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The map label for this gene is ffh [H]

Identifier: 167040350

GI number: 167040350

Start: 1720569

End: 1721909

Strand: Reverse

Name: ffh [H]

Synonym: Teth514_1713

Alternate gene names: 167040350

Gene position: 1721909-1720569 (Counterclockwise)

Preceding gene: 167040351

Following gene: 167040349

Centisome position: 70.07

GC content: 37.88

Gene sequence:

>1341_bases
ATGGCTTTTGAAAGCCTATCTGAAAGGCTGCAGGAAATCTTTAAAAAGTTAAGAGGAAAAGGAAAACTCACAGAAAAAGA
TATAAAAGAAGCTATGAGGGAAGTAAAAGTTGCCCTCTTAGAAGCGGATGTCAACTTTAAGGTAGTAAAAGACTTTATAA
ACTCTGTTACAGAAAAAGCTTTAGGACAAGAAGTGATGGAAAGCCTGACCCCGGGGCAACAGGTGATAAAGATAGTCAAT
GATGAGCTTATAGCCCTTATGGGGTCTACTCAAAGCCGGTTAAATATAGGGAATAAAGTTCCTGCAGTTATAATGATGGT
TGGACTTCAAGGTTCTGGAAAGACCACTGCTTGTGGGAAATTGGCAAACTTGTTAAAGAAGCAGGGAAAAAATCCCCTAC
TAGTAGCCTGTGACGTCGTCAGACCGGCTGCGATAAAGCAGTTACAGGTTGTAGGAGCTAATGTAAATGTACCAGTTTTT
ACAATGGGGGACAAAGTAAACCCTGTTGATATTGCAAAAGCTTCTATTGATTATGCAAAGTCTCATAACTCTGACGTAAT
TATCATAGATACTGCGGGTAGGCTTCACGTAGATGAAGAATTAATGGAGGAACTTGTAAATATAAAAAAAGCTGTACAAC
CAGATGAGATTTTGTTAGTAGTAGATGCGATGACAGGTCAAGACGCAGTAAACGTAGCGTCTTCCTTTAATGCAAGGTTA
GATATAACAGGAGTTATATTGACAAAATTGGATGGAGATACGAGGGGTGGAGCAGCTCTTTCTATTAAGGCTGTTACACA
AAAACCTATAAAATACATTGGAACAGGTGAAAAACTAACAGACTTAGAGCCCTTTTATCCTGATAGAATGGCCTCTCGTA
TTTTGGGAATGGGAGATGTTTTGACTTTAATTGAAAAGGCCCAAGCAGCAATTGATGAGAAAAAGGCACAAGAGCTAGGG
CAAAAGCTTTTAACAAAACAGTTTACACTGGAAGATTTCTTAGAACAATTGCAGAGTCTTAAAAATATGGGGCCTTTAGA
CCAACTTCTCAGTATGATCCCTGGAATGAACAAAAACATGCTTAAAAATGTGGACTTTTCAGAAAAAGACTTAAAGAGGA
TAGAAGCCATTATTCAATCTATGACTAAAGAAGAAAGGCAAAACCCTTCTATTATAAATGGCAGTAGAAAGAAAAGAATT
GCCAAAGGCAGCGGTACCACCATCCAACAGGTAAATAGCCTCTTAAAACAGTTTGAAGAAACTAAAAAGATGATGAAGAA
ATTTGCTGATATTGACAAAGACCTAAAGAAAGGTAAAATGAGGCTGCCTTTCTTTAGATGA

Upstream 100 bases:

>100_bases
GAAATAATACGGGAAAGAGAAAGAGACCCAGAAATTTTAAAAATTATTGAGGAGATAGCTCGTGAAATAGAAGAGCTAAA
TCTGTAGGAGGTAAATTTTA

Downstream 100 bases:

>100_bases
TATCGGAAGGTGGGCAACTTTTGAAGGAGGTGAGAAAGTGGCAGTCAGAATAAGATTAAAAAGGTTTGGGGCTAAGAAAA
GACCTTTTTACAGGATAGTA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAFESLSERLQEIFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKALGQEVMESLTPGQQVIKIVN
DELIALMGSTQSRLNIGNKVPAVIMMVGLQGSGKTTACGKLANLLKKQGKNPLLVACDVVRPAAIKQLQVVGANVNVPVF
TMGDKVNPVDIAKASIDYAKSHNSDVIIIDTAGRLHVDEELMEELVNIKKAVQPDEILLVVDAMTGQDAVNVASSFNARL
DITGVILTKLDGDTRGGAALSIKAVTQKPIKYIGTGEKLTDLEPFYPDRMASRILGMGDVLTLIEKAQAAIDEKKAQELG
QKLLTKQFTLEDFLEQLQSLKNMGPLDQLLSMIPGMNKNMLKNVDFSEKDLKRIEAIIQSMTKEERQNPSIINGSRKKRI
AKGSGTTIQQVNSLLKQFEETKKMMKKFADIDKDLKKGKMRLPFFR

Sequences:

>Translated_446_residues
MAFESLSERLQEIFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKALGQEVMESLTPGQQVIKIVN
DELIALMGSTQSRLNIGNKVPAVIMMVGLQGSGKTTACGKLANLLKKQGKNPLLVACDVVRPAAIKQLQVVGANVNVPVF
TMGDKVNPVDIAKASIDYAKSHNSDVIIIDTAGRLHVDEELMEELVNIKKAVQPDEILLVVDAMTGQDAVNVASSFNARL
DITGVILTKLDGDTRGGAALSIKAVTQKPIKYIGTGEKLTDLEPFYPDRMASRILGMGDVLTLIEKAQAAIDEKKAQELG
QKLLTKQFTLEDFLEQLQSLKNMGPLDQLLSMIPGMNKNMLKNVDFSEKDLKRIEAIIQSMTKEERQNPSIINGSRKKRI
AKGSGTTIQQVNSLLKQFEETKKMMKKFADIDKDLKKGKMRLPFFR
>Mature_445_residues
AFESLSERLQEIFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKALGQEVMESLTPGQQVIKIVND
ELIALMGSTQSRLNIGNKVPAVIMMVGLQGSGKTTACGKLANLLKKQGKNPLLVACDVVRPAAIKQLQVVGANVNVPVFT
MGDKVNPVDIAKASIDYAKSHNSDVIIIDTAGRLHVDEELMEELVNIKKAVQPDEILLVVDAMTGQDAVNVASSFNARLD
ITGVILTKLDGDTRGGAALSIKAVTQKPIKYIGTGEKLTDLEPFYPDRMASRILGMGDVLTLIEKAQAAIDEKKAQELGQ
KLLTKQFTLEDFLEQLQSLKNMGPLDQLLSMIPGMNKNMLKNVDFSEKDLKRIEAIIQSMTKEERQNPSIINGSRKKRIA
KGSGTTIQQVNSLLKQFEETKKMMKKFADIDKDLKKGKMRLPFFR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=451, Percent_Identity=35.2549889135255, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI226371618, Length=349, Percent_Identity=38.6819484240688, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=43.6619718309859, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI23308697, Length=302, Percent_Identity=27.8145695364238, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI295424842, Length=302, Percent_Identity=27.8145695364238, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=52.112676056338, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=37.1212121212121, Blast_Score=174, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=32.7354260089686, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=29.3918918918919, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=410, Percent_Identity=36.0975609756098, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6320498, Length=320, Percent_Identity=28.4375, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=33.3333333333333, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24641198, Length=306, Percent_Identity=27.7777777777778, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49208; Mature: 49077

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFESLSERLQEIFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGQEVMESLTPGQQVIKIVNDELIALMGSTQSRLNIGNKVPAVIMMVGLQGSGKTTACGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHEEEECCCCCCCHHHHH
LANLLKKQGKNPLLVACDVVRPAAIKQLQVVGANVNVPVFTMGDKVNPVDIAKASIDYAK
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
SHNSDVIIIDTAGRLHVDEELMEELVNIKKAVQPDEILLVVDAMTGQDAVNVASSFNARL
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCE
DITGVILTKLDGDTRGGAALSIKAVTQKPIKYIGTGEKLTDLEPFYPDRMASRILGMGDV
EEEEEEEEEECCCCCCCCEEEEEHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHH
LTLIEKAQAAIDEKKAQELGQKLLTKQFTLEDFLEQLQSLKNMGPLDQLLSMIPGMNKNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHH
LKNVDFSEKDLKRIEAIIQSMTKEERQNPSIINGSRKKRIAKGSGTTIQQVNSLLKQFEE
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
TKKMMKKFADIDKDLKKGKMRLPFFR
HHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AFESLSERLQEIFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGQEVMESLTPGQQVIKIVNDELIALMGSTQSRLNIGNKVPAVIMMVGLQGSGKTTACGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHEEEECCCCCCCHHHHH
LANLLKKQGKNPLLVACDVVRPAAIKQLQVVGANVNVPVFTMGDKVNPVDIAKASIDYAK
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
SHNSDVIIIDTAGRLHVDEELMEELVNIKKAVQPDEILLVVDAMTGQDAVNVASSFNARL
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCE
DITGVILTKLDGDTRGGAALSIKAVTQKPIKYIGTGEKLTDLEPFYPDRMASRILGMGDV
EEEEEEEEEECCCCCCCCEEEEEHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHH
LTLIEKAQAAIDEKKAQELGQKLLTKQFTLEDFLEQLQSLKNMGPLDQLLSMIPGMNKNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHH
LKNVDFSEKDLKRIEAIIQSMTKEERQNPSIINGSRKKRIAKGSGTTIQQVNSLLKQFEE
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
TKKMMKKFADIDKDLKKGKMRLPFFR
HHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]