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The map label for this gene is rnc [H]

Identifier: 167040357

GI number: 167040357

Start: 1728671

End: 1729411

Strand: Reverse

Name: rnc [H]

Synonym: Teth514_1720

Alternate gene names: 167040357

Gene position: 1729411-1728671 (Counterclockwise)

Preceding gene: 167040358

Following gene: 167040356

Centisome position: 70.38

GC content: 35.09

Gene sequence:

>741_bases
ATGGGACATTACTTTTTAAAAAATTTTAAAAGAGGTATGGAAGTGAAAAGAGAAAATTTGTCTGAATTAGAGGAGAGAAT
AAATTATAGTTTTAAAGATAAAAATTTGCTTATAGAGGCTTTAACTCACAGTTCATGGGCTCACGAAGGTAAAAATAGCA
AGATTAGCAATGAAAGATTGGAGTTTTTGGGAGATTCTGTTCTAAGCCTTGTAATAAGCGAGTATTTGTACAAGAATAGA
AAAGATTTAGAAGAAGGTTCTCTTTCTAAATATAGAGCTGAAATAGTTTGTGAGCCCTCCCTTGCTAGATGTGCAAGAGA
AATAGAATTAGGCAACTTTTTGCGCATTGGCAAAGGAGAAGAACTGACTGGAGGAAGAGAAAGGGATTCTATTCTTGCAG
ATGCTATGGAAGCGATACTGGCTGCTGTATATCTGGATGGAGGGTTAGAAGTTGTTCGCAATGTAATTTTAGAATTGTTC
AAAAATATCATTGAAGAAGTTTTGGAAGGGCTTATTTATCGCGACTATAAAACAAAACTGCAAGAAGTTGTTCAAAGCAT
GGAAATAGGGAAAATTATCTATGAGCTAATAGAGGAAATGGGCCCTGACCATAATAAAACTTTTGTAACCCAAGTGCGGA
TTGGAGATGTAATATTAGGAAAGGGTTATGGTAAAAGTAAAAAAGAAGCTGAGCAAGCTGCGGCTATGGAAGCATTGATT
AAATTGGGGATATTGAAATGA

Upstream 100 bases:

>100_bases
ACTCCTGATCCAGAGTGCGATTTGAATTATGTGCCTAACAAGGCTATAGAAAAAGAAGTAAATTATGCGATTTCTAATTC
CTTTGGCTTTGGAGGACATA

Downstream 100 bases:

>100_bases
AAAAAAAGATGTATATAATACCACTTTTTATACCCCATTTAGGTTGTCCTTTTAAGTGTGTTTTTTGCAATCAAAATTCA
ATAACAGGCCAACAACAGGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MGHYFLKNFKRGMEVKRENLSELEERINYSFKDKNLLIEALTHSSWAHEGKNSKISNERLEFLGDSVLSLVISEYLYKNR
KDLEEGSLSKYRAEIVCEPSLARCAREIELGNFLRIGKGEELTGGRERDSILADAMEAILAAVYLDGGLEVVRNVILELF
KNIIEEVLEGLIYRDYKTKLQEVVQSMEIGKIIYELIEEMGPDHNKTFVTQVRIGDVILGKGYGKSKKEAEQAAAMEALI
KLGILK

Sequences:

>Translated_246_residues
MGHYFLKNFKRGMEVKRENLSELEERINYSFKDKNLLIEALTHSSWAHEGKNSKISNERLEFLGDSVLSLVISEYLYKNR
KDLEEGSLSKYRAEIVCEPSLARCAREIELGNFLRIGKGEELTGGRERDSILADAMEAILAAVYLDGGLEVVRNVILELF
KNIIEEVLEGLIYRDYKTKLQEVVQSMEIGKIIYELIEEMGPDHNKTFVTQVRIGDVILGKGYGKSKKEAEQAAAMEALI
KLGILK
>Mature_245_residues
GHYFLKNFKRGMEVKRENLSELEERINYSFKDKNLLIEALTHSSWAHEGKNSKISNERLEFLGDSVLSLVISEYLYKNRK
DLEEGSLSKYRAEIVCEPSLARCAREIELGNFLRIGKGEELTGGRERDSILADAMEAILAAVYLDGGLEVVRNVILELFK
NIIEEVLEGLIYRDYKTKLQEVVQSMEIGKIIYELIEEMGPDHNKTFVTQVRIGDVILGKGYGKSKKEAEQAAAMEALIK
LGILK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=236, Percent_Identity=30.9322033898305, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI155030234, Length=236, Percent_Identity=30.9322033898305, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=36.9668246445498, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193202651, Length=100, Percent_Identity=40, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506883, Length=100, Percent_Identity=40, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=29.1304347826087, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27965; Mature: 27833

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHYFLKNFKRGMEVKRENLSELEERINYSFKDKNLLIEALTHSSWAHEGKNSKISNERL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHH
EFLGDSVLSLVISEYLYKNRKDLEEGSLSKYRAEIVCEPSLARCAREIELGNFLRIGKGE
HHHHHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHEECCHHHHHHHHHHHCCEEECCCCC
ELTGGRERDSILADAMEAILAAVYLDGGLEVVRNVILELFKNIIEEVLEGLIYRDYKTKL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEVVQSMEIGKIIYELIEEMGPDHNKTFVTQVRIGDVILGKGYGKSKKEAEQAAAMEALI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHH
KLGILK
HHHCCC
>Mature Secondary Structure 
GHYFLKNFKRGMEVKRENLSELEERINYSFKDKNLLIEALTHSSWAHEGKNSKISNERL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHH
EFLGDSVLSLVISEYLYKNRKDLEEGSLSKYRAEIVCEPSLARCAREIELGNFLRIGKGE
HHHHHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHEECCHHHHHHHHHHHCCEEECCCCC
ELTGGRERDSILADAMEAILAAVYLDGGLEVVRNVILELFKNIIEEVLEGLIYRDYKTKL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEVVQSMEIGKIIYELIEEMGPDHNKTFVTQVRIGDVILGKGYGKSKKEAEQAAAMEALI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHH
KLGILK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]