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The map label for this gene is comEC [H]

Identifier: 167040962

GI number: 167040962

Start: 2392384

End: 2393340

Strand: Reverse

Name: comEC [H]

Synonym: Teth514_2351

Alternate gene names: 167040962

Gene position: 2393340-2392384 (Counterclockwise)

Preceding gene: 167040963

Following gene: 167040961

Centisome position: 97.4

GC content: 33.33

Gene sequence:

>957_bases
ATGTACAAGAAGAGATTACTGTTGCCCTTTATATTAATACTATTTGCATTTATATTGACAAATTATACAATATTTGACAA
TACCCTTACTCATGAAGTTCAACAGGTTTTACAGGATGAAGGAATAAAAAAACAGCACGAAGCAGTTAAAAAATCCGCAA
CAGACAGTTTAACAGTAAATTATATAGACGTAGGACAAGGAGACAGTATATTTATACAAACTCCATCAGGCAAGACGATG
TTAATAGATGCAGGAACACCTGAAATGGGTAGCAAAGTTATAAAGTACATAAAAAGCCAGGGAATTAATAAAATTGACGT
ACTTATAGGTACCCATCCTCATAATGACCACATAGGAGGTATAGTGGAGATTATAAAAACCTTCAAAATAGGAAAGTTTT
ATATGCCTAAAGTAACCACTACAACGAGGACATTTGAAGAAGTTCTAAAGGCAGCAAAATCAAAAGGACTTTCGATAAAC
GTTGCAAAAACAGGAGTAGTAATTGACCTTGGAGATGGTATAATTGCAAAAATGCTTGCGCCAAATAGTTCCCATTACGA
GGACTTAAATAATTATAGTGCGGTAATAAAAATTACGTATGGTAATACATCTTTTTTGTTTACAGGAGATGCTAGTGAAC
AATCTGAAAAGGAAATGCTAAGTAAAGGATATAATTTAAAAGCCGACGTCTTAAAAATTGGACATCATGGCAGTTCTTCA
TCTTCTACTTGGGCATTTTTAAAGGCAGTACATCCTAAATATGCTGTTATATCTTGCGGTAAATACAATGACTATGGTCA
TCCCCACAAAGAAACAATGAAAAAGCTTAGGTCATTAGGAATAATAGTATATAGAACAGATGAATGTGGGACTGTAATTG
CAGTAAGTGATGGCAAAACTATAAATTTTAATGTAGAACCAGGTGATAATTTGTCGGGAAGTGAGATTAAAAGATAA

Upstream 100 bases:

>100_bases
GCAAAAAGGCTATTGAAGATTTGGCGAAGGACCTATTTAAAGATGAATAAAGATGGATAAATGTTAAAAAGGTGCATAAT
TTGAAGGAGAGGTTTTAGCT

Downstream 100 bases:

>100_bases
TTTACGATCATCCGCCGAGAACGCTTTCCAATTTACTGAGAGATGAAAGGCGGTAAAAAATGTGATAAAATAAAGTAGAG
TTAAAACAGGAAGGAGGTGA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MYKKRLLLPFILILFAFILTNYTIFDNTLTHEVQQVLQDEGIKKQHEAVKKSATDSLTVNYIDVGQGDSIFIQTPSGKTM
LIDAGTPEMGSKVIKYIKSQGINKIDVLIGTHPHNDHIGGIVEIIKTFKIGKFYMPKVTTTTRTFEEVLKAAKSKGLSIN
VAKTGVVIDLGDGIIAKMLAPNSSHYEDLNNYSAVIKITYGNTSFLFTGDASEQSEKEMLSKGYNLKADVLKIGHHGSSS
SSTWAFLKAVHPKYAVISCGKYNDYGHPHKETMKKLRSLGIIVYRTDECGTVIAVSDGKTINFNVEPGDNLSGSEIKR

Sequences:

>Translated_318_residues
MYKKRLLLPFILILFAFILTNYTIFDNTLTHEVQQVLQDEGIKKQHEAVKKSATDSLTVNYIDVGQGDSIFIQTPSGKTM
LIDAGTPEMGSKVIKYIKSQGINKIDVLIGTHPHNDHIGGIVEIIKTFKIGKFYMPKVTTTTRTFEEVLKAAKSKGLSIN
VAKTGVVIDLGDGIIAKMLAPNSSHYEDLNNYSAVIKITYGNTSFLFTGDASEQSEKEMLSKGYNLKADVLKIGHHGSSS
SSTWAFLKAVHPKYAVISCGKYNDYGHPHKETMKKLRSLGIIVYRTDECGTVIAVSDGKTINFNVEPGDNLSGSEIKR
>Mature_318_residues
MYKKRLLLPFILILFAFILTNYTIFDNTLTHEVQQVLQDEGIKKQHEAVKKSATDSLTVNYIDVGQGDSIFIQTPSGKTM
LIDAGTPEMGSKVIKYIKSQGINKIDVLIGTHPHNDHIGGIVEIIKTFKIGKFYMPKVTTTTRTFEEVLKAAKSKGLSIN
VAKTGVVIDLGDGIIAKMLAPNSSHYEDLNNYSAVIKITYGNTSFLFTGDASEQSEKEMLSKGYNLKADVLKIGHHGSSS
SSTWAFLKAVHPKYAVISCGKYNDYGHPHKETMKKLRSLGIIVYRTDECGTVIAVSDGKTINFNVEPGDNLSGSEIKR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=225, Percent_Identity=26.2222222222222, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 35041; Mature: 35041

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKKRLLLPFILILFAFILTNYTIFDNTLTHEVQQVLQDEGIKKQHEAVKKSATDSLTVN
CCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEE
YIDVGQGDSIFIQTPSGKTMLIDAGTPEMGSKVIKYIKSQGINKIDVLIGTHPHNDHIGG
EEEECCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHH
IVEIIKTFKIGKFYMPKVTTTTRTFEEVLKAAKSKGLSINVAKTGVVIDLGDGIIAKMLA
HHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCEEHHCC
PNSSHYEDLNNYSAVIKITYGNTSFLFTGDASEQSEKEMLSKGYNLKADVLKIGHHGSSS
CCCCHHHHCCCCEEEEEEEECCEEEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCC
SSTWAFLKAVHPKYAVISCGKYNDYGHPHKETMKKLRSLGIIVYRTDECGTVIAVSDGKT
CCHHHEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCEEEEEECCCE
INFNVEPGDNLSGSEIKR
EEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MYKKRLLLPFILILFAFILTNYTIFDNTLTHEVQQVLQDEGIKKQHEAVKKSATDSLTVN
CCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEE
YIDVGQGDSIFIQTPSGKTMLIDAGTPEMGSKVIKYIKSQGINKIDVLIGTHPHNDHIGG
EEEECCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHH
IVEIIKTFKIGKFYMPKVTTTTRTFEEVLKAAKSKGLSINVAKTGVVIDLGDGIIAKMLA
HHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCEEHHCC
PNSSHYEDLNNYSAVIKITYGNTSFLFTGDASEQSEKEMLSKGYNLKADVLKIGHHGSSS
CCCCHHHHCCCCEEEEEEEECCEEEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCC
SSTWAFLKAVHPKYAVISCGKYNDYGHPHKETMKKLRSLGIIVYRTDECGTVIAVSDGKT
CCHHHEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCEEEEEECCCE
INFNVEPGDNLSGSEIKR
EEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]