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The map label for this gene is galK [H]

Identifier: 167039736

GI number: 167039736

Start: 1123002

End: 1124165

Strand: Direct

Name: galK [H]

Synonym: Teth514_1087

Alternate gene names: 167039736

Gene position: 1123002-1124165 (Clockwise)

Preceding gene: 167039735

Following gene: 167039737

Centisome position: 45.7

GC content: 34.71

Gene sequence:

>1164_bases
ATGAAAACGGCTGTAATTGAAGCACTTGAAAAATTCTACGGTAAAAATGATGCTGAAATAAGGCTTTTCTATTCTCCGGG
ACGAGTGAATCTTATTGGAGAGCATACAGATTACAATGGAGGCTATGTATTTCCTTGTGCCCTTGACTTTGGAACATATG
CTGCGATTAGAAAAAGAAATGACAAAAAAGTCTTCATGGCTTCTTTAAATTTCGATTTAAAGGTGGAAGTAGACCTTGAT
GCACTCAATTTTGATAAAAGCCATGATTGGGCTAATTATCCTAAAGGGGTTTTAAAAGTGTTACAGGATGAGGGGTATGA
CTTTTCTGGATTTGAAATTGTGTTTGAAGGCAACATTCCAAATGGCGCTGGACTTTCCTCATCTGCTTCAATAGAGCTGG
TTACTGCTGTTGCAGTAAATGAAGTTTTCAATTTAAATATTGACAGAATAAAATTGGTGAAATTGTGTCAAAAAGCAGAA
AATACTTTTGTTGGGGTAAATTGTGGCATAATGGACCAATTTGCTGTTGGAATGGGTAAAAAAGACCATGCTATTTTATT
AAAAAGCGATACATTAGAGTATTCATACGTGCCTTTGAAGTTAGAAGGTTATAAAATTTTGATAACAAATACAAATAAAA
GGAGAGGGCTCTTGGATTCGAAATATAATGAAAGAAGAAGTGAATGTGAAAAGGCCCTTTCATATCTTCAAAAAGCTTTG
CCTGTAAAAAATCTATCTGAAATTACAATTGAACAATTTGAAGAATACAAAGATTTGATACCTGACGAAGTGCTTAGAAA
AAGGGCAAAACATGTTATAACTGAAAATAAAAGAGTTTTAGATGCAGTAAAAGCACTTAATGATAAAGACTTAATCAAAT
TTGGAGAATTAATGGTTGAATCTCACAATTCTTTGAGAGATGATTACGAAGTTACAGGGAAAGAACTGGACACTTTGGTA
GAAGAAGCGTTAAAATTAAAGGGAGTAATAGGTTCCCGTATGACTGGAGCAGGCTTTGGTGGCTGCACTGTAAGCATTGT
AAAAGAAGATGCAGTAGAGGAATTTATAAAAGTGGTGACTCACAATTACACTCAAAAAATAGGCTACAGGCCAACAGTCT
ATATAACGGGAATAGGTGAAGGAGCAGGAGAAATTAAATACTGA

Upstream 100 bases:

>100_bases
ATGCAGGAGTTTTTAAAAGAGATGAAAAAGGGAAAAAAGCCTTTGAAAAATTTATAAAAACAGTAGGCTTTGAAAAAATA
GATATGAAAGGAGACCTTAA

Downstream 100 bases:

>100_bases
AGGAGGTAAAAATATGGCGGTTTTAGTATGCGGTGGTGCAGGTTATATTGGAAGCCACACAGTTGCAGCACTTTTAAGGA
GAAATGAAGAAGTTGTCGTT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKTAVIEALEKFYGKNDAEIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRNDKKVFMASLNFDLKVEVDLD
ALNFDKSHDWANYPKGVLKVLQDEGYDFSGFEIVFEGNIPNGAGLSSSASIELVTAVAVNEVFNLNIDRIKLVKLCQKAE
NTFVGVNCGIMDQFAVGMGKKDHAILLKSDTLEYSYVPLKLEGYKILITNTNKRRGLLDSKYNERRSECEKALSYLQKAL
PVKNLSEITIEQFEEYKDLIPDEVLRKRAKHVITENKRVLDAVKALNDKDLIKFGELMVESHNSLRDDYEVTGKELDTLV
EEALKLKGVIGSRMTGAGFGGCTVSIVKEDAVEEFIKVVTHNYTQKIGYRPTVYITGIGEGAGEIKY

Sequences:

>Translated_387_residues
MKTAVIEALEKFYGKNDAEIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRNDKKVFMASLNFDLKVEVDLD
ALNFDKSHDWANYPKGVLKVLQDEGYDFSGFEIVFEGNIPNGAGLSSSASIELVTAVAVNEVFNLNIDRIKLVKLCQKAE
NTFVGVNCGIMDQFAVGMGKKDHAILLKSDTLEYSYVPLKLEGYKILITNTNKRRGLLDSKYNERRSECEKALSYLQKAL
PVKNLSEITIEQFEEYKDLIPDEVLRKRAKHVITENKRVLDAVKALNDKDLIKFGELMVESHNSLRDDYEVTGKELDTLV
EEALKLKGVIGSRMTGAGFGGCTVSIVKEDAVEEFIKVVTHNYTQKIGYRPTVYITGIGEGAGEIKY
>Mature_387_residues
MKTAVIEALEKFYGKNDAEIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRNDKKVFMASLNFDLKVEVDLD
ALNFDKSHDWANYPKGVLKVLQDEGYDFSGFEIVFEGNIPNGAGLSSSASIELVTAVAVNEVFNLNIDRIKLVKLCQKAE
NTFVGVNCGIMDQFAVGMGKKDHAILLKSDTLEYSYVPLKLEGYKILITNTNKRRGLLDSKYNERRSECEKALSYLQKAL
PVKNLSEITIEQFEEYKDLIPDEVLRKRAKHVITENKRVLDAVKALNDKDLIKFGELMVESHNSLRDDYEVTGKELDTLV
EEALKLKGVIGSRMTGAGFGGCTVSIVKEDAVEEFIKVVTHNYTQKIGYRPTVYITGIGEGAGEIKY

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=386, Percent_Identity=40.9326424870466, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI4503897, Length=415, Percent_Identity=28.433734939759, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI48527957, Length=415, Percent_Identity=28.433734939759, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786972, Length=366, Percent_Identity=42.0765027322404, Blast_Score=301, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI71989053, Length=414, Percent_Identity=29.2270531400966, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319494, Length=257, Percent_Identity=31.9066147859922, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320212, Length=232, Percent_Identity=31.0344827586207, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24661292, Length=428, Percent_Identity=27.1028037383178, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355577, Length=428, Percent_Identity=27.1028037383178, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24661285, Length=428, Percent_Identity=27.1028037383178, Blast_Score=114, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43382; Mature: 43382

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAVIEALEKFYGKNDAEIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRN
CCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHCCC
DKKVFMASLNFDLKVEVDLDALNFDKSHDWANYPKGVLKVLQDEGYDFSGFEIVFEGNIP
CCEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
NGAGLSSSASIELVTAVAVNEVFNLNIDRIKLVKLCQKAENTFVGVNCGIMDQFAVGMGK
CCCCCCCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCC
KDHAILLKSDTLEYSYVPLKLEGYKILITNTNKRRGLLDSKYNERRSECEKALSYLQKAL
CCCEEEEEECCCEEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
PVKNLSEITIEQFEEYKDLIPDEVLRKRAKHVITENKRVLDAVKALNDKDLIKFGELMVE
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHH
SHNSLRDDYEVTGKELDTLVEEALKLKGVIGSRMTGAGFGGCTVSIVKEDAVEEFIKVVT
HHHCCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
HNYTQKIGYRPTVYITGIGEGAGEIKY
HHHHHHCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MKTAVIEALEKFYGKNDAEIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRN
CCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHCCC
DKKVFMASLNFDLKVEVDLDALNFDKSHDWANYPKGVLKVLQDEGYDFSGFEIVFEGNIP
CCEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
NGAGLSSSASIELVTAVAVNEVFNLNIDRIKLVKLCQKAENTFVGVNCGIMDQFAVGMGK
CCCCCCCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCC
KDHAILLKSDTLEYSYVPLKLEGYKILITNTNKRRGLLDSKYNERRSECEKALSYLQKAL
CCCEEEEEECCCEEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
PVKNLSEITIEQFEEYKDLIPDEVLRKRAKHVITENKRVLDAVKALNDKDLIKFGELMVE
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHH
SHNSLRDDYEVTGKELDTLVEEALKLKGVIGSRMTGAGFGGCTVSIVKEDAVEEFIKVVT
HHHCCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
HNYTQKIGYRPTVYITGIGEGAGEIKY
HHHHHHCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]