Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 167623863

GI number: 167623863

Start: 2324560

End: 2326563

Strand: Direct

Name: uvrB [H]

Synonym: Shal_1933

Alternate gene names: 167623863

Gene position: 2324560-2326563 (Clockwise)

Preceding gene: 167623853

Following gene: 167623866

Centisome position: 44.47

GC content: 45.96

Gene sequence:

>2004_bases
GTGTCAAAATCTGTATTTCAATTAGAGTCTATGTATAAGCCTGCAGGCGATCAGCCCACAGCGATTAATAAGCTTGTGGA
TGGGTTAGAGTCAGGCGTTGCTTGCCAAACATTACTAGGTGTTACGGGCTCAGGTAAAACCTTTACGATTGCCAACGTTA
TCGAAAAAATGTCGCGCCCAACGATTATCATGGCACCCAATAAGACCCTTGCTGCACAGCTTTATGGAGAGATGAAAGAA
TTCTTTCCTCATAATGCTGTTGAGTATTTTGTTTCTTACTATGACTATTATCAGCCTGAGGCTTACGTTCCTTCAACAGG
CACATTCATTGAAAAAGATGCATCGGTTAATGCACACATTGAGCAGATGCGACTCTCTGCGACGAAAGCACTGTTAGAAC
GAAAAGACGTTGTACTTATCGCCTCTGTTTCCGCTATTTACGGCTTGGGCGATCCAAAAGCGTATATGAAGATGCTGTTA
CACCTTCGAGAAGGTGGCAATATGGAGCAGCGCGATATCTTAAAACGCCTGAGTGAGCTGCAATACACCCGTAATGATAT
TGAGCTCCAGCGCGGCACCTATCGAGTTCGCGGCGAAGTCATCGACATATTTCCGGCAGATTCAGACAAAAATGCCATCA
GAATCGAGCTTTTTGATGACGAGATAGAACGTTTGAGCCTGTTTGACCCGTTAACGGGTCACATTGTAAAGCGAATAGCT
CGAATTACGGTTTATCCTAAGAGCCATTATGTGACGCCTCGTGAGTCCATTTTAGCGGCGACAGAAGAGATTAAAGAAGA
ATTAAGAGAGCGTAAAAAACAGCTCCTCGATTTGAATAAGCTCATCGAAGAGCAACGTATTACAGAGCGGGTTCAGTATG
ATCTCGAGATGATGACAGAGCTTGGCTATTGTTCAGGTATTGAGAACTATTCCCGATACCTGTCGGGGCGAGCTTCTGGC
GATGGCCCCCCAACCTTGTTAGATTATCTGCCTGAAGATGGTTTACTTATCATCGATGAGTCCCATGTGACGGTACCGCA
AATTGGCGCCATGTATAAAGGCGATCGCTCGCGCAAGATGAACTTGGTTGAGTACGGTTTTCGTTTGCCGTCAGCGCTTG
ATAACCGCCCATTGAAATTCGAGGAGTTCGAAGCGTTAATGCCCCAAAGCATTTTTGTTTCTGCGACTCCTAGCGCTTAT
GAGATCGAGAAGTCAGATGGTGAAATAGCCGAGCAGGTCGTTAGGCCAACGGGCTTACTTGATCCCGAGATTGAAGTCAG
GCCTGTGAGTACTCAGGTGGACGATCTGTTATCAGAGATTGGCAAACGTGTGGCTGTGAATGAGCGCGTACTGGTGACGA
CCTTAACTAAGCGAATGTCAGAGGATTTGACCGAATACCTCGATGAGCACGGCGTAAAGGTCAGGTACTTGCATTCAGAC
ATCGACACAGTTGAGCGTGTTGAGATCATTAGAGACTTACGATTAGGTGTCTTTGATGTACTGATCGGCATTAACTTGCT
ACGAGAAGGCTTAGACATGCCTGAAGTGTCTTTGGTGTGTATTCTCGATGCAGATAAAGAGGGCTTCTTACGATCAGAGC
GTTCGCTTATTCAGACGATTGGCCGCGCGGCACGTAATGTAAACGGCAAGGTGATTTTATACGGGGACCGTATTACTAAG
TCGATGGACAAGGCGATCACAGAGACAAATCGCCGTCGTGAGATGCAGCATCAGCATAACCTTGATAATGGCATCATTCC
TAAAGGAGTGATTAAAAAGATCACCGATGTTATGGATGTTGGCGATCATGAATATGTGGATAGCGAACGAGGCGTTGCAG
AGATAGAGGGGGAATATCATGTGGCTAAACCCGCTGATATTAGCCATGACATTGATAGGCTAGAAAAGCAGATGCATGAA
CACGCTAAAAATCTTGAATTTGAAGAGGCCGCTGCGATCCGTGACAAAGTCGGTCGTCTAAGAGAGCAATTCATTAAGGC
CTAG

Upstream 100 bases:

>100_bases
TATCAAAAATGGAGTCGAACAAAAACTAGTCTAGAAAGTTAAGCAGTTAATAGCCGAATTAGGGTAAAATAATTGCTCAT
TTTTCGAGGGAAGTATCTGA

Downstream 100 bases:

>100_bases
CTTTTAAAAGAGTCGTTTTTAGGCGTAGTTTTTAACACATAGCTTGTTAAGGCCTAGTTTATTAAGACGTTAAAAAGGAG
AGCAAAGTAAAACTTAGCTC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSKSVFQLESMYKPAGDQPTAINKLVDGLESGVACQTLLGVTGSGKTFTIANVIEKMSRPTIIMAPNKTLAAQLYGEMKE
FFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLL
HLREGGNMEQRDILKRLSELQYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHIVKRIA
RITVYPKSHYVTPRESILAATEEIKEELRERKKQLLDLNKLIEEQRITERVQYDLEMMTELGYCSGIENYSRYLSGRASG
DGPPTLLDYLPEDGLLIIDESHVTVPQIGAMYKGDRSRKMNLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSAY
EIEKSDGEIAEQVVRPTGLLDPEIEVRPVSTQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYGDRITK
SMDKAITETNRRREMQHQHNLDNGIIPKGVIKKITDVMDVGDHEYVDSERGVAEIEGEYHVAKPADISHDIDRLEKQMHE
HAKNLEFEEAAAIRDKVGRLREQFIKA

Sequences:

>Translated_667_residues
MSKSVFQLESMYKPAGDQPTAINKLVDGLESGVACQTLLGVTGSGKTFTIANVIEKMSRPTIIMAPNKTLAAQLYGEMKE
FFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLL
HLREGGNMEQRDILKRLSELQYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHIVKRIA
RITVYPKSHYVTPRESILAATEEIKEELRERKKQLLDLNKLIEEQRITERVQYDLEMMTELGYCSGIENYSRYLSGRASG
DGPPTLLDYLPEDGLLIIDESHVTVPQIGAMYKGDRSRKMNLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSAY
EIEKSDGEIAEQVVRPTGLLDPEIEVRPVSTQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYGDRITK
SMDKAITETNRRREMQHQHNLDNGIIPKGVIKKITDVMDVGDHEYVDSERGVAEIEGEYHVAKPADISHDIDRLEKQMHE
HAKNLEFEEAAAIRDKVGRLREQFIKA
>Mature_666_residues
SKSVFQLESMYKPAGDQPTAINKLVDGLESGVACQTLLGVTGSGKTFTIANVIEKMSRPTIIMAPNKTLAAQLYGEMKEF
FPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLLH
LREGGNMEQRDILKRLSELQYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHIVKRIAR
ITVYPKSHYVTPRESILAATEEIKEELRERKKQLLDLNKLIEEQRITERVQYDLEMMTELGYCSGIENYSRYLSGRASGD
GPPTLLDYLPEDGLLIIDESHVTVPQIGAMYKGDRSRKMNLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSAYE
IEKSDGEIAEQVVRPTGLLDPEIEVRPVSTQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSDI
DTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYGDRITKS
MDKAITETNRRREMQHQHNLDNGIIPKGVIKKITDVMDVGDHEYVDSERGVAEIEGEYHVAKPADISHDIDRLEKQMHEH
AKNLEFEEAAAIRDKVGRLREQFIKA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=673, Percent_Identity=72.2139673105498, Blast_Score=975, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=24.1042345276873, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75737; Mature: 75605

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSVFQLESMYKPAGDQPTAINKLVDGLESGVACQTLLGVTGSGKTFTIANVIEKMSRP
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TIIMAPNKTLAAQLYGEMKEFFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLLHLREGGNMEQRDILKRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHIVKRIA
HHHHHHHHHHCCEEEECCEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHH
RITVYPKSHYVTPRESILAATEEIKEELRERKKQLLDLNKLIEEQRITERVQYDLEMMTE
HHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRASGDGPPTLLDYLPEDGLLIIDESHVTVPQIGAMYKGDRSRKM
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCC
NLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSAYEIEKSDGEIAEQVVRPTGLL
HHHHHCCCCCHHHCCCCCCHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHCCCCCC
DPEIEVRPVSTQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
CCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYGDRITKSMDKAITETNRRREMQHQHNLDNGIIPKGVIKKITDVMDV
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GDHEYVDSERGVAEIEGEYHVAKPADISHDIDRLEKQMHEHAKNLEFEEAAAIRDKVGRL
CCCHHCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
REQFIKA
HHHHHCC
>Mature Secondary Structure 
SKSVFQLESMYKPAGDQPTAINKLVDGLESGVACQTLLGVTGSGKTFTIANVIEKMSRP
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TIIMAPNKTLAAQLYGEMKEFFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLLHLREGGNMEQRDILKRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHIVKRIA
HHHHHHHHHHCCEEEECCEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHH
RITVYPKSHYVTPRESILAATEEIKEELRERKKQLLDLNKLIEEQRITERVQYDLEMMTE
HHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRASGDGPPTLLDYLPEDGLLIIDESHVTVPQIGAMYKGDRSRKM
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCC
NLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSAYEIEKSDGEIAEQVVRPTGLL
HHHHHCCCCCHHHCCCCCCHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHCCCCCC
DPEIEVRPVSTQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
CCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYGDRITKSMDKAITETNRRREMQHQHNLDNGIIPKGVIKKITDVMDV
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GDHEYVDSERGVAEIEGEYHVAKPADISHDIDRLEKQMHEHAKNLEFEEAAAIRDKVGRL
CCCHHCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
REQFIKA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA