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The map label for this gene is algA [H]

Identifier: 167040892

GI number: 167040892

Start: 2285034

End: 2286107

Strand: Reverse

Name: algA [H]

Synonym: Teth514_2275

Alternate gene names: 167040892

Gene position: 2286107-2285034 (Counterclockwise)

Preceding gene: 167040893

Following gene: 167040891

Centisome position: 93.03

GC content: 33.8

Gene sequence:

>1074_bases
ATGATAACAGGTGTTATTATGGCGGGTGGCAAAGGCGAAAGGTTTTGGCCTAAAAGTAGGATAAAGATGCCAAAGCAGTT
TTTGAATCTTTATGGAGATAAAACAATGATTCAACAAACAGTGGATAGACTGAAGAGAATCATGCCTGTAGAGAATATTT
TTGTTGTTACTAATATGGATTATGCGGGAATAATTAGTGACCAAATTCCTGATTTGCCAACAGAAAATATTTTAATAGAG
CCTATGGCTAAAAATACTGCGGCATGCATTGGCCTTGCAGCACTTCACACAGAAAGGCTTGATAAAGAGTCTATAATGGT
TGTTGTTCCTTCTGACCATGTCATAAAAGACGAAGAAGCATATATTGAAATATTAAAAACAGCAATAGAAAAAGCAAAAG
CAGGGGACAATCTTGTCACAATAGGTATAAAACCTACACGTCCTGAGACAGGATATGGTTACATAAAATTCAAGAAGGTA
ACGAGAGAAATAATAAATAAAAATCCTGTACATAAAGTAGAAAGATTTGTAGAAAAACCTGATTATGATACAGCAGTAAA
ATATGTAGAAAGCGGAGATTATCTTTGGAATAGCGGTATGTTTATATGGAAGACATCATCAATATTAAGCGCTATATGCG
AATACATGCCTGATTTACACAAAGCATTGGAAAATATAAGGAAAAACTTTGATGCAGATGATATAGAAAAAGTATTATAC
GATGAATACTCAAAACTTGAAAGCATATCAATAGATTACGGCATAATGGAAAAAGCCAAAAATGTATATGTCGTGCCAGG
AGATTTTGGCTGGGATGATGTAGGAAGCTGGACTTCTATTGAAAGGCTTTATGAAAAAGATGATAATGGCAATGTCATAA
AAGGCAATGTAGTAAGTGTAGATACAAAGAAATGCATAATAACTGGTAACGAAAGGCTTATTGCGACATTGGGTATAGAA
GATGTAATAATTGTAGATACAGAGGATGCTCTTTTAATTTGTTCAAAAGATAAGGCACAGAATGTGAAAGAGGTATTGAA
GGAGTTGAAAGAGAAAAAAAGTGAGTATTTATAA

Upstream 100 bases:

>100_bases
TTAAATTTTATTCGTGGTTGATGGAAAGTATTAATTAAAAACTTTTGCTTGGATATTGAGTAAGTTGAGTTGAACAAATT
AACTAAAAAGGATGATGCAA

Downstream 100 bases:

>100_bases
GGAGTTAAAATTGTACACTGATAAAATGGAGTTTTTATCTATTTTTAACCTTTCTATGGCTGTGGAGGTGAATTTGTTTA
AGTAATGAAATAATAAGTGA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MITGVIMAGGKGERFWPKSRIKMPKQFLNLYGDKTMIQQTVDRLKRIMPVENIFVVTNMDYAGIISDQIPDLPTENILIE
PMAKNTAACIGLAALHTERLDKESIMVVVPSDHVIKDEEAYIEILKTAIEKAKAGDNLVTIGIKPTRPETGYGYIKFKKV
TREIINKNPVHKVERFVEKPDYDTAVKYVESGDYLWNSGMFIWKTSSILSAICEYMPDLHKALENIRKNFDADDIEKVLY
DEYSKLESISIDYGIMEKAKNVYVVPGDFGWDDVGSWTSIERLYEKDDNGNVIKGNVVSVDTKKCIITGNERLIATLGIE
DVIIVDTEDALLICSKDKAQNVKEVLKELKEKKSEYL

Sequences:

>Translated_357_residues
MITGVIMAGGKGERFWPKSRIKMPKQFLNLYGDKTMIQQTVDRLKRIMPVENIFVVTNMDYAGIISDQIPDLPTENILIE
PMAKNTAACIGLAALHTERLDKESIMVVVPSDHVIKDEEAYIEILKTAIEKAKAGDNLVTIGIKPTRPETGYGYIKFKKV
TREIINKNPVHKVERFVEKPDYDTAVKYVESGDYLWNSGMFIWKTSSILSAICEYMPDLHKALENIRKNFDADDIEKVLY
DEYSKLESISIDYGIMEKAKNVYVVPGDFGWDDVGSWTSIERLYEKDDNGNVIKGNVVSVDTKKCIITGNERLIATLGIE
DVIIVDTEDALLICSKDKAQNVKEVLKELKEKKSEYL
>Mature_357_residues
MITGVIMAGGKGERFWPKSRIKMPKQFLNLYGDKTMIQQTVDRLKRIMPVENIFVVTNMDYAGIISDQIPDLPTENILIE
PMAKNTAACIGLAALHTERLDKESIMVVVPSDHVIKDEEAYIEILKTAIEKAKAGDNLVTIGIKPTRPETGYGYIKFKKV
TREIINKNPVHKVERFVEKPDYDTAVKYVESGDYLWNSGMFIWKTSSILSAICEYMPDLHKALENIRKNFDADDIEKVLY
DEYSKLESISIDYGIMEKAKNVYVVPGDFGWDDVGSWTSIERLYEKDDNGNVIKGNVVSVDTKKCIITGNERLIATLGIE
DVIIVDTEDALLICSKDKAQNVKEVLKELKEKKSEYL

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=354, Percent_Identity=40.1129943502825, Blast_Score=248, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 40460; Mature: 40460

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGVIMAGGKGERFWPKSRIKMPKQFLNLYGDKTMIQQTVDRLKRIMPVENIFVVTNMD
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCC
YAGIISDQIPDLPTENILIEPMAKNTAACIGLAALHTERLDKESIMVVVPSDHVIKDEEA
HHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCHHH
YIEILKTAIEKAKAGDNLVTIGIKPTRPETGYGYIKFKKVTREIINKNPVHKVERFVEKP
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHCC
DYDTAVKYVESGDYLWNSGMFIWKTSSILSAICEYMPDLHKALENIRKNFDADDIEKVLY
CHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DEYSKLESISIDYGIMEKAKNVYVVPGDFGWDDVGSWTSIERLYEKDDNGNVIKGNVVSV
HHHHHHHHEECCHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEECCEEEE
DTKKCIITGNERLIATLGIEDVIIVDTEDALLICSKDKAQNVKEVLKELKEKKSEYL
ECCEEEEECCCEEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITGVIMAGGKGERFWPKSRIKMPKQFLNLYGDKTMIQQTVDRLKRIMPVENIFVVTNMD
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCC
YAGIISDQIPDLPTENILIEPMAKNTAACIGLAALHTERLDKESIMVVVPSDHVIKDEEA
HHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCHHH
YIEILKTAIEKAKAGDNLVTIGIKPTRPETGYGYIKFKKVTREIINKNPVHKVERFVEKP
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHCC
DYDTAVKYVESGDYLWNSGMFIWKTSSILSAICEYMPDLHKALENIRKNFDADDIEKVLY
CHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DEYSKLESISIDYGIMEKAKNVYVVPGDFGWDDVGSWTSIERLYEKDDNGNVIKGNVVSV
HHHHHHHHEECCHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEECCEEEE
DTKKCIITGNERLIATLGIEDVIIVDTEDALLICSKDKAQNVKEVLKELKEKKSEYL
ECCEEEEECCCEEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]