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The map label for this gene is nhaB

Identifier: 167623771

GI number: 167623771

Start: 2196700

End: 2198286

Strand: Reverse

Name: nhaB

Synonym: Shal_1841

Alternate gene names: 167623771

Gene position: 2198286-2196700 (Counterclockwise)

Preceding gene: 167623773

Following gene: 167623770

Centisome position: 42.06

GC content: 44.3

Gene sequence:

>1587_bases
ATGCCTGTGACAATGAGTCGGGCGATTCTTGACAACTTCCTGGGTAATTCACCGAAGTGGTTCAAACTCGCGATCATATC
GTTTTTGGTGATCAACCCAATCGTATTTTACTTTAATCCGTTTATTGCGGGCTGGCTATTAGTTGTTGAGTTTATCTTCA
CCTTAGCTATGGCTCTAAAATGTTACCCACTGCAACCTGGCGGTCTATTAGCGATTGAAGCTGTAGCTATCGGTATGACG
TCACCGAGCCAAGTACTACATGAAATTGAAGCAAACTTAGAAGTCGTATTACTGCTGGTCTTTATGGTCGCTGGTATCTA
CTTCATGAAGCAGTTACTACTGTTCGTGTTTACCAAGATGATCACTAAGGTTCGTTCAAAAGTTTACGTATCTTTGTTGT
TCTGTGTTTCCTCGGCTTTCTTATCGGCTTTCTTAGATGCACTGACTGTTATCGCGGTTATTATCACCGTTGCCGTTGGT
TTCTATTCTATTTACCATAGAGTGGCATCGGGTAAGAGCTTTGCAGACAGCCACGATCATACCTCTGACGGTCATCCACA
ACTATGTGAAGAAGAACTTGAATCTTTCCGTGGTTTCTTACGTAACTTGTTGATGCATGCTGGTGTTGGTACTGCTTTAG
GTGGTGTGTGCACCATGGTTGGTGAACCACAAAACCTAATTATTGCAGCACAAGCAAACTGGCAGTTCGCTGAATTTGCG
ATCCGCATGTCGCCAGTGACTGTACCGGTATTCTTTGCGGGTGTTACCACCTGTTTCTTGGTTGAGAAATTTAAAGTCTT
CGGCTACGGGCAACAACTACCAGAAGCGGTTCATAAGATCCTATCCGATTACGATGCTCATGAAGATGCAAACCGCACCA
AGCACGATAAAGTTAAGCTTCTTGTCCAAGCGTTTATCGGTGTATGGTTAATCGCAGGTCTTGCACTGCACTTAGCTTCT
GTTGGTTTAATCGGTCTGTCAGTGATTATTCTTGCTACGGCATTTAACGGTATCACTAACGAACACGCACTGGGTAAGGC
CTTCGAAGAAGCGCTACCATTTACAGCGTTATTAGCAGTCTTCTTTGCCATCGTAGCCGTAATTATCGATCTACAACTGT
TCGCACCTGTAATTCAGTGGGCACTGAGCTATGAAGGTAACACTCAGTTAGTGGTCTTCTATATCGCCAACGGTCTACTC
TCAATGGTGAGTGATAACGTATTCGTAGGTACGGTTTACATTAACGAAGTGAAAGCTGCGCTACTTAACGGCCAGATCAC
TCGTGATCAGTTCGATCTACTTGCGGTTGCGATTAACACTGGTACTAACCTACCTTCTGTTGCAACACCAAACGGTCAGG
CTGCGTTCCTATTCCTACTAACATCTGCGATTGCTCCACTCATCCGTCTTTCTTACGGAAGAATGGTATGGATGGCGCTA
CCGTACACTATCGTATTATCTATCGTGGGTGTTCTTGCAATCCAGTTAGGCGCCCTAGAGCAGATGACTCAGTATTTTTA
TGATACACAACTATTGATTCATCACTCTGCTCAAGCCGTCACAGATAGTGTAGTATCAGGACATTGA

Upstream 100 bases:

>100_bases
AACTCATCAAAAAAGCTTTTACCTTTTCATTATCGCTAGTAGCATACGATGCAAATTTGTTTGCTACTCGTAAATATAGA
AAATCAATAGAGAGGATTCC

Downstream 100 bases:

>100_bases
TAAGCATTTTCTGAACTATCTAACAAATAGTTAGTCATATAAAACGCCCTATTCAATAGGGCGTTTTTTTTATCTGCAAT
GGAGACACAATCGTTGAATG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MPVTMSRAILDNFLGNSPKWFKLAIISFLVINPIVFYFNPFIAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVAIGMT
SPSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKMITKVRSKVYVSLLFCVSSAFLSAFLDALTVIAVIITVAVG
FYSIYHRVASGKSFADSHDHTSDGHPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFA
IRMSPVTVPVFFAGVTTCFLVEKFKVFGYGQQLPEAVHKILSDYDAHEDANRTKHDKVKLLVQAFIGVWLIAGLALHLAS
VGLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAVFFAIVAVIIDLQLFAPVIQWALSYEGNTQLVVFYIANGLL
SMVSDNVFVGTVYINEVKAALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMAL
PYTIVLSIVGVLAIQLGALEQMTQYFYDTQLLIHHSAQAVTDSVVSGH

Sequences:

>Translated_528_residues
MPVTMSRAILDNFLGNSPKWFKLAIISFLVINPIVFYFNPFIAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVAIGMT
SPSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKMITKVRSKVYVSLLFCVSSAFLSAFLDALTVIAVIITVAVG
FYSIYHRVASGKSFADSHDHTSDGHPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFA
IRMSPVTVPVFFAGVTTCFLVEKFKVFGYGQQLPEAVHKILSDYDAHEDANRTKHDKVKLLVQAFIGVWLIAGLALHLAS
VGLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAVFFAIVAVIIDLQLFAPVIQWALSYEGNTQLVVFYIANGLL
SMVSDNVFVGTVYINEVKAALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMAL
PYTIVLSIVGVLAIQLGALEQMTQYFYDTQLLIHHSAQAVTDSVVSGH
>Mature_527_residues
PVTMSRAILDNFLGNSPKWFKLAIISFLVINPIVFYFNPFIAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVAIGMTS
PSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKMITKVRSKVYVSLLFCVSSAFLSAFLDALTVIAVIITVAVGF
YSIYHRVASGKSFADSHDHTSDGHPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFAI
RMSPVTVPVFFAGVTTCFLVEKFKVFGYGQQLPEAVHKILSDYDAHEDANRTKHDKVKLLVQAFIGVWLIAGLALHLASV
GLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAVFFAIVAVIIDLQLFAPVIQWALSYEGNTQLVVFYIANGLLS
MVSDNVFVGTVYINEVKAALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMALP
YTIVLSIVGVLAIQLGALEQMTQYFYDTQLLIHHSAQAVTDSVVSGH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family

Homologues:

Organism=Escherichia coli, GI1787435, Length=507, Percent_Identity=66.6666666666667, Blast_Score=659, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAB_SHEHH (B0TRI8)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674065.1
- GeneID:   5904052
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1841
- HOGENOM:   HBG296776
- OMA:   CFLVEKF
- ProtClustDB:   PRK09547
- BioCyc:   SHAL458817:SHAL_1841-MONOMER
- HAMAP:   MF_01599
- InterPro:   IPR004671
- TIGRFAMs:   TIGR00774

Pfam domain/function: PF06450 NhaB

EC number: NA

Molecular weight: Translated: 57629; Mature: 57497

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xe1111ec)-; HASH(0xe2ceb5c)-; HASH(0xe071e10)-; HASH(0x408b80ec)-; HASH(0xe29970c)-; HASH(0xd7fe1b4)-; HASH(0xe3e89d4)-; HASH(0xe115518)-; HASH(0x408c89ac)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
PVTMSRAILDNFLGNSPKWFKLAIISFLVINPIVFYFNPFIAGWLLVVEFIFTLAMALK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA