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The map label for this gene is hpt [H]

Identifier: 167622685

GI number: 167622685

Start: 926422

End: 926997

Strand: Direct

Name: hpt [H]

Synonym: Shal_0745

Alternate gene names: 167622685

Gene position: 926422-926997 (Clockwise)

Preceding gene: 167622684

Following gene: 167622686

Centisome position: 17.72

GC content: 44.62

Gene sequence:

>576_bases
ATGACAAGCATAACGTTAGCGACATCGACTACTGAGAGTTTTATGAAACACACCACTGAAGTGATGATCACTGCTGAAGA
GATCGATCAAAAATTGGATATTTTGGCAGAGCAGATCAATGCTCATTACGCCGATAGCGACCGCCTACTTATGGTTGGCC
TGCTAAAAGGTTCTGTTGTTTTTATGGCAGATCTTTGCAGACGCATTAAAGGTCACGTTGAGATCGATTTTATGTCGGTG
TCAAGCTACGGTAATGAGATGAGTAGCAGCCGCGATGTAAAAATCTTAAAAGACGTCCAGTCTGAAATTCAGGGGCGTGA
TGTACTGATCGTTGAAGATCTTATTGATTCAGGCAATACCTTGAACAAGGTACGCGAAATGCTGATGATCCGTGAGCCAA
AGAGCCTAGCGCTTTGTACGCTATTGGATAAGCCTGAACGCCGCGAAGTTGATGTACCCGTTGACTTTATTGGCTTTACT
ATCCCTGACGAGTTTATCGTTGGTTATGGTATCGACTACGCGGAGCAGTACCGTAATCTGCCGTACATCGCTAAAGTTGT
GCCGCTAGAGGACTAA

Upstream 100 bases:

>100_bases
TATCATAATCCCAAATCGGTCGAAGATCTGGTAGACTTCATGGTCGCTCGAATTCTTGACCATTTGGGCGTTAACCATGC
ACTAACGAATCGTTGGGGTT

Downstream 100 bases:

>100_bases
ATTTCAGCCCTAATATCGGCCTTAAAGTGACTCGTTAGTTAAGTTAACGGATTGCGCTGCTATTAGGGATGCAATTAGAC
TATCGACTCCCGCAATCGCG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MTSITLATSTTESFMKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSV
SSYGNEMSSSRDVKILKDVQSEIQGRDVLIVEDLIDSGNTLNKVREMLMIREPKSLALCTLLDKPERREVDVPVDFIGFT
IPDEFIVGYGIDYAEQYRNLPYIAKVVPLED

Sequences:

>Translated_191_residues
MTSITLATSTTESFMKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSV
SSYGNEMSSSRDVKILKDVQSEIQGRDVLIVEDLIDSGNTLNKVREMLMIREPKSLALCTLLDKPERREVDVPVDFIGFT
IPDEFIVGYGIDYAEQYRNLPYIAKVVPLED
>Mature_190_residues
TSITLATSTTESFMKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVS
SYGNEMSSSRDVKILKDVQSEIQGRDVLIVEDLIDSGNTLNKVREMLMIREPKSLALCTLLDKPERREVDVPVDFIGFTI
PDEFIVGYGIDYAEQYRNLPYIAKVVPLED

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=162, Percent_Identity=34.5679012345679, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=31.2138728323699, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI87081689, Length=178, Percent_Identity=64.6067415730337, Blast_Score=243, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17510817, Length=161, Percent_Identity=34.7826086956522, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21582; Mature: 21451

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSITLATSTTESFMKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVV
CCEEEEECCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHH
FMADLCRRIKGHVEIDFMSVSSYGNEMSSSRDVKILKDVQSEIQGRDVLIVEDLIDSGNT
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCH
LNKVREMLMIREPKSLALCTLLDKPERREVDVPVDFIGFTIPDEFIVGYGIDYAEQYRNL
HHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCHHEEEECCCCHHHEECCCCHHHHHCCC
PYIAKVVPLED
CCEEEEEECCC
>Mature Secondary Structure 
TSITLATSTTESFMKHTTEVMITAEEIDQKLDILAEQINAHYADSDRLLMVGLLKGSVV
CEEEEECCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHH
FMADLCRRIKGHVEIDFMSVSSYGNEMSSSRDVKILKDVQSEIQGRDVLIVEDLIDSGNT
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCH
LNKVREMLMIREPKSLALCTLLDKPERREVDVPVDFIGFTIPDEFIVGYGIDYAEQYRNL
HHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCHHEEEECCCCHHHEECCCCHHHHHCCC
PYIAKVVPLED
CCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]