Click here to switch to the map view.

The map label for this gene is purM

Identifier: 167623611

GI number: 167623611

Start: 2014661

End: 2015701

Strand: Reverse

Name: purM

Synonym: Shal_1680

Alternate gene names: 167623611

Gene position: 2015701-2014661 (Counterclockwise)

Preceding gene: 167623613

Following gene: 167623610

Centisome position: 38.56

GC content: 46.3

Gene sequence:

>1041_bases
GTGAGCACTCCTACTACCCCACTAAGCTATAAAGATGCAGGCGTTGATATTGATGCCGGAAATGCACTAGTTAACAACAT
CAAGTCAGCAGTAAAACGTACCCGCCGTCCAGAAGTTATGGGCAACTTAGGTGGTTTTGGTGCCCTTTGTGAGCTACCAA
CTAAGTATAAGCATCCAGTACTGGTTTCTGGTACTGATGGTGTTGGCACTAAGCTACGCCTTGCTATCGACTTTAAAAAG
CACGATAACGTTGGTATCGACCTAGTCGCCATGTGTTCAAATGATCTCATCGTTTCTGGTGCAGAGCCTCTGTTCTTCCT
TGACTACTACGCGACAGGCAAACTCGATGTTGAAGTTGCTACTGCCGTTGTTAAAGGGATCGCTGAAGGCTGTGTGCAAT
CAGGCTGTGCACTTATCGGCGGTGAAACGGCTGAAATGCCAGGCATGTATGAAGGCGACGACTATGACCTAGCAGGATTC
TGCGTCGGCGTAGTAGAAAAAGAAGAGATCATCGACGGCACTAAGGTGCAAGACGGTGATGCACTTATCGCGCTTGCTTC
AAGCGGTCCTCATTCAAATGGTTTCTCACTTATCCGTAAGGTATTAGAAGTGAGCAAGGCAGACCCTGAACTCGAACTTG
CTGGTAAGCCACTAATAGATCATCTATTAGAACCTACAAAAATTTATGTAAAGTCACTGCTTAAATTGCTTGAACAACAT
GATGTTCACGCAATGTCGCATATTACAGGTGGTGGATTCTGGGAGAATATCCCACGCGTACTACCTGAAGATTGCAAAGC
GGTGGTTAACAGCGACTCTTGGCAGTGGCCTGTTGTATTTAACTGGTTGATGGAAAACGGCAACATTTCTGAATTTGAAA
TGTACCGCACCTTCAACTGCGGCGTTGGTATGGTTATCGCCCTACCAGCAGATAAAGTCGATTCAGCCTTAGCGTTGCTA
AAAACAGAAGGCGAGAACGCATGGTTAATCGGAAACATTGCCAAGCGTAACGGCGAAGAAGAGCAAGTGGAGATCCTGTA
A

Upstream 100 bases:

>100_bases
TTTATTGAAAAACTTAGCTTTCGACGCTACCCACAAGCTGATAGAATGACGCCGCATAAAATCCTATAACAATCTATACC
CGTACCCGAAGAGGATCTCC

Downstream 100 bases:

>100_bases
TGCCCCAGAGTTGTCGCGTTTTAGTATTAATTTCAGGTAATGGCAGTAATTTACAAGCCATTATCGATGGCTGTGATGAT
AACCTGCAAGCCGATGTGGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSTPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDFKK
HDNVGIDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVATAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGF
CVGVVEKEEIIDGTKVQDGDALIALASSGPHSNGFSLIRKVLEVSKADPELELAGKPLIDHLLEPTKIYVKSLLKLLEQH
DVHAMSHITGGGFWENIPRVLPEDCKAVVNSDSWQWPVVFNWLMENGNISEFEMYRTFNCGVGMVIALPADKVDSALALL
KTEGENAWLIGNIAKRNGEEEQVEIL

Sequences:

>Translated_346_residues
MSTPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDFKK
HDNVGIDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVATAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGF
CVGVVEKEEIIDGTKVQDGDALIALASSGPHSNGFSLIRKVLEVSKADPELELAGKPLIDHLLEPTKIYVKSLLKLLEQH
DVHAMSHITGGGFWENIPRVLPEDCKAVVNSDSWQWPVVFNWLMENGNISEFEMYRTFNCGVGMVIALPADKVDSALALL
KTEGENAWLIGNIAKRNGEEEQVEIL
>Mature_345_residues
STPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDFKKH
DNVGIDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVATAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGFC
VGVVEKEEIIDGTKVQDGDALIALASSGPHSNGFSLIRKVLEVSKADPELELAGKPLIDHLLEPTKIYVKSLLKLLEQHD
VHAMSHITGGGFWENIPRVLPEDCKAVVNSDSWQWPVVFNWLMENGNISEFEMYRTFNCGVGMVIALPADKVDSALALLK
TEGENAWLIGNIAKRNGEEEQVEIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=344, Percent_Identity=48.8372093023256, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI209869995, Length=344, Percent_Identity=48.8372093023256, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI209869993, Length=344, Percent_Identity=48.8372093023256, Blast_Score=328, Evalue=6e-90,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=73.6842105263158, Blast_Score=533, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=42.6086956521739, Blast_Score=250, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=47.7744807121662, Blast_Score=307, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24582400, Length=315, Percent_Identity=42.8571428571429, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SHEHH (B0TPW7)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673905.1
- ProteinModelPortal:   B0TPW7
- SMR:   B0TPW7
- GeneID:   5902613
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1680
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   SHAL458817:SHAL_1680-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37295; Mature: 37164

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPV
CCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCCCCCCCE
LVSGTDGVGTKLRLAIDFKKHDNVGIDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVA
EEECCCCCCCEEEEEEEEECCCCCCEEEEEECCCCEEEECCCCEEEEEEEECCEEEHHHH
TAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGFCVGVVEKEEIIDGTKVQDGD
HHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHEEEECCHHHHCCCCEECCCC
ALIALASSGPHSNGFSLIRKVLEVSKADPELELAGKPLIDHLLEPTKIYVKSLLKLLEQH
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHC
DVHAMSHITGGGFWENIPRVLPEDCKAVVNSDSWQWPVVFNWLMENGNISEFEMYRTFNC
CHHHHHHCCCCCHHHHHHHCCCHHHHHHHCCCCCCCHHEEEEECCCCCCCEEEEEEEECC
GVGMVIALPADKVDSALALLKTEGENAWLIGNIAKRNGEEEQVEIL
CCEEEEEECCHHHHHHHHHEEECCCCEEEEEEHHHCCCCCCEEEEC
>Mature Secondary Structure 
STPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPV
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCCCCCCCE
LVSGTDGVGTKLRLAIDFKKHDNVGIDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVA
EEECCCCCCCEEEEEEEEECCCCCCEEEEEECCCCEEEECCCCEEEEEEEECCEEEHHHH
TAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGFCVGVVEKEEIIDGTKVQDGD
HHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHEEEECCHHHHCCCCEECCCC
ALIALASSGPHSNGFSLIRKVLEVSKADPELELAGKPLIDHLLEPTKIYVKSLLKLLEQH
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHC
DVHAMSHITGGGFWENIPRVLPEDCKAVVNSDSWQWPVVFNWLMENGNISEFEMYRTFNC
CHHHHHHCCCCCHHHHHHHCCCHHHHHHHCCCCCCCHHEEEEECCCCCCCEEEEEEEECC
GVGMVIALPADKVDSALALLKTEGENAWLIGNIAKRNGEEEQVEIL
CCEEEEEECCHHHHHHHHHEEECCCCEEEEEEHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA