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The map label for this gene is ndhS [H]

Identifier: 167622592

GI number: 167622592

Start: 798423

End: 798902

Strand: Direct

Name: ndhS [H]

Synonym: Shal_0652

Alternate gene names: 167622592

Gene position: 798423-798902 (Clockwise)

Preceding gene: 167622591

Following gene: 167622593

Centisome position: 15.28

GC content: 48.12

Gene sequence:

>480_bases
ATGAAAATCAGCTTTAAACTTAATAGCGAATTGGTCACCGTCGATGTCGACCCATTACAACCTTTACTGACCACCCTAAG
GGATGAGTTACACATGCAGGCAGCAAAACAGGGCTGCGGTGAAGGTGAGTGTGGTAGTTGCTCTGTTATCATGAATAATT
TAATGGTTAATACCTGTTTGATCCCCACGATTCAGGCTAAAGGAGCCGCATTAGTCACGCTTGAAGGGTTAAGGGATACC
CCTAAGGGACAGCTCGTTATCAATGCATTGCTCGAGGCTAAAGGGGTGCAATGCGGCTTTTGCACCCCCTCTATGGTACT
GGCGCTTTATCACCTGCTCGACAACCGCACTTATGCGGATATAACGCCAACGGATAAGCAAATTCGTCAGGCTTTAGCGG
GTAATCTTTGTCGCTGCACCGGTTACGGAATGATCGTTGAAGCGGCCAAAATTGCTGCGAAGCTGTGGGGGGAAGTATGA

Upstream 100 bases:

>100_bases
CATCCTATCAATGCTATCCCAGTGACCCCCGAGGTCGTGTGTTCTTTGCTTTATGGCAAGAAAAGTGGTTTAGAGTCAAT
GACTCAAGAGGAGCAAGGCC

Downstream 100 bases:

>100_bases
TAAAAGTCTATCGTCCAACTAAATTACCTCAGGCATTGAACTATAAAGCGCTATGGGGTGCCACCCTCTTTGCTGGTGGT
ACAGATATCATGGTTCGTGG

Product: 2Fe-2S iron-sulfur cluster-binding domain-containing protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKISFKLNSELVTVDVDPLQPLLTTLRDELHMQAAKQGCGEGECGSCSVIMNNLMVNTCLIPTIQAKGAALVTLEGLRDT
PKGQLVINALLEAKGVQCGFCTPSMVLALYHLLDNRTYADITPTDKQIRQALAGNLCRCTGYGMIVEAAKIAAKLWGEV

Sequences:

>Translated_159_residues
MKISFKLNSELVTVDVDPLQPLLTTLRDELHMQAAKQGCGEGECGSCSVIMNNLMVNTCLIPTIQAKGAALVTLEGLRDT
PKGQLVINALLEAKGVQCGFCTPSMVLALYHLLDNRTYADITPTDKQIRQALAGNLCRCTGYGMIVEAAKIAAKLWGEV
>Mature_159_residues
MKISFKLNSELVTVDVDPLQPLLTTLRDELHMQAAKQGCGEGECGSCSVIMNNLMVNTCLIPTIQAKGAALVTLEGLRDT
PKGQLVINALLEAKGVQCGFCTPSMVLALYHLLDNRTYADITPTDKQIRQALAGNLCRCTGYGMIVEAAKIAAKLWGEV

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=165, Percent_Identity=39.3939393939394, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI91823271, Length=166, Percent_Identity=36.7469879518072, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1786480, Length=164, Percent_Identity=33.5365853658537, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1789232, Length=146, Percent_Identity=38.3561643835616, Blast_Score=96, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=155, Percent_Identity=41.9354838709677, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=157, Percent_Identity=36.3057324840764, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32566215, Length=157, Percent_Identity=35.6687898089172, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737937, Length=163, Percent_Identity=41.1042944785276, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24647195, Length=168, Percent_Identity=34.5238095238095, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24647197, Length=168, Percent_Identity=34.5238095238095, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24647199, Length=161, Percent_Identity=32.2981366459627, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24647201, Length=161, Percent_Identity=31.6770186335404, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24647193, Length=161, Percent_Identity=29.8136645962733, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17109; Mature: 17109

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.8 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISFKLNSELVTVDVDPLQPLLTTLRDELHMQAAKQGCGEGECGSCSVIMNNLMVNTCL
CEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
IPTIQAKGAALVTLEGLRDTPKGQLVINALLEAKGVQCGFCTPSMVLALYHLLDNRTYAD
CEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEC
ITPTDKQIRQALAGNLCRCTGYGMIVEAAKIAAKLWGEV
CCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKISFKLNSELVTVDVDPLQPLLTTLRDELHMQAAKQGCGEGECGSCSVIMNNLMVNTCL
CEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
IPTIQAKGAALVTLEGLRDTPKGQLVINALLEAKGVQCGFCTPSMVLALYHLLDNRTYAD
CEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEC
ITPTDKQIRQALAGNLCRCTGYGMIVEAAKIAAKLWGEV
CCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA