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The map label for this gene is cysS

Identifier: 167039500

GI number: 167039500

Start: 883709

End: 885109

Strand: Direct

Name: cysS

Synonym: Teth514_0846

Alternate gene names: 167039500

Gene position: 883709-885109 (Clockwise)

Preceding gene: 167039499

Following gene: 167039501

Centisome position: 35.96

GC content: 32.98

Gene sequence:

>1401_bases
ATGAAGCTGTATAATACTCTTTCAAGGACAAAAGAAGAATTTGAACCTTTAAATGATAAGATAGTGAACATGTATGTTTG
TGGACCTACTGTATATAATTACATCCACATAGGAAATGCAAGGGCTTTTATTGTATTTGATACAGTGAGAAGATATTTAG
AATATAAAGGTTATAAAGTAAATTACGTTCAAAATTTTACTGATATTGACGATAAAATAATTAAAAGAGCCCAAGAAGAA
AATGTTACTACAAAAGAAGTAGCGGAAAAATATATAGAAGAATATTTTATAGATGCAGATAATTTGGGTATAAAAAGAGC
AACAGTTCATCCTAAAGCGACAGAGCATATAGAAGATATAATCGAATTTATAAAGATTTTAATCGACAAAGGATATGCTT
ATGTGGTAAATGGAAATGTTTATTTTGAAACTGCGAAATTTAAGGATTATGGAAAGCTTTCTCACAAAAATATAGAAGAA
TTGCAAGCAGGGGCAAGAATTGAGATAAACGAAGAAAAGAAAAATCCATTGGATTTTGTTCTCTGGAAAGCTCAAAAGCC
CGGTGAACCTGCATGGGATAGTCCCTGGGGAAAGGGAAGACCAGGATGGCATATAGAATGCTCTGTTATGTCTACGAAAT
ATTTGGGGAAAACTTTAGATATCCACGCAGGAGGTCCTGATTTGGTATTCCCTCATCATGAGAACGAAATTGCTCAGAGC
GAAGCAGCATATGGTCAACCGTTTTCCAAATATTGGATGCACATAGGGTATTTAAATATAAACAATGAAAAGATGTCAAA
ATCTAAAGGGAATTTCTTTACAGTAAGAGAAATAACAGAGAAATACAATCCTGAAGTTTTAAGACTTTTTATGCTTATGG
CTCACTACAGAAGTCCCATTAATTTTAGTTTAGATTTAATGGAGCAGGCTAAGTCCGCTTATGAAAGATTGTTAAATGCG
GTGGCCAATTTAAAACATTTGCTTACTGTGTGCAAAGACAGGGAATTAAACGAAGAAGAAAAGAGAATAAAGGAAAAGTT
TGAAGAATATAAAAAGGAATTTGAAGATGCAATGGATGACGATTTTAACACTGCGGATGCCATATCGGTTTTGTTTGAAA
TGTCAAAAACTGCCAATACAAATATCAGTGGAAATTCTTCGAAGAAATTGGTAGAATATATTTTAGATATATTTTTAAAA
CTCTCAGAAATTTTAGGACTTTCTTACAGAGGCGTGGAGACTGAGCTCAATGATGAAGAAATACTTGCTTTAATAGAAGA
AAGGCAAAAAGCAAGAAAAGAAAAGAATTGGAAGTTAGCTGATGAAATAAGAGATAGACTGAGAGAAAAAGGAATAATTT
TGGAAGACACACCAGAGGGAGTAAGATGGAAAAGAGTATGA

Upstream 100 bases:

>100_bases
CATGGTAAACTTCCTGACCCTGTGGAAGAGGAATTGCAAAAATTGAGAAAGAGGATTGAGAGGTTAGAGCAAATTTTAAT
TGAAAGGAAGGGAGAGAAAG

Downstream 100 bases:

>100_bases
TGGGGTTTTTGGAAAATACAGAGTTACTTACGAAGGAGGGGGTGTTAAGTTTATCCCCCCTTGTTTTAGCTTTTATTGGA
GATGCTGTGTATAGTTTATA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKLYNTLSRTKEEFEPLNDKIVNMYVCGPTVYNYIHIGNARAFIVFDTVRRYLEYKGYKVNYVQNFTDIDDKIIKRAQEE
NVTTKEVAEKYIEEYFIDADNLGIKRATVHPKATEHIEDIIEFIKILIDKGYAYVVNGNVYFETAKFKDYGKLSHKNIEE
LQAGARIEINEEKKNPLDFVLWKAQKPGEPAWDSPWGKGRPGWHIECSVMSTKYLGKTLDIHAGGPDLVFPHHENEIAQS
EAAYGQPFSKYWMHIGYLNINNEKMSKSKGNFFTVREITEKYNPEVLRLFMLMAHYRSPINFSLDLMEQAKSAYERLLNA
VANLKHLLTVCKDRELNEEEKRIKEKFEEYKKEFEDAMDDDFNTADAISVLFEMSKTANTNISGNSSKKLVEYILDIFLK
LSEILGLSYRGVETELNDEEILALIEERQKARKEKNWKLADEIRDRLREKGIILEDTPEGVRWKRV

Sequences:

>Translated_466_residues
MKLYNTLSRTKEEFEPLNDKIVNMYVCGPTVYNYIHIGNARAFIVFDTVRRYLEYKGYKVNYVQNFTDIDDKIIKRAQEE
NVTTKEVAEKYIEEYFIDADNLGIKRATVHPKATEHIEDIIEFIKILIDKGYAYVVNGNVYFETAKFKDYGKLSHKNIEE
LQAGARIEINEEKKNPLDFVLWKAQKPGEPAWDSPWGKGRPGWHIECSVMSTKYLGKTLDIHAGGPDLVFPHHENEIAQS
EAAYGQPFSKYWMHIGYLNINNEKMSKSKGNFFTVREITEKYNPEVLRLFMLMAHYRSPINFSLDLMEQAKSAYERLLNA
VANLKHLLTVCKDRELNEEEKRIKEKFEEYKKEFEDAMDDDFNTADAISVLFEMSKTANTNISGNSSKKLVEYILDIFLK
LSEILGLSYRGVETELNDEEILALIEERQKARKEKNWKLADEIRDRLREKGIILEDTPEGVRWKRV
>Mature_466_residues
MKLYNTLSRTKEEFEPLNDKIVNMYVCGPTVYNYIHIGNARAFIVFDTVRRYLEYKGYKVNYVQNFTDIDDKIIKRAQEE
NVTTKEVAEKYIEEYFIDADNLGIKRATVHPKATEHIEDIIEFIKILIDKGYAYVVNGNVYFETAKFKDYGKLSHKNIEE
LQAGARIEINEEKKNPLDFVLWKAQKPGEPAWDSPWGKGRPGWHIECSVMSTKYLGKTLDIHAGGPDLVFPHHENEIAQS
EAAYGQPFSKYWMHIGYLNINNEKMSKSKGNFFTVREITEKYNPEVLRLFMLMAHYRSPINFSLDLMEQAKSAYERLLNA
VANLKHLLTVCKDRELNEEEKRIKEKFEEYKKEFEDAMDDDFNTADAISVLFEMSKTANTNISGNSSKKLVEYILDIFLK
LSEILGLSYRGVETELNDEEILALIEERQKARKEKNWKLADEIRDRLREKGIILEDTPEGVRWKRV

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=482, Percent_Identity=34.4398340248963, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI303304987, Length=411, Percent_Identity=35.036496350365, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI21269877, Length=411, Percent_Identity=35.036496350365, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI62240992, Length=411, Percent_Identity=35.036496350365, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI10835051, Length=411, Percent_Identity=35.036496350365, Blast_Score=222, Evalue=7e-58,
Organism=Escherichia coli, GI1786737, Length=475, Percent_Identity=46.3157894736842, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17509795, Length=331, Percent_Identity=35.9516616314199, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17509797, Length=331, Percent_Identity=35.9516616314199, Blast_Score=199, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324082, Length=331, Percent_Identity=36.5558912386707, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI19922218, Length=505, Percent_Identity=35.6435643564356, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI19922364, Length=363, Percent_Identity=36.6391184573003, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_THEP3 (B0KCH9)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664358.1
- ProteinModelPortal:   B0KCH9
- SMR:   B0KCH9
- GeneID:   5874203
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0353
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- ProtClustDB:   PRK00260
- BioCyc:   TPSE340099:TETH39_0353-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 54431; Mature: 54431

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNTLSRTKEEFEPLNDKIVNMYVCGPTVYNYIHIGNARAFIVFDTVRRYLEYKGYKV
CCCHHHHHHHHHHHCCCCCEEEEEEEECCHHEEEEEECCCEEEEEHHHHHHHHHHCCCEE
NYVQNFTDIDDKIIKRAQEENVTTKEVAEKYIEEYFIDADNLGIKRATVHPKATEHIEDI
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHH
IEFIKILIDKGYAYVVNGNVYFETAKFKDYGKLSHKNIEELQAGARIEINEEKKNPLDFV
HHHHHHHHCCCEEEEEECEEEEEECCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCEEE
LWKAQKPGEPAWDSPWGKGRPGWHIECSVMSTKYLGKTLDIHAGGPDLVFPHHENEIAQS
EEECCCCCCCCCCCCCCCCCCCCEEEEEEECHHHCCCEEEEECCCCCEECCCCCCHHHHH
EAAYGQPFSKYWMHIGYLNINNEKMSKSKGNFFTVREITEKYNPEVLRLFMLMAHYRSPI
HHHCCCCHHHHHHEEEEEEECCHHHHCCCCCEEEHHHHHHHHCHHHHHHHHHHHHHCCCC
NFSLDLMEQAKSAYERLLNAVANLKHLLTVCKDRELNEEEKRIKEKFEEYKKEFEDAMDD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DFNTADAISVLFEMSKTANTNISGNSSKKLVEYILDIFLKLSEILGLSYRGVETELNDEE
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ILALIEERQKARKEKNWKLADEIRDRLREKGIILEDTPEGVRWKRV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCEECCC
>Mature Secondary Structure
MKLYNTLSRTKEEFEPLNDKIVNMYVCGPTVYNYIHIGNARAFIVFDTVRRYLEYKGYKV
CCCHHHHHHHHHHHCCCCCEEEEEEEECCHHEEEEEECCCEEEEEHHHHHHHHHHCCCEE
NYVQNFTDIDDKIIKRAQEENVTTKEVAEKYIEEYFIDADNLGIKRATVHPKATEHIEDI
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHH
IEFIKILIDKGYAYVVNGNVYFETAKFKDYGKLSHKNIEELQAGARIEINEEKKNPLDFV
HHHHHHHHCCCEEEEEECEEEEEECCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCEEE
LWKAQKPGEPAWDSPWGKGRPGWHIECSVMSTKYLGKTLDIHAGGPDLVFPHHENEIAQS
EEECCCCCCCCCCCCCCCCCCCCEEEEEEECHHHCCCEEEEECCCCCEECCCCCCHHHHH
EAAYGQPFSKYWMHIGYLNINNEKMSKSKGNFFTVREITEKYNPEVLRLFMLMAHYRSPI
HHHCCCCHHHHHHEEEEEEECCHHHHCCCCCEEEHHHHHHHHCHHHHHHHHHHHHHCCCC
NFSLDLMEQAKSAYERLLNAVANLKHLLTVCKDRELNEEEKRIKEKFEEYKKEFEDAMDD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
DFNTADAISVLFEMSKTANTNISGNSSKKLVEYILDIFLKLSEILGLSYRGVETELNDEE
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ILALIEERQKARKEKNWKLADEIRDRLREKGIILEDTPEGVRWKRV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA