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The map label for this gene is typA [H]

Identifier: 167040773

GI number: 167040773

Start: 2151637

End: 2153457

Strand: Reverse

Name: typA [H]

Synonym: Teth514_2150

Alternate gene names: 167040773

Gene position: 2153457-2151637 (Counterclockwise)

Preceding gene: 167040774

Following gene: 167040771

Centisome position: 87.64

GC content: 35.8

Gene sequence:

>1821_bases
ATGAAATATGTAAGAGAAGATGTAAGAAATATAGCCATTATTGCTCATGTTGATCATGGAAAAACTACTTTGGTTGATGC
TATGCTTAAACAAAGCGGTATTTTTAGGGCAAATGAAAAAGTTGAGGAAAGGATTTTGGATTTTAACGATTTAGAAAGAG
AAAGAGGCATAACAATTCTTGCCAAAAATACTGCTGTTAGATATAAAGATGTAAAAATAAATATAGTTGATACACCTGGA
CATGCGGATTTTAGCGGTGAAGTAGAGCGAGTATTAAAAATGGTAGATGGGGTACTTTTGTTGGTGGATTCTTTTGAAGG
ACCTATGCCACAGACCCGTTTTGTATTAAGTAAAGCCTTGGAACTGGATCTAAAACCTATAGTTGTCATAAATAAAATTG
ATAGGCCTGATGCAAGGCCTCAGGAGGTTATTGACGAAGTCTTAGATTTATTTATTGAATTAGGAGCAAATGATGACCAA
ATCGATTTCCCTATTGTCTACACCTCTGCGAAAGAAGGTATAGCGAAATTAAGTTTAGAAGGAGAATCTCATGATTTGAG
ACCTCTTTTTGATACGATTTTAGACTATATTCCTGCACCAATAGGAGATGTTGAAGCACCATTGCAACTTATAGTGACTA
CTCTAGATTATGATGATTACATTGGGAGAATTGCCATTGGAAAAGTAGTTAGAGGAAAAATAATTTCAGGGGAAGAAGCG
GCTATATGTAAAAGAGATGGGTCAATACAAAAAGTTCACATAAATAATCTATATCAGTTTGAAGGACTAAAAAGAGTGCA
AGTAGAAGAAGCAAGTTTAGGAGATATTGTGGCAGTTTCAGGCATAAGCGATATTGAGATTGGAGAGACCATTGCAGATA
GGGATAATCCTGAAGCGGTAGACTTTGTTCGAATAGAAGAGCCTACAGTTTCTATGACTTTTAGTGTAAATACCAGTCCT
TTTGCTGGAACTGAAGGTAAATACGTTACTTCAAGACATTTAAGAGAAAGGCTTTTTAAAGAGCTAGAGACAAACGTAGC
ATTGCGAGTTGAAGAAACAGATTCTACTGATTCTTTTAAGGTATCTGGAAGAGGGGAATTGCATCTTTCTATTTTAATTG
AGACTATGAGACGGGAAGGGTATGAATTACAGGTTTCTAAGCCTACCGTGATTTTTAAAGAAGTAAATGGAGTAAAAATG
GAACCTATTGAACTTTTGATAATAGATATTCCTGAAGAATATATGGGAGTTGTAATGGAAAAATTAGGACCGAGAAAAGC
TGAATTGATGGATATGCACACATTAAAGCCAGGAACTATAAGGCTTAAGTTTAAAATACCTACACGAGGCTTAATAGGGT
ATCGGTCTGAATTTTTAACAGATACAAAAGGAAATGGCATAATGACCTCTGTCTTTTATGATTATGCACCTTACAAAGGA
GACATTCCTTCTCGTACGAGAGGCGCTCTTGTAGCTTTTGAGACGGGGGTTGCGACAACTTATGGCCTTTACAATGCTCA
AGAGAGAGGGACACTTTTTATAGAGCCAGGTACAAAAGTGTATGAAGGGATGGTTGTGGGAGTTAATTCAAGAAGTGGAG
ATATTGATGTCAATGTATGTAAGAAAAAACATGTGACAAATTTAAGGTCTGCAACGGCGGATGAGGCTTTGAGGCTATCT
CCTGTAAAAAAGATGTCCTTAGAAGAAGCATTAGAGTTTATAGATAATGATGAATTAGTGGAAGTTACTCCTCAAAGCAT
TAGAATACGAAAAAAGATTTTGGATTCTCAACAAAGATATAAAAGTGCAAAATACAAATAA

Upstream 100 bases:

>100_bases
TCCAAGGAGTGCTCTTTTTTATATTGACTATTTTTATTCCTTGATATATCATATAATACTGTATACGCGATATAGCCTAT
TTTATGGAAGGAGATACCTT

Downstream 100 bases:

>100_bases
GGGAGCCTTTTTGGCTCCTTTATTATTTATTATATAAGTCATTTAAAATTTTGTTTATATAATTTATAGTTTCTTGGTAA
GGGGGAATACCTTGATATTT

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MKYVREDVRNIAIIAHVDHGKTTLVDAMLKQSGIFRANEKVEERILDFNDLERERGITILAKNTAVRYKDVKINIVDTPG
HADFSGEVERVLKMVDGVLLLVDSFEGPMPQTRFVLSKALELDLKPIVVINKIDRPDARPQEVIDEVLDLFIELGANDDQ
IDFPIVYTSAKEGIAKLSLEGESHDLRPLFDTILDYIPAPIGDVEAPLQLIVTTLDYDDYIGRIAIGKVVRGKIISGEEA
AICKRDGSIQKVHINNLYQFEGLKRVQVEEASLGDIVAVSGISDIEIGETIADRDNPEAVDFVRIEEPTVSMTFSVNTSP
FAGTEGKYVTSRHLRERLFKELETNVALRVEETDSTDSFKVSGRGELHLSILIETMRREGYELQVSKPTVIFKEVNGVKM
EPIELLIIDIPEEYMGVVMEKLGPRKAELMDMHTLKPGTIRLKFKIPTRGLIGYRSEFLTDTKGNGIMTSVFYDYAPYKG
DIPSRTRGALVAFETGVATTYGLYNAQERGTLFIEPGTKVYEGMVVGVNSRSGDIDVNVCKKKHVTNLRSATADEALRLS
PVKKMSLEEALEFIDNDELVEVTPQSIRIRKKILDSQQRYKSAKYK

Sequences:

>Translated_606_residues
MKYVREDVRNIAIIAHVDHGKTTLVDAMLKQSGIFRANEKVEERILDFNDLERERGITILAKNTAVRYKDVKINIVDTPG
HADFSGEVERVLKMVDGVLLLVDSFEGPMPQTRFVLSKALELDLKPIVVINKIDRPDARPQEVIDEVLDLFIELGANDDQ
IDFPIVYTSAKEGIAKLSLEGESHDLRPLFDTILDYIPAPIGDVEAPLQLIVTTLDYDDYIGRIAIGKVVRGKIISGEEA
AICKRDGSIQKVHINNLYQFEGLKRVQVEEASLGDIVAVSGISDIEIGETIADRDNPEAVDFVRIEEPTVSMTFSVNTSP
FAGTEGKYVTSRHLRERLFKELETNVALRVEETDSTDSFKVSGRGELHLSILIETMRREGYELQVSKPTVIFKEVNGVKM
EPIELLIIDIPEEYMGVVMEKLGPRKAELMDMHTLKPGTIRLKFKIPTRGLIGYRSEFLTDTKGNGIMTSVFYDYAPYKG
DIPSRTRGALVAFETGVATTYGLYNAQERGTLFIEPGTKVYEGMVVGVNSRSGDIDVNVCKKKHVTNLRSATADEALRLS
PVKKMSLEEALEFIDNDELVEVTPQSIRIRKKILDSQQRYKSAKYK
>Mature_606_residues
MKYVREDVRNIAIIAHVDHGKTTLVDAMLKQSGIFRANEKVEERILDFNDLERERGITILAKNTAVRYKDVKINIVDTPG
HADFSGEVERVLKMVDGVLLLVDSFEGPMPQTRFVLSKALELDLKPIVVINKIDRPDARPQEVIDEVLDLFIELGANDDQ
IDFPIVYTSAKEGIAKLSLEGESHDLRPLFDTILDYIPAPIGDVEAPLQLIVTTLDYDDYIGRIAIGKVVRGKIISGEEA
AICKRDGSIQKVHINNLYQFEGLKRVQVEEASLGDIVAVSGISDIEIGETIADRDNPEAVDFVRIEEPTVSMTFSVNTSP
FAGTEGKYVTSRHLRERLFKELETNVALRVEETDSTDSFKVSGRGELHLSILIETMRREGYELQVSKPTVIFKEVNGVKM
EPIELLIIDIPEEYMGVVMEKLGPRKAELMDMHTLKPGTIRLKFKIPTRGLIGYRSEFLTDTKGNGIMTSVFYDYAPYKG
DIPSRTRGALVAFETGVATTYGLYNAQERGTLFIEPGTKVYEGMVVGVNSRSGDIDVNVCKKKHVTNLRSATADEALRLS
PVKKMSLEEALEFIDNDELVEVTPQSIRIRKKILDSQQRYKSAKYK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=493, Percent_Identity=27.1805273833671, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=41.3533834586466, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=38.7755102040816, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=38.0952380952381, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI34147630, Length=261, Percent_Identity=32.5670498084291, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI25306283, Length=142, Percent_Identity=36.6197183098592, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI19923640, Length=133, Percent_Identity=39.0977443609023, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI25306287, Length=133, Percent_Identity=39.0977443609023, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=37.8378378378378, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=37.8378378378378, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=37.8378378378378, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI217272892, Length=141, Percent_Identity=36.8794326241135, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI217272894, Length=141, Percent_Identity=36.8794326241135, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=32.5581395348837, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI48994988, Length=600, Percent_Identity=53.1666666666667, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=473, Percent_Identity=27.906976744186, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1789738, Length=161, Percent_Identity=36.6459627329193, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1790835, Length=175, Percent_Identity=31.4285714285714, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790412, Length=304, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789737, Length=304, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557151, Length=326, Percent_Identity=30.6748466257669, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17533571, Length=183, Percent_Identity=37.7049180327869, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=38.7323943661972, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17506493, Length=177, Percent_Identity=33.8983050847458, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=37.6923076923077, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=37.6923076923077, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=36.2962962962963, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=285, Percent_Identity=29.1228070175439, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=278, Percent_Identity=28.7769784172662, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=484, Percent_Identity=28.9256198347107, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=45.578231292517, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=45.578231292517, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=30.4029304029304, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=38.9261744966443, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323098, Length=179, Percent_Identity=35.7541899441341, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=36.6666666666667, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI78706572, Length=492, Percent_Identity=24.7967479674797, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=43.5714285714286, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24582462, Length=204, Percent_Identity=36.2745098039216, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24585711, Length=153, Percent_Identity=39.2156862745098, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585713, Length=153, Percent_Identity=39.2156862745098, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585709, Length=153, Percent_Identity=39.2156862745098, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357743, Length=173, Percent_Identity=37.5722543352601, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI281363316, Length=322, Percent_Identity=28.2608695652174, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17864358, Length=322, Percent_Identity=28.2608695652174, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221458488, Length=144, Percent_Identity=41.6666666666667, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19921738, Length=272, Percent_Identity=27.9411764705882, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28572034, Length=227, Percent_Identity=28.1938325991189, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67919; Mature: 67919

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVREDVRNIAIIAHVDHGKTTLVDAMLKQSGIFRANEKVEERILDFNDLERERGITIL
CCHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHCCEEEE
AKNTAVRYKDVKINIVDTPGHADFSGEVERVLKMVDGVLLLVDSFEGPMPQTRFVLSKAL
EECCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
ELDLKPIVVINKIDRPDARPQEVIDEVLDLFIELGANDDQIDFPIVYTSAKEGIAKLSLE
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEC
GESHDLRPLFDTILDYIPAPIGDVEAPLQLIVTTLDYDDYIGRIAIGKVVRGKIISGEEA
CCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHCHHHCCHHHCCEEECCCCC
AICKRDGSIQKVHINNLYQFEGLKRVQVEEASLGDIVAVSGISDIEIGETIADRDNPEAV
EEEECCCCEEEEEECCEEECCCCEEEEEECCCCCCEEEECCCCCCCCCCHHCCCCCCCCE
DFVRIEEPTVSMTFSVNTSPFAGTEGKYVTSRHLRERLFKELETNVALRVEETDSTDSFK
EEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEE
VSGRGELHLSILIETMRREGYELQVSKPTVIFKEVNGVKMEPIELLIIDIPEEYMGVVME
ECCCCCEEHHHHHHHHHCCCCEEEECCCEEEEEECCCCEECCEEEEEEECCHHHHHHHHH
KLGPRKAELMDMHTLKPGTIRLKFKIPTRGLIGYRSEFLTDTKGNGIMTSVFYDYAPYKG
HCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCC
DIPSRTRGALVAFETGVATTYGLYNAQERGTLFIEPGTKVYEGMVVGVNSRSGDIDVNVC
CCCCCCCCEEEEEECCCCEEEECCCCCCCCEEEECCCCCEECCEEEEECCCCCCEEEEEC
KKKHVTNLRSATADEALRLSPVKKMSLEEALEFIDNDELVEVTPQSIRIRKKILDSQQRY
CHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHH
KSAKYK
HHCCCC
>Mature Secondary Structure
MKYVREDVRNIAIIAHVDHGKTTLVDAMLKQSGIFRANEKVEERILDFNDLERERGITIL
CCHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHCCEEEE
AKNTAVRYKDVKINIVDTPGHADFSGEVERVLKMVDGVLLLVDSFEGPMPQTRFVLSKAL
EECCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
ELDLKPIVVINKIDRPDARPQEVIDEVLDLFIELGANDDQIDFPIVYTSAKEGIAKLSLE
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEC
GESHDLRPLFDTILDYIPAPIGDVEAPLQLIVTTLDYDDYIGRIAIGKVVRGKIISGEEA
CCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHCHHHCCHHHCCEEECCCCC
AICKRDGSIQKVHINNLYQFEGLKRVQVEEASLGDIVAVSGISDIEIGETIADRDNPEAV
EEEECCCCEEEEEECCEEECCCCEEEEEECCCCCCEEEECCCCCCCCCCHHCCCCCCCCE
DFVRIEEPTVSMTFSVNTSPFAGTEGKYVTSRHLRERLFKELETNVALRVEETDSTDSFK
EEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEE
VSGRGELHLSILIETMRREGYELQVSKPTVIFKEVNGVKMEPIELLIIDIPEEYMGVVME
ECCCCCEEHHHHHHHHHCCCCEEEECCCEEEEEECCCCEECCEEEEEEECCHHHHHHHHH
KLGPRKAELMDMHTLKPGTIRLKFKIPTRGLIGYRSEFLTDTKGNGIMTSVFYDYAPYKG
HCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCC
DIPSRTRGALVAFETGVATTYGLYNAQERGTLFIEPGTKVYEGMVVGVNSRSGDIDVNVC
CCCCCCCCEEEEEECCCCEEEECCCCCCCCEEEECCCCCEECCEEEEECCCCCCEEEEEC
KKKHVTNLRSATADEALRLSPVKKMSLEEALEFIDNDELVEVTPQSIRIRKKILDSQQRY
CHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHH
KSAKYK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]