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The map label for this gene is mtnA

Identifier: 167040512

GI number: 167040512

Start: 1895671

End: 1896708

Strand: Reverse

Name: mtnA

Synonym: Teth514_1881

Alternate gene names: 167040512

Gene position: 1896708-1895671 (Counterclockwise)

Preceding gene: 167040513

Following gene: 167040511

Centisome position: 77.19

GC content: 33.72

Gene sequence:

>1038_bases
ATGAAAGAAATTAAATCAATAGAGTTTAAAAACGAAGTTTTGTATTTAATTGACCAAAGGAAATTACCTAATAGTTATGA
GATTTTTGAATGCAAAACTTATAGGGATGTAAATTTTGCTATAAAAGAAATGGTAGTAAGAGGGGCTCCTGCTATTGGTG
CTGCAGCAGCCTATGGTGTTGTGCTGGCAGCTAAAGAATTTCTCAAAGAAGATAGAGAAATATTTTTTGAAAAAATAGAG
GAGGCCTTAGAAGTTATTGCAAACTCGAGACCTACAGCTGTAAATCTTATGTGGGCAGTAAAAAGGATGAAGAAAGTTAT
AGAGAAAAACAAGGAGTTAGAACTAATAGATATATATCAAGCTTTAAAAAAGGAAGCAGATAGTATTTATTTAGAAGATA
TAGAGACTAATAAAAAAATGGCTAAGTTTGGTAACGAAGTAATTAAAGAAAATGCTGTTATTTTAACCCACTGCAATACA
GGAGCGCTTGCCACTGTAGGATATGGTACAGCCTTAGGTGTCATTAGAGAGGCTCACTATAGTGGTAAGAATATATTTGT
GTACGCTGATGAGACAAGGCCTCGATTACAGGGCAGTAAGTTGACAGCTTGGGAATTAGTACAAGAAGGAATTCCTGCAA
AATTAATTGCTGATAGTGTTGCTGCTACTTTAATAAGGGATGGGAAAATAGATGTGATATTAGTAGGAGCTGATAGAATT
GCTTTAAATGGAGATACTGCTAACAAGATTGGGACTTTTATGTTATCTGTAATTGCAAAAGTATATAATGTTCCCTTTTA
TGTAGTAGCTCCTACCAGTACAATTGATTTTGAAATTGAGAGCGGAAAAGAAATAATAATAGAAGAAAGAAGTCCTGAGG
AAGTTACTCATATAAACGGTGTTAGAATTGCTCCAGAGGGGATAGAAGTATACAATCCAGCTTTTGATGTGACTCCTCAT
GAAAACATCACGGGTATAATAACAGAAAAAGGGATAATTAAACCTCCATATAAAGAAAATATATTAAAACTAAAGTGA

Upstream 100 bases:

>100_bases
CATCTATTCTTTAGAGGAATATCAAGAGGCTTTTTCAAAAAAGAATAAATTAAAAGCAGTTATAGATCTGCGAAAATAAT
GAAGAGGACGAGGTGAAAAA

Downstream 100 bases:

>100_bases
GGGAGATAGGATGTCAGTTATTGAAACAAATGTTAATTCAAAGGAGATTGTGATAAAGGATTTAACTTTTAGATATAAAG
ACCAAAAAGAAAGAAATGCA

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKEIKSIEFKNEVLYLIDQRKLPNSYEIFECKTYRDVNFAIKEMVVRGAPAIGAAAAYGVVLAAKEFLKEDREIFFEKIE
EALEVIANSRPTAVNLMWAVKRMKKVIEKNKELELIDIYQALKKEADSIYLEDIETNKKMAKFGNEVIKENAVILTHCNT
GALATVGYGTALGVIREAHYSGKNIFVYADETRPRLQGSKLTAWELVQEGIPAKLIADSVAATLIRDGKIDVILVGADRI
ALNGDTANKIGTFMLSVIAKVYNVPFYVVAPTSTIDFEIESGKEIIIEERSPEEVTHINGVRIAPEGIEVYNPAFDVTPH
ENITGIITEKGIIKPPYKENILKLK

Sequences:

>Translated_345_residues
MKEIKSIEFKNEVLYLIDQRKLPNSYEIFECKTYRDVNFAIKEMVVRGAPAIGAAAAYGVVLAAKEFLKEDREIFFEKIE
EALEVIANSRPTAVNLMWAVKRMKKVIEKNKELELIDIYQALKKEADSIYLEDIETNKKMAKFGNEVIKENAVILTHCNT
GALATVGYGTALGVIREAHYSGKNIFVYADETRPRLQGSKLTAWELVQEGIPAKLIADSVAATLIRDGKIDVILVGADRI
ALNGDTANKIGTFMLSVIAKVYNVPFYVVAPTSTIDFEIESGKEIIIEERSPEEVTHINGVRIAPEGIEVYNPAFDVTPH
ENITGIITEKGIIKPPYKENILKLK
>Mature_345_residues
MKEIKSIEFKNEVLYLIDQRKLPNSYEIFECKTYRDVNFAIKEMVVRGAPAIGAAAAYGVVLAAKEFLKEDREIFFEKIE
EALEVIANSRPTAVNLMWAVKRMKKVIEKNKELELIDIYQALKKEADSIYLEDIETNKKMAKFGNEVIKENAVILTHCNT
GALATVGYGTALGVIREAHYSGKNIFVYADETRPRLQGSKLTAWELVQEGIPAKLIADSVAATLIRDGKIDVILVGADRI
ALNGDTANKIGTFMLSVIAKVYNVPFYVVAPTSTIDFEIESGKEIIIEERSPEEVTHINGVRIAPEGIEVYNPAFDVTPH
ENITGIITEKGIIKPPYKENILKLK

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=348, Percent_Identity=41.3793103448276, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI23943880, Length=337, Percent_Identity=36.7952522255193, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI4503503, Length=229, Percent_Identity=29.2576419213974, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI78000156, Length=272, Percent_Identity=22.0588235294118, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI78000158, Length=284, Percent_Identity=21.830985915493, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI187607323, Length=272, Percent_Identity=22.7941176470588, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=348, Percent_Identity=38.7931034482759, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17557123, Length=224, Percent_Identity=29.9107142857143, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325375, Length=390, Percent_Identity=38.2051282051282, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322878, Length=268, Percent_Identity=26.1194029850746, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357667, Length=363, Percent_Identity=42.4242424242424, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24651647, Length=363, Percent_Identity=42.4242424242424, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_THEP3 (B0K8S2)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664871.1
- ProteinModelPortal:   B0K8S2
- SMR:   B0K8S2
- GeneID:   5873639
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0879
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK901319
- BioCyc:   TPSE340099:TETH39_0879-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38523; Mature: 38523

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: ACT_SITE 238-238 BINDING 90-90 BINDING 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIKSIEFKNEVLYLIDQRKLPNSYEIFECKTYRDVNFAIKEMVVRGAPAIGAAAAYGV
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHH
VLAAKEFLKEDREIFFEKIEEALEVIANSRPTAVNLMWAVKRMKKVIEKNKELELIDIYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCEEHHHHHH
ALKKEADSIYLEDIETNKKMAKFGNEVIKENAVILTHCNTGALATVGYGTALGVIREAHY
HHHHCCCEEEEEHHHCCHHHHHHHHHHHHCCCEEEEECCCCCEEEECCHHHHHHHHHHHC
SGKNIFVYADETRPRLQGSKLTAWELVQEGIPAKLIADSVAATLIRDGKIDVILVGADRI
CCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCEE
ALNGDTANKIGTFMLSVIAKVYNVPFYVVAPTSTIDFEIESGKEIIIEERSPEEVTHING
EECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEECCCCCHHHHCCC
VRIAPEGIEVYNPAFDVTPHENITGIITEKGIIKPPYKENILKLK
EEECCCCCEEECCEECCCCCCCEEEEEECCCCCCCCCCCCCEECC
>Mature Secondary Structure
MKEIKSIEFKNEVLYLIDQRKLPNSYEIFECKTYRDVNFAIKEMVVRGAPAIGAAAAYGV
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHH
VLAAKEFLKEDREIFFEKIEEALEVIANSRPTAVNLMWAVKRMKKVIEKNKELELIDIYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCEEHHHHHH
ALKKEADSIYLEDIETNKKMAKFGNEVIKENAVILTHCNTGALATVGYGTALGVIREAHY
HHHHCCCEEEEEHHHCCHHHHHHHHHHHHCCCEEEEECCCCCEEEECCHHHHHHHHHHHC
SGKNIFVYADETRPRLQGSKLTAWELVQEGIPAKLIADSVAATLIRDGKIDVILVGADRI
CCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCEE
ALNGDTANKIGTFMLSVIAKVYNVPFYVVAPTSTIDFEIESGKEIIIEERSPEEVTHING
EECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEECCCCCHHHHCCC
VRIAPEGIEVYNPAFDVTPHENITGIITEKGIIKPPYKENILKLK
EEECCCCCEEECCEECCCCCCCEEEEEECCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA