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The map label for this gene is hutH [H]

Identifier: 167040793

GI number: 167040793

Start: 2168972

End: 2170498

Strand: Reverse

Name: hutH [H]

Synonym: Teth514_2170

Alternate gene names: 167040793

Gene position: 2170498-2168972 (Counterclockwise)

Preceding gene: 167040794

Following gene: 167040792

Centisome position: 88.33

GC content: 36.48

Gene sequence:

>1527_bases
ATGGGGAAGGTCATAATAGATGGGAATAATCTTACAATAGAGGATGTAGTGCACGTAGCAAGAGATGGCTATAGGGTAGA
GCTTAGTAGCATTGCTGAAGAAAGAGTACTTCATTCTAGAAAAATAGTAGAAAGATATGTAAATGATGAAAAAGTGGTTT
ATGGAATTACAACTGGTTTTGGGAATTTTAGCGATGTAGTAATATCTAAAGAGGATACAGAAATTTTGCAAAAGAATTTG
ATTATGAGTCACTCTTGCGGGGTAGGGAAGCCACTTCCAGAAGAAGTAGTAAGAGCAATAATGCTTTTGAGGGCAAATGC
TCTTGCAAAGGGTTTTTCAGGAGTAAGGCTTGAAACTTTAAAGACATTGATTGAAATGTTAAACAAAGGAGTAACTCCTG
TTATACCTGAAAAAGGATCTTTAGGAGCAAGCGGAGACCTTGCACCTTTAGCTCACATGGTTCTTGTGATGATAGGAAAG
GGAGAAGCTTTATACAAAGGTAAAAGAATGTCTGGAGAAAAAGCAATGAAAGAGGCAGGAATTGCTCCAGTTGTTTTGAG
TTCAAAAGAAGGTTTAGCATTGATAAATGGTACTCAAGTAATGACGGCAATAGGGTGTTTAAATGTATATGATTCTAAAA
GACTTATAAAATCTGCTGATGCTATATCTTCTATTACTTTAGAAGCTTTGAGAGGAATAATTGATGCTTTTGACGATAGA
GTCCAAATGGTGAGGCCTCATAGGGGTCAAATGGTTGTGGCTAAAAATATAAAGAAAATGTGTGAGGAAAGTACGCTCAT
AACGAGACAGGGAGAAATACGGGTTCAAGACGCTTATACGTTAAGATGTATTCCCCAAGTCCATGGAGCTATAAGGGATG
CCATTGAATATGTAGAAGATGTTCTCATAAGGGAGATAAATTCTGCAACAGATAATCCTTTAATTTTTCCTGGCGATGGC
GATGTAATATCTGGGGGTAACTTTCACGGTGAACCTATTGCATTAGCTATGGATTTTTTAGGTATTGCAGTTTCTGAAAT
TGCTAATATTTCCGAAAGAAGGATTGAAAGGCTTGTAAATTATCAATTAAACGACTTTCCTCCTTTTTTGACTGAAAAAG
GGGGACTAAATTCTGGTATGATGATAGCTCAATACACAGCAGCTTCTTTAGTGTCAGAAAATAAGGTTTTGGCGCATCCA
GCTTCTGTTGATTCTATACCATCTTCTGCAAATCAAGAAGACCATGTGAGTATGGGCACTATTGCTGCGAGAAAGGCAAG
GGAAATAATAGAAAACGCTACAAGGGTTATAGCAATAGAACTTATGGCAGCTTTGCAGGCAATGGAGTTTAAGAAAGGTT
TTAAAAAAGGGAAAGGATCACAAGTAATATATGATTTAGTAAGAAAATACGTTAAGCCGTTGGAAGAAGATAGGGAACTT
TATATTGACATAAATGCCTGTTTTGATATTATAAAATCAGGTAAAGTATTGGAGGCCCTTGAAAAAGAAGGTATAATATT
AGAATAA

Upstream 100 bases:

>100_bases
GATAGAAAAATTTTGCAATTTAATAAAAAACGCGAGAGGATAAACTCTCGCGTTTTTTGTTTTATTGCGATAAAGAATTA
ACGTAAAAAGGAGGTAGATT

Downstream 100 bases:

>100_bases
AGGTGATTTTGTGAATAGGATAAAACAATATTTTAAAGCGAAAAAGGCCAAAATTTATGAGGAAGATTATAAATTTTTAA
TGAATTTTTTAAACGAAAAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MGKVIIDGNNLTIEDVVHVARDGYRVELSSIAEERVLHSRKIVERYVNDEKVVYGITTGFGNFSDVVISKEDTEILQKNL
IMSHSCGVGKPLPEEVVRAIMLLRANALAKGFSGVRLETLKTLIEMLNKGVTPVIPEKGSLGASGDLAPLAHMVLVMIGK
GEALYKGKRMSGEKAMKEAGIAPVVLSSKEGLALINGTQVMTAIGCLNVYDSKRLIKSADAISSITLEALRGIIDAFDDR
VQMVRPHRGQMVVAKNIKKMCEESTLITRQGEIRVQDAYTLRCIPQVHGAIRDAIEYVEDVLIREINSATDNPLIFPGDG
DVISGGNFHGEPIALAMDFLGIAVSEIANISERRIERLVNYQLNDFPPFLTEKGGLNSGMMIAQYTAASLVSENKVLAHP
ASVDSIPSSANQEDHVSMGTIAARKAREIIENATRVIAIELMAALQAMEFKKGFKKGKGSQVIYDLVRKYVKPLEEDREL
YIDINACFDIIKSGKVLEALEKEGIILE

Sequences:

>Translated_508_residues
MGKVIIDGNNLTIEDVVHVARDGYRVELSSIAEERVLHSRKIVERYVNDEKVVYGITTGFGNFSDVVISKEDTEILQKNL
IMSHSCGVGKPLPEEVVRAIMLLRANALAKGFSGVRLETLKTLIEMLNKGVTPVIPEKGSLGASGDLAPLAHMVLVMIGK
GEALYKGKRMSGEKAMKEAGIAPVVLSSKEGLALINGTQVMTAIGCLNVYDSKRLIKSADAISSITLEALRGIIDAFDDR
VQMVRPHRGQMVVAKNIKKMCEESTLITRQGEIRVQDAYTLRCIPQVHGAIRDAIEYVEDVLIREINSATDNPLIFPGDG
DVISGGNFHGEPIALAMDFLGIAVSEIANISERRIERLVNYQLNDFPPFLTEKGGLNSGMMIAQYTAASLVSENKVLAHP
ASVDSIPSSANQEDHVSMGTIAARKAREIIENATRVIAIELMAALQAMEFKKGFKKGKGSQVIYDLVRKYVKPLEEDREL
YIDINACFDIIKSGKVLEALEKEGIILE
>Mature_507_residues
GKVIIDGNNLTIEDVVHVARDGYRVELSSIAEERVLHSRKIVERYVNDEKVVYGITTGFGNFSDVVISKEDTEILQKNLI
MSHSCGVGKPLPEEVVRAIMLLRANALAKGFSGVRLETLKTLIEMLNKGVTPVIPEKGSLGASGDLAPLAHMVLVMIGKG
EALYKGKRMSGEKAMKEAGIAPVVLSSKEGLALINGTQVMTAIGCLNVYDSKRLIKSADAISSITLEALRGIIDAFDDRV
QMVRPHRGQMVVAKNIKKMCEESTLITRQGEIRVQDAYTLRCIPQVHGAIRDAIEYVEDVLIREINSATDNPLIFPGDGD
VISGGNFHGEPIALAMDFLGIAVSEIANISERRIERLVNYQLNDFPPFLTEKGGLNSGMMIAQYTAASLVSENKVLAHPA
SVDSIPSSANQEDHVSMGTIAARKAREIIENATRVIAIELMAALQAMEFKKGFKKGKGSQVIYDLVRKYVKPLEEDRELY
IDINACFDIIKSGKVLEALEKEGIILE

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=499, Percent_Identity=48.8977955911824, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17567831, Length=503, Percent_Identity=45.3280318091451, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55517; Mature: 55386

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVIIDGNNLTIEDVVHVARDGYRVELSSIAEERVLHSRKIVERYVNDEKVVYGITTGF
CCEEEECCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GNFSDVVISKEDTEILQKNLIMSHSCGVGKPLPEEVVRAIMLLRANALAKGFSGVRLETL
CCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KTLIEMLNKGVTPVIPEKGSLGASGDLAPLAHMVLVMIGKGEALYKGKRMSGEKAMKEAG
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHCC
IAPVVLSSKEGLALINGTQVMTAIGCLNVYDSKRLIKSADAISSITLEALRGIIDAFDDR
CCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMVRPHRGQMVVAKNIKKMCEESTLITRQGEIRVQDAYTLRCIPQVHGAIRDAIEYVED
HHHCCCCCCCCHHHHHHHHHHHHHHEEEECCCEEEECCEEEEEHHHHHHHHHHHHHHHHH
VLIREINSATDNPLIFPGDGDVISGGNFHGEPIALAMDFLGIAVSEIANISERRIERLVN
HHHHHHCCCCCCCEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YQLNDFPPFLTEKGGLNSGMMIAQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGT
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHH
IAARKAREIIENATRVIAIELMAALQAMEFKKGFKKGKGSQVIYDLVRKYVKPLEEDREL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEE
YIDINACFDIIKSGKVLEALEKEGIILE
EEEHHHHHHHHHCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
GKVIIDGNNLTIEDVVHVARDGYRVELSSIAEERVLHSRKIVERYVNDEKVVYGITTGF
CEEEECCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GNFSDVVISKEDTEILQKNLIMSHSCGVGKPLPEEVVRAIMLLRANALAKGFSGVRLETL
CCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KTLIEMLNKGVTPVIPEKGSLGASGDLAPLAHMVLVMIGKGEALYKGKRMSGEKAMKEAG
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHCC
IAPVVLSSKEGLALINGTQVMTAIGCLNVYDSKRLIKSADAISSITLEALRGIIDAFDDR
CCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMVRPHRGQMVVAKNIKKMCEESTLITRQGEIRVQDAYTLRCIPQVHGAIRDAIEYVED
HHHCCCCCCCCHHHHHHHHHHHHHHEEEECCCEEEECCEEEEEHHHHHHHHHHHHHHHHH
VLIREINSATDNPLIFPGDGDVISGGNFHGEPIALAMDFLGIAVSEIANISERRIERLVN
HHHHHHCCCCCCCEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YQLNDFPPFLTEKGGLNSGMMIAQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGT
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHH
IAARKAREIIENATRVIAIELMAALQAMEFKKGFKKGKGSQVIYDLVRKYVKPLEEDREL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEE
YIDINACFDIIKSGKVLEALEKEGIILE
EEEHHHHHHHHHCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]