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The map label for this gene is pepA2 [H]

Identifier: 167622902

GI number: 167622902

Start: 1183832

End: 1185340

Strand: Reverse

Name: pepA2 [H]

Synonym: Shal_0962

Alternate gene names: 167622902

Gene position: 1185340-1183832 (Counterclockwise)

Preceding gene: 167622905

Following gene: 167622900

Centisome position: 22.68

GC content: 47.71

Gene sequence:

>1509_bases
ATGGAGTTTAGCGTAAAGAGCGGTAGTCCAGAGAAACAACGCTCAGCTTGTATCGTCGTAGGTGTATACGAACCAAGACG
CTTGTCCGGTATTGCCGAACAGTTAGATAAAATTAGTGAAGGCTATATCAGCAATTTACTTCGTCGTGGTGATTTGGAAG
GGAAGCCTGGACAGATGTTATTACTTCATCATGTCCCTAACGTACTCAGTGAACGTGTTTTGCTTGTCGGTTGCGGTAAA
GAGCGTGAGCTAGATGAACGCCAGTATAAACAGATCATCACCAAAACAATCAACACCTTGAATGAAACGGGTTCAATGGA
AGCGGTTTGCTTCCTTACCGAGTTACATGTCAAAGGACGCGATACTTACTGGAAAGTACGTGAAGCGGTTGAAACTACGC
AAAACAGCTTATATAGCTTCGATGCACTCAAAACCCGAAAAGACGAAACCCGTCGCCCACTGCGCAAATTGGTATTTAAC
GTACCGACACGTCGTGAGCTGACTGTTGGTGAACGCGCTATTGAGCACGGCATGGCGGTTTCAGAAGGAATGCACCTTTG
CCGCGACGTGGCAAATATGCCGCCAAACATCTGTAACCCAGCTTACCTTGCCTCACAGGCTCGCCAAATGGCGGAAAACA
CAGAAAACCTAACGGTGACAACTGTCGGTGAAGAGCAGATGGAAGCGCTAGGCATGAATTCATACCTCGCGGTTGGCCGT
GGTAGCGATAATGAGTCAGTAATGACTATTATGGAATACAAGGGCGCTGTTGATAATACTGAAAAGCCAATCGTTTTAGT
CGGTAAAGGACTTACTTTTGATTCAGGTGGTATTTCCCTTAAGCCTGGCGAAGCCATGGATGAGATGAAGTACGATATGG
GCGGCGCTGCGGGTGTTATCGGTGCGATGAAAGCTCTGTGTGATTTGCAACTCCCTATCAACGTAATTGGTATTTTGGCT
GGTTGTGAAAACATGCCATCGAGTAATGCATACCGTCCTGGTGATATCCTCACGACTATGTCAGGTCAAACTGTTGAAGT
ACTCAATACTGATGCCGAAGGTCGCTTAGTATTATGTGACGTTCTCACCTATGTTGAGCGCTTCGACCCAGAACTGGTTG
TTGATACAGCAACACTAACGGGCGCTTGTGTTATTGCACTTGGTAAGCATGCATCAGGTTTGTTCTCTGGCCACAATCCT
CTGGCACATGAACTACTCAATGCGGGTGAGCAAAGTGGTGATCGCGCATGGCGCATGCCTTTATGGGATGAGTATCAGGA
GCACTTGGAAAGTCCATTTGCCGATATGACAAACCTAGGTGGCCGTGCAGCGGGGTCAATTACCGCTGCTTGCTTCCTGT
CTCGCTTTGCTAAGAAGTATAACTGGGCCCATCTAGATGTGGCTGGTACGGCTTGGAACAGCGGAGCGAATAAAGGCTCA
ACCGGTCGTCCGGTGCCTTTGTTGACTCAATTTTTAATCAATCGCGCTGGAGTTGACCAAGGCGAGTAA

Upstream 100 bases:

>100_bases
AAGAAAATTCTTGAGAGCGCCATATCTAAGCCCTTTTTGGGCACAAGCAGACATTATCTAATAAATAATAAAATTTGTCT
TTAAGAATCTAGGAGAGCTC

Downstream 100 bases:

>100_bases
GCCAAAGTTAAGTGCCACGACTTTGAAAGGCTAAACCTCATTGGTTTAGCCTTTTTTATTTCAAACTCCCACATAGCGAC
TCAACCACGATTTCCCGACC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase 2; LAP 2; Leucyl aminopeptidase 2 [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVREAVETTQNSLYSFDALKTRKDETRRPLRKLVFN
VPTRRELTVGERAIEHGMAVSEGMHLCRDVANMPPNICNPAYLASQARQMAENTENLTVTTVGEEQMEALGMNSYLAVGR
GSDNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGAMKALCDLQLPINVIGILA
GCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNP
LAHELLNAGEQSGDRAWRMPLWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINRAGVDQGE

Sequences:

>Translated_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVREAVETTQNSLYSFDALKTRKDETRRPLRKLVFN
VPTRRELTVGERAIEHGMAVSEGMHLCRDVANMPPNICNPAYLASQARQMAENTENLTVTTVGEEQMEALGMNSYLAVGR
GSDNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGAMKALCDLQLPINVIGILA
GCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNP
LAHELLNAGEQSGDRAWRMPLWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINRAGVDQGE
>Mature_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVREAVETTQNSLYSFDALKTRKDETRRPLRKLVFN
VPTRRELTVGERAIEHGMAVSEGMHLCRDVANMPPNICNPAYLASQARQMAENTENLTVTTVGEEQMEALGMNSYLAVGR
GSDNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGAMKALCDLQLPINVIGILA
GCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNP
LAHELLNAGEQSGDRAWRMPLWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINRAGVDQGE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=490, Percent_Identity=34.4897959183673, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI47155554, Length=326, Percent_Identity=30.6748466257669, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1790710, Length=500, Percent_Identity=76.4, Blast_Score=808, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=309, Percent_Identity=41.1003236245955, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=300, Percent_Identity=33, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=459, Percent_Identity=27.2331154684096, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20129969, Length=519, Percent_Identity=30.2504816955684, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=33.641975308642, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=33.9506172839506, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI161077148, Length=501, Percent_Identity=29.3413173652695, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI20130057, Length=501, Percent_Identity=29.3413173652695, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24662227, Length=508, Percent_Identity=29.5275590551181, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI21355645, Length=506, Percent_Identity=30.0395256916996, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24662223, Length=506, Percent_Identity=30.0395256916996, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI20129963, Length=504, Percent_Identity=29.3650793650794, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI19922386, Length=498, Percent_Identity=29.9196787148594, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI221379063, Length=288, Percent_Identity=32.2916666666667, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221379062, Length=288, Percent_Identity=32.2916666666667, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357381, Length=288, Percent_Identity=32.2916666666667, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646701, Length=246, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646703, Length=246, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21358201, Length=246, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54821; Mature: 54821

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGR
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCC
DTYWKVREAVETTQNSLYSFDALKTRKDETRRPLRKLVFNVPTRRELTVGERAIEHGMAV
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHH
SEGMHLCRDVANMPPNICNPAYLASQARQMAENTENLTVTTVGEEQMEALGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCEEEEEC
GSDNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCCCEEEHEECCCCCCCCCCCEEEEECCCEECCCCCEECCCCHHHHHHHHCCCHHHHH
GAMKALCDLQLPINVIGILAGCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNPLAHELLNAGEQSGDRAWRMP
HHHHHHHCCCCEEEECHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TGRPVPLLTQFLINRAGVDQGE
CCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGR
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCC
DTYWKVREAVETTQNSLYSFDALKTRKDETRRPLRKLVFNVPTRRELTVGERAIEHGMAV
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHH
SEGMHLCRDVANMPPNICNPAYLASQARQMAENTENLTVTTVGEEQMEALGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCEEEEEC
GSDNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCCCEEEHEECCCCCCCCCCCEEEEECCCEECCCCCEECCCCHHHHHHHHCCCHHHHH
GAMKALCDLQLPINVIGILAGCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNPLAHELLNAGEQSGDRAWRMP
HHHHHHHCCCCEEEECHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TGRPVPLLTQFLINRAGVDQGE
CCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]