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The map label for this gene is thiC [H]

Identifier: 167623830

GI number: 167623830

Start: 2282952

End: 2284940

Strand: Direct

Name: thiC [H]

Synonym: Shal_1900

Alternate gene names: 167623830

Gene position: 2282952-2284940 (Clockwise)

Preceding gene: 167623829

Following gene: 167623831

Centisome position: 43.68

GC content: 48.22

Gene sequence:

>1989_bases
ATGTCAAATCGTCGCGAAACCCGAGCTCAAGCTCAACAGTTTATTGATAACTTAAAGCCACTGCAGCACCCCAATTCTGA
GAAAATTTACCTACAAGGCAGTCGAGCCGATCTAAAAGTGGGTATGCGTCAAATACACCAAGCAGATACCTTGATTGGTG
GCAATGAAACTAATCCTGTTTTTGAAGCGAATCCACCGCTAAAGGTTTATGACTGCGCCGGTGCTTATTCCGATCCCGAT
GCTAATATCGATGTGCGCAAAGGGCTTGAAAAATTCCGTGAACACTGGATAGAAGAGCGCGGCGATACCGAGCAACTTGC
CGGTGTGAGCTCGGGCTTTACCCAACAGCGATTAGCCGATGATGGCCTAGATCATTTACGCTTCGAGTCTTTATTGCCGC
CACGCCGCGCAAAAACGGCTAAACGCGTGACCCAGTTACACTACGCAAGGCAGGGTATTATCACTCCAGAGATGGAGTAT
ATTGCCATTCGTGAAAACATGGCGCTGGCAGAAGTTAATGACCCCATTTTAACTCAAAAAGATAAAGGCGAAAGTTTTGG
CGCAGTGATTGGCGAGCCGATAACGCCTGAATTTGTCAGGCAAGAAGTTGCCCGTGGCCGCGCCATTATCCCATTAAATA
TTAACCATCCTGAAGCTGAACCGATGATTATAGGGCGTAACTTTTTGGTTAAAGTGAATGCCAATATTGGTAATTCCGCC
GTGACATCGTCAATCGAAGAGGAAGTCGAAAAGCTGGTATGGTCGACTCGTTGGGGCGCCGATACCGTAATGGATCTGTC
TACCGGACGTTATATTCATGAAACCCGCGAGTGGATTATTCGTAACTCGCCAGTGCCAATCGGTACGGTGCCTATTTACC
AAGCGCTTGAGAAAGTTAATGGCATTGCTGAAGATCTTAACTGGGAAACCTTTCGCGATACCTTGATAGAGCAAGCCGAG
CAGGGCGTTGATTACTTCACCATTCATGCCGGTGTGCTACTACGTTATGTGCCAATGACGGCAAAACGCTTAACTGGCAT
CGTTTCTCGTGGCGGTTCAATCATGGCCAAATGGTGCTTGTCGCACCATAAAGAAAACTTCCTCTATGAACATTTTAGAG
ATATTTGCGAGATCTGCGCCGCATACGATGTTTCATTATCGCTGGGTGACGGCATGCGTCCTGGTTCAATTGCCGATGCG
AACGACGAAGCGCAATTTTCGGAGTTAACCACCTTAGGCGAGCTGGTTAAAATCGCTTGGCAATATGATGTTCAGACCAT
TATCGAAGGTCCCGGTCATATTCCAATGAATCTCATCAAAGAGAATATGGATAAGCAGCTTGAGCTGTGTGATGAAGCGC
CGTTTTACACCTTAGGCCCGCAAACGACCGATATTGCACCGGGTTACGATCATTTCACTTCAGGCATTGGCGCGGCAATG
ATCGCTTGGTATGGCTGCGCCATGCTGTGTTACGTCACGCCAAAAGAGCATCTTGGTCTGCCGAACAAAGAAGATGTAAA
GCAAGGACTCATTACCTACAAGATTGCTGCTCATGCAGGTGATGTGGCGAAGGGCCATCCTAGCGCGCAAATCCGTGATA
ACGCACTGTCTAAGGCGCGTTTTGAGTTCCGTTGGGAAGATCAGTATAACTTGGGTTTAGACCCTGATACGGCGCGGGCC
TATCATGATGAATCTTTACCTCAAGAGTCTGCCAAAGTGGCACATTTTTGCTCCATGTGTGGTCCTAAATTCTGTTCAAT
GAAGATCACCCAAGAGGTACGAGATTATGCCGCGGCGAAAGAGCGTGACGAGCTAGCAAACAACATCGATATCAAATCCG
ATGCCGAGTATCAATCATGCGCAGATAGCGAAACGACGTCAGAGCGAGAGCTGGGCATGGCGCAGATGTCAGCCGAGTTT
AAGGCTAAGGGCGCAGAGCTCTATCATGAAGCCGCCGATAAACAGCGTGATGCGGTATTAGAGGACTAG

Upstream 100 bases:

>100_bases
ACGTGTAACTAGCGTTTTATTTTTGGCTATACGTTCAACTTTTCACATTCTCATTTCTCCTGACAAGCAACTTCATTTCT
TTCTAAAAGTGAGTTTGCTA

Downstream 100 bases:

>100_bases
TCATGACAAGTGCTCGTCAAGTTTTGCCTGCTGTTCGTCCGATTGTGTGGACGATTGCGGGCTCTGATAGCGGAGGCGGC
GCGGGTATTCAAGCAGATCT

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MSNRRETRAQAQQFIDNLKPLQHPNSEKIYLQGSRADLKVGMRQIHQADTLIGGNETNPVFEANPPLKVYDCAGAYSDPD
ANIDVRKGLEKFREHWIEERGDTEQLAGVSSGFTQQRLADDGLDHLRFESLLPPRRAKTAKRVTQLHYARQGIITPEMEY
IAIRENMALAEVNDPILTQKDKGESFGAVIGEPITPEFVRQEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSA
VTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGIAEDLNWETFRDTLIEQAE
QGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLYEHFRDICEICAAYDVSLSLGDGMRPGSIADA
NDEAQFSELTTLGELVKIAWQYDVQTIIEGPGHIPMNLIKENMDKQLELCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAM
IAWYGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAGDVAKGHPSAQIRDNALSKARFEFRWEDQYNLGLDPDTARA
YHDESLPQESAKVAHFCSMCGPKFCSMKITQEVRDYAAAKERDELANNIDIKSDAEYQSCADSETTSERELGMAQMSAEF
KAKGAELYHEAADKQRDAVLED

Sequences:

>Translated_662_residues
MSNRRETRAQAQQFIDNLKPLQHPNSEKIYLQGSRADLKVGMRQIHQADTLIGGNETNPVFEANPPLKVYDCAGAYSDPD
ANIDVRKGLEKFREHWIEERGDTEQLAGVSSGFTQQRLADDGLDHLRFESLLPPRRAKTAKRVTQLHYARQGIITPEMEY
IAIRENMALAEVNDPILTQKDKGESFGAVIGEPITPEFVRQEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSA
VTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGIAEDLNWETFRDTLIEQAE
QGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLYEHFRDICEICAAYDVSLSLGDGMRPGSIADA
NDEAQFSELTTLGELVKIAWQYDVQTIIEGPGHIPMNLIKENMDKQLELCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAM
IAWYGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAGDVAKGHPSAQIRDNALSKARFEFRWEDQYNLGLDPDTARA
YHDESLPQESAKVAHFCSMCGPKFCSMKITQEVRDYAAAKERDELANNIDIKSDAEYQSCADSETTSERELGMAQMSAEF
KAKGAELYHEAADKQRDAVLED
>Mature_661_residues
SNRRETRAQAQQFIDNLKPLQHPNSEKIYLQGSRADLKVGMRQIHQADTLIGGNETNPVFEANPPLKVYDCAGAYSDPDA
NIDVRKGLEKFREHWIEERGDTEQLAGVSSGFTQQRLADDGLDHLRFESLLPPRRAKTAKRVTQLHYARQGIITPEMEYI
AIRENMALAEVNDPILTQKDKGESFGAVIGEPITPEFVRQEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAV
TSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGIAEDLNWETFRDTLIEQAEQ
GVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLYEHFRDICEICAAYDVSLSLGDGMRPGSIADAN
DEAQFSELTTLGELVKIAWQYDVQTIIEGPGHIPMNLIKENMDKQLELCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAMI
AWYGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAGDVAKGHPSAQIRDNALSKARFEFRWEDQYNLGLDPDTARAY
HDESLPQESAKVAHFCSMCGPKFCSMKITQEVRDYAAAKERDELANNIDIKSDAEYQSCADSETTSERELGMAQMSAEFK
AKGAELYHEAADKQRDAVLED

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=646, Percent_Identity=73.5294117647059, Blast_Score=1000, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 74114; Mature: 73983

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRRETRAQAQQFIDNLKPLQHPNSEKIYLQGSRADLKVGMRQIHQADTLIGGNETNPV
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCE
FEANPPLKVYDCAGAYSDPDANIDVRKGLEKFREHWIEERGDTEQLAGVSSGFTQQRLAD
EECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHH
DGLDHLRFESLLPPRRAKTAKRVTQLHYARQGIITPEMEYIAIRENMALAEVNDPILTQK
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCCCC
DKGESFGAVIGEPITPEFVRQEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSA
CCCCCCCHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEECCEEEEEEECCCCCHH
VTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVN
HHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
GIAEDLNWETFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCL
HHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SHHKENFLYEHFRDICEICAAYDVSLSLGDGMRPGSIADANDEAQFSELTTLGELVKIAW
HHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QYDVQTIIEGPGHIPMNLIKENMDKQLELCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAM
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
IAWYGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAGDVAKGHPSAQIRDNALSKAR
HHHHHHHHHEEECCHHHCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCE
FEFRWEDQYNLGLDPDTARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQEVRDYAAAK
EEEEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ERDELANNIDIKSDAEYQSCADSETTSERELGMAQMSAEFKAKGAELYHEAADKQRDAVL
HHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ED
CC
>Mature Secondary Structure 
SNRRETRAQAQQFIDNLKPLQHPNSEKIYLQGSRADLKVGMRQIHQADTLIGGNETNPV
CCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCE
FEANPPLKVYDCAGAYSDPDANIDVRKGLEKFREHWIEERGDTEQLAGVSSGFTQQRLAD
EECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHH
DGLDHLRFESLLPPRRAKTAKRVTQLHYARQGIITPEMEYIAIRENMALAEVNDPILTQK
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCCCC
DKGESFGAVIGEPITPEFVRQEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSA
CCCCCCCHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEECCEEEEEEECCCCCHH
VTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVN
HHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
GIAEDLNWETFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCL
HHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SHHKENFLYEHFRDICEICAAYDVSLSLGDGMRPGSIADANDEAQFSELTTLGELVKIAW
HHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QYDVQTIIEGPGHIPMNLIKENMDKQLELCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAM
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
IAWYGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAGDVAKGHPSAQIRDNALSKAR
HHHHHHHHHEEECCHHHCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCE
FEFRWEDQYNLGLDPDTARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQEVRDYAAAK
EEEEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ERDELANNIDIKSDAEYQSCADSETTSERELGMAQMSAEFKAKGAELYHEAADKQRDAVL
HHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ED
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA