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The map label for this gene is cadA [H]

Identifier: 167039808

GI number: 167039808

Start: 1198539

End: 1200515

Strand: Direct

Name: cadA [H]

Synonym: Teth514_1162

Alternate gene names: 167039808

Gene position: 1198539-1200515 (Clockwise)

Preceding gene: 167039807

Following gene: 167039809

Centisome position: 48.78

GC content: 35.56

Gene sequence:

>1977_bases
ATGCAAAATAATAAAAGGGCCTTTGTTTTAGAGAGGTTTGGTTGTAGAAGTTGTGCCCTAGATGCAAAAGGAAATCCACT
GAACGCAAATTGTGATTCTGATAGTTGTAAGCTTTCTTTTGATAATGATGACTCTAATAAAGTATACAGGAGAATCATTC
AATATGGGATTTCTGCTATCTTGTTTACTGTTGCATTGATATTTAATTTATCTGTTTATGTTAAATTTACTTTATTTTTC
ATAAGCTATATAATCGTAGGTGGAGAAGTCATCTTAACAGCTGGTAAAAAGATTTTAAAAGGGCAGGTTTTTGATGAACA
TTTTCTTATGAGCATAGCGACAATTGGTGCTTTTGTTATTGGAGAGTATCCGGAAAGTGTAGCTGTAATGCTTTTTTACC
AAATTGGGGAACTTCTGCAGGATATTGCTGTTGACCGTTCGAAAAGGTCTATTAAAGAGTTAATGAATATTCGTCCCGAT
TATGCTAACTTAAAAATTGGATATGAAATAAAGAGGGTTTCACCACAAGAAGTAAGACCGGGAGACGTCATCATAGTAAA
GCCTGGTGAAAAAATACCACTTGATGGGAAGGTAATCGAAGGGGAATCGATGGTGGATACTTCTGCATTAACAGGAGAAT
CTGTTTTAAAAGAGGTTTATAAAGGCGCGGACGTTTTAAGTGGCTTTATAAATAAAAATGGACTTCTCACAATAGAAGTA
ACCAGAGAGTTTGCAGAATCAACTGTTTCAAAAATACTAGGACTTATTGAAGAGGCTAGCAGTAAGAAAGCTCCTACAGA
AAAATTTATGACAAAGTTTGCCAAATATTACACTCCTATTGTTGTTTTTTTGGCATTGATTATTGCAGTAATTCCTCCTT
TAATTATACCAGCAGCAACCTTCAAGGAATTTATATATAGAGCACTTATTTTTCTTGTAATATCGTGCCCCTGTGCACTG
GTGTTATCGATTCCTTTAACCTTTTTTGCTGGTATAGGTGCTGCCTCAAAAAATGGCATCCTTGTAAAAGGAAGTAACTA
TTTGGAAGCGTTAAGCAATGTAGAAACTGTTGTATTTGATAAAACAGGTACCCTTACAAAAGGGGTATTTAAGTTAACGG
AAATTAAACCTGTAAATGGTATAAGTAGGGATGCGCTTTTAGAATATACGGCATATGCCGAAAGTTTTTCAAACCATCCT
ATAGCAGAATCCATTTTAAAAGCCTATGGAAAAGAAGTAGACAGATCTAAAATAAAAAAGTATGAAGAAATTTCAGGAAA
TGGCGTAAGAGCAAATATAGATGGAAAAAAAGTCCTTGTAGGTAATGCTAAATTAATGAAGGCCGAAAATATTGATTGTG
TTACCAGTGACTCAATAGGTACTATCATTCATGTAGCTATAGATAACAAATATTCTGGTTATATCGTCATATCCGATGAA
GTAAAAGAAGATTCCTCAAGAGCCATAGAAGGCCTAAGAGAAATGGGCATTAAGAGGATTGTCATGCTTACGGGGGATAA
CAAAGCTATCAGCGATAAAATCGCTGCTTCATTAAGGATTGATGAAGTGTATTCAGAACTTTTTCCAAATGAGAAAGTTG
GTATACTTGAGAAGTTATATGCTAACAATAAAAAGGGCAAACTCATATTTGTCGGTGATGGCATAAATGATGCACCGGTT
TTAGCGAGAGCTGATGTGGGTGTTGCAATGGGTGGAATCGGGTCAGATGTTGCTATAGAAGCAGCCGATGTAGTTTTAAT
GACAGATGAACCTTCAAAACTGGTAACAGCGATAAAGATATCCAAAAAAACAAAATTAATAGTATGGGAAAATATCCTTC
TTGCGCTGGGAGTAAAAATAGTAGTTTTAGCACTTGGTGCTTTAGGGGTTGCTACAATGTGGGAAGCTGTGTTCGCCGAC
GTAGGTGTTGCACTCCTTGCAGTCCTTAATTCTTTAAGATTGCTTAATAAAAAATAA

Upstream 100 bases:

>100_bases
GGAAAAGTGGTTTATTATTCTTTGGCGGATGACCATGTAAAGAAAATATTTGAACAGGGTTTTGACCATATTAATGAATG
AATCAGGAGAGGTGAATACT

Downstream 100 bases:

>100_bases
AAATATTACTAACTTTTAAAAAAGGAGGATATGAATCATGGGTTTGTTTGGACCTAAGGGTGAGACTATCGTCATAAATG
TTAAGGGGATGACATGCAAC

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MQNNKRAFVLERFGCRSCALDAKGNPLNANCDSDSCKLSFDNDDSNKVYRRIIQYGISAILFTVALIFNLSVYVKFTLFF
ISYIIVGGEVILTAGKKILKGQVFDEHFLMSIATIGAFVIGEYPESVAVMLFYQIGELLQDIAVDRSKRSIKELMNIRPD
YANLKIGYEIKRVSPQEVRPGDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAATFKEFIYRALIFLVISCPCAL
VLSIPLTFFAGIGAASKNGILVKGSNYLEALSNVETVVFDKTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHP
IAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLVGNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDE
VKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRIDEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPV
LARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKISKKTKLIVWENILLALGVKIVVLALGALGVATMWEAVFAD
VGVALLAVLNSLRLLNKK

Sequences:

>Translated_658_residues
MQNNKRAFVLERFGCRSCALDAKGNPLNANCDSDSCKLSFDNDDSNKVYRRIIQYGISAILFTVALIFNLSVYVKFTLFF
ISYIIVGGEVILTAGKKILKGQVFDEHFLMSIATIGAFVIGEYPESVAVMLFYQIGELLQDIAVDRSKRSIKELMNIRPD
YANLKIGYEIKRVSPQEVRPGDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAATFKEFIYRALIFLVISCPCAL
VLSIPLTFFAGIGAASKNGILVKGSNYLEALSNVETVVFDKTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHP
IAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLVGNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDE
VKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRIDEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPV
LARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKISKKTKLIVWENILLALGVKIVVLALGALGVATMWEAVFAD
VGVALLAVLNSLRLLNKK
>Mature_658_residues
MQNNKRAFVLERFGCRSCALDAKGNPLNANCDSDSCKLSFDNDDSNKVYRRIIQYGISAILFTVALIFNLSVYVKFTLFF
ISYIIVGGEVILTAGKKILKGQVFDEHFLMSIATIGAFVIGEYPESVAVMLFYQIGELLQDIAVDRSKRSIKELMNIRPD
YANLKIGYEIKRVSPQEVRPGDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAATFKEFIYRALIFLVISCPCAL
VLSIPLTFFAGIGAASKNGILVKGSNYLEALSNVETVVFDKTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHP
IAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLVGNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDE
VKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRIDEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPV
LARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKISKKTKLIVWENILLALGVKIVVLALGALGVATMWEAVFAD
VGVALLAVLNSLRLLNKK

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=610, Percent_Identity=31.9672131147541, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI55743071, Length=595, Percent_Identity=30.5882352941176, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI55743073, Length=522, Percent_Identity=31.4176245210728, Blast_Score=233, Evalue=6e-61,
Organism=Escherichia coli, GI1789879, Length=586, Percent_Identity=37.542662116041, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1786691, Length=570, Percent_Identity=30.3508771929825, Blast_Score=258, Evalue=1e-69,
Organism=Escherichia coli, GI1786914, Length=485, Percent_Identity=29.4845360824742, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI2367363, Length=512, Percent_Identity=22.4609375, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17556548, Length=636, Percent_Identity=29.874213836478, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17557770, Length=181, Percent_Identity=33.7016574585635, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32566766, Length=181, Percent_Identity=33.7016574585635, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557486, Length=180, Percent_Identity=30.5555555555556, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17531459, Length=151, Percent_Identity=30.4635761589404, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=542, Percent_Identity=29.8892988929889, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=556, Percent_Identity=27.6978417266187, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325221, Length=638, Percent_Identity=24.4514106583072, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321430, Length=515, Percent_Identity=23.6893203883495, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321271, Length=260, Percent_Identity=28.4615384615385, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321432, Length=183, Percent_Identity=31.1475409836066, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221329854, Length=342, Percent_Identity=31.2865497076023, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24668708, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281366617, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24668704, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24668696, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI161085803, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 71624; Mature: 71624

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNKRAFVLERFGCRSCALDAKGNPLNANCDSDSCKLSFDNDDSNKVYRRIIQYGISAI
CCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
LFTVALIFNLSVYVKFTLFFISYIIVGGEVILTAGKKILKGQVFDEHFLMSIATIGAFVI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHH
GEYPESVAVMLFYQIGELLQDIAVDRSKRSIKELMNIRPDYANLKIGYEIKRVSPQEVRP
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
GDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
CCEEEECCCCCCCCCCEEECCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAAT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FKEFIYRALIFLVISCPCALVLSIPLTFFAGIGAASKNGILVKGSNYLEALSNVETVVFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCEEEEE
KTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHPIAESILKAYGKEVDRSKIKK
CCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
YEEISGNGVRANIDGKKVLVGNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDE
HHHCCCCCEEEECCCCEEEECCCEEEEECCCCEEECCCCCEEEEEEECCCCCCEEEEECC
VKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRIDEVYSELFPNEKVGILEKLY
CCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ANNKKGKLIFVGDGINDAPVLARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKI
CCCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCEEEEEEEEEECCCCHHHEEEEEE
SKKTKLIVWENILLALGVKIVVLALGALGVATMWEAVFADVGVALLAVLNSLRLLNKK
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNNKRAFVLERFGCRSCALDAKGNPLNANCDSDSCKLSFDNDDSNKVYRRIIQYGISAI
CCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
LFTVALIFNLSVYVKFTLFFISYIIVGGEVILTAGKKILKGQVFDEHFLMSIATIGAFVI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHH
GEYPESVAVMLFYQIGELLQDIAVDRSKRSIKELMNIRPDYANLKIGYEIKRVSPQEVRP
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
GDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
CCEEEECCCCCCCCCCEEECCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAAT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FKEFIYRALIFLVISCPCALVLSIPLTFFAGIGAASKNGILVKGSNYLEALSNVETVVFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCEEEEE
KTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHPIAESILKAYGKEVDRSKIKK
CCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
YEEISGNGVRANIDGKKVLVGNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDE
HHHCCCCCEEEECCCCEEEECCCEEEEECCCCEEECCCCCEEEEEEECCCCCCEEEEECC
VKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRIDEVYSELFPNEKVGILEKLY
CCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ANNKKGKLIFVGDGINDAPVLARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKI
CCCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCEEEEEEEEEECCCCHHHEEEEEE
SKKTKLIVWENILLALGVKIVVLALGALGVATMWEAVFADVGVALLAVLNSLRLLNKK
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]