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The map label for this gene is glpK [H]

Identifier: 167039670

GI number: 167039670

Start: 1049795

End: 1051288

Strand: Direct

Name: glpK [H]

Synonym: Teth514_1020

Alternate gene names: 167039670

Gene position: 1049795-1051288 (Clockwise)

Preceding gene: 167039669

Following gene: 167039671

Centisome position: 42.72

GC content: 38.69

Gene sequence:

>1494_bases
ATGGCAAAGTACATTATGGCTTTTGACCAGGGGACAACAAGTTCCCGTGCGATAATTTTTGACCATAGTGGGAAAATTGT
GGCTTCACAAAATCAAGAATTTAAGCAAATTTATCCTAAGGCAGGTTGGGTAGAACATGATCCAATGGAGATATGGGGTA
CACAAATAGGTGTTGCAAAAGGTGTTATAGAAAAAGCGGGTATTAATCCGGAGGATATTGCAGCTATTGGCATTACAAAT
CAGAGAGAGACAACTGTTGTATGGGATAAAAATACAGGAAAACCTATTTACAATGCAATAGTGTGGCAATGCAGAAGAAC
TGCTCCTATATGCGATGAACTAAAAAATAAAGGTTTTGACAAGAAAATTAGAGAAAAAACCGGACTTGTAGTAGATGCAT
ATTTTTCTGGTACTAAAATAAAATGGATTTTGGATAATGTTGAAGGAGCAAGAGAAAAAGCAGAAAAAGGAGAATTGCTT
TTTGGAAATATTGATACCTGGCTTATTTGGAATTTGACAAGGGGTAAGGTACACGTAACTGACTATTCTAATGCGTCAAG
GACGATGCTTTTTAATATCCATGAATTAAAATGGGATAAAGAGATATTAGAAGAACTTAATGTCCCAGAGCAAATGCTTC
CTGAAGTTAAGCCTTCCAGTTATGTATATGGCTATACTGATAAAAGTATATTTGGAGTAGAGATACCTATTGCCGGAGAT
GCGGGAGACCAGCAGGCAGCTTTGTTTGGTCAAGCCTGTTTCAAACCTGGGATGGCAAAAAACACCTATGGAACAGGCTG
CTTTATGCTCATGAATACTGGTGAAAAGGCTGTACCTTCCAATACTGGACTTCTCACTACAATCGCTTGGGGAATTGATG
GCAAAGTAGAATATGCCTTAGAGGGTAGTATATTTATAGCAGGTGCTGCGATACAGTGGCTGAGAGACGAGCTTAGAATA
ATTGACAATTCACCTCAAAGTGAGGAATATGCGCTGAAAGTTGAAGACACAAATGGTGTATATGTTGTTCCTGCTTTTGT
AGGATTAGGAGCCCCTTATTGGGATATGTATGCGAGAGGCACTATTGTAGGACTTACAAGAGGCGCAAAGAGAGAGCATA
TAATAAGGGCAACACTGGAGTCTATTGCTTATCAGACAAGAGATGTATTAGAGGCTATGCAAGAGGATTCAGGTATTAAA
TTGCAGGCTTTAAAAATTGACGGTGGAGCAAGTGCTAATAACTTCTTGATGCAATTCCAATCTGACATTTTAGGTGTTCC
AGTTGACAGGCCTCAAGTAATTGAAACTACTGCTCTTGGCGCTTCTTATCTTGCGGGATTGGCAGTAGGATTCTGGAACA
GCAAAGAAGAAATAGAGAAGAATTGGAATGTTGATAAACATTTTGAACCAGCTATGGATAATGAAAAGAGAGAAAAATTG
TATAAAGGTTGGAAAAAGGCTGTAGAAAGGGCTATGAAATGGGCTGAAGAATAA

Upstream 100 bases:

>100_bases
TTACCAACTTATTGTGAATATACATTAGTGAAAGAGCTTAAATCGGCGAGAGTTTTTCTCTCGCCGACAAATATAACAAA
AATTATGAGGGGGAAAAGAG

Downstream 100 bases:

>100_bases
AATAAAAAATTGATAAAAAGTAGCAGGAATTTTAAGATGTTTGTAGAATATATTTATTAAAGAGAAGAAAAAATAAATAT
GAGTATGGTGGAGATTTGGA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MAKYIMAFDQGTTSSRAIIFDHSGKIVASQNQEFKQIYPKAGWVEHDPMEIWGTQIGVAKGVIEKAGINPEDIAAIGITN
QRETTVVWDKNTGKPIYNAIVWQCRRTAPICDELKNKGFDKKIREKTGLVVDAYFSGTKIKWILDNVEGAREKAEKGELL
FGNIDTWLIWNLTRGKVHVTDYSNASRTMLFNIHELKWDKEILEELNVPEQMLPEVKPSSYVYGYTDKSIFGVEIPIAGD
AGDQQAALFGQACFKPGMAKNTYGTGCFMLMNTGEKAVPSNTGLLTTIAWGIDGKVEYALEGSIFIAGAAIQWLRDELRI
IDNSPQSEEYALKVEDTNGVYVVPAFVGLGAPYWDMYARGTIVGLTRGAKREHIIRATLESIAYQTRDVLEAMQEDSGIK
LQALKIDGGASANNFLMQFQSDILGVPVDRPQVIETTALGASYLAGLAVGFWNSKEEIEKNWNVDKHFEPAMDNEKREKL
YKGWKKAVERAMKWAEE

Sequences:

>Translated_497_residues
MAKYIMAFDQGTTSSRAIIFDHSGKIVASQNQEFKQIYPKAGWVEHDPMEIWGTQIGVAKGVIEKAGINPEDIAAIGITN
QRETTVVWDKNTGKPIYNAIVWQCRRTAPICDELKNKGFDKKIREKTGLVVDAYFSGTKIKWILDNVEGAREKAEKGELL
FGNIDTWLIWNLTRGKVHVTDYSNASRTMLFNIHELKWDKEILEELNVPEQMLPEVKPSSYVYGYTDKSIFGVEIPIAGD
AGDQQAALFGQACFKPGMAKNTYGTGCFMLMNTGEKAVPSNTGLLTTIAWGIDGKVEYALEGSIFIAGAAIQWLRDELRI
IDNSPQSEEYALKVEDTNGVYVVPAFVGLGAPYWDMYARGTIVGLTRGAKREHIIRATLESIAYQTRDVLEAMQEDSGIK
LQALKIDGGASANNFLMQFQSDILGVPVDRPQVIETTALGASYLAGLAVGFWNSKEEIEKNWNVDKHFEPAMDNEKREKL
YKGWKKAVERAMKWAEE
>Mature_496_residues
AKYIMAFDQGTTSSRAIIFDHSGKIVASQNQEFKQIYPKAGWVEHDPMEIWGTQIGVAKGVIEKAGINPEDIAAIGITNQ
RETTVVWDKNTGKPIYNAIVWQCRRTAPICDELKNKGFDKKIREKTGLVVDAYFSGTKIKWILDNVEGAREKAEKGELLF
GNIDTWLIWNLTRGKVHVTDYSNASRTMLFNIHELKWDKEILEELNVPEQMLPEVKPSSYVYGYTDKSIFGVEIPIAGDA
GDQQAALFGQACFKPGMAKNTYGTGCFMLMNTGEKAVPSNTGLLTTIAWGIDGKVEYALEGSIFIAGAAIQWLRDELRII
DNSPQSEEYALKVEDTNGVYVVPAFVGLGAPYWDMYARGTIVGLTRGAKREHIIRATLESIAYQTRDVLEAMQEDSGIKL
QALKIDGGASANNFLMQFQSDILGVPVDRPQVIETTALGASYLAGLAVGFWNSKEEIEKNWNVDKHFEPAMDNEKREKLY
KGWKKAVERAMKWAEE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=507, Percent_Identity=47.1400394477318, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI4504007, Length=507, Percent_Identity=47.1400394477318, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI42794763, Length=512, Percent_Identity=46.875, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI41393575, Length=501, Percent_Identity=45.9081836327345, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI88196792, Length=507, Percent_Identity=35.3057199211045, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI164663828, Length=159, Percent_Identity=32.0754716981132, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790361, Length=496, Percent_Identity=67.5403225806452, Blast_Score=711, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=502, Percent_Identity=25.8964143426295, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790005, Length=486, Percent_Identity=22.0164609053498, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1789168, Length=495, Percent_Identity=23.4343434343434, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789987, Length=496, Percent_Identity=22.1774193548387, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789138, Length=297, Percent_Identity=23.9057239057239, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17535599, Length=503, Percent_Identity=42.1471172962227, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71986140, Length=516, Percent_Identity=26.7441860465116, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71986147, Length=271, Percent_Identity=32.1033210332103, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321755, Length=550, Percent_Identity=37.4545454545455, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17864214, Length=505, Percent_Identity=44.950495049505, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24655555, Length=499, Percent_Identity=41.4829659318637, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24655560, Length=499, Percent_Identity=41.4829659318637, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24655570, Length=499, Percent_Identity=41.4829659318637, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24655574, Length=499, Percent_Identity=41.4829659318637, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24655565, Length=499, Percent_Identity=41.4829659318637, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24654573, Length=448, Percent_Identity=45.5357142857143, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19922058, Length=528, Percent_Identity=34.6590909090909, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24652871, Length=494, Percent_Identity=35.2226720647773, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24656367, Length=515, Percent_Identity=27.7669902912621, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI21357867, Length=529, Percent_Identity=26.6540642722117, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24656372, Length=361, Percent_Identity=29.3628808864266, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI45552909, Length=302, Percent_Identity=28.8079470198675, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55507; Mature: 55376

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYIMAFDQGTTSSRAIIFDHSGKIVASQNQEFKQIYPKAGWVEHDPMEIWGTQIGVAK
CCCEEEEECCCCCCCEEEEEECCCCEEECCCCHHHHHCCCCCCCCCCCHHHHCCHHHHHH
GVIEKAGINPEDIAAIGITNQRETTVVWDKNTGKPIYNAIVWQCRRTAPICDELKNKGFD
HHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHCCCCC
KKIREKTGLVVDAYFSGTKIKWILDNVEGAREKAEKGELLFGNIDTWLIWNLTRGKVHVT
HHHHHHCCEEEEEEECCCEEEEEEECCHHHHHHHHCCCEEEECCCEEEEEEEECCEEEEE
DYSNASRTMLFNIHELKWDKEILEELNVPEQMLPEVKPSSYVYGYTDKSIFGVEIPIAGD
ECCCCCCEEEEEEHHHCCCHHHHHHCCCCHHHCCCCCCCCEEEECCCCCEEEEEEEECCC
AGDQQAALFGQACFKPGMAKNTYGTGCFMLMNTGEKAVPSNTGLLTTIAWGIDGKVEYAL
CCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEE
EGSIFIAGAAIQWLRDELRIIDNSPQSEEYALKVEDTNGVYVVPAFVGLGAPYWDMYARG
CCCEEEEHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCEEEEEHHHHCCCCHHHHHHCC
TIVGLTRGAKREHIIRATLESIAYQTRDVLEAMQEDSGIKLQALKIDGGASANNFLMQFQ
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
SDILGVPVDRPQVIETTALGASYLAGLAVGFWNSKEEIEKNWNVDKHFEPAMDNEKREKL
HHHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHH
YKGWKKAVERAMKWAEE
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKYIMAFDQGTTSSRAIIFDHSGKIVASQNQEFKQIYPKAGWVEHDPMEIWGTQIGVAK
CCEEEEECCCCCCCEEEEEECCCCEEECCCCHHHHHCCCCCCCCCCCHHHHCCHHHHHH
GVIEKAGINPEDIAAIGITNQRETTVVWDKNTGKPIYNAIVWQCRRTAPICDELKNKGFD
HHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHCCCCC
KKIREKTGLVVDAYFSGTKIKWILDNVEGAREKAEKGELLFGNIDTWLIWNLTRGKVHVT
HHHHHHCCEEEEEEECCCEEEEEEECCHHHHHHHHCCCEEEECCCEEEEEEEECCEEEEE
DYSNASRTMLFNIHELKWDKEILEELNVPEQMLPEVKPSSYVYGYTDKSIFGVEIPIAGD
ECCCCCCEEEEEEHHHCCCHHHHHHCCCCHHHCCCCCCCCEEEECCCCCEEEEEEEECCC
AGDQQAALFGQACFKPGMAKNTYGTGCFMLMNTGEKAVPSNTGLLTTIAWGIDGKVEYAL
CCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEE
EGSIFIAGAAIQWLRDELRIIDNSPQSEEYALKVEDTNGVYVVPAFVGLGAPYWDMYARG
CCCEEEEHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCEEEEEHHHHCCCCHHHHHHCC
TIVGLTRGAKREHIIRATLESIAYQTRDVLEAMQEDSGIKLQALKIDGGASANNFLMQFQ
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
SDILGVPVDRPQVIETTALGASYLAGLAVGFWNSKEEIEKNWNVDKHFEPAMDNEKREKL
HHHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHH
YKGWKKAVERAMKWAEE
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA