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The map label for this gene is uraA [H]

Identifier: 167040982

GI number: 167040982

Start: 2414329

End: 2415558

Strand: Reverse

Name: uraA [H]

Synonym: Teth514_2371

Alternate gene names: 167040982

Gene position: 2415558-2414329 (Counterclockwise)

Preceding gene: 167040983

Following gene: 167040981

Centisome position: 98.3

GC content: 48.94

Gene sequence:

>1230_bases
ATGAAAGTACTTACTGTAGGTACAAAAGAATTGTCAGGTCCGATAAAGGAGGGAGACAAAATTTCTCTGCTACAGCTTCT
TATTCTAGGATTACAACATACTTTTACGATGTTCGGTGCCACAGTATTGGTGCCACTGCTTACCGGGCTTGATGTGGGAG
TAGCTCTTTTTACTGCGGGGATTGGGACTCTCTGGTTTCACTTGGTTACAAAAAGAAAAGTTCCCATTTTTCTAGGTTCT
TCCTTTGCTTTCATTGCACCAGTGGCACTAGTGGTAAAACAGTGGGGAGTTCCGGCGGCCCAGGGGGGCATCATTGTGGC
CGGCTTGCTTTACGGGTTGATGGCGGTGCTGGTTTACTTTCTGGGGCGCGAATTCATGGAAAACCTTCTGCCACCGGTGG
TGACCGGTCCGATAATAATGGTCATAGGTCTCAACCTGGCACCGGTAGCAATCAAAAGCGCCTCTCAAAACTGGATGGTT
GCCTTGATAGTGCTTACTACGGTAATACTTGTCAGCATGTATGGCAGGGGATTTTTCAAACTGGTACCGGTGCTCGTGGG
ATTAATTGTAGGTTATGGGGTGAGTTTGATTTTCGGAATCGTGGACTTGAAACCTGTGCAGGAGGCGGCGTTGTTTGCCG
TGCCGGCCTTTACCAAACCCGAATTCAACCCGGCGGCCATTGGCCTTATTGCGCCTGTGGCGGTGGCTACTATAGTGGAA
CACGTGGGCGATGTGCTTGCTGTGGGAGCTACGGTGCAGAAGGACTTTGTAAAAGACCCAGGCCTTCATAGGACTCTAAT
AGGCGATGGTATAGCCACATCCTTGGCGGGTCTATTTGGAGGCCCGGCCAACACCACCTATTCTGAAAACACTGGCGTTT
TAGCGTTGACTGGAGTCTGGAAACCCGAGGTGATGAGGGTGGCAGCAGTCATGGCTATGATACTTTCTACCTGTCAGAAA
CTTACTGCCCTAATAAGGACAGTGCCAGAGCCAGTCATAGGCGGCATATCTATAATCCTGTTTGGCATGATAGCCAGCAT
CGGCATCAGGACCGTTGTGGAGAACGCCGTAGATTTCAAAAAGTCAAGAAACCTTATAATATCTAGCGCTATTCTAGTCT
TTGGCATAGGTGGTGCTGTAGTGAACCTGTGGGGTGGCATTCAGTTGGGAGGTGTAGGTCTGGCTGCTATTATCGGCATA
ATATTAAACCAGGTGCTGCCAAAAGAATAA

Upstream 100 bases:

>100_bases
AGAGAGAAAGCCTTTCTCCGCCTGATGGGAAAGGCTTTTTTGATGAGGAAAAGCCTCTGCTACTCACAGCAGAGGCTTAA
TTTTTGAGAGGAGGAAAATT

Downstream 100 bases:

>100_bases
TTTGAGCGGGGATTATATTTCCCTGCTTTTTTATTTACTATGTTATATCCACTAAGTTGTGAAATTATCGTTTTATTTTT
GCTTATTTATTCATTGTTTT

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKVLTVGTKELSGPIKEGDKISLLQLLILGLQHTFTMFGATVLVPLLTGLDVGVALFTAGIGTLWFHLVTKRKVPIFLGS
SFAFIAPVALVVKQWGVPAAQGGIIVAGLLYGLMAVLVYFLGREFMENLLPPVVTGPIIMVIGLNLAPVAIKSASQNWMV
ALIVLTTVILVSMYGRGFFKLVPVLVGLIVGYGVSLIFGIVDLKPVQEAALFAVPAFTKPEFNPAAIGLIAPVAVATIVE
HVGDVLAVGATVQKDFVKDPGLHRTLIGDGIATSLAGLFGGPANTTYSENTGVLALTGVWKPEVMRVAAVMAMILSTCQK
LTALIRTVPEPVIGGISIILFGMIASIGIRTVVENAVDFKKSRNLIISSAILVFGIGGAVVNLWGGIQLGGVGLAAIIGI
ILNQVLPKE

Sequences:

>Translated_409_residues
MKVLTVGTKELSGPIKEGDKISLLQLLILGLQHTFTMFGATVLVPLLTGLDVGVALFTAGIGTLWFHLVTKRKVPIFLGS
SFAFIAPVALVVKQWGVPAAQGGIIVAGLLYGLMAVLVYFLGREFMENLLPPVVTGPIIMVIGLNLAPVAIKSASQNWMV
ALIVLTTVILVSMYGRGFFKLVPVLVGLIVGYGVSLIFGIVDLKPVQEAALFAVPAFTKPEFNPAAIGLIAPVAVATIVE
HVGDVLAVGATVQKDFVKDPGLHRTLIGDGIATSLAGLFGGPANTTYSENTGVLALTGVWKPEVMRVAAVMAMILSTCQK
LTALIRTVPEPVIGGISIILFGMIASIGIRTVVENAVDFKKSRNLIISSAILVFGIGGAVVNLWGGIQLGGVGLAAIIGI
ILNQVLPKE
>Mature_409_residues
MKVLTVGTKELSGPIKEGDKISLLQLLILGLQHTFTMFGATVLVPLLTGLDVGVALFTAGIGTLWFHLVTKRKVPIFLGS
SFAFIAPVALVVKQWGVPAAQGGIIVAGLLYGLMAVLVYFLGREFMENLLPPVVTGPIIMVIGLNLAPVAIKSASQNWMV
ALIVLTTVILVSMYGRGFFKLVPVLVGLIVGYGVSLIFGIVDLKPVQEAALFAVPAFTKPEFNPAAIGLIAPVAVATIVE
HVGDVLAVGATVQKDFVKDPGLHRTLIGDGIATSLAGLFGGPANTTYSENTGVLALTGVWKPEVMRVAAVMAMILSTCQK
LTALIRTVPEPVIGGISIILFGMIASIGIRTVVENAVDFKKSRNLIISSAILVFGIGGAVVNLWGGIQLGGVGLAAIIGI
ILNQVLPKE

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=437, Percent_Identity=25.629290617849, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI40316845, Length=437, Percent_Identity=25.629290617849, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI44680145, Length=460, Percent_Identity=23.695652173913, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI44680143, Length=464, Percent_Identity=23.4913793103448, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1788843, Length=399, Percent_Identity=42.1052631578947, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI87081818, Length=419, Percent_Identity=42.2434367541766, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082181, Length=387, Percent_Identity=28.9405684754522, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1790087, Length=445, Percent_Identity=24.0449438202247, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082178, Length=267, Percent_Identity=28.0898876404494, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=302, Percent_Identity=22.5165562913907, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=209, Percent_Identity=26.7942583732057, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=161, Percent_Identity=27.9503105590062, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17541904, Length=318, Percent_Identity=22.3270440251572, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17542260, Length=209, Percent_Identity=25.8373205741627, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21356175, Length=422, Percent_Identity=25.1184834123223, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 42714; Mature: 42714

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLTVGTKELSGPIKEGDKISLLQLLILGLQHTFTMFGATVLVPLLTGLDVGVALFTAG
CCEEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGTLWFHLVTKRKVPIFLGSSFAFIAPVALVVKQWGVPAAQGGIIVAGLLYGLMAVLVYF
HHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
LGREFMENLLPPVVTGPIIMVIGLNLAPVAIKSASQNWMVALIVLTTVILVSMYGRGFFK
HHHHHHHHCCCCHHHCCCHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
LVPVLVGLIVGYGVSLIFGIVDLKPVQEAALFAVPAFTKPEFNPAAIGLIAPVAVATIVE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
HVGDVLAVGATVQKDFVKDPGLHRTLIGDGIATSLAGLFGGPANTTYSENTGVLALTGVW
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
KPEVMRVAAVMAMILSTCQKLTALIRTVPEPVIGGISIILFGMIASIGIRTVVENAVDFK
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSRNLIISSAILVFGIGGAVVNLWGGIQLGGVGLAAIIGIILNQVLPKE
HHCCHHHHHHHHHHCCCHHHHHHHCCCEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHCCHHHHHHHHHHCCCHHHHHHHCCCEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]