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The map label for this gene is pepQ

Identifier: 167621958

GI number: 167621958

Start: 21349

End: 22671

Strand: Direct

Name: pepQ

Synonym: Shal_0017

Alternate gene names: 167621958

Gene position: 21349-22671 (Clockwise)

Preceding gene: 167621949

Following gene: 167621959

Centisome position: 0.41

GC content: 45.05

Gene sequence:

>1323_bases
ATGGAACAGTTAGCGCGCCTCTATCATGACCATCTTCGAGTGCTAAATCAGCGTGTCTGCGAAATTCTCTCTCGTGAAAA
CTTATCGGGGCTCGTTATCCATTCCGGTCAGCCCCATAGACAGTTTTTAGATGATTTGGATTATCCATTTAAGGTGAACC
CCCACTTTAAGGCTTGGTTACCCGTTATCGATAACCCTAACTCTTGGTTGGTGGTGAACGGCACTGACAAACCACTGTTA
ATTTTTTATCGCCCAGTCGACTTTTGGCATAAGGTGGCCGATGAACCTAACGAGTTTTGGGCTGAGCATGTTGATATTAA
GTTTCTTACCAAGGCGGATAAAGTCGCTGAATATCTTCCCGCAGATATTGATGAGTGGGCTTATATTGGTGAGCATTTAG
ATGTTGCCGATGTGTTGGGCTTTGCTCGGAGAAATCCTGATTCGGTATTGAGCTACCTTAATTATCACCGCGCAACAAAA
ACCGAGTATGAGTTGGCTTGTATGCGTAAAGCTAACGAAATAGCGGTGACCGGGCATCAAGCGGCAAAAACGGCTTTTTA
TAATGGTGCTAGTGAGTTTGAGATCTTGCAGGTTTATCTGTCGGCTATTTCACAAGGTGAGAATCAAGTGCCTTATAGCA
GCATCGTCGCACTCAACGAAAACTCAGCTATTTTGCATTACACCGCACTTGAACATACCGCGCCTGCACAGCGTCGCTCG
TTTTTAATCGATGCCGGTGCTAACTTTAATGGCTACGCCTCTGATATTACCCGCAGCTATGCCTTCGAAAAGAATATTTT
CGATGATTTGATTACTGCAATCGACAATATGCAGTTACAGATCATTAATCTGATGCAGCCCGGTGTGAGCTATGCGCAAT
TGCACGTTGAAACTCATTATAAGTTAGCGCAGATCTTGTTGGATTTTGATATTGTCAGCGGCGATGTTCAGGGACTGGTC
GAGCAGGGCATCACGAGTGTGTTTTTCCCCCATGGATTAGGCCATATGTTGGGCATACAGGTTCACGATATGGGCGGTTT
CCTTGGTGATGATAAGGGAGCGCATATTGCGGTGCCAGAGGCACATCCATTCTTGCGTTGTACCCGAGAGTTAGATGTTA
ATCAGGTTCTGACGATTGAGCCTGGCGTTTATATTATTGATTCGCTGTTAAATGAACTGAAACAGGACAAGCGCCAATCA
CAAATAAACTGGAATACAGTAGAGGTGTTACGCCCGTTTGGCGGTATTCGTATTGAAGATAACGTGATTGTTCATCGCGA
TCGTATCGAGAATATGACGCGTAATTGGGGTCTTAACCGTTAG

Upstream 100 bases:

>100_bases
GTAAAAGCGAATAACGTGTTTGCCGAAAAATTAATTGGCTATGTGATAGACTGAGTCAGTGTCGATAAATTGGCTAAATA
ATAACAATAGGGTAACCCTC

Downstream 100 bases:

>100_bases
TCTTAAGCCATATTACGGACAATCGTTGATGATAAAAGGTCTAAAGGTAATCAGTTGAGAGAAATATTTTGAGTGAGAGT
TATCTCATCCCTGCAGCAGA

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MEQLARLYHDHLRVLNQRVCEILSRENLSGLVIHSGQPHRQFLDDLDYPFKVNPHFKAWLPVIDNPNSWLVVNGTDKPLL
IFYRPVDFWHKVADEPNEFWAEHVDIKFLTKADKVAEYLPADIDEWAYIGEHLDVADVLGFARRNPDSVLSYLNYHRATK
TEYELACMRKANEIAVTGHQAAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEHTAPAQRRS
FLIDAGANFNGYASDITRSYAFEKNIFDDLITAIDNMQLQIINLMQPGVSYAQLHVETHYKLAQILLDFDIVSGDVQGLV
EQGITSVFFPHGLGHMLGIQVHDMGGFLGDDKGAHIAVPEAHPFLRCTRELDVNQVLTIEPGVYIIDSLLNELKQDKRQS
QINWNTVEVLRPFGGIRIEDNVIVHRDRIENMTRNWGLNR

Sequences:

>Translated_440_residues
MEQLARLYHDHLRVLNQRVCEILSRENLSGLVIHSGQPHRQFLDDLDYPFKVNPHFKAWLPVIDNPNSWLVVNGTDKPLL
IFYRPVDFWHKVADEPNEFWAEHVDIKFLTKADKVAEYLPADIDEWAYIGEHLDVADVLGFARRNPDSVLSYLNYHRATK
TEYELACMRKANEIAVTGHQAAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEHTAPAQRRS
FLIDAGANFNGYASDITRSYAFEKNIFDDLITAIDNMQLQIINLMQPGVSYAQLHVETHYKLAQILLDFDIVSGDVQGLV
EQGITSVFFPHGLGHMLGIQVHDMGGFLGDDKGAHIAVPEAHPFLRCTRELDVNQVLTIEPGVYIIDSLLNELKQDKRQS
QINWNTVEVLRPFGGIRIEDNVIVHRDRIENMTRNWGLNR
>Mature_440_residues
MEQLARLYHDHLRVLNQRVCEILSRENLSGLVIHSGQPHRQFLDDLDYPFKVNPHFKAWLPVIDNPNSWLVVNGTDKPLL
IFYRPVDFWHKVADEPNEFWAEHVDIKFLTKADKVAEYLPADIDEWAYIGEHLDVADVLGFARRNPDSVLSYLNYHRATK
TEYELACMRKANEIAVTGHQAAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEHTAPAQRRS
FLIDAGANFNGYASDITRSYAFEKNIFDDLITAIDNMQLQIINLMQPGVSYAQLHVETHYKLAQILLDFDIVSGDVQGLV
EQGITSVFFPHGLGHMLGIQVHDMGGFLGDDKGAHIAVPEAHPFLRCTRELDVNQVLTIEPGVYIIDSLLNELKQDKRQS
QINWNTVEVLRPFGGIRIEDNVIVHRDRIENMTRNWGLNR

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily

Homologues:

Organism=Homo sapiens, GI149589008, Length=289, Percent_Identity=33.2179930795848, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI260593665, Length=289, Percent_Identity=33.2179930795848, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI260593663, Length=431, Percent_Identity=27.8422273781903, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1790282, Length=442, Percent_Identity=49.0950226244344, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1789275, Length=288, Percent_Identity=29.8611111111111, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=354, Percent_Identity=31.3559322033898, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321118, Length=289, Percent_Identity=31.1418685121107, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=286, Percent_Identity=29.020979020979, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21357079, Length=441, Percent_Identity=26.0770975056689, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19920384, Length=287, Percent_Identity=27.5261324041812, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPQ_SHEHH (B0TLC0)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672252.1
- MEROPS:   M24.003
- GeneID:   5904872
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0017
- HOGENOM:   HBG296884
- OMA:   PYGNIVA
- ProtClustDB:   PRK13607
- BioCyc:   SHAL458817:SHAL_0017-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01279
- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.13.9

Molecular weight: Translated: 50129; Mature: 50129

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLARLYHDHLRVLNQRVCEILSRENLSGLVIHSGQPHRQFLDDLDYPFKVNPHFKAWL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCEEECCCCEEEE
PVIDNPNSWLVVNGTDKPLLIFYRPVDFWHKVADEPNEFWAEHVDIKFLTKADKVAEYLP
EEEECCCCEEEEECCCCCEEEEECCHHHHHHHHCCHHHHHHHHCCEEEEHHHHHHHHHCC
ADIDEWAYIGEHLDVADVLGFARRNPDSVLSYLNYHRATKTEYELACMRKANEIAVTGHQ
CCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCH
AAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEHTAPAQRRS
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCEEEEEEECCCCCCHHHCE
FLIDAGANFNGYASDITRSYAFEKNIFDDLITAIDNMQLQIINLMQPGVSYAQLHVETHY
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEHHHHH
KLAQILLDFDIVSGDVQGLVEQGITSVFFPHGLGHMLGIQVHDMGGFLGDDKGAHIAVPE
HHHHHHHHHHHHCHHHHHHHHHCHHHHCCCCCCCHHHEEEEEECCCCCCCCCCCEEECCC
AHPFLRCTRELDVNQVLTIEPGVYIIDSLLNELKQDKRQSQINWNTVEVLRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEC
NVIVHRDRIENMTRNWGLNR
CEEEEHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEQLARLYHDHLRVLNQRVCEILSRENLSGLVIHSGQPHRQFLDDLDYPFKVNPHFKAWL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCEEECCCCEEEE
PVIDNPNSWLVVNGTDKPLLIFYRPVDFWHKVADEPNEFWAEHVDIKFLTKADKVAEYLP
EEEECCCCEEEEECCCCCEEEEECCHHHHHHHHCCHHHHHHHHCCEEEEHHHHHHHHHCC
ADIDEWAYIGEHLDVADVLGFARRNPDSVLSYLNYHRATKTEYELACMRKANEIAVTGHQ
CCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCH
AAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEHTAPAQRRS
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCEEEEEEECCCCCCHHHCE
FLIDAGANFNGYASDITRSYAFEKNIFDDLITAIDNMQLQIINLMQPGVSYAQLHVETHY
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEHHHHH
KLAQILLDFDIVSGDVQGLVEQGITSVFFPHGLGHMLGIQVHDMGGFLGDDKGAHIAVPE
HHHHHHHHHHHHCHHHHHHHHHCHHHHCCCCCCCHHHEEEEEECCCCCCCCCCCEEECCC
AHPFLRCTRELDVNQVLTIEPGVYIIDSLLNELKQDKRQSQINWNTVEVLRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEC
NVIVHRDRIENMTRNWGLNR
CEEEEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA