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The map label for this gene is lon [H]

Identifier: 167040913

GI number: 167040913

Start: 2310538

End: 2312874

Strand: Reverse

Name: lon [H]

Synonym: Teth514_2299

Alternate gene names: 167040913

Gene position: 2312874-2310538 (Counterclockwise)

Preceding gene: 167040914

Following gene: 167040912

Centisome position: 94.12

GC content: 35.22

Gene sequence:

>2337_bases
ATGACAGAAAAAAAGTATATATTGCCAATGATTCCTTTAAGAGGATTAACTATTTTTCCATACATGGTGCTTCATTTTGA
TATAGGAAGAGAAAAGTCAATTAGGGCTTTGGAAGAAGCTTTTATGAAAAATCAGTTAATATTTGTTACAACGCAAAAAG
AAGCTGAGATAGAAGACCCTTCTATTGACGACGTCTACAAAGTTGGCACTATTACAAAAGTCAAACAAATGTTAAAACTG
CCAGGAGAACTTATAAGAGTTTTGGTAGAAGGGATAAGTCGTGCTGAAATTCAGCAAGTGACAAGAGATGATGAATTTTT
TGAGGTAGAAGTTATAGAAAAAGAAGTGCAAAAAGAAATTGAAAAGACACCAGAGCTTGAAGCTTTAATGAGAAGTGTTA
TTTCTGCTTTTGAAGAATATGTAAATATGACTTCGAGACTGCCTATAGATAGTTTATACAGTGTTATAAGCATAGAAGAG
CCTGGAAGACTCGCAGACATGATTGCGGCCCATATATCTTTAAATACGAGTCAAAGTCAGCAGCTTTTGGAGTGTTTTGA
TGCAAATAAAAGGTTAGAAACTCTTTTAGGGTTTTTAATGAAAGAATTAGAAATACTAAACATTGAAAAAGAAATAAATG
CAAAGGTGAGAAGCCAAATTGACAAATTGCAGAAGGAATATTATTTAAGAGAACAGTTAAAAGCTATAAAAGCTGAATTA
GGAGAGACAGATGAAGTTGACCAAGAGATTGAGGAGTATGAAAAGAAATTAAATGAAAAAGATTTACCAGAAGAAGTTAG
AAAAAAGGCAAAAGAAGAATTAAAGCGCCTTTCTAAAATGGCGCCTGGTTCTGCAGAAGCTTCTGTAGTGAGGACATATT
TGGATTGGATTTTGGATTTACCTTGGAATTACGAAACAGAAGATATTTTAGATTTAAAAAGAGCACAAAAAATATTGGAT
GAGGACCATTACGGCTTAAAGAAAGTAAAAGAGAGGATAATAGAGTTTTTAGCAGTTAGAAGTTTTTACAACAAAATTAA
AAGTCCTATTTTATGCCTTGTAGGTCCTCCAGGTGTTGGTAAGACTTCATTAGGCAGGTCTATAGCGCGGGCTATGAATA
GAAAATTTGTCAGATTATCTCTTGGTGGAGTGAGAGATGAAGCAGAAATAAGGGGACATAGGCGTACCTACGTCGGAGCT
ATACCAGGAGGTATTATAAATTCCATAAAAATAGCCGGTTCAAAAAATCCTGTGTTTTTACTGGATGAAATAGACAAAAT
GAGCTCAGACTTTAGAGGAGACCCTGCTTCTGCAATGCTTGAAGTTCTTGACCCAGAACAAAACTCCACTTTTAGAGACC
ATTACCTTGATTTGCCTTTTGACCTTTCAAAGGTATTGTTTATAACAACGGCTAATACGGTAGATACTATACCGGCGCCT
CTTTTAGATAGAATGGAAGTTATATATGTTTCTGGATATACTGAAGAAGAAAAACTTCATATTGCAAAAGATTATTTAAT
CCCTAAGATTTTAAAAGAACATGGGGTGCCAGATAACAAGATAATAATCCAAGAATCTGCTATCAAAGGAATAATTTCGG
AATATACTCGTGAAGCAGGAGTAAGAGGCTTAGAAAAGAATTTATCTCAAATTGTGAGGAAAGCTATAAAGAAGATAGTG
GAAGAAAATGCACAAGTAGTAAAAGTGGGAAAAAGAAATTTACAGTCTTATTTAGACAAGCCTATTTACCGCCCTGACAA
AGCGAATCAAAAAGACGAAGTAGGGATAGTTTTTGGACTTGCATGGACAAGGGTAGGAGGAGAAATTTTAACTGTAGAAG
CTTCTATAATGCCAGGAAGTGGCAAGCTCAATCTTACAGGGCAATTAGGGGATGTGATGAAAGAATCTGCACAAGCTGGT
TTTAGCTATATAAGGGCGAATGCCGAGAAACTGAATATAGATAAAGATTTTTACAAAAATATCGATATACATATACACGT
TCCTGAAGGTGCAATTCCAAAAGATGGACCTTCTGCTGGCATAACAATGGTGACAGCAATGGTGTCTGCTCTTAAAAAAG
TTCCTGTGAGAAAAGATGTAGCAATGACAGGAGAAATAACTTTGACGGGCAAAGTCCTTCCAATTGGAGGAGTAAAGGAA
AAAGTTTTAGCAGCCCATAGAGCAGGAATAGGAAAAGTAATACTTCCTCAAGAAAACAAAAGGGATTTAGATGAAATTCC
TCAAAGTGTAAAGCGAAAATTAGAATTCAAGTTTGTAGAAAAGATTGACGAAGTTCTTGACTTTGCACTGGTTAAGGAGG
GCTTTTATGAAAATTAA

Upstream 100 bases:

>100_bases
AAAAATAGAGAATTTTTACATCAATCCCCCTTCTCCTTCACATACTAAAATAGTGAATGGGAAGGGGGCTTGGTTATATT
GCATAAAAGAGGGTGAAGAT

Downstream 100 bases:

>100_bases
AACTGTAGAATTTGCCCGTTCTGCTTTTAATGAGGAACAGTATCCTAAAGATAATCTTCCACAAATAGTAATTGTCGGGA
GGTCAAACGTAGGCAAGTCT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 778; Mature: 777

Protein sequence:

>778_residues
MTEKKYILPMIPLRGLTIFPYMVLHFDIGREKSIRALEEAFMKNQLIFVTTQKEAEIEDPSIDDVYKVGTITKVKQMLKL
PGELIRVLVEGISRAEIQQVTRDDEFFEVEVIEKEVQKEIEKTPELEALMRSVISAFEEYVNMTSRLPIDSLYSVISIEE
PGRLADMIAAHISLNTSQSQQLLECFDANKRLETLLGFLMKELEILNIEKEINAKVRSQIDKLQKEYYLREQLKAIKAEL
GETDEVDQEIEEYEKKLNEKDLPEEVRKKAKEELKRLSKMAPGSAEASVVRTYLDWILDLPWNYETEDILDLKRAQKILD
EDHYGLKKVKERIIEFLAVRSFYNKIKSPILCLVGPPGVGKTSLGRSIARAMNRKFVRLSLGGVRDEAEIRGHRRTYVGA
IPGGIINSIKIAGSKNPVFLLDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTVDTIPAP
LLDRMEVIYVSGYTEEEKLHIAKDYLIPKILKEHGVPDNKIIIQESAIKGIISEYTREAGVRGLEKNLSQIVRKAIKKIV
EENAQVVKVGKRNLQSYLDKPIYRPDKANQKDEVGIVFGLAWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAG
FSYIRANAEKLNIDKDFYKNIDIHIHVPEGAIPKDGPSAGITMVTAMVSALKKVPVRKDVAMTGEITLTGKVLPIGGVKE
KVLAAHRAGIGKVILPQENKRDLDEIPQSVKRKLEFKFVEKIDEVLDFALVKEGFYEN

Sequences:

>Translated_778_residues
MTEKKYILPMIPLRGLTIFPYMVLHFDIGREKSIRALEEAFMKNQLIFVTTQKEAEIEDPSIDDVYKVGTITKVKQMLKL
PGELIRVLVEGISRAEIQQVTRDDEFFEVEVIEKEVQKEIEKTPELEALMRSVISAFEEYVNMTSRLPIDSLYSVISIEE
PGRLADMIAAHISLNTSQSQQLLECFDANKRLETLLGFLMKELEILNIEKEINAKVRSQIDKLQKEYYLREQLKAIKAEL
GETDEVDQEIEEYEKKLNEKDLPEEVRKKAKEELKRLSKMAPGSAEASVVRTYLDWILDLPWNYETEDILDLKRAQKILD
EDHYGLKKVKERIIEFLAVRSFYNKIKSPILCLVGPPGVGKTSLGRSIARAMNRKFVRLSLGGVRDEAEIRGHRRTYVGA
IPGGIINSIKIAGSKNPVFLLDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTVDTIPAP
LLDRMEVIYVSGYTEEEKLHIAKDYLIPKILKEHGVPDNKIIIQESAIKGIISEYTREAGVRGLEKNLSQIVRKAIKKIV
EENAQVVKVGKRNLQSYLDKPIYRPDKANQKDEVGIVFGLAWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAG
FSYIRANAEKLNIDKDFYKNIDIHIHVPEGAIPKDGPSAGITMVTAMVSALKKVPVRKDVAMTGEITLTGKVLPIGGVKE
KVLAAHRAGIGKVILPQENKRDLDEIPQSVKRKLEFKFVEKIDEVLDFALVKEGFYEN
>Mature_777_residues
TEKKYILPMIPLRGLTIFPYMVLHFDIGREKSIRALEEAFMKNQLIFVTTQKEAEIEDPSIDDVYKVGTITKVKQMLKLP
GELIRVLVEGISRAEIQQVTRDDEFFEVEVIEKEVQKEIEKTPELEALMRSVISAFEEYVNMTSRLPIDSLYSVISIEEP
GRLADMIAAHISLNTSQSQQLLECFDANKRLETLLGFLMKELEILNIEKEINAKVRSQIDKLQKEYYLREQLKAIKAELG
ETDEVDQEIEEYEKKLNEKDLPEEVRKKAKEELKRLSKMAPGSAEASVVRTYLDWILDLPWNYETEDILDLKRAQKILDE
DHYGLKKVKERIIEFLAVRSFYNKIKSPILCLVGPPGVGKTSLGRSIARAMNRKFVRLSLGGVRDEAEIRGHRRTYVGAI
PGGIINSIKIAGSKNPVFLLDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTVDTIPAPL
LDRMEVIYVSGYTEEEKLHIAKDYLIPKILKEHGVPDNKIIIQESAIKGIISEYTREAGVRGLEKNLSQIVRKAIKKIVE
ENAQVVKVGKRNLQSYLDKPIYRPDKANQKDEVGIVFGLAWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAGF
SYIRANAEKLNIDKDFYKNIDIHIHVPEGAIPKDGPSAGITMVTAMVSALKKVPVRKDVAMTGEITLTGKVLPIGGVKEK
VLAAHRAGIGKVILPQENKRDLDEIPQSVKRKLEFKFVEKIDEVLDFALVKEGFYEN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=832, Percent_Identity=39.5432692307692, Blast_Score=576, Evalue=1e-164,
Organism=Homo sapiens, GI31377667, Length=772, Percent_Identity=40.5440414507772, Blast_Score=559, Evalue=1e-159,
Organism=Escherichia coli, GI1786643, Length=769, Percent_Identity=53.185955786736, Blast_Score=827, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=704, Percent_Identity=40.7670454545455, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17556486, Length=788, Percent_Identity=36.2944162436548, Blast_Score=475, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319449, Length=702, Percent_Identity=41.4529914529915, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221513036, Length=681, Percent_Identity=43.9060205580029, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24666867, Length=681, Percent_Identity=43.9060205580029, Blast_Score=561, Evalue=1e-160,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87940; Mature: 87809

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKYILPMIPLRGLTIFPYMVLHFDIGREKSIRALEEAFMKNQLIFVTTQKEAEIEDP
CCCCCEEEECCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
SIDDVYKVGTITKVKQMLKLPGELIRVLVEGISRAEIQQVTRDDEFFEVEVIEKEVQKEI
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
EKTPELEALMRSVISAFEEYVNMTSRLPIDSLYSVISIEEPGRLADMIAAHISLNTSQSQ
HCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHH
QLLECFDANKRLETLLGFLMKELEILNIEKEINAKVRSQIDKLQKEYYLREQLKAIKAEL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GETDEVDQEIEEYEKKLNEKDLPEEVRKKAKEELKRLSKMAPGSAEASVVRTYLDWILDL
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
PWNYETEDILDLKRAQKILDEDHYGLKKVKERIIEFLAVRSFYNKIKSPILCLVGPPGVG
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGRSIARAMNRKFVRLSLGGVRDEAEIRGHRRTYVGAIPGGIINSIKIAGSKNPVFL
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCEEEECCCCHHHHCEEEECCCCCEEE
LDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTVDTIPAP
EHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEEEECCCHHCCCHH
LLDRMEVIYVSGYTEEEKLHIAKDYLIPKILKEHGVPDNKIIIQESAIKGIISEYTREAG
HHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHC
VRGLEKNLSQIVRKAIKKIVEENAQVVKVGKRNLQSYLDKPIYRPDKANQKDEVGIVFGL
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEE
AWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAGFSYIRANAEKLNIDKDFYKN
HHHHCCCEEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCC
IDIHIHVPEGAIPKDGPSAGITMVTAMVSALKKVPVRKDVAMTGEITLTGKVLPIGGVKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEEEEECCCHHH
KVLAAHRAGIGKVILPQENKRDLDEIPQSVKRKLEFKFVEKIDEVLDFALVKEGFYEN
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEKKYILPMIPLRGLTIFPYMVLHFDIGREKSIRALEEAFMKNQLIFVTTQKEAEIEDP
CCCCEEEECCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
SIDDVYKVGTITKVKQMLKLPGELIRVLVEGISRAEIQQVTRDDEFFEVEVIEKEVQKEI
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
EKTPELEALMRSVISAFEEYVNMTSRLPIDSLYSVISIEEPGRLADMIAAHISLNTSQSQ
HCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHH
QLLECFDANKRLETLLGFLMKELEILNIEKEINAKVRSQIDKLQKEYYLREQLKAIKAEL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GETDEVDQEIEEYEKKLNEKDLPEEVRKKAKEELKRLSKMAPGSAEASVVRTYLDWILDL
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
PWNYETEDILDLKRAQKILDEDHYGLKKVKERIIEFLAVRSFYNKIKSPILCLVGPPGVG
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGRSIARAMNRKFVRLSLGGVRDEAEIRGHRRTYVGAIPGGIINSIKIAGSKNPVFL
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCEEEECCCCHHHHCEEEECCCCCEEE
LDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTVDTIPAP
EHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEEEECCCHHCCCHH
LLDRMEVIYVSGYTEEEKLHIAKDYLIPKILKEHGVPDNKIIIQESAIKGIISEYTREAG
HHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHC
VRGLEKNLSQIVRKAIKKIVEENAQVVKVGKRNLQSYLDKPIYRPDKANQKDEVGIVFGL
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEE
AWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAGFSYIRANAEKLNIDKDFYKN
HHHHCCCEEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCC
IDIHIHVPEGAIPKDGPSAGITMVTAMVSALKKVPVRKDVAMTGEITLTGKVLPIGGVKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEEEEECCCHHH
KVLAAHRAGIGKVILPQENKRDLDEIPQSVKRKLEFKFVEKIDEVLDFALVKEGFYEN
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA