAVSEAYFARLLGLPFIAVMPSTTAKKKVQQIEFYGGQCHFVDHSCKIYAESERLAQELDGHYMDQFTYAERATDWRGN
NNIANSIFNQMEKEQHSIPTWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVTCSNGSKIEGI
GRPRAEPSFIPGVVDEMRKIPDPASVATINWLEKIIGRKTGASTGTNLYGALQLASEMAARGETGSIVTLICDSGERYLD
TYYNADWIKDNIGDLTPYTEALSQFSETSVLHCPRAK

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=305, Percent_Identity=25.5737704918033, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI295821200, Length=305, Percent_Identity=25.5737704918033, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4557415, Length=305, Percent_Identity=25.5737704918033, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI2367138, Length=315, Percent_Identity=27.6190476190476, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=359, Percent_Identity=34.5403899721448, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17539800, Length=357, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17539640, Length=359, Percent_Identity=29.5264623955432, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562970, Length=327, Percent_Identity=27.82874617737, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32566674, Length=316, Percent_Identity=28.4810126582279, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17535051, Length=348, Percent_Identity=26.4367816091954, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115535073, Length=296, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=24.8484848484848, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=26.3322884012539, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=26.3322884012539, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39766; Mature: 39635

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSWVNQAIEKIEADFQRSADTHLIKLETPSLTGIDIYLKDESTHPTGSLKHRLARSLF
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
LYALCNGWIKEGTTVIESSSGSTAVSEAYFARLLGLPFIAVMPSTTAKKKVQQIEFYGGQ
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHEECCE
CHFVDHSCKIYAESERLAQELDGHYMDQFTYAERATDWRGNNNIANSIFNQMEKEQHSIP
EEEECCCEEEEECHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
TWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVTCSNGSKIEG
EEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCEEEECCCCEECC
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLEKIIGRKTGASTGTNLYGALQLASEMA
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ARGETGSIVTLICDSGERYLDTYYNADWIKDNIGDLTPYTEALSQFSETSVLHCPRAK
HCCCCCCEEEEEECCCCHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TNSWVNQAIEKIEADFQRSADTHLIKLETPSLTGIDIYLKDESTHPTGSLKHRLARSLF
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
LYALCNGWIKEGTTVIESSSGSTAVSEAYFARLLGLPFIAVMPSTTAKKKVQQIEFYGGQ
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHEECCE
CHFVDHSCKIYAESERLAQELDGHYMDQFTYAERATDWRGNNNIANSIFNQMEKEQHSIP
EEEECCCEEEEECHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
TWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVTCSNGSKIEG
EEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCEEEECCCCEECC
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLEKIIGRKTGASTGTNLYGALQLASEMA
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ARGETGSIVTLICDSGERYLDTYYNADWIKDNIGDLTPYTEALSQFSETSVLHCPRAK
HCCCCCCEEEEEECCCCHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]