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The map label for this gene is ywqF [H]

Identifier: 167040894

GI number: 167040894

Start: 2287775

End: 2289130

Strand: Reverse

Name: ywqF [H]

Synonym: Teth514_2277

Alternate gene names: 167040894

Gene position: 2289130-2287775 (Counterclockwise)

Preceding gene: 167040895

Following gene: 167040893

Centisome position: 93.16

GC content: 32.52

Gene sequence:

>1356_bases
ATGAATATTTCTATAGCAGGTACCGGTTATGTAGGTTTGGTTACAGGAGTATGTCTTGCAGAAATAGGACACAATGTAAC
TTGTGTAGATGTTGATGAGAAAAAAATAGAGATATTAAAGGCAGGAAAGTCGCCAATATATGAACCGGGACTCGAAGAGC
TGATGATTAAAAATAAAGAAAGATTGACATATACGACTGATTATAGAAGTGCTTATAAAGATGCGGATGTTATTTTTATA
GCTGTTGGTACTCCTGAGAAAAAGGATGGTTCGGCAAATTTAAAATATGTATATGAAGTTACAAAACAAATAGCTGAGTC
GATAGAAAAGGATTGTATAGTTGTTGTAAAGTCTACTGTACCTGTTGGTACAAGTGATAAAGTTGAAAAGATGTTAAAAG
AAAATTTAAAACATAATATTCATGTGGAAGTTGTTTCAAATCCTGAATTTTTATCACAAGGGACAGCAGTAAGAGATACG
TTAAAAGCTCATAGGATAGTATTAGGAGTAGAATCAAAACATGCAGAGGAAGTTATGCGAAAAGTATATGATGGTTTTGG
ACAACCTTATGTAATTACAGATAGGAAAAGTGCAGAGATGATAAAATATGCTTCAAATGACTTTTTAGCACTGAAAATTT
CTTATATCAATGAAATAGCTAATTTATGTGAAATAGTAGGGGCTAATATAGAGGATGTAGCAAAAGGAATGGGAATGGAC
CCACGCATAGGAGACAAATTTTTGAATGCCGGCATTGGATATGGTGGTTCGTGCTTCCCGAAAGATACAAAAGCATTACA
CTGGTTAGCTAATTTTTATGACTATGAGCTTAAAACAATTAAGGCTGCAATTGAGGTAAATGAAAACCAAAAAATAAAAC
TTATCAAAAAAGCAAGAAAATATTATGATAATTTTAATGGATTGACTGTGGCAATTCTTGGACTTACTTTTAAACCAGGT
ACAGACGATTTGAGGGAGGCTCCATCATTACAAAATATTCCTATACTCCTTGAAGATAGCGCCAATATTAAAGCATGGGA
CCCTGTAGGAATAGAGAATTGTAAAAAAATTTATCCTAATGAAATCAAGTATTGTGATACAATTGAAGAAGCGATTAAAG
ATGCTGATATTTGCTTTATATTTACTGAATGGCCCCAAATAAAAAATTTTGATGTATCATTATTTGCAAAATTGATGAAA
TATCCTTTGGTGATTGACGGAAGGAATTGTTATGATTTAGAGAAAGTTAAGGGAGTAGGCATTATTTATGAATCGATAGG
AAGAAATACGGTTAATGGATTAGAATTAAACAATAAAATTTATCGAGATGAGGCTGCAGCTTCGGTAAGTAAATAA

Upstream 100 bases:

>100_bases
TATCACTTTTAGTATATGTTACATGGATTTTTAGTTTTGATTAATGATGTAAAGTGCGAAAAGTTTTATCTACTTATAAT
TTTAGAAAGGAGTATTTGCA

Downstream 100 bases:

>100_bases
TTACTTAAGTGAAGCATAAGGATTAAGAGATTTGACGAATTAATATTATCGGGGGGTGAGATGATGTGGTATAGAAGATG
GAGTATTGTACTTGACATTA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNISIAGTGYVGLVTGVCLAEIGHNVTCVDVDEKKIEILKAGKSPIYEPGLEELMIKNKERLTYTTDYRSAYKDADVIFI
AVGTPEKKDGSANLKYVYEVTKQIAESIEKDCIVVVKSTVPVGTSDKVEKMLKENLKHNIHVEVVSNPEFLSQGTAVRDT
LKAHRIVLGVESKHAEEVMRKVYDGFGQPYVITDRKSAEMIKYASNDFLALKISYINEIANLCEIVGANIEDVAKGMGMD
PRIGDKFLNAGIGYGGSCFPKDTKALHWLANFYDYELKTIKAAIEVNENQKIKLIKKARKYYDNFNGLTVAILGLTFKPG
TDDLREAPSLQNIPILLEDSANIKAWDPVGIENCKKIYPNEIKYCDTIEEAIKDADICFIFTEWPQIKNFDVSLFAKLMK
YPLVIDGRNCYDLEKVKGVGIIYESIGRNTVNGLELNNKIYRDEAAASVSK

Sequences:

>Translated_451_residues
MNISIAGTGYVGLVTGVCLAEIGHNVTCVDVDEKKIEILKAGKSPIYEPGLEELMIKNKERLTYTTDYRSAYKDADVIFI
AVGTPEKKDGSANLKYVYEVTKQIAESIEKDCIVVVKSTVPVGTSDKVEKMLKENLKHNIHVEVVSNPEFLSQGTAVRDT
LKAHRIVLGVESKHAEEVMRKVYDGFGQPYVITDRKSAEMIKYASNDFLALKISYINEIANLCEIVGANIEDVAKGMGMD
PRIGDKFLNAGIGYGGSCFPKDTKALHWLANFYDYELKTIKAAIEVNENQKIKLIKKARKYYDNFNGLTVAILGLTFKPG
TDDLREAPSLQNIPILLEDSANIKAWDPVGIENCKKIYPNEIKYCDTIEEAIKDADICFIFTEWPQIKNFDVSLFAKLMK
YPLVIDGRNCYDLEKVKGVGIIYESIGRNTVNGLELNNKIYRDEAAASVSK
>Mature_451_residues
MNISIAGTGYVGLVTGVCLAEIGHNVTCVDVDEKKIEILKAGKSPIYEPGLEELMIKNKERLTYTTDYRSAYKDADVIFI
AVGTPEKKDGSANLKYVYEVTKQIAESIEKDCIVVVKSTVPVGTSDKVEKMLKENLKHNIHVEVVSNPEFLSQGTAVRDT
LKAHRIVLGVESKHAEEVMRKVYDGFGQPYVITDRKSAEMIKYASNDFLALKISYINEIANLCEIVGANIEDVAKGMGMD
PRIGDKFLNAGIGYGGSCFPKDTKALHWLANFYDYELKTIKAAIEVNENQKIKLIKKARKYYDNFNGLTVAILGLTFKPG
TDDLREAPSLQNIPILLEDSANIKAWDPVGIENCKKIYPNEIKYCDTIEEAIKDADICFIFTEWPQIKNFDVSLFAKLMK
YPLVIDGRNCYDLEKVKGVGIIYESIGRNTVNGLELNNKIYRDEAAASVSK

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=461, Percent_Identity=33.8394793926247, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI296040438, Length=368, Percent_Identity=32.8804347826087, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI296040443, Length=316, Percent_Identity=32.9113924050633, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1788340, Length=341, Percent_Identity=35.1906158357771, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI48994968, Length=415, Percent_Identity=26.2650602409639, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=33.8394793926247, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=34.6320346320346, Blast_Score=245, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 50332; Mature: 50332

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISIAGTGYVGLVTGVCLAEIGHNVTCVDVDEKKIEILKAGKSPIYEPGLEELMIKNKE
CEEEEECCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHCCCC
RLTYTTDYRSAYKDADVIFIAVGTPEKKDGSANLKYVYEVTKQIAESIEKDCIVVVKSTV
CEEEEECHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
PVGTSDKVEKMLKENLKHNIHVEVVSNPEFLSQGTAVRDTLKAHRIVLGVESKHAEEVMR
CCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHCEEEEEECCHHHHHHHH
KVYDGFGQPYVITDRKSAEMIKYASNDFLALKISYINEIANLCEIVGANIEDVAKGMGMD
HHHHCCCCCEEEECCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHCCCCC
PRIGDKFLNAGIGYGGSCFPKDTKALHWLANFYDYELKTIKAAIEVNENQKIKLIKKARK
CCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHH
YYDNFNGLTVAILGLTFKPGTDDLREAPSLQNIPILLEDSANIKAWDPVGIENCKKIYPN
HHCCCCCEEEEEEEEEECCCCHHHHHCCCCCCCCEEEECCCCCEECCCCCHHHHHHHCCC
EIKYCDTIEEAIKDADICFIFTEWPQIKNFDVSLFAKLMKYPLVIDGRNCYDLEKVKGVG
CCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCCCHHHHCCCE
IIYESIGRNTVNGLELNNKIYRDEAAASVSK
EEEHHCCCCCCCCEECCCCHHHHHHHHCCCC
>Mature Secondary Structure
MNISIAGTGYVGLVTGVCLAEIGHNVTCVDVDEKKIEILKAGKSPIYEPGLEELMIKNKE
CEEEEECCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHCCCC
RLTYTTDYRSAYKDADVIFIAVGTPEKKDGSANLKYVYEVTKQIAESIEKDCIVVVKSTV
CEEEEECHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
PVGTSDKVEKMLKENLKHNIHVEVVSNPEFLSQGTAVRDTLKAHRIVLGVESKHAEEVMR
CCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHCEEEEEECCHHHHHHHH
KVYDGFGQPYVITDRKSAEMIKYASNDFLALKISYINEIANLCEIVGANIEDVAKGMGMD
HHHHCCCCCEEEECCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHCCCCC
PRIGDKFLNAGIGYGGSCFPKDTKALHWLANFYDYELKTIKAAIEVNENQKIKLIKKARK
CCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHH
YYDNFNGLTVAILGLTFKPGTDDLREAPSLQNIPILLEDSANIKAWDPVGIENCKKIYPN
HHCCCCCEEEEEEEEEECCCCHHHHHCCCCCCCCEEEECCCCCEECCCCCHHHHHHHCCC
EIKYCDTIEEAIKDADICFIFTEWPQIKNFDVSLFAKLMKYPLVIDGRNCYDLEKVKGVG
CCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCCCHHHHCCCE
IIYESIGRNTVNGLELNNKIYRDEAAASVSK
EEEHHCCCCCCCCEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]