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The map label for this gene is dxr [H]

Identifier: 167040291

GI number: 167040291

Start: 1672833

End: 1673981

Strand: Reverse

Name: dxr [H]

Synonym: Teth514_1654

Alternate gene names: 167040291

Gene position: 1673981-1672833 (Counterclockwise)

Preceding gene: 167040292

Following gene: 167040290

Centisome position: 68.12

GC content: 31.77

Gene sequence:

>1149_bases
ATGAAAAAGGTAATAATTCTCGGCTCAACTGGTTCTATAGGTACACAAACATTAGACGTAATAAAAAATTTTAGAGAAAA
TTTTGAAATAGTAGGACTTACAGCTTATAACAATGTAGAACTTTTATCGAAACAAATTAGAGAATTTAATCCTAAAGTTG
TAGCAGTAAAAGATGAAGATAAAGCTAACCAATTAAGAGAGAATCTAAAGAAAAATGTCGAAATTCTAACTGGCAGTAAA
GGGCTTCAAGAAATTGTAAAGTACGATGCCGATTTAGTGGTGGTAGCTGTAGAAGGGATTGCTGGCCTTATTCCAACAGT
TACAGCTATCCAGATGGGAAAAGATATTGCTTTAGCGAATAAAGAAGTACTTGTAACAGCTGGACAAATTGTAATGGATT
TGGTAAAAAAGAAGGATATAAGTCTTTTACCTGTAGATAGTGAACACTCTGCTATACTCCAATGTTTAAGAGGAAATGAC
AAAAAAGAAGTATCTCGATTGATTTTAACAGCCTCTGGAGGTCCTTTTAGAGGGAAAAAAAAAGAAGATTTGAGAAAAGT
AACTGTAAATGAGGCTCTAAATCATCCTAATTGGAAAATGGGTAAAAAAATCACGATAGATTCTGCCACTTTGATGAATA
AAGGGTTTGAAGTAATAGAAGCAAAATGGCTCTTTGACATTTCTGAAGATAAAATTGATGTGATTGTGCATCCCCAGAGT
ATAATTCACTCAATGGTAGAATATATAGATGGTAGTGTAATTGCACAATTGGCTACTGCCGATATGAGGATACCTATTCA
CTATGCATTAAATTATCCTACTCGCAATTACATAAATGGAATGAATTTTTTAGATTTTTCTCTTACAACTCAACTAACTT
TTGAAAAACCCGATTTAGAAACTTTTAGATGTTTGTCGTTAGCATATGAGGCTTTAAAAATTGGAGGAACTATGACTACC
GTATTAAATGCAGCTGATGAAATAGCTGTATCTTTGTTTTTAAATAAAAAAATAGAATTTTTGCAAATAGCTGAAATCAT
AGAGGAGAGCATGAAAGAACATAATAATATACAAAATCCAACTTTAGATGATATAATAAATGTGGATGAAGAGGTTAAGG
AAAAAATAGCAAAAAAATATATGAGGTGA

Upstream 100 bases:

>100_bases
TGGCCATGGAGGAATTTTAGATAGATTTGATAGTATTTTATTTGTTTCTCCTTTCATATACTTTATTTTTCAGTACTTAA
TTTAGAAAGGGATGTACTTC

Downstream 100 bases:

>100_bases
TACATTTTGACAATTTTGATAAGTATAATTGTTTTAAGCGTTTTAGTAATGTTTCACGAATTTGGACATTTTATCGTTGC
AAAACTTTCTGGAGCTAGAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKKVIILGSTGSIGTQTLDVIKNFRENFEIVGLTAYNNVELLSKQIREFNPKVVAVKDEDKANQLRENLKKNVEILTGSK
GLQEIVKYDADLVVVAVEGIAGLIPTVTAIQMGKDIALANKEVLVTAGQIVMDLVKKKDISLLPVDSEHSAILQCLRGND
KKEVSRLILTASGGPFRGKKKEDLRKVTVNEALNHPNWKMGKKITIDSATLMNKGFEVIEAKWLFDISEDKIDVIVHPQS
IIHSMVEYIDGSVIAQLATADMRIPIHYALNYPTRNYINGMNFLDFSLTTQLTFEKPDLETFRCLSLAYEALKIGGTMTT
VLNAADEIAVSLFLNKKIEFLQIAEIIEESMKEHNNIQNPTLDDIINVDEEVKEKIAKKYMR

Sequences:

