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The map label for this gene is nhaC [H]

Identifier: 167622675

GI number: 167622675

Start: 913630

End: 915048

Strand: Reverse

Name: nhaC [H]

Synonym: Shal_0735

Alternate gene names: 167622675

Gene position: 915048-913630 (Counterclockwise)

Preceding gene: 167622680

Following gene: 167622674

Centisome position: 17.51

GC content: 46.44

Gene sequence:

>1419_bases
ATGACTAGTCTGTTCCAGCTAGGAGGGCGATGGGAACAATGGTTCGAAGATAGATTGAAGATAAGAGAGATAACATTGAC
GACTTCCAGTAATGCCCAAAATGCTGCAGCGACCACTGCACCATCGTTTTTAGCCCTGACGCCACTATTTCTGTTCCTTG
CACTTTTTATTGGTGCAGGCGTTTACTTTCAAAGCCAAGGCGTAGATTTTGCCTTTTATCAATTACCAAGCGTAGTGGCA
ATTTTACCGGCCATTATTTTTGCCATTTTGATTTCAAAGCAAAAACTTAACCAAACGATTGAAACCTTTATCGCAGGCAT
TGGCCACTCAAATATCATCGCCATGTGTATGATTTATTTGTTGGCGGGTGCCTTTGCCGCAGTCGCTAAAGCCACTGGTG
GTGTCGATGCCACTGTCGCCTTAGGTCTGTCGCTAGTGCCATCTAACTTACTGCTACCAGGCTTCTTTGTGATAGCGGCA
TTTATCGCAACAGCCATGGGTACTTCAATGGGCACCATCGCAGCGGTAGCGCCGATTGCACTAGGTGTCGCCAACGAGGC
ACAAATTGACTTAGCCATTATGGCGGGTGCGGTGATCTCGGGCGCACTATTCGGTGACAACTTATCGATCATCTCTGACA
CCACTATTGCAGCCACTCGTACTCAGGGCTGTCATATGAGAGATAAGTTTAAAGAAAACCTTATCTTTGCTATTCCTGCT
TCAATCATCACTTTAGTGATATTTACCCTTGCAGGACAAGGCCAAGCGGATGTTGCCCCACAAGATGTCGACTTTATCAA
AGTCATCCCATATCTAACGATTTTATTCTTAGCCGTTGCCGGTGTTAACGTATTTGTTGTACTGACAATCGGTATCTTAC
TCGCGGGCGTTACAGGCATAACCACTATGGATTACGGCGTGATCCAGTTCGGTCAAGATATCTACGCGGGCTTTGGTAGC
ATGCAAGAGATCTTCATCCTGTCTATGTTAGTCGGTGGTTTAGCGGCACTAATGCAGCAGCAAGGTGGCTTAGCGTTTGT
TAGCCAACAGATTGAAAAGCTAATCGGTCGTTTCTCTAAAGCTAAAGGCGAAGCATCATGCCGCGCATCAGAGCTTGGTA
TGGCAGCTATTGTGGCAACGACTAACACTTGTGTGGCAAATAACACGGTATCGATTGTCGTTACAGGCGATATTGCTAAA
GACTTAGCACAGAAGCATGGCGTTACACCAAAGCGTGCGGCCAGTATTTTGGATATCTTCTCCTGTATCATTCAGGGTCT
TATCCCATACGGTGCACAGGCGCTATTAGTGGCCTCAACCTTTAGCCTATCTCCGCTTGAAGTTGTCAGCCACGCTTGGT
ACTGCATGATTTTAGCAGTAGTCGCCGTTGCGATAGTCATCTTGCGCAAACGTCATTAA

Upstream 100 bases:

>100_bases
TAGCAGTAAAAACATCTAGACGTCTAAATTGACAGACGTCTTTCGATCTCATATCCTCTCAACTATTGAGATGTACCATT
CTATGATTTAGCAAACACTA

Downstream 100 bases:

>100_bases
TCAGGCTGTTTACTCGTTCGCGGTAAAAAAAGTGTGTTCAAGATGAACACTCTCATATAATTAGAGGAGTACATGTAGAT
GTGCTCCTTTTTTTATTGCT

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MTSLFQLGGRWEQWFEDRLKIREITLTTSSNAQNAAATTAPSFLALTPLFLFLALFIGAGVYFQSQGVDFAFYQLPSVVA
ILPAIIFAILISKQKLNQTIETFIAGIGHSNIIAMCMIYLLAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAA
FIATAMGTSMGTIAAVAPIALGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCHMRDKFKENLIFAIPA
SIITLVIFTLAGQGQADVAPQDVDFIKVIPYLTILFLAVAGVNVFVVLTIGILLAGVTGITTMDYGVIQFGQDIYAGFGS
MQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLIGRFSKAKGEASCRASELGMAAIVATTNTCVANNTVSIVVTGDIAK
DLAQKHGVTPKRAASILDIFSCIIQGLIPYGAQALLVASTFSLSPLEVVSHAWYCMILAVVAVAIVILRKRH

Sequences:

>Translated_472_residues
MTSLFQLGGRWEQWFEDRLKIREITLTTSSNAQNAAATTAPSFLALTPLFLFLALFIGAGVYFQSQGVDFAFYQLPSVVA
ILPAIIFAILISKQKLNQTIETFIAGIGHSNIIAMCMIYLLAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAA
FIATAMGTSMGTIAAVAPIALGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCHMRDKFKENLIFAIPA
SIITLVIFTLAGQGQADVAPQDVDFIKVIPYLTILFLAVAGVNVFVVLTIGILLAGVTGITTMDYGVIQFGQDIYAGFGS
MQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLIGRFSKAKGEASCRASELGMAAIVATTNTCVANNTVSIVVTGDIAK
DLAQKHGVTPKRAASILDIFSCIIQGLIPYGAQALLVASTFSLSPLEVVSHAWYCMILAVVAVAIVILRKRH
>Mature_471_residues
TSLFQLGGRWEQWFEDRLKIREITLTTSSNAQNAAATTAPSFLALTPLFLFLALFIGAGVYFQSQGVDFAFYQLPSVVAI
LPAIIFAILISKQKLNQTIETFIAGIGHSNIIAMCMIYLLAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAAF
IATAMGTSMGTIAAVAPIALGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCHMRDKFKENLIFAIPAS
IITLVIFTLAGQGQADVAPQDVDFIKVIPYLTILFLAVAGVNVFVVLTIGILLAGVTGITTMDYGVIQFGQDIYAGFGSM
QEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLIGRFSKAKGEASCRASELGMAAIVATTNTCVANNTVSIVVTGDIAKD
LAQKHGVTPKRAASILDIFSCIIQGLIPYGAQALLVASTFSLSPLEVVSHAWYCMILAVVAVAIVILRKRH

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 49582; Mature: 49451

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLFQLGGRWEQWFEDRLKIREITLTTSSNAQNAAATTAPSFLALTPLFLFLALFIGAG
CCCHHHHCCCHHHHHHHHHEEEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCC
VYFQSQGVDFAFYQLPSVVAILPAIIFAILISKQKLNQTIETFIAGIGHSNIIAMCMIYL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCHMRDKFKENLIFAIPA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCHHHHHHCCEEEEEHH
SIITLVIFTLAGQGQADVAPQDVDFIKVIPYLTILFLAVAGVNVFVVLTIGILLAGVTGI
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTMDYGVIQFGQDIYAGFGSMQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLIGRFSK
HHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKGEASCRASELGMAAIVATTNTCVANNTVSIVVTGDIAKDLAQKHGVTPKRAASILDIF
CCCCCCCCHHHCCCEEEEEECCCEEECCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHH
SCIIQGLIPYGAQALLVASTFSLSPLEVVSHAWYCMILAVVAVAIVILRKRH
HHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSLFQLGGRWEQWFEDRLKIREITLTTSSNAQNAAATTAPSFLALTPLFLFLALFIGAG
CCHHHHCCCHHHHHHHHHEEEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCC
VYFQSQGVDFAFYQLPSVVAILPAIIFAILISKQKLNQTIETFIAGIGHSNIIAMCMIYL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCHMRDKFKENLIFAIPA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCHHHHHHCCEEEEEHH
SIITLVIFTLAGQGQADVAPQDVDFIKVIPYLTILFLAVAGVNVFVVLTIGILLAGVTGI
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTMDYGVIQFGQDIYAGFGSMQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLIGRFSK
HHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKGEASCRASELGMAAIVATTNTCVANNTVSIVVTGDIAKDLAQKHGVTPKRAASILDIF
CCCCCCCCHHHCCCEEEEEECCCEEECCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHH
SCIIQGLIPYGAQALLVASTFSLSPLEVVSHAWYCMILAVVAVAIVILRKRH
HHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]