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The map label for this gene is bhbA [H]

Identifier: 167040486

GI number: 167040486

Start: 1870465

End: 1872147

Strand: Reverse

Name: bhbA [H]

Synonym: Teth514_1855

Alternate gene names: 167040486

Gene position: 1872147-1870465 (Counterclockwise)

Preceding gene: 167040487

Following gene: 167040485

Centisome position: 76.19

GC content: 47.71

Gene sequence:

>1683_bases
ATGTACCATAACAAGGAGTTCCTTAAAAAACTCGAAGAGGAAAAGAAAAGATGGGAAAGCACTACCGTAGAAAAAGTCAT
AAGTAAGGCCCCCGAGAGGTATGAAAAATTCTATACAGGTTCCAACTTAGAAGTAGACCGCCTGTATACACCGTTGGATG
CACAGGAAAACGACTACATAAAAGACTTAGGGTTTCCCGGCGAATACCCATTTACCAGAGGAATCCAGCCTACCATGTAC
CGTGGTCGCTTGTGGACCATGAGACAGTATGCAGGTTTTGGCACAGCAGAGGAATCCAACGAGAGATATAAGTTTTTGTT
ATCCCAGGGACAGACGGGCCTGAGTGTGGCTTTCGACCTGCCCACCCAGATAGGCTACGATTCCGACCACCCCATGGCTC
AAGGTGAGGTGGGCAAAGTAGGTGTGGCCATCGACTCGCTGAAAGACATGGAGATACTGTTTGACGGCATACCCCTGGAC
CAAGTCAGCACTTCAATGACCATAAATGCTCCTGCCGCGATACTTCTTGCCATGTATATAGCTGTAGCAGAAAAACAGGG
AGTCAGCCCGGAGAAACTTTCCGGTACCATCCAGAACGACATACTGAAAGAATATGTGGCCAGGGGTACCTATATATTTC
CACCTGAACCTTCTATGAAACTCATAACTGACATTTTTGAATTCTGTTCCAGGAACGTGCCCAAGTGGAACACCATAAGC
ATAAGCGGCTACCACATAAGAGAAGCTGGAGCAACGGCGGTACAGGAAGTGGCCTTCACGTTGGCCAACGGCATAGCGTA
CGTAGAAGCTGCTATAAAGGCAGGGCTTGACGTCGATGACTTTGCTCCGAGACTTTCCTTTTTCTTCAATGCCCATAATG
ACCTTCTGGAAGAAGTCGCTAAATTCAGGGCCGCGAGGAGACTATGGGCGAAAATAATGAAAGAACGTTTCAAAGCTAAA
AACCCAAGGTCTATGATGCTGCGCTTCCATACCCAAACTGCTGGCTCTACTCTAACTGCCCAGCAGCCCGACAACAACAT
AGTAAGAGTAGCCATCCAGGCCCTGGCGGCAGTGTTAGGAGGCACTCAATCGCTGCACACCAACTCAAGGGACGAAGCCT
TGGCTTTGCCTACCGAAGAATCTGTGAGAATAGCCCTGAGGACCCAGCAGATAATAGCCTACGAAAGCGGAGTGACAGAG
ACCGTAGACCCGCTGGCTGGCTCTTACTACGTAGAACACCTGACAAACCTCATAGAACAAAAGGCCATGGAATATATACA
AAAAATAGATGAACTAGGGGGTGCTCCGAAGGCCATAGAAAAAGGCTACATCCAGCAGGAAATCCAAGACAGTGCCTACA
GATACCAGCAGGAAATTGAATCAGGTCGCAGGATAGTAGTGGGAGTAAACAAATTCCAGATAGAAGAAGAACCGCCCAAG
AACCTTTTAAAAGTGAATCCCGAAGTAGAAAAAATCCAGAGGAAGAAACTGGAAGTACTGAGGGCTACGCGGGACAACAT
AGCCGTCAAAAGCGCTCTGGAAGAACTTTCCTGTAAGGCGAAAACCAGTGAAAACCTCATGCCGAGCATAATAAACTGCG
TAAAGGTGTATGCTACCCTAGGTGAAATAAGTGACACCCTGCGAGGGGTATTTGGTGAATACAAGGCCACTGTAACCTTT
TAG

Upstream 100 bases:

>100_bases
ATAATAATAGAAGATAATTATACAAAATTAAGCAAATTACTCAATACCCCCTTTATATCCTGCAGTTAACCAAATTCTAA
GTGTGGAGGTGTTTAAAGAA

Downstream 100 bases:

>100_bases
TGGGAGGTGGAATAATGGAACAAACAAAGAAGATAAGAGTATTAATAGCAAAACCAGGTCTTGACGGCCATGACAGGGGA
GCAAAAGTAATAGCCAGGGG

Product: methylmalonyl-CoA mutase, large subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MYHNKEFLKKLEEEKKRWESTTVEKVISKAPERYEKFYTGSNLEVDRLYTPLDAQENDYIKDLGFPGEYPFTRGIQPTMY
RGRLWTMRQYAGFGTAEESNERYKFLLSQGQTGLSVAFDLPTQIGYDSDHPMAQGEVGKVGVAIDSLKDMEILFDGIPLD
QVSTSMTINAPAAILLAMYIAVAEKQGVSPEKLSGTIQNDILKEYVARGTYIFPPEPSMKLITDIFEFCSRNVPKWNTIS
ISGYHIREAGATAVQEVAFTLANGIAYVEAAIKAGLDVDDFAPRLSFFFNAHNDLLEEVAKFRAARRLWAKIMKERFKAK
NPRSMMLRFHTQTAGSTLTAQQPDNNIVRVAIQALAAVLGGTQSLHTNSRDEALALPTEESVRIALRTQQIIAYESGVTE
TVDPLAGSYYVEHLTNLIEQKAMEYIQKIDELGGAPKAIEKGYIQQEIQDSAYRYQQEIESGRRIVVGVNKFQIEEEPPK
NLLKVNPEVEKIQRKKLEVLRATRDNIAVKSALEELSCKAKTSENLMPSIINCVKVYATLGEISDTLRGVFGEYKATVTF

Sequences:

>Translated_560_residues
MYHNKEFLKKLEEEKKRWESTTVEKVISKAPERYEKFYTGSNLEVDRLYTPLDAQENDYIKDLGFPGEYPFTRGIQPTMY
RGRLWTMRQYAGFGTAEESNERYKFLLSQGQTGLSVAFDLPTQIGYDSDHPMAQGEVGKVGVAIDSLKDMEILFDGIPLD
QVSTSMTINAPAAILLAMYIAVAEKQGVSPEKLSGTIQNDILKEYVARGTYIFPPEPSMKLITDIFEFCSRNVPKWNTIS
ISGYHIREAGATAVQEVAFTLANGIAYVEAAIKAGLDVDDFAPRLSFFFNAHNDLLEEVAKFRAARRLWAKIMKERFKAK
NPRSMMLRFHTQTAGSTLTAQQPDNNIVRVAIQALAAVLGGTQSLHTNSRDEALALPTEESVRIALRTQQIIAYESGVTE
TVDPLAGSYYVEHLTNLIEQKAMEYIQKIDELGGAPKAIEKGYIQQEIQDSAYRYQQEIESGRRIVVGVNKFQIEEEPPK
NLLKVNPEVEKIQRKKLEVLRATRDNIAVKSALEELSCKAKTSENLMPSIINCVKVYATLGEISDTLRGVFGEYKATVTF
>Mature_560_residues
MYHNKEFLKKLEEEKKRWESTTVEKVISKAPERYEKFYTGSNLEVDRLYTPLDAQENDYIKDLGFPGEYPFTRGIQPTMY
RGRLWTMRQYAGFGTAEESNERYKFLLSQGQTGLSVAFDLPTQIGYDSDHPMAQGEVGKVGVAIDSLKDMEILFDGIPLD
QVSTSMTINAPAAILLAMYIAVAEKQGVSPEKLSGTIQNDILKEYVARGTYIFPPEPSMKLITDIFEFCSRNVPKWNTIS
ISGYHIREAGATAVQEVAFTLANGIAYVEAAIKAGLDVDDFAPRLSFFFNAHNDLLEEVAKFRAARRLWAKIMKERFKAK
NPRSMMLRFHTQTAGSTLTAQQPDNNIVRVAIQALAAVLGGTQSLHTNSRDEALALPTEESVRIALRTQQIIAYESGVTE
TVDPLAGSYYVEHLTNLIEQKAMEYIQKIDELGGAPKAIEKGYIQQEIQDSAYRYQQEIESGRRIVVGVNKFQIEEEPPK
NLLKVNPEVEKIQRKKLEVLRATRDNIAVKSALEELSCKAKTSENLMPSIINCVKVYATLGEISDTLRGVFGEYKATVTF

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=542, Percent_Identity=49.4464944649446, Blast_Score=529, Evalue=1e-150,
Organism=Escherichia coli, GI1789284, Length=517, Percent_Identity=54.1586073500967, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI25144500, Length=521, Percent_Identity=51.4395393474088, Blast_Score=533, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 62945; Mature: 62945

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHNKEFLKKLEEEKKRWESTTVEKVISKAPERYEKFYTGSNLEVDRLYTPLDAQENDYI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHCCCCCCCCCCCHH
KDLGFPGEYPFTRGIQPTMYRGRLWTMRQYAGFGTAEESNERYKFLLSQGQTGLSVAFDL
HHCCCCCCCCCCCCCCCCHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
PTQIGYDSDHPMAQGEVGKVGVAIDSLKDMEILFDGIPLDQVSTSMTINAPAAILLAMYI
CHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHCCCEEECCHHHHHHHHHH
AVAEKQGVSPEKLSGTIQNDILKEYVARGTYIFPPEPSMKLITDIFEFCSRNVPKWNTIS
HHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCCEEEE
ISGYHIREAGATAVQEVAFTLANGIAYVEAAIKAGLDVDDFAPRLSFFFNAHNDLLEEVA
ECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
KFRAARRLWAKIMKERFKAKNPRSMMLRFHTQTAGSTLTAQQPDNNIVRVAIQALAAVLG
HHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHC
GTQSLHTNSRDEALALPTEESVRIALRTQQIIAYESGVTETVDPLAGSYYVEHLTNLIEQ
CCHHCCCCCCCCEEECCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KAMEYIQKIDELGGAPKAIEKGYIQQEIQDSAYRYQQEIESGRRIVVGVNKFQIEEEPPK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCH
NLLKVNPEVEKIQRKKLEVLRATRDNIAVKSALEELSCKAKTSENLMPSIINCVKVYATL
HHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GEISDTLRGVFGEYKATVTF
HHHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MYHNKEFLKKLEEEKKRWESTTVEKVISKAPERYEKFYTGSNLEVDRLYTPLDAQENDYI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHCCCCCCCCCCCHH
KDLGFPGEYPFTRGIQPTMYRGRLWTMRQYAGFGTAEESNERYKFLLSQGQTGLSVAFDL
HHCCCCCCCCCCCCCCCCHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
PTQIGYDSDHPMAQGEVGKVGVAIDSLKDMEILFDGIPLDQVSTSMTINAPAAILLAMYI
CHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHCCCEEECCHHHHHHHHHH
AVAEKQGVSPEKLSGTIQNDILKEYVARGTYIFPPEPSMKLITDIFEFCSRNVPKWNTIS
HHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCCEEEE
ISGYHIREAGATAVQEVAFTLANGIAYVEAAIKAGLDVDDFAPRLSFFFNAHNDLLEEVA
ECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
KFRAARRLWAKIMKERFKAKNPRSMMLRFHTQTAGSTLTAQQPDNNIVRVAIQALAAVLG
HHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHC
GTQSLHTNSRDEALALPTEESVRIALRTQQIIAYESGVTETVDPLAGSYYVEHLTNLIEQ
CCHHCCCCCCCCEEECCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KAMEYIQKIDELGGAPKAIEKGYIQQEIQDSAYRYQQEIESGRRIVVGVNKFQIEEEPPK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCH
NLLKVNPEVEKIQRKKLEVLRATRDNIAVKSALEELSCKAKTSENLMPSIINCVKVYATL
HHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GEISDTLRGVFGEYKATVTF
HHHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]