>Translated_382_residues
MKKVIILGSTGSIGTQTLDVIKNFRENFEIVGLTAYNNVELLSKQIREFNPKVVAVKDEDKANQLRENLKKNVEILTGSK
GLQEIVKYDADLVVVAVEGIAGLIPTVTAIQMGKDIALANKEVLVTAGQIVMDLVKKKDISLLPVDSEHSAILQCLRGND
KKEVSRLILTASGGPFRGKKKEDLRKVTVNEALNHPNWKMGKKITIDSATLMNKGFEVIEAKWLFDISEDKIDVIVHPQS
IIHSMVEYIDGSVIAQLATADMRIPIHYALNYPTRNYINGMNFLDFSLTTQLTFEKPDLETFRCLSLAYEALKIGGTMTT
VLNAADEIAVSLFLNKKIEFLQIAEIIEESMKEHNNIQNPTLDDIINVDEEVKEKIAKKYMR
>Mature_382_residues
MKKVIILGSTGSIGTQTLDVIKNFRENFEIVGLTAYNNVELLSKQIREFNPKVVAVKDEDKANQLRENLKKNVEILTGSK
GLQEIVKYDADLVVVAVEGIAGLIPTVTAIQMGKDIALANKEVLVTAGQIVMDLVKKKDISLLPVDSEHSAILQCLRGND
KKEVSRLILTASGGPFRGKKKEDLRKVTVNEALNHPNWKMGKKITIDSATLMNKGFEVIEAKWLFDISEDKIDVIVHPQS
IIHSMVEYIDGSVIAQLATADMRIPIHYALNYPTRNYINGMNFLDFSLTTQLTFEKPDLETFRCLSLAYEALKIGGTMTT
VLNAADEIAVSLFLNKKIEFLQIAEIIEESMKEHNNIQNPTLDDIINVDEEVKEKIAKKYMR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=44.8362720403023, Blast_Score=327, Evalue=9e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42730; Mature: 42730

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVIILGSTGSIGTQTLDVIKNFRENFEIVGLTAYNNVELLSKQIREFNPKVVAVKDED
CCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEECCH
KANQLRENLKKNVEILTGSKGLQEIVKYDADLVVVAVEGIAGLIPTVTAIQMGKDIALAN
HHHHHHHHHHCCEEEEECCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCCEEECC
KEVLVTAGQIVMDLVKKKDISLLPVDSEHSAILQCLRGNDKKEVSRLILTASGGPFRGKK
CEEEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHHHEEEEEECCCCCCCCC
KEDLRKVTVNEALNHPNWKMGKKITIDSATLMNKGFEVIEAKWLFDISEDKIDVIVHPQS
HHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHCCHHHEEEEEEEEECCCCEEEEECCHH
IIHSMVEYIDGSVIAQLATADMRIPIHYALNYPTRNYINGMNFLDFSLTTQLTFEKPDLE
HHHHHHHHHCCHHHHHHHHCCEEEEEEEEECCCCHHHCCCCCEEEEEEEEEEEECCCCHH
TFRCLSLAYEALKIGGTMTTVLNAADEIAVSLFLNKKIEFLQIAEIIEESMKEHNNIQNP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
TLDDIINVDEEVKEKIAKKYMR
CHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVIILGSTGSIGTQTLDVIKNFRENFEIVGLTAYNNVELLSKQIREFNPKVVAVKDED
CCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEECCH
KANQLRENLKKNVEILTGSKGLQEIVKYDADLVVVAVEGIAGLIPTVTAIQMGKDIALAN
HHHHHHHHHHCCEEEEECCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCCEEECC
KEVLVTAGQIVMDLVKKKDISLLPVDSEHSAILQCLRGNDKKEVSRLILTASGGPFRGKK
CEEEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHHHEEEEEECCCCCCCCC
KEDLRKVTVNEALNHPNWKMGKKITIDSATLMNKGFEVIEAKWLFDISEDKIDVIVHPQS
HHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHCCHHHEEEEEEEEECCCCEEEEECCHH
IIHSMVEYIDGSVIAQLATADMRIPIHYALNYPTRNYINGMNFLDFSLTTQLTFEKPDLE
HHHHHHHHHCCHHHHHHHHCCEEEEEEEEECCCCHHHCCCCCEEEEEEEEEEEECCCCHH
TFRCLSLAYEALKIGGTMTTVLNAADEIAVSLFLNKKIEFLQIAEIIEESMKEHNNIQNP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
TLDDIINVDEEVKEKIAKKYMR
CHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA