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The map label for this gene is hydA [H]

Identifier: 167040768

GI number: 167040768

Start: 2148004

End: 2149311

Strand: Reverse

Name: hydA [H]

Synonym: Teth514_2145

Alternate gene names: 167040768

Gene position: 2149311-2148004 (Counterclockwise)

Preceding gene: 167040769

Following gene: 167040767

Centisome position: 87.47

GC content: 35.24

Gene sequence:

>1308_bases
ATGTCATATTTTCACTCTGTTACATTAGATAAGGATAGATGTAGAGGGTGTACTAATTGCATAAAAAGATGTCCTACGGA
GGCAATAAGGGTAAGAGATGGGAAAGCAATGATTATAAATGAAAGGTGCATAGATTGTGGTGAATGTATACGTGTGTGCC
CATATCATGCTAAATTGGCGGTAACTGATAGTTTGGATACGATGAAAAATTTTAAGTACAAGATTGCACTTCCTGCTCCT
TCTTTATATGGACAATTTAGGGATTTAACTATTAATCAAATATTGAGTGCATTGCTGGATATAGGCTTTGATGAAGTTTT
TGAAGTGGCATATGCTGCTGAAATTGTTTCTAAATTTACGCGGGAAGCATTGGCAAAAGGAAATTTAAAAAAGCCAGTTA
TATCTTCTGCTTGCCCCGCTGTTGTGCGATTCGTACAAATCAAATTTCCCTCTTTGATTGATAATTTATTGGATATATGT
TCTCCTATGGATACTGCGGCAATATTAGCAAAAAAGGAAGCAATTAAAAAGACGGGACTGAAGCAAGAGGAAATAGGAGT
TTTTTTCATTTCCCCCTGTGCTGCAAAAGTGACAAGTGTGAAAAATCCTATTGGTATAGAAAAATCCAAAATTGATGGGG
TTTTTTCTATGAAAGAAATATATGGCCTAATCATTGAAAAAGCTAAGACTACTGTTGTCAGAGATTTAAGCAAAGCTTCT
ATGATAGGTGTTGGATGGGCAAACTCTGGTGGAGAAGCTTTTGGCACTTTTACAGAAAATAGTATTTATGTAGACGGGAT
ACACAATGTTGGAGATGTCTTAGAAGAGATTGAATTAGGAAAATTGAACGATTTAGACTTTTTTGAAGGTCTTGCATGTA
TCGGTGGGTGTATTGGTGGACCTTTAGCTGTTGAAAATAATTTTGTGGCCAAAAATAGAATAAGAAAACTGACAGAAAAA
CTTCCTAAAAGAGAAGAGCCTTTGTTTGATGAGAAAGAGATTGATTTTGGAGAGGTGAAATGGAAAAAGAAAATAGAAAA
AAGTGAAGTTATGAAGTTGGACAAAGACATTTCAAAAGCACTTGAAATGATGAAACAAATAGACACCCAATACAAAGCCT
TACCAGGACTTGACTGTGGTTCTTGTGGTTCACCTACTTGTAGGGCATTGGCAGAAGATATAATGAAAGGCTATGCTACT
GAGTATGATTGCATTTTTATATTAAAAGACAAAATAAAAAATTTGGCTCAAGAATTAAATGATCTGGCAGGTAAAATTCC
TCCAGTTTTAAGTGAGGGAAAGGAGTGA

Upstream 100 bases:

>100_bases
GACTTCCTAATATGAAGGAAAATTCTGATTTTATGGATATAAAAAGCAGTAAAAATGGGACAACTGTGGTAATGGAAATT
TTATTTAAGTAGGTGATAAA

Downstream 100 bases:

>100_bases
AATGTTATGAGGATAAAAGTAGTGGAGCTTGTTGAGAAAGGATTTAGATTAGTTGCGGGTGACAACGGAATTGACAAAGA
AATTGAAGGGGTGTATATAT

Product: Fe-S cluster domain-containing protein

Products: NA

Alternate protein names: Fe hydrogenlyase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSYFHSVTLDKDRCRGCTNCIKRCPTEAIRVRDGKAMIINERCIDCGECIRVCPYHAKLAVTDSLDTMKNFKYKIALPAP
SLYGQFRDLTINQILSALLDIGFDEVFEVAYAAEIVSKFTREALAKGNLKKPVISSACPAVVRFVQIKFPSLIDNLLDIC
SPMDTAAILAKKEAIKKTGLKQEEIGVFFISPCAAKVTSVKNPIGIEKSKIDGVFSMKEIYGLIIEKAKTTVVRDLSKAS
MIGVGWANSGGEAFGTFTENSIYVDGIHNVGDVLEEIELGKLNDLDFFEGLACIGGCIGGPLAVENNFVAKNRIRKLTEK
LPKREEPLFDEKEIDFGEVKWKKKIEKSEVMKLDKDISKALEMMKQIDTQYKALPGLDCGSCGSPTCRALAEDIMKGYAT
EYDCIFILKDKIKNLAQELNDLAGKIPPVLSEGKE

Sequences:

>Translated_435_residues
MSYFHSVTLDKDRCRGCTNCIKRCPTEAIRVRDGKAMIINERCIDCGECIRVCPYHAKLAVTDSLDTMKNFKYKIALPAP
SLYGQFRDLTINQILSALLDIGFDEVFEVAYAAEIVSKFTREALAKGNLKKPVISSACPAVVRFVQIKFPSLIDNLLDIC
SPMDTAAILAKKEAIKKTGLKQEEIGVFFISPCAAKVTSVKNPIGIEKSKIDGVFSMKEIYGLIIEKAKTTVVRDLSKAS
MIGVGWANSGGEAFGTFTENSIYVDGIHNVGDVLEEIELGKLNDLDFFEGLACIGGCIGGPLAVENNFVAKNRIRKLTEK
LPKREEPLFDEKEIDFGEVKWKKKIEKSEVMKLDKDISKALEMMKQIDTQYKALPGLDCGSCGSPTCRALAEDIMKGYAT
EYDCIFILKDKIKNLAQELNDLAGKIPPVLSEGKE
>Mature_434_residues
SYFHSVTLDKDRCRGCTNCIKRCPTEAIRVRDGKAMIINERCIDCGECIRVCPYHAKLAVTDSLDTMKNFKYKIALPAPS
LYGQFRDLTINQILSALLDIGFDEVFEVAYAAEIVSKFTREALAKGNLKKPVISSACPAVVRFVQIKFPSLIDNLLDICS
PMDTAAILAKKEAIKKTGLKQEEIGVFFISPCAAKVTSVKNPIGIEKSKIDGVFSMKEIYGLIIEKAKTTVVRDLSKASM
IGVGWANSGGEAFGTFTENSIYVDGIHNVGDVLEEIELGKLNDLDFFEGLACIGGCIGGPLAVENNFVAKNRIRKLTEKL
PKREEPLFDEKEIDFGEVKWKKKIEKSEVMKLDKDISKALEMMKQIDTQYKALPGLDCGSCGSPTCRALAEDIMKGYATE
YDCIFILKDKIKNLAQELNDLAGKIPPVLSEGKE

Specific function: May be involved in hydrogen uptake for the reduction of sulfate to hydrogen sulfide in an electron transport chain. Cytochrome c3 is likely to be the physiological electron carrier for the enzyme [H]

COG id: COG4624

COG function: function code R; Iron only hydrogenase large subunit, C-terminal domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR009016
- InterPro:   IPR004108
- InterPro:   IPR013352 [H]

Pfam domain/function: PF02906 Fe_hyd_lg_C; PF00037 Fer4 [H]

EC number: =1.12.7.2 [H]

Molecular weight: Translated: 48061; Mature: 47929

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYFHSVTLDKDRCRGCTNCIKRCPTEAIRVRDGKAMIINERCIDCGECIRVCPYHAKLA
CCCCCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCEEEEECHHCCHHHHHHHCCCCCEEE
VTDSLDTMKNFKYKIALPAPSLYGQFRDLTINQILSALLDIGFDEVFEVAYAAEIVSKFT
EECCHHHHHCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
REALAKGNLKKPVISSACPAVVRFVQIKFPSLIDNLLDICSPMDTAAILAKKEAIKKTGL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KQEEIGVFFISPCAAKVTSVKNPIGIEKSKIDGVFSMKEIYGLIIEKAKTTVVRDLSKAS
CHHHCCEEEECCHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIGVGWANSGGEAFGTFTENSIYVDGIHNVGDVLEEIELGKLNDLDFFEGLACIGGCIGG
EEEEEECCCCCCEEEEECCCCEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
PLAVENNFVAKNRIRKLTEKLPKREEPLFDEKEIDFGEVKWKKKIEKSEVMKLDKDISKA
CEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEMMKQIDTQYKALPGLDCGSCGSPTCRALAEDIMKGYATEYDCIFILKDKIKNLAQELN
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
DLAGKIPPVLSEGKE
HHHHCCCCHHCCCCC
>Mature Secondary Structure 
SYFHSVTLDKDRCRGCTNCIKRCPTEAIRVRDGKAMIINERCIDCGECIRVCPYHAKLA
CCCCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCEEEEECHHCCHHHHHHHCCCCCEEE
VTDSLDTMKNFKYKIALPAPSLYGQFRDLTINQILSALLDIGFDEVFEVAYAAEIVSKFT
EECCHHHHHCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
REALAKGNLKKPVISSACPAVVRFVQIKFPSLIDNLLDICSPMDTAAILAKKEAIKKTGL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KQEEIGVFFISPCAAKVTSVKNPIGIEKSKIDGVFSMKEIYGLIIEKAKTTVVRDLSKAS
CHHHCCEEEECCHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIGVGWANSGGEAFGTFTENSIYVDGIHNVGDVLEEIELGKLNDLDFFEGLACIGGCIGG
EEEEEECCCCCCEEEEECCCCEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
PLAVENNFVAKNRIRKLTEKLPKREEPLFDEKEIDFGEVKWKKKIEKSEVMKLDKDISKA
CEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEMMKQIDTQYKALPGLDCGSCGSPTCRALAEDIMKGYATEYDCIFILKDKIKNLAQELN
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
DLAGKIPPVLSEGKE
HHHHCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3888621; 3322275; 11456963; 10368269; 11456758 [H]