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The map label for this gene is hslU [H]

Identifier: 167040335

GI number: 167040335

Start: 1707586

End: 1708965

Strand: Reverse

Name: hslU [H]

Synonym: Teth514_1698

Alternate gene names: 167040335

Gene position: 1708965-1707586 (Counterclockwise)

Preceding gene: 167040336

Following gene: 167040334

Centisome position: 69.55

GC content: 34.06

Gene sequence:

>1380_bases
GTGAAGAATTATACTCCCAAGGAGATTGTAGAGGAATTAGATAAGTATATTGTAGGACAAAAGGAAGCTAAAAAGTCAGT
AGCAGTGGCTTTAAGAAATAGATATAGGAGAAATCTTTTATCTGACGATTTTAAAGAAGAAGTGACCCCCAAAAATATAA
TTATGGTAGGCCCTACTGGAGTAGGAAAGACAGAGATTGCTCGAAGAATTGCGAAATTAGTAGAAGCTCCTTTTGTTAAA
GTGGAGGCTACTAAGTTTACTGAGGTAGGATACGTAGGACGAGATGTGGATTCCATGGTTAGAGACCTTGTAGAGGCTGC
TGTAAGAATGGTAAAAGAGGAAAAATTAAAAAAAGTTACTGAAAAAGCGAAAAAAATTGCAGAAGATAGACTAATTGATT
ACATAGTCGGAAAAAGAAAAAAACAGGCTAAAAATCCTTTTGAAATGTTGTTTAATTATCCTGCAGCCGAGAAAAGTGAA
GAGACAGAAGAAGAAAGTATGCAATATAAAAGAGAAGAAATAAGGCAAAAGTTAAGAAATGGCGAGCTAGATAACTATGT
AGTGGAAATAGAAGTAACAGATACATCTACACCAATGATGGAGATGTATACTAATTTAGGGTCCGAAGAAATGAACATAA
ATTTGCAAGATATATTTGCTGACATTTTACCTAAAAAGAAAAAAATTAAAAAAGTTCCTGTTTATGAAGCAAAAAGAATT
CTAGAGTCTGAAGAAGCTCAAAACCTTATAGATATGGATGAAGTAATTGAAGAGGCTATTAAAAGAGCAGAAAACGATGG
AATAATTTTCATAGATGAAATTGACAAAATTGCCAGCAGTGGTTATACAGCAGGACCAGATGTATCAAGGGAAGGAGTTC
AAAGGGATATTCTTCCTATAATTGAAGGTTGTACAGTAATGACAAAATACGGTCCTGTTAAGACAGACCATATATTGTTT
ATAGCAGCTGGTGCTTTTAACATTGCAAAAGTGTCTGATTTAATCCCGGAGCTACAAGGAAGATTTCCTGTAAGAGTTAG
TTTAAAACCTCTCACAAAAGAGGACTTTATAAGAATATTAAAGGAGCCTAAAAATGCTCTTACAAAACAGTATCAAGAGC
TTTTAAGAACGGAAGGAATAGAAGTTAAATACACTGATGAAGCAATTGAGGCTATTGCAGAAGTAGCATATCTTATAAAT
CAACAATCGGAGGACATTGGCGCAAGAAGATTGCACACTGTCATGGAGAAGTTGTTTGAAGAATTATCTTTTAATGCGCC
AGACCTGAAAGGACAGCAAATAGTGATAACTGAAGAGTATGTAAAAGAGCAATTAAAGGATAGTCTCAATAAATACGAAG
TTAATAAATACATTTTATGA

Upstream 100 bases:

>100_bases
TACAGAAGATATAGCAAAAAAAGCTTTAGAGATAGCTTCAAAGATTTGCGTTTACACTAATAACAACATAACAGTTGAGA
CTTTATAGGGGGTGCTTTAA

Downstream 100 bases:

>100_bases
TAATAAAAAAACATAGGAGGATTAAAAATATGAGCACACTATTAGAAAAAACTAGAAAAGTAAATCGGATTTTGCAAAAA
ACAGGAATTCAACCAGTTGA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKNYTPKEIVEELDKYIVGQKEAKKSVAVALRNRYRRNLLSDDFKEEVTPKNIIMVGPTGVGKTEIARRIAKLVEAPFVK
VEATKFTEVGYVGRDVDSMVRDLVEAAVRMVKEEKLKKVTEKAKKIAEDRLIDYIVGKRKKQAKNPFEMLFNYPAAEKSE
ETEEESMQYKREEIRQKLRNGELDNYVVEIEVTDTSTPMMEMYTNLGSEEMNINLQDIFADILPKKKKIKKVPVYEAKRI
LESEEAQNLIDMDEVIEEAIKRAENDGIIFIDEIDKIASSGYTAGPDVSREGVQRDILPIIEGCTVMTKYGPVKTDHILF
IAAGAFNIAKVSDLIPELQGRFPVRVSLKPLTKEDFIRILKEPKNALTKQYQELLRTEGIEVKYTDEAIEAIAEVAYLIN
QQSEDIGARRLHTVMEKLFEELSFNAPDLKGQQIVITEEYVKEQLKDSLNKYEVNKYIL

Sequences:

>Translated_459_residues
MKNYTPKEIVEELDKYIVGQKEAKKSVAVALRNRYRRNLLSDDFKEEVTPKNIIMVGPTGVGKTEIARRIAKLVEAPFVK
VEATKFTEVGYVGRDVDSMVRDLVEAAVRMVKEEKLKKVTEKAKKIAEDRLIDYIVGKRKKQAKNPFEMLFNYPAAEKSE
ETEEESMQYKREEIRQKLRNGELDNYVVEIEVTDTSTPMMEMYTNLGSEEMNINLQDIFADILPKKKKIKKVPVYEAKRI
LESEEAQNLIDMDEVIEEAIKRAENDGIIFIDEIDKIASSGYTAGPDVSREGVQRDILPIIEGCTVMTKYGPVKTDHILF
IAAGAFNIAKVSDLIPELQGRFPVRVSLKPLTKEDFIRILKEPKNALTKQYQELLRTEGIEVKYTDEAIEAIAEVAYLIN
QQSEDIGARRLHTVMEKLFEELSFNAPDLKGQQIVITEEYVKEQLKDSLNKYEVNKYIL
>Mature_459_residues
MKNYTPKEIVEELDKYIVGQKEAKKSVAVALRNRYRRNLLSDDFKEEVTPKNIIMVGPTGVGKTEIARRIAKLVEAPFVK
VEATKFTEVGYVGRDVDSMVRDLVEAAVRMVKEEKLKKVTEKAKKIAEDRLIDYIVGKRKKQAKNPFEMLFNYPAAEKSE
ETEEESMQYKREEIRQKLRNGELDNYVVEIEVTDTSTPMMEMYTNLGSEEMNINLQDIFADILPKKKKIKKVPVYEAKRI
LESEEAQNLIDMDEVIEEAIKRAENDGIIFIDEIDKIASSGYTAGPDVSREGVQRDILPIIEGCTVMTKYGPVKTDHILF
IAAGAFNIAKVSDLIPELQGRFPVRVSLKPLTKEDFIRILKEPKNALTKQYQELLRTEGIEVKYTDEAIEAIAEVAYLIN
QQSEDIGARRLHTVMEKLFEELSFNAPDLKGQQIVITEEYVKEQLKDSLNKYEVNKYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=95, Percent_Identity=40, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790366, Length=460, Percent_Identity=51.7391304347826, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1786642, Length=448, Percent_Identity=26.3392857142857, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319704, Length=120, Percent_Identity=36.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648291, Length=251, Percent_Identity=29.8804780876494, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24648289, Length=251, Percent_Identity=29.8804780876494, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52618; Mature: 52618

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYTPKEIVEELDKYIVGQKEAKKSVAVALRNRYRRNLLSDDFKEEVTPKNIIMVGPTG
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCC
VGKTEIARRIAKLVEAPFVKVEATKFTEVGYVGRDVDSMVRDLVEAAVRMVKEEKLKKVT
CCHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKAKKIAEDRLIDYIVGKRKKQAKNPFEMLFNYPAAEKSEETEEESMQYKREEIRQKLRN
HHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GELDNYVVEIEVTDTSTPMMEMYTNLGSEEMNINLQDIFADILPKKKKIKKVPVYEAKRI
CCCCCEEEEEEECCCCCHHHHHHHCCCCHHCCCCHHHHHHHHCCCHHHHHCCCHHHHHHH
LESEEAQNLIDMDEVIEEAIKRAENDGIIFIDEIDKIASSGYTAGPDVSREGVQRDILPI
HHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHH
IEGCTVMTKYGPVKTDHILFIAAGAFNIAKVSDLIPELQGRFPVRVSLKPLTKEDFIRIL
HHCCEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
KEPKNALTKQYQELLRTEGIEVKYTDEAIEAIAEVAYLINQQSEDIGARRLHTVMEKLFE
HHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ELSFNAPDLKGQQIVITEEYVKEQLKDSLNKYEVNKYIL
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNYTPKEIVEELDKYIVGQKEAKKSVAVALRNRYRRNLLSDDFKEEVTPKNIIMVGPTG
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCC
VGKTEIARRIAKLVEAPFVKVEATKFTEVGYVGRDVDSMVRDLVEAAVRMVKEEKLKKVT
CCHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKAKKIAEDRLIDYIVGKRKKQAKNPFEMLFNYPAAEKSEETEEESMQYKREEIRQKLRN
HHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GELDNYVVEIEVTDTSTPMMEMYTNLGSEEMNINLQDIFADILPKKKKIKKVPVYEAKRI
CCCCCEEEEEEECCCCCHHHHHHHCCCCHHCCCCHHHHHHHHCCCHHHHHCCCHHHHHHH
LESEEAQNLIDMDEVIEEAIKRAENDGIIFIDEIDKIASSGYTAGPDVSREGVQRDILPI
HHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHH
IEGCTVMTKYGPVKTDHILFIAAGAFNIAKVSDLIPELQGRFPVRVSLKPLTKEDFIRIL
HHCCEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
KEPKNALTKQYQELLRTEGIEVKYTDEAIEAIAEVAYLINQQSEDIGARRLHTVMEKLFE
HHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ELSFNAPDLKGQQIVITEEYVKEQLKDSLNKYEVNKYIL
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA