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The map label for this gene is gltP [H]

Identifier: 167622713

GI number: 167622713

Start: 960923

End: 962179

Strand: Direct

Name: gltP [H]

Synonym: Shal_0773

Alternate gene names: 167622713

Gene position: 960923-962179 (Clockwise)

Preceding gene: 167622712

Following gene: 167622716

Centisome position: 18.38

GC content: 48.05

Gene sequence:

>1257_bases
ATGAAAAAATCACTTTCGACTCGGATCTTTATCGGTCTATTTTCAGGGCTAATTTTTGGCTCTATCATTCAATACTTCCT
CGCAGACATTAGTTTTTTCTCTGGCACTATCGTTGACTTAGCCTCAGGCGCAGGCACCATGTTCGTTAATATGATCATGA
TGTTAGTGGTACCTTTAGTTTTTGTTAGTATCGTTTGCGGCGTGAGTGAGCTTAAAGATCTCAACAGCTTCGGCCGCCTA
GGCGGTAAAACATTCGGCTTTTACATCATCAACACCTTAGTGGCGATCTTCGCGGCATTGGGCGTGGCGTTATTGCTCGC
TCCTGGTAAGGGCGTTGATATGTCTAGCGGTGGCGGTGTCGATATCGTCGCAACGGAGCTACCTAATCTTGTCGATTTGA
TTGTGAGTATCGTACCGAGCAACCCGATTACCGCATTTGGCTCGGGTAACATGCTACAAGTTATCTTTATGGCACTGTTA
CTCGGTGGCGTGATTAAATCTCTTGGTGAGGCGGCGCAAAGCGCGGTAAACGGCTTCCAAGTGGCAAACAAGATCATGAT
GAAGCTGATAAGTGTAGTGATGCAGCTAGCGCCAATCGGTGTATTTGCACTGATGCTAAAGCTTGGTGCGACACTAGAGG
CGGCGATATTTGGCAGCGTGGTTGAATACCTAGCGCTGATCTTAAGCCTATTATTACTGTGGATTTTTGTGGTCTACCCA
TTCGCCGTTAGTCTATTTACTCCTATATCGGCAAAAGAGTTTCGCGCTAAGACTCGTGAGCAAATTTTGTTTTCACTGTC
GACTGCTAGCTCAAATGCGACCATTCCAGTGACTATGCGCACCCTAACCGAGAAGCTCGGTGTTAATCGCTCTGTTGCAG
GCTTTGGCGTACCGCTCGGCGCGACCATGAACATGGGCGGCGTATCGATTTATATCACTATCGCTATCTTCTTTGTGGCT
AACGCATTTGGCGCGCCAATTCCGATGGAGCAGCTACCCGCATTGTTATTTAGTATTTTCTTACTGTCAGTCGGCGCTGG
TGGCGTACCTGGCGGCGGCATGGTGATGATTGGTGTGCTTATCCATCAGATGGGGCTACCTATCGAAGCGTTCGCAATTG
TGGCAGCCCTAGACCGCTTAATCGATATGGTGCTGACTTCTTGTAACGTCGTGGGTGACACTGCAGTACTGACTATTGTT
GATGAAACAGAAAAGAGCGGCGACGCTAAGTTAGTCGCAGCGCAGGCTCAAGTATAA

Upstream 100 bases:

>100_bases
GTTTCACTATCCTCGACACAAAGAGATGAAAACCTATAACTCATCAAAATTGAAGGCAATAGAAGGCATGCGCTAAGACA
TGTCCCAATAAGGCAAGCAA

Downstream 100 bases:

>100_bases
TCCGCTGTAGAGCCCTCTATTATTAAAGATAAAAAATGCCAGCAACTTGCTGGCATTTTTGTTTTCTGCTTCTTGTTTCT
TTTCTTTAGTTTCTTATCTT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKKSLSTRIFIGLFSGLIFGSIIQYFLADISFFSGTIVDLASGAGTMFVNMIMMLVVPLVFVSIVCGVSELKDLNSFGRL
GGKTFGFYIINTLVAIFAALGVALLLAPGKGVDMSSGGGVDIVATELPNLVDLIVSIVPSNPITAFGSGNMLQVIFMALL
LGGVIKSLGEAAQSAVNGFQVANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILSLLLLWIFVVYP
FAVSLFTPISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTEKLGVNRSVAGFGVPLGATMNMGGVSIYITIAIFFVA
NAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPIEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIV
DETEKSGDAKLVAAQAQV

Sequences:

>Translated_418_residues
MKKSLSTRIFIGLFSGLIFGSIIQYFLADISFFSGTIVDLASGAGTMFVNMIMMLVVPLVFVSIVCGVSELKDLNSFGRL
GGKTFGFYIINTLVAIFAALGVALLLAPGKGVDMSSGGGVDIVATELPNLVDLIVSIVPSNPITAFGSGNMLQVIFMALL
LGGVIKSLGEAAQSAVNGFQVANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILSLLLLWIFVVYP
FAVSLFTPISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTEKLGVNRSVAGFGVPLGATMNMGGVSIYITIAIFFVA
NAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPIEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIV
DETEKSGDAKLVAAQAQV
>Mature_418_residues
MKKSLSTRIFIGLFSGLIFGSIIQYFLADISFFSGTIVDLASGAGTMFVNMIMMLVVPLVFVSIVCGVSELKDLNSFGRL
GGKTFGFYIINTLVAIFAALGVALLLAPGKGVDMSSGGGVDIVATELPNLVDLIVSIVPSNPITAFGSGNMLQVIFMALL
LGGVIKSLGEAAQSAVNGFQVANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILSLLLLWIFVVYP
FAVSLFTPISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTEKLGVNRSVAGFGVPLGATMNMGGVSIYITIAIFFVA
NAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPIEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIV
DETEKSGDAKLVAAQAQV

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=442, Percent_Identity=28.2805429864253, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI21314632, Length=432, Percent_Identity=26.1574074074074, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI169790839, Length=454, Percent_Identity=25.1101321585903, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI66773030, Length=399, Percent_Identity=26.3157894736842, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI5032093, Length=401, Percent_Identity=26.1845386533666, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4827012, Length=271, Percent_Identity=29.1512915129151, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=26.4492753623188, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=26.4492753623188, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI194239697, Length=482, Percent_Identity=23.2365145228216, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI262359914, Length=381, Percent_Identity=24.9343832020997, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI301601644, Length=122, Percent_Identity=34.4262295081967, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1790514, Length=435, Percent_Identity=31.0344827586207, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1789947, Length=419, Percent_Identity=27.9236276849642, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789473, Length=262, Percent_Identity=32.824427480916, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788024, Length=431, Percent_Identity=29.0023201856148, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71983106, Length=427, Percent_Identity=27.1662763466042, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983099, Length=427, Percent_Identity=27.1662763466042, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17537407, Length=384, Percent_Identity=27.8645833333333, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=420, Percent_Identity=26.9047619047619, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193206505, Length=431, Percent_Identity=24.8259860788863, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=428, Percent_Identity=27.5700934579439, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=394, Percent_Identity=25.6345177664975, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24583025, Length=443, Percent_Identity=24.8306997742664, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137668, Length=443, Percent_Identity=24.8306997742664, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583023, Length=443, Percent_Identity=24.8306997742664, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360481, Length=462, Percent_Identity=24.025974025974, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281360483, Length=463, Percent_Identity=23.9740820734341, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17137666, Length=463, Percent_Identity=23.9740820734341, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43684; Mature: 43684

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLSTRIFIGLFSGLIFGSIIQYFLADISFFSGTIVDLASGAGTMFVNMIMMLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHH
FVSIVCGVSELKDLNSFGRLGGKTFGFYIINTLVAIFAALGVALLLAPGKGVDMSSGGGV
HHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
DIVATELPNLVDLIVSIVPSNPITAFGSGNMLQVIFMALLLGGVIKSLGEAAQSAVNGFQ
EEEHHHCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILSLLLLWIFVVYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAVSLFTPISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTEKLGVNRSVAGFGVPLG
HHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCC
ATMNMGGVSIYITIAIFFVANAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IHQMGLPIEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIVDETEKSGDAKLVAAQAQV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEECCCCC
>Mature Secondary Structure
MKKSLSTRIFIGLFSGLIFGSIIQYFLADISFFSGTIVDLASGAGTMFVNMIMMLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHH
FVSIVCGVSELKDLNSFGRLGGKTFGFYIINTLVAIFAALGVALLLAPGKGVDMSSGGGV
HHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
DIVATELPNLVDLIVSIVPSNPITAFGSGNMLQVIFMALLLGGVIKSLGEAAQSAVNGFQ
EEEHHHCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VANKIMMKLISVVMQLAPIGVFALMLKLGATLEAAIFGSVVEYLALILSLLLLWIFVVYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAVSLFTPISAKEFRAKTREQILFSLSTASSNATIPVTMRTLTEKLGVNRSVAGFGVPLG
HHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCC
ATMNMGGVSIYITIAIFFVANAFGAPIPMEQLPALLFSIFLLSVGAGGVPGGGMVMIGVL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IHQMGLPIEAFAIVAALDRLIDMVLTSCNVVGDTAVLTIVDETEKSGDAKLVAAQAQV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]