Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 167040396

GI number: 167040396

Start: 1764150

End: 1765349

Strand: Reverse

Name: coaBC [H]

Synonym: Teth514_1759

Alternate gene names: 167040396

Gene position: 1765349-1764150 (Counterclockwise)

Preceding gene: 167040397

Following gene: 167040395

Centisome position: 71.84

GC content: 34.42

Gene sequence:

>1200_bases
ATGAATACAAGCAAAAAAAATGTAGTATTAGGGGTTACAGGAGGTATAGCAGCTTATAAAGCTGCAGACCTTACATCTCG
ACTCGTAAAAAAAGACATAAATGTGGATGTCATAATGACAAAGGAAGCTACAAATTTTATAAATCCTCTCACTTTTGAGG
CTTTAACTAACAATAAAGTAGTTGTTGATATGTTTGAGGATAGGAAATATTGGGAAATTGAGCATATTTCTTTAGCAAAA
AAAGCTGATGTATTTGCAATAGTTCCTGCAACCGCAAATATTATTGCTAAAATTGCTCATGGGATTGCAGACGATATGTT
AACTACTACTATTCTTGCTACAAAGAGTCCTGTACTAATTGCTCCCGCCATGAATACAAACATGTATACCAATCCTGTGA
CTCAAAAGAATATTAAAATTTTAAAAGAATATGGTTTTTTATTTGTGGAGCCAGCTGCCGGAAGGCTTGCTTGTGGAACT
TATGGCGCAGGAAGATTGGCTGATGTAGAGGAGATTGAAAAAGCTATTTTAGAGTTATTGGACAATGAGAAAAAAAGAGA
TTTTGAAGGGAAAAAGGTGTTAGTAACAGCAGGGCCTACTCGAGAGCCTCTTGATCCTGTAAGATACATTACAAATCGCT
CTTCGGGTAAAATGGGCTATGAGATTGCAAAAGCTTTAGTGGAAAGAGGGGCACAAGTGATTTTAATTTCTGGGCCTACT
TATATAGAGGTACCTAAAGATGTGACTTTTATTCCTGTAGAAACAGCGGTAGATATGTACAATGCTGTCATGATGCACCT
TAATGAAGTAGACATTGTCATAGGGGCTGCAGCTGTTTCTGACTACAGACCTAAAGAGATGAAAAAAGAAAAGATAAAAA
AAGATGAAGAGAAATTAACTATTGAATTAGTTAAAAATCCAGACATAATGTATGAAGTAGGACAGAAAAAAGGAAACAAG
ATTTCGATAGGTTTTGCTGCTGAAACTACTAATTTAGTAGAATATGCACAAAGAAAGTTAAAGGAGAAAAATATGGATTT
AATAGTTGCAAATGATGTAACTCAAAAGGGAGCAGGTTTTGAAGTAGACACGAATATAATAAAAATCATAGATAGAGATT
TAAACGTAAAGGAGTATCCTTTGATGACAAAGATAGAAGCTTCTCATGTGATATTAGATGAAATAGCTAAATTGTTGTAA

Upstream 100 bases:

>100_bases
ATTCTGATAAACCTGTAACAATTGCTACAGAAGAAGTAAACAATGGACTTATTACTTATCAAAGACCGCAAAAATATGGA
ATAAAATAGAGGGTGTTGAA

Downstream 100 bases:

>100_bases
GGCCTTTCGGCTTTTTTTATTTGGTAAATATTTAACAGGCGGAGGTTGCCATGTTTGCCGAGGTCGTTGTAGACATTAAA
TCTTCTAATACTGACAGGGT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNTSKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTNNKVVVDMFEDRKYWEIEHISLAK
KADVFAIVPATANIIAKIAHGIADDMLTTTILATKSPVLIAPAMNTNMYTNPVTQKNIKILKEYGFLFVEPAAGRLACGT
YGAGRLADVEEIEKAILELLDNEKKRDFEGKKVLVTAGPTREPLDPVRYITNRSSGKMGYEIAKALVERGAQVILISGPT
YIEVPKDVTFIPVETAVDMYNAVMMHLNEVDIVIGAAAVSDYRPKEMKKEKIKKDEEKLTIELVKNPDIMYEVGQKKGNK
ISIGFAAETTNLVEYAQRKLKEKNMDLIVANDVTQKGAGFEVDTNIIKIIDRDLNVKEYPLMTKIEASHVILDEIAKLL

Sequences:

>Translated_399_residues
MNTSKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTNNKVVVDMFEDRKYWEIEHISLAK
KADVFAIVPATANIIAKIAHGIADDMLTTTILATKSPVLIAPAMNTNMYTNPVTQKNIKILKEYGFLFVEPAAGRLACGT
YGAGRLADVEEIEKAILELLDNEKKRDFEGKKVLVTAGPTREPLDPVRYITNRSSGKMGYEIAKALVERGAQVILISGPT
YIEVPKDVTFIPVETAVDMYNAVMMHLNEVDIVIGAAAVSDYRPKEMKKEKIKKDEEKLTIELVKNPDIMYEVGQKKGNK
ISIGFAAETTNLVEYAQRKLKEKNMDLIVANDVTQKGAGFEVDTNIIKIIDRDLNVKEYPLMTKIEASHVILDEIAKLL
>Mature_399_residues
MNTSKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTNNKVVVDMFEDRKYWEIEHISLAK
KADVFAIVPATANIIAKIAHGIADDMLTTTILATKSPVLIAPAMNTNMYTNPVTQKNIKILKEYGFLFVEPAAGRLACGT
YGAGRLADVEEIEKAILELLDNEKKRDFEGKKVLVTAGPTREPLDPVRYITNRSSGKMGYEIAKALVERGAQVILISGPT
YIEVPKDVTFIPVETAVDMYNAVMMHLNEVDIVIGAAAVSDYRPKEMKKEKIKKDEEKLTIELVKNPDIMYEVGQKKGNK
ISIGFAAETTNLVEYAQRKLKEKNMDLIVANDVTQKGAGFEVDTNIIKIIDRDLNVKEYPLMTKIEASHVILDEIAKLL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=187, Percent_Identity=33.6898395721925, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082301, Length=400, Percent_Identity=43, Blast_Score=295, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17560194, Length=195, Percent_Identity=34.3589743589744, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322762, Length=212, Percent_Identity=31.6037735849057, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=31.5508021390374, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44208; Mature: 44208

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTNNKV
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCE
VVDMFEDRKYWEIEHISLAKKADVFAIVPATANIIAKIAHGIADDMLTTTILATKSPVLI
EEEEECCCCEEEEEEEEHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
APAMNTNMYTNPVTQKNIKILKEYGFLFVEPAAGRLACGTYGAGRLADVEEIEKAILELL
EECCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHH
DNEKKRDFEGKKVLVTAGPTREPLDPVRYITNRSSGKMGYEIAKALVERGAQVILISGPT
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCE
YIEVPKDVTFIPVETAVDMYNAVMMHLNEVDIVIGAAAVSDYRPKEMKKEKIKKDEEKLT
EEECCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCHHHHHHHHCCCCCEEE
IELVKNPDIMYEVGQKKGNKISIGFAAETTNLVEYAQRKLKEKNMDLIVANDVTQKGAGF
EEEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
EVDTNIIKIIDRDLNVKEYPLMTKIEASHVILDEIAKLL
EECCCEEEEECCCCCCCCCCCEEEECHHHHHHHHHHHHC
>Mature Secondary Structure
MNTSKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTNNKV
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCE
VVDMFEDRKYWEIEHISLAKKADVFAIVPATANIIAKIAHGIADDMLTTTILATKSPVLI
EEEEECCCCEEEEEEEEHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
APAMNTNMYTNPVTQKNIKILKEYGFLFVEPAAGRLACGTYGAGRLADVEEIEKAILELL
EECCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHH
DNEKKRDFEGKKVLVTAGPTREPLDPVRYITNRSSGKMGYEIAKALVERGAQVILISGPT
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCE
YIEVPKDVTFIPVETAVDMYNAVMMHLNEVDIVIGAAAVSDYRPKEMKKEKIKKDEEKLT
EEECCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCHHHHHHHHCCCCCEEE
IELVKNPDIMYEVGQKKGNKISIGFAAETTNLVEYAQRKLKEKNMDLIVANDVTQKGAGF
EEEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
EVDTNIIKIIDRDLNVKEYPLMTKIEASHVILDEIAKLL
EECCCEEEEECCCCCCCCCCCEEEECHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]