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The map label for this gene is ldh [H]

Identifier: 167039590

GI number: 167039590

Start: 960699

End: 961766

Strand: Direct

Name: ldh [H]

Synonym: Teth514_0938

Alternate gene names: 167039590

Gene position: 960699-961766 (Clockwise)

Preceding gene: 167039589

Following gene: 167039591

Centisome position: 39.1

GC content: 38.11

Gene sequence:

>1068_bases
ATGAAAATATTTGACATAATGGAAACTAAAGATTATGAAAATGTGATTTTATGCCATGACAAGACTTCAGGTCTTAAGGC
GATAATTGCAATTCATGACACAACTTTAGGTCCTGCTTTAGGCGGATGTAGGATGTGGACTTATGACTCAGAAGAGGATG
CAATAAACGATGCATTAAGGCTTGCAAGGGGAATGACTTACAAAAATGCTGCTGCTGGTTTAAACTTAGGTGGTGGCAAA
ACAGTTGTAATTGGAAATCCGAGAAAAGACAAATCAGAAGCATTGTTTAGAAGTCTTGGAAGGTATATAGAGTCCCTTAA
AGGAAGATATATAACTGCTGAGGACGTGGGAACAAACTTAAAAGATATGGAATATATACGTTATGAGACAAAATACGTTG
CAGGGCTGGCTGAAACCAGTGGTGACCCATCTCCTTTTACAGCATATGGGGTATTTAGAGGAATACAAGCAGCAAGCGAA
GAAGTTTTTGGTACTTCAGATCTTAAAGGCATGAGAATTGCAATACAAGGAGTAGGAAATGTAGGATACAATTTAGCAAA
GCACCTATATGAAGCAGGAGCAAAGCTAATTGTGACAGACATATTTGAGGACAATGTAAAAAGAGCAGTGGAAGAATTCA
AAGCCGAATATGTAAAACCAGATGAGATATACGGAGTAGAGTGTGACATATTTGCGCCTTGTGCTTTAGGAGCGATAATA
AACGATGAGACAATTCCACAGCTTAAGTGCAAGATAGTAGCAGGTTCAGCTAATAACCAGTTAAAAGAAGAAAGGCATGG
AGACATACTGCAGGAGAAAGGGATACTCTATGTTCCGGATTATATCATAAATGCGGGTGGAGTTATAAATGTAGCTGATG
AGCTCAATCCTTCTGGTTATAACAGAGATAGGGCTATGAGAAAGGTTTCAATGATATTTGATACAGTGAAAAAGGTGATA
CAGAAGTCCAAAGAAGAGAACATTCCGACATATGTTGCAGCTGACAGAGTTGCGGAAGAGAGGATAAAAACTATTGCTGC
CGTAAAAGACAATTATATTGTTAAATAA

Upstream 100 bases:

>100_bases
TTGACTTCAAGGGCAGACTCCAGTGAAGCTAAATTTAACTCTATAATGTTGGCATCTCTTGCTTCTAATGTTTGATTATT
AAAGAGGGGGGAAGATATTT

Downstream 100 bases:

>100_bases
TGAGCAGGATCTTCCTGCTCATTCCTTAAAATTTTGAAATAACATTAATAAATTTTTGAAAAAACTTTAATGTAAAAACG
AAGTGTAATATAATATAAAT

Product: Glu/Leu/Phe/Val dehydrogenase, C terminal

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKIFDIMETKDYENVILCHDKTSGLKAIIAIHDTTLGPALGGCRMWTYDSEEDAINDALRLARGMTYKNAAAGLNLGGGK
TVVIGNPRKDKSEALFRSLGRYIESLKGRYITAEDVGTNLKDMEYIRYETKYVAGLAETSGDPSPFTAYGVFRGIQAASE
EVFGTSDLKGMRIAIQGVGNVGYNLAKHLYEAGAKLIVTDIFEDNVKRAVEEFKAEYVKPDEIYGVECDIFAPCALGAII
NDETIPQLKCKIVAGSANNQLKEERHGDILQEKGILYVPDYIINAGGVINVADELNPSGYNRDRAMRKVSMIFDTVKKVI
QKSKEENIPTYVAADRVAEERIKTIAAVKDNYIVK

Sequences:

>Translated_355_residues
MKIFDIMETKDYENVILCHDKTSGLKAIIAIHDTTLGPALGGCRMWTYDSEEDAINDALRLARGMTYKNAAAGLNLGGGK
TVVIGNPRKDKSEALFRSLGRYIESLKGRYITAEDVGTNLKDMEYIRYETKYVAGLAETSGDPSPFTAYGVFRGIQAASE
EVFGTSDLKGMRIAIQGVGNVGYNLAKHLYEAGAKLIVTDIFEDNVKRAVEEFKAEYVKPDEIYGVECDIFAPCALGAII
NDETIPQLKCKIVAGSANNQLKEERHGDILQEKGILYVPDYIINAGGVINVADELNPSGYNRDRAMRKVSMIFDTVKKVI
QKSKEENIPTYVAADRVAEERIKTIAAVKDNYIVK
>Mature_355_residues
MKIFDIMETKDYENVILCHDKTSGLKAIIAIHDTTLGPALGGCRMWTYDSEEDAINDALRLARGMTYKNAAAGLNLGGGK
TVVIGNPRKDKSEALFRSLGRYIESLKGRYITAEDVGTNLKDMEYIRYETKYVAGLAETSGDPSPFTAYGVFRGIQAASE
EVFGTSDLKGMRIAIQGVGNVGYNLAKHLYEAGAKLIVTDIFEDNVKRAVEEFKAEYVKPDEIYGVECDIFAPCALGAII
NDETIPQLKCKIVAGSANNQLKEERHGDILQEKGILYVPDYIINAGGVINVADELNPSGYNRDRAMRKVSMIFDTVKKVI
QKSKEENIPTYVAADRVAEERIKTIAAVKDNYIVK

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=304, Percent_Identity=27.9605263157895, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4885281, Length=304, Percent_Identity=27.3026315789474, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45553475, Length=306, Percent_Identity=28.1045751633987, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45549226, Length=306, Percent_Identity=28.1045751633987, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24649283, Length=298, Percent_Identity=27.5167785234899, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24649460, Length=270, Percent_Identity=27.4074074074074, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 39147; Mature: 39147

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFDIMETKDYENVILCHDKTSGLKAIIAIHDTTLGPALGGCRMWTYDSEEDAINDALR
CCCEECCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHH
LARGMTYKNAAAGLNLGGGKTVVIGNPRKDKSEALFRSLGRYIESLKGRYITAEDVGTNL
HHHCCCCCHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHCCCH
KDMEYIRYETKYVAGLAETSGDPSPFTAYGVFRGIQAASEEVFGTSDLKGMRIAIQGVGN
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
VGYNLAKHLYEAGAKLIVTDIFEDNVKRAVEEFKAEYVKPDEIYGVECDIFAPCALGAII
CHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEECCEECEECHHHHHHHC
NDETIPQLKCKIVAGSANNQLKEERHGDILQEKGILYVPDYIINAGGVINVADELNPSGY
CCCCCCCEEEEEEECCCCCHHHHHHCCCHHHHCCCEEECHHHCCCCCEEEEHHHCCCCCC
NRDRAMRKVSMIFDTVKKVIQKSKEENIPTYVAADRVAEERIKTIAAVKDNYIVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKIFDIMETKDYENVILCHDKTSGLKAIIAIHDTTLGPALGGCRMWTYDSEEDAINDALR
CCCEECCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHH
LARGMTYKNAAAGLNLGGGKTVVIGNPRKDKSEALFRSLGRYIESLKGRYITAEDVGTNL
HHHCCCCCHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHCCCH
KDMEYIRYETKYVAGLAETSGDPSPFTAYGVFRGIQAASEEVFGTSDLKGMRIAIQGVGN
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
VGYNLAKHLYEAGAKLIVTDIFEDNVKRAVEEFKAEYVKPDEIYGVECDIFAPCALGAII
CHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEECCEECEECHHHHHHHC
NDETIPQLKCKIVAGSANNQLKEERHGDILQEKGILYVPDYIINAGGVINVADELNPSGY
CCCCCCCEEEEEEECCCCCHHHHHHCCCHHHHCCCEEECHHHCCCCCEEEEHHHCCCCCC
NRDRAMRKVSMIFDTVKKVIQKSKEENIPTYVAADRVAEERIKTIAAVKDNYIVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9188201 [H]