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The map label for this gene is xapA [C]

Identifier: 167040509

GI number: 167040509

Start: 1892384

End: 1893154

Strand: Reverse

Name: xapA [C]

Synonym: Teth514_1878

Alternate gene names: 167040509

Gene position: 1893154-1892384 (Counterclockwise)

Preceding gene: 167040510

Following gene: 167040508

Centisome position: 77.04

GC content: 34.24

Gene sequence:

>771_bases
ATGGAAAAGGCGATCATTGGTGGTACTGGATTTTACGAAATAGGACAAAAGGTGTCAAAAAAATTGGTAGAGACAAAATA
TGGAGAAGTGGAAATTGATATTGTGACTATTGAAGGGGAAAAAATTGGCTTTTTGCCCCGACACGGGAAAGGTCATGCAG
TTCCACCTCATCTCGTAAATTATAGGGCAAATATTATGGCATTGAAACAAATGGGAGTAAAATATGTGTATGCAACAGCT
GCAGTTGGTTCTTTTAATGAAAATTATGAGCCAGGGGATGTTGTAGTACTTAAAGATTTTTTAGATTTCACTAAATCGAG
ACCATTGACCTTTTTTGAAGGGGAAGATGGAGTGGTAAGACATGTAGATATGAGTGACCCTTATTGTAGCAATTTAAGGG
CAAAATTTTACAATGCTGCTAAAAAAGAAGACTTATTAATAAAAGGAGATGCAGTTTATGTATGCACTGAAGGTCCACGA
TTTGAAACTGCACAAGAGATAAGAATGTATAAAAATTTAGGTGCCGATGTAGTAGGGATGACTAATGTTCCAGAAGTAAT
TTTAGCGAAAGAATTAGGAATGTGCTATGCTGCGGTGGGAATAGTTTCAAATTGGGCTACAGGAATGAAGGGCAGTATAA
CATTACATGAAATAAAAGATACTTTAGAATTGAACAAAGAAAAAGTGATAAAAACATTTATAAGAGTTTTTTTAGAAGAA
AAATTAGATCAAAATCACTGTAGTTGTAATAGAGCAGTGATTGAATTATAA

Upstream 100 bases:

>100_bases
ATACAGCTAAAGATTATATACTAATAGCAATCGCAATTGTAGTATTGATAATTGCTATATTTTTCAAAGTTAAATACAAA
ATGTAGGAGGTACATTTTAA

Downstream 100 bases:

>100_bases
TATTTTTGATTATTTTTATAGTTGAGGACAAAATTTATGGTATATTTTCATAAAAAGGAAGGAGGTGGGAAAGTTATTTG
GGTATAACTGTTAGATGGCA

Product: purine phosphorylase family 2

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MEKAIIGGTGFYEIGQKVSKKLVETKYGEVEIDIVTIEGEKIGFLPRHGKGHAVPPHLVNYRANIMALKQMGVKYVYATA
AVGSFNENYEPGDVVVLKDFLDFTKSRPLTFFEGEDGVVRHVDMSDPYCSNLRAKFYNAAKKEDLLIKGDAVYVCTEGPR
FETAQEIRMYKNLGADVVGMTNVPEVILAKELGMCYAAVGIVSNWATGMKGSITLHEIKDTLELNKEKVIKTFIRVFLEE
KLDQNHCSCNRAVIEL

Sequences:

>Translated_256_residues
MEKAIIGGTGFYEIGQKVSKKLVETKYGEVEIDIVTIEGEKIGFLPRHGKGHAVPPHLVNYRANIMALKQMGVKYVYATA
AVGSFNENYEPGDVVVLKDFLDFTKSRPLTFFEGEDGVVRHVDMSDPYCSNLRAKFYNAAKKEDLLIKGDAVYVCTEGPR
FETAQEIRMYKNLGADVVGMTNVPEVILAKELGMCYAAVGIVSNWATGMKGSITLHEIKDTLELNKEKVIKTFIRVFLEE
KLDQNHCSCNRAVIEL
>Mature_256_residues
MEKAIIGGTGFYEIGQKVSKKLVETKYGEVEIDIVTIEGEKIGFLPRHGKGHAVPPHLVNYRANIMALKQMGVKYVYATA
AVGSFNENYEPGDVVVLKDFLDFTKSRPLTFFEGEDGVVRHVDMSDPYCSNLRAKFYNAAKKEDLLIKGDAVYVCTEGPR
FETAQEIRMYKNLGADVVGMTNVPEVILAKELGMCYAAVGIVSNWATGMKGSITLHEIKDTLELNKEKVIKTFIRVFLEE
KLDQNHCSCNRAVIEL

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=208, Percent_Identity=39.4230769230769, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI157168362, Length=220, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI1788746, Length=168, Percent_Identity=32.1428571428571, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980569, Length=238, Percent_Identity=35.7142857142857, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17541190, Length=145, Percent_Identity=26.2068965517241, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323045, Length=219, Percent_Identity=30.1369863013699, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323238, Length=226, Percent_Identity=28.7610619469027, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI20130079, Length=268, Percent_Identity=33.5820895522388, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI221459247, Length=209, Percent_Identity=36.3636363636364, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24656093, Length=146, Percent_Identity=30.1369863013699, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24656090, Length=146, Percent_Identity=30.1369863013699, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45552887, Length=146, Percent_Identity=30.1369863013699, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45552885, Length=146, Percent_Identity=30.1369863013699, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 28566; Mature: 28566

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAIIGGTGFYEIGQKVSKKLVETKYGEVEIDIVTIEGEKIGFLPRHGKGHAVPPHLVN
CCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCHHHH
YRANIMALKQMGVKYVYATAAVGSFNENYEPGDVVVLKDFLDFTKSRPLTFFEGEDGVVR
HHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCCCEEE
HVDMSDPYCSNLRAKFYNAAKKEDLLIKGDAVYVCTEGPRFETAQEIRMYKNLGADVVGM
EEECCCCHHHHHHHHHHHCCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHCCCCEEEC
TNVPEVILAKELGMCYAAVGIVSNWATGMKGSITLHEIKDTLELNKEKVIKTFIRVFLEE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHH
KLDQNHCSCNRAVIEL
HHCCCCCCCCEEEEEC
>Mature Secondary Structure
MEKAIIGGTGFYEIGQKVSKKLVETKYGEVEIDIVTIEGEKIGFLPRHGKGHAVPPHLVN
CCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCHHHH
YRANIMALKQMGVKYVYATAAVGSFNENYEPGDVVVLKDFLDFTKSRPLTFFEGEDGVVR
HHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCCCEEE
HVDMSDPYCSNLRAKFYNAAKKEDLLIKGDAVYVCTEGPRFETAQEIRMYKNLGADVVGM
EEECCCCHHHHHHHHHHHCCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHCCCCEEEC
TNVPEVILAKELGMCYAAVGIVSNWATGMKGSITLHEIKDTLELNKEKVIKTFIRVFLEE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHH
KLDQNHCSCNRAVIEL
HHCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]