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The map label for this gene is uppS [H]

Identifier: 167040293

GI number: 167040293

Start: 1674796

End: 1675545

Strand: Reverse

Name: uppS [H]

Synonym: Teth514_1656

Alternate gene names: 167040293

Gene position: 1675545-1674796 (Counterclockwise)

Preceding gene: 167040294

Following gene: 167040292

Centisome position: 68.19

GC content: 32.27

Gene sequence:

>750_bases
ATGGTGTTTTTTAGACAAAAAAATAGAGATTTGAGTGACAAGATTGATAAAAATAAATTGCCTATTCACATAGGGATTAT
CATGGACGGAAATGGAAGATGGGCTCAAAAAAGAGGGATGATGAGATTTTATGGCCATAAAGCTGGTGTTAATGCTGTAA
GAGAGGTTGTAAAAGCCTCTAGAGAATTAGGGATAAAATATTTAACTTTGTACGCTTTTTCAACCGAAAACTGGAAAAGA
CCTAAAGAAGAAGTAAATTTTTTAATGGATTTACTCGTTGAATTTCTTTCTAAAGAAATAGACGAATTGAACAAAAATAA
TGTATTGATTAACTTTATAGGGGATATTTCCGTTTTACCACAGAAGTGTAAAATTGAAATAGAGAGGGCGCAAAATGTAA
CAAAAAACAACTCTGGACTTGTACTTAATATAGCGTTAAATTATGGCGGAAGAGATGAAATAGTAAAGGCTGTGAAAAAA
ATTTGCACAAAGATTTTAAATAAAGAATTGTCCATTGAGGAAATTACAGAACAAACTATAAGTGAAAATTTGTATACTAA
AAACCAGCCAGATCCAGATCTTATAATAAGAACAAGTGGAGAAAAAAGATTGAGCAATTTCTTATTATGGCAATCTGCTT
ATTCTGAGCTTTGGTTTACAGAGGTACTGTGGCCGGATTTTGGCAAAGAACATCTTATTGAAGCAATATTGTATTACCAA
ACTCGCCAAAGAAGATTTGGGGGAGTATAG

Upstream 100 bases:

>100_bases
CCAGGATAAAAGAACAAAATAACATTCTTGAAATTACTGTTATTAGAATTTAATCCCCCTCTGACGAGGGGGCGCCCTTA
TAAAATGAGGAGGAAAATAA

Downstream 100 bases:

>100_bases
TAAGGAGTGGTAAATAAATATGCTAAAAACAAGAGTTATAAGTGCGATAGTAGGCTTGCCAATTTTATTTTTCATTTTAA
TAAAAGGGGGGAATATGCTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MVFFRQKNRDLSDKIDKNKLPIHIGIIMDGNGRWAQKRGMMRFYGHKAGVNAVREVVKASRELGIKYLTLYAFSTENWKR
PKEEVNFLMDLLVEFLSKEIDELNKNNVLINFIGDISVLPQKCKIEIERAQNVTKNNSGLVLNIALNYGGRDEIVKAVKK
ICTKILNKELSIEEITEQTISENLYTKNQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFGKEHLIEAILYYQ
TRQRRFGGV

Sequences:

>Translated_249_residues
MVFFRQKNRDLSDKIDKNKLPIHIGIIMDGNGRWAQKRGMMRFYGHKAGVNAVREVVKASRELGIKYLTLYAFSTENWKR
PKEEVNFLMDLLVEFLSKEIDELNKNNVLINFIGDISVLPQKCKIEIERAQNVTKNNSGLVLNIALNYGGRDEIVKAVKK
ICTKILNKELSIEEITEQTISENLYTKNQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFGKEHLIEAILYYQ
TRQRRFGGV
>Mature_249_residues
MVFFRQKNRDLSDKIDKNKLPIHIGIIMDGNGRWAQKRGMMRFYGHKAGVNAVREVVKASRELGIKYLTLYAFSTENWKR
PKEEVNFLMDLLVEFLSKEIDELNKNNVLINFIGDISVLPQKCKIEIERAQNVTKNNSGLVLNIALNYGGRDEIVKAVKK
ICTKILNKELSIEEITEQTISENLYTKNQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFGKEHLIEAILYYQ
TRQRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=235, Percent_Identity=41.2765957446808, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI45580738, Length=235, Percent_Identity=41.2765957446808, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=46.3829787234043, Blast_Score=227, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI71993029, Length=231, Percent_Identity=35.0649350649351, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=40.2777777777778, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=31.0185185185185, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=37.5, Blast_Score=167, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28974; Mature: 28974

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFFRQKNRDLSDKIDKNKLPIHIGIIMDGNGRWAQKRGMMRFYGHKAGVNAVREVVKAS
CCEECCCCCCHHHHCCCCCCCEEEEEEECCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHH
RELGIKYLTLYAFSTENWKRPKEEVNFLMDLLVEFLSKEIDELNKNNVLINFIGDISVLP
HHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCC
QKCKIEIERAQNVTKNNSGLVLNIALNYGGRDEIVKAVKKICTKILNKELSIEEITEQTI
HHHHEEHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SENLYTKNQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFGKEHLIEAILYYQ
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TRQRRFGGV
HHHHHCCCC
>Mature Secondary Structure
MVFFRQKNRDLSDKIDKNKLPIHIGIIMDGNGRWAQKRGMMRFYGHKAGVNAVREVVKAS
CCEECCCCCCHHHHCCCCCCCEEEEEEECCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHH
RELGIKYLTLYAFSTENWKRPKEEVNFLMDLLVEFLSKEIDELNKNNVLINFIGDISVLP
HHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCC
QKCKIEIERAQNVTKNNSGLVLNIALNYGGRDEIVKAVKKICTKILNKELSIEEITEQTI
HHHHEEHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SENLYTKNQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFGKEHLIEAILYYQ
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TRQRRFGGV
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]