Click here to switch to the map view.

The map label for this gene is ddl [H]

Identifier: 167623784

GI number: 167623784

Start: 2218082

End: 2219083

Strand: Reverse

Name: ddl [H]

Synonym: Shal_1854

Alternate gene names: 167623784

Gene position: 2219083-2218082 (Counterclockwise)

Preceding gene: 167623785

Following gene: 167623779

Centisome position: 42.45

GC content: 41.82

Gene sequence:

>1002_bases
ATGACCCAAAAGAATTTATTACTATTGTGTGGCGGCGGTGGCGATGAGCACAGCATCTCACTCTTATCGGCCAATTTTTT
TGAAACTCAATTAGCGACTCTACCACACTTCAATGTGCTGCGTGTCGAGCTTAATGCAAAAGGCCAATACCGTACTCAAG
CGGGTGAGCTGTGTGAGTTAACCAACAGCAAACAAATTCGCTTCAATGATCAGAGCAAAGCGCCATGGGATGTTGATTAC
GTTATTCCTTGTATTCATGGCTATCCGGGTGAAACTGGCGATATTCAATCTTACTTTGAGTTGATAAACCTTCCGTACTT
TGGTTGTGACTCAGAAGCGAGCAGTAACTGCTTTAATAAAGTCACCGCAAAAATGTGGTTCAGTGCGCTTGGGATCCGTA
ATACGCCATATATTTTCTTAAATGAGTTTAATCAACAAGCCATTGAAGAGACCGAACGAGCGCTAGAAAAGTGGGGCTCT
ATTTTTATCAAGGCCGCATCACAAGGCTCATCTGTGGGTTGTTACCGTGTAGATAATAAAGAGCAACTTGCCAACTCTTT
AGAAGAAGCCTTTAAATACTCACCTTATGTTGTGGTAGAAAAAACCATTAATGCTCGTGAGCTAGAAGTCGCCGCCTATG
AGGTCGACGGTGAGATCATCGCCACTAAGCCGGGTGAAATCATTTGTGCGAGTAACACTTTCTATAGTTTCGATGAAAAA
TATGCTGAAAATAGCCAAGCACAAACGGTTATTGAAGCCGATGTTGACGAGGTTATTGCTAAGCAAATTCAAGAATATGC
AATTAAAGCCTTTAAAGGGATGAAGTTAAGACACCTGTCGAGAATCGACTTCTTCTTAACTGATGAAAATGAGATCCTAC
TCAATGAGATCAATACATTTCCAGGGCAAACTCAGATCTCTATGTTCCCTAAGATGCTGCAAAACCACGGTCATAACTTT
GCTCAGTATCTTTCAGGCAACATCATGGCGCAACTTAAATAG

Upstream 100 bases:

>100_bases
CAGCATTTAAGCTAAATCGACTCGGCAAAACTTGCATTAAAAAGTGATTCAGCCATAGTGATCCAGCTGACTTTTATCAT
GGGTAACCGGTGGAGACAAA

Downstream 100 bases:

>100_bases
TCAGGCTTAGAAGCGAGACGTTACAAGCTTATAGTGACGCCATAGCGTAAATATAAGCTATCAATAAAACCATCTTGATA
CATTGCCAATAAGGCAGAAT

Product: D-alanyl-alanine synthetase A

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTQKNLLLLCGGGGDEHSISLLSANFFETQLATLPHFNVLRVELNAKGQYRTQAGELCELTNSKQIRFNDQSKAPWDVDY
VIPCIHGYPGETGDIQSYFELINLPYFGCDSEASSNCFNKVTAKMWFSALGIRNTPYIFLNEFNQQAIEETERALEKWGS
IFIKAASQGSSVGCYRVDNKEQLANSLEEAFKYSPYVVVEKTINARELEVAAYEVDGEIIATKPGEIICASNTFYSFDEK
YAENSQAQTVIEADVDEVIAKQIQEYAIKAFKGMKLRHLSRIDFFLTDENEILLNEINTFPGQTQISMFPKMLQNHGHNF
AQYLSGNIMAQLK

Sequences:

>Translated_333_residues
MTQKNLLLLCGGGGDEHSISLLSANFFETQLATLPHFNVLRVELNAKGQYRTQAGELCELTNSKQIRFNDQSKAPWDVDY
VIPCIHGYPGETGDIQSYFELINLPYFGCDSEASSNCFNKVTAKMWFSALGIRNTPYIFLNEFNQQAIEETERALEKWGS
IFIKAASQGSSVGCYRVDNKEQLANSLEEAFKYSPYVVVEKTINARELEVAAYEVDGEIIATKPGEIICASNTFYSFDEK
YAENSQAQTVIEADVDEVIAKQIQEYAIKAFKGMKLRHLSRIDFFLTDENEILLNEINTFPGQTQISMFPKMLQNHGHNF
AQYLSGNIMAQLK
>Mature_332_residues
TQKNLLLLCGGGGDEHSISLLSANFFETQLATLPHFNVLRVELNAKGQYRTQAGELCELTNSKQIRFNDQSKAPWDVDYV
IPCIHGYPGETGDIQSYFELINLPYFGCDSEASSNCFNKVTAKMWFSALGIRNTPYIFLNEFNQQAIEETERALEKWGSI
FIKAASQGSSVGCYRVDNKEQLANSLEEAFKYSPYVVVEKTINARELEVAAYEVDGEIIATKPGEIICASNTFYSFDEKY
AENSQAQTVIEADVDEVIAKQIQEYAIKAFKGMKLRHLSRIDFFLTDENEILLNEINTFPGQTQISMFPKMLQNHGHNFA
QYLSGNIMAQLK

Specific function: Cell wall formation [H]

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786579, Length=347, Percent_Identity=31.4121037463977, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786280, Length=247, Percent_Identity=29.1497975708502, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185 [H]

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N [H]

EC number: =6.3.2.4 [H]

Molecular weight: Translated: 37584; Mature: 37453

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50975 ATP_GRASP ; PS00843 DALA_DALA_LIGASE_1 ; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKNLLLLCGGGGDEHSISLLSANFFETQLATLPHFNVLRVELNAKGQYRTQAGELCEL
CCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHH
TNSKQIRFNDQSKAPWDVDYVIPCIHGYPGETGDIQSYFELINLPYFGCDSEASSNCFNK
CCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
VTAKMWFSALGIRNTPYIFLNEFNQQAIEETERALEKWGSIFIKAASQGSSVGCYRVDNK
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCH
EQLANSLEEAFKYSPYVVVEKTINARELEVAAYEVDGEIIATKPGEIICASNTFYSFDEK
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEECCEEEEECCCCEEEECCCCCCCHHH
YAENSQAQTVIEADVDEVIAKQIQEYAIKAFKGMKLRHLSRIDFFLTDENEILLNEINTF
HCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCEEEEHHCCC
PGQTQISMFPKMLQNHGHNFAQYLSGNIMAQLK
CCCCHHHHHHHHHHHCCCHHHHHHCCCEEEEEC
>Mature Secondary Structure 
TQKNLLLLCGGGGDEHSISLLSANFFETQLATLPHFNVLRVELNAKGQYRTQAGELCEL
CCCCEEEEECCCCCCCEEEEEECHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHH
TNSKQIRFNDQSKAPWDVDYVIPCIHGYPGETGDIQSYFELINLPYFGCDSEASSNCFNK
CCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
VTAKMWFSALGIRNTPYIFLNEFNQQAIEETERALEKWGSIFIKAASQGSSVGCYRVDNK
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCH
EQLANSLEEAFKYSPYVVVEKTINARELEVAAYEVDGEIIATKPGEIICASNTFYSFDEK
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEECCEEEEECCCCEEEECCCCCCCHHH
YAENSQAQTVIEADVDEVIAKQIQEYAIKAFKGMKLRHLSRIDFFLTDENEILLNEINTF
HCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCEEEEHHCCC
PGQTQISMFPKMLQNHGHNFAQYLSGNIMAQLK
CCCCHHHHHHHHHHHCCCHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA