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The map label for this gene is hutC [H]

Identifier: 167622013

GI number: 167622013

Start: 81834

End: 82538

Strand: Direct

Name: hutC [H]

Synonym: Shal_0072

Alternate gene names: 167622013

Gene position: 81834-82538 (Clockwise)

Preceding gene: 167622011

Following gene: 167622014

Centisome position: 1.57

GC content: 49.79

Gene sequence:

>705_bases
ATGGCGACGCCAAAGTTTGAAGAGATTAAGCAATATATTTTAGCGCAAATTGAGTCTGGCGAGTGGGCCGAAGACAGCCG
CGTGCCGTCTGAAAATCAATTAGCCGAGTTGTTTAACTGTAGCCGCATGACAGCGCGTCGAGGCTTAACTGAGCTGACAG
AATCCGGTGTATTAGAACGTTCTCAAGGCTTAGGTACTTTCGTTGCCGGACTCAAAACCCAGTCTTCTATGATGGCAATT
CGTAACATTGCCGATGAGATTAAAGACCGTGGCCACGGCTATAGTGTGCAGCAAGTTGAGCTGACCCAGACCCATGCGAC
TGGTGCCATCGCTATTGCGCTAGGTTTAGAGGAGGGCGGCAATGTGTATCGTTCGGTTTTAGTACACTGCGAGCAAGGCA
CACCGCTGCAGTTAGAAGAGCGCTTCGTTAATCCGAAACTGGTGCCTGATTATTTAGCCCAAGATTTTACCAAGCAGACT
CCCCACGAATATCTATCTATGGTGGCACCGCTTACCGAAGCCAAGCACACCATCGAGGCTAAGCTCGCCGATAATGCGCA
GTTAGCTTTGCTCAACATCGATGCGTCAGAACCCTGTTTACAGATCACTCGCCGTACTTGGTCGCGCCAAGGTGTGGTGA
GTTTTGCACGTTTAGTGCACCCGGGAAGTCGATTTAGATTAGGTGGTCACCTGACTTTTAGCTAA

Upstream 100 bases:

>100_bases
GAGCCCGCTTGTATTTACTTGTATATACAAGCTAGGATTGTAGCCGAGTTTTTAAGCATGTAAATAGCTGTTTGCAAGTT
CAGCTGCAACGGGAAGGTTA

Downstream 100 bases:

>100_bases
AGCTTATTGGCCGTTAGGGATAGCTGGCTACCGTTCCACAAGTAAAAACGCTCAACAACACGATTTATAAAATGCTCTAA
AAAATTAAAAAGACCGTAAA

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRGLTELTESGVLERSQGLGTFVAGLKTQSSMMAI
RNIADEIKDRGHGYSVQQVELTQTHATGAIAIALGLEEGGNVYRSVLVHCEQGTPLQLEERFVNPKLVPDYLAQDFTKQT
PHEYLSMVAPLTEAKHTIEAKLADNAQLALLNIDASEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS

Sequences:

>Translated_234_residues
MATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRGLTELTESGVLERSQGLGTFVAGLKTQSSMMAI
RNIADEIKDRGHGYSVQQVELTQTHATGAIAIALGLEEGGNVYRSVLVHCEQGTPLQLEERFVNPKLVPDYLAQDFTKQT
PHEYLSMVAPLTEAKHTIEAKLADNAQLALLNIDASEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS
>Mature_233_residues
ATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRGLTELTESGVLERSQGLGTFVAGLKTQSSMMAIR
NIADEIKDRGHGYSVQQVELTQTHATGAIAIALGLEEGGNVYRSVLVHCEQGTPLQLEERFVNPKLVPDYLAQDFTKQTP
HEYLSMVAPLTEAKHTIEAKLADNAQLALLNIDASEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=203, Percent_Identity=24.1379310344828, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790118, Length=229, Percent_Identity=23.1441048034935, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 25939; Mature: 25808

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRGLTELTESGVLER
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SQGLGTFVAGLKTQSSMMAIRNIADEIKDRGHGYSVQQVELTQTHATGAIAIALGLEEGG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCCEEEEEEECCCCH
NVYRSVLVHCEQGTPLQLEERFVNPKLVPDYLAQDFTKQTPHEYLSMVAPLTEAKHTIEA
HHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KLADNAQLALLNIDASEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS
EECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECC
>Mature Secondary Structure 
ATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRGLTELTESGVLER
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SQGLGTFVAGLKTQSSMMAIRNIADEIKDRGHGYSVQQVELTQTHATGAIAIALGLEEGG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCCEEEEEEECCCCH
NVYRSVLVHCEQGTPLQLEERFVNPKLVPDYLAQDFTKQTPHEYLSMVAPLTEAKHTIEA
HHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KLADNAQLALLNIDASEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS
EECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]