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The map label for this gene is galE [H]

Identifier: 167623460

GI number: 167623460

Start: 1844331

End: 1845350

Strand: Reverse

Name: galE [H]

Synonym: Shal_1529

Alternate gene names: 167623460

Gene position: 1845350-1844331 (Counterclockwise)

Preceding gene: 167623461

Following gene: 167623459

Centisome position: 35.3

GC content: 45.29

Gene sequence:

>1020_bases
ATGACGATTTTAGTTACTGGCGGCGCCGGTTATATCGGTACTCATACGGTTGTTGAGCTACTCAACAGCGGTAATGAGGT
CGTTATCTTAGATAACCTCAGCAACTCGAGTGTGACAGCACTTGAGCGAGTCGAGCAGATCACTGGAAAAGCAGTGACAT
TTTATCAAGGCGATGTTCTCAATAGAGCCTTTTTGCAAAAACTGTTTACAGATCATGATATTAAATCTGTCATTCACTTT
GCAGGTTTGAAAGCCGTGGGTGAATCTGTTGCTCAGCCACTGCGCTACTATGAAAACAATGTCACTGGCACCATAGTATT
ATGTGAAGTGATGGCAGAGTTTAATGTCAAAAATTTAGTATTTAGCTCTTCAGCCACAGTCTATGGCGATCCAGCTAGCC
TACCGATTACCGAAGACTTCCCAACTGGGGCGACTAATCCCTATGGCCAGTCCAAGTTAATGGTTGAGCACATTCTTGCG
GATCTCTATCACTCTGACAACAGCTGGAATATCGCGCTATTACGCTACTTTAATCCGGTTGGAGCCCATAAGAGCGGCTT
AATTGGTGAAGACCCCAATGATATTCCTAATAACCTAATGCCTTTTATCACCCAAGTTGCGGTGGGTAAGCGTGAGCAAT
TAAGCGTATTCGGAAGCGACTATGATACTGTAGATGGCACTGGCGTAAGGGATTACATCCATGTCGTCGACTTAGCCATT
GGTCACCTACGAGCCCTTGATAAGCTACATAGTCAGTCAGGGTTAGTGACCTATAACTTAGGTACAGGTCAGGGTTACAG
TGTACTTGAGATGGTTAAGGCGTTTGAAAAAGCGAGCGGCACTCAGATTAAGTACCAGTTGGTTGCAAGAAGACCTGGTG
ATATCGCCGCATGCTATGCAAATCCAGACAAGGCTCATAAAGAGTTAGGCTGGCAAGCGACCCATAGCATCGATGATATG
GCGCAAAGCAGCTGGCATTGGCAATCGACTAATCCTAATGGGTATGTGACTGAAGAGTAA

Upstream 100 bases:

>100_bases
AAGACTCTTAAATAATAGCCTCTTAAGTAACAGACGCTTGAGTAATAAACGCTTAGCGAATGTCTCTTGAACATCAGCCT
AGATGAAAGGATTTTAAATA

Downstream 100 bases:

>100_bases
AGAAAGGTAAGCCGAGAAGGACGCTACGCTGCTAGGACGAGACTTCGTATCTTCGAGAGTGTCACGTGGCGACTTCTAGA
TTCGACAAAACAGCTCAAAA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTILVTGGAGYIGTHTVVELLNSGNEVVILDNLSNSSVTALERVEQITGKAVTFYQGDVLNRAFLQKLFTDHDIKSVIHF
AGLKAVGESVAQPLRYYENNVTGTIVLCEVMAEFNVKNLVFSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILA
DLYHSDNSWNIALLRYFNPVGAHKSGLIGEDPNDIPNNLMPFITQVAVGKREQLSVFGSDYDTVDGTGVRDYIHVVDLAI
GHLRALDKLHSQSGLVTYNLGTGQGYSVLEMVKAFEKASGTQIKYQLVARRPGDIAACYANPDKAHKELGWQATHSIDDM
AQSSWHWQSTNPNGYVTEE

Sequences:

>Translated_339_residues
MTILVTGGAGYIGTHTVVELLNSGNEVVILDNLSNSSVTALERVEQITGKAVTFYQGDVLNRAFLQKLFTDHDIKSVIHF
AGLKAVGESVAQPLRYYENNVTGTIVLCEVMAEFNVKNLVFSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILA
DLYHSDNSWNIALLRYFNPVGAHKSGLIGEDPNDIPNNLMPFITQVAVGKREQLSVFGSDYDTVDGTGVRDYIHVVDLAI
GHLRALDKLHSQSGLVTYNLGTGQGYSVLEMVKAFEKASGTQIKYQLVARRPGDIAACYANPDKAHKELGWQATHSIDDM
AQSSWHWQSTNPNGYVTEE
>Mature_338_residues
TILVTGGAGYIGTHTVVELLNSGNEVVILDNLSNSSVTALERVEQITGKAVTFYQGDVLNRAFLQKLFTDHDIKSVIHFA
GLKAVGESVAQPLRYYENNVTGTIVLCEVMAEFNVKNLVFSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILAD
LYHSDNSWNIALLRYFNPVGAHKSGLIGEDPNDIPNNLMPFITQVAVGKREQLSVFGSDYDTVDGTGVRDYIHVVDLAIG
HLRALDKLHSQSGLVTYNLGTGQGYSVLEMVKAFEKASGTQIKYQLVARRPGDIAACYANPDKAHKELGWQATHSIDDMA
QSSWHWQSTNPNGYVTEE

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=343, Percent_Identity=59.7667638483965, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI56118217, Length=343, Percent_Identity=59.7667638483965, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI189083684, Length=343, Percent_Identity=59.7667638483965, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI7657641, Length=338, Percent_Identity=26.0355029585799, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI42516563, Length=331, Percent_Identity=25.3776435045317, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=58.0357142857143, Blast_Score=413, Evalue=1e-117,
Organism=Escherichia coli, GI48994969, Length=360, Percent_Identity=27.7777777777778, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788353, Length=364, Percent_Identity=25, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=54.178674351585, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=53.6231884057971, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17568069, Length=335, Percent_Identity=24.4776119402985, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=271, Percent_Identity=23.9852398523985, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=342, Percent_Identity=54.6783625730994, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19923002, Length=346, Percent_Identity=59.5375722543353, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI21356223, Length=285, Percent_Identity=25.9649122807018, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37042; Mature: 36911

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTGGAGYIGTHTVVELLNSGNEVVILDNLSNSSVTALERVEQITGKAVTFYQGDVL
CEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHH
NRAFLQKLFTDHDIKSVIHFAGLKAVGESVAQPLRYYENNVTGTIVLCEVMAEFNVKNLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCHHHEE
FSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILADLYHSDNSWNIALLRYFNPV
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GAHKSGLIGEDPNDIPNNLMPFITQVAVGKREQLSVFGSDYDTVDGTGVRDYIHVVDLAI
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHEEEECCCCCCCCCCCHHHHHHHHHHHH
GHLRALDKLHSQSGLVTYNLGTGQGYSVLEMVKAFEKASGTQIKYQLVARRPGDIAACYA
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEC
NPDKAHKELGWQATHSIDDMAQSSWHWQSTNPNGYVTEE
CHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEECC
>Mature Secondary Structure 
TILVTGGAGYIGTHTVVELLNSGNEVVILDNLSNSSVTALERVEQITGKAVTFYQGDVL
EEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHH
NRAFLQKLFTDHDIKSVIHFAGLKAVGESVAQPLRYYENNVTGTIVLCEVMAEFNVKNLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCHHHEE
FSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILADLYHSDNSWNIALLRYFNPV
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GAHKSGLIGEDPNDIPNNLMPFITQVAVGKREQLSVFGSDYDTVDGTGVRDYIHVVDLAI
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHEEEECCCCCCCCCCCHHHHHHHHHHHH
GHLRALDKLHSQSGLVTYNLGTGQGYSVLEMVKAFEKASGTQIKYQLVARRPGDIAACYA
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEC
NPDKAHKELGWQATHSIDDMAQSSWHWQSTNPNGYVTEE
CHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]