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The map label for this gene is ispD [H]

Identifier: 167039493

GI number: 167039493

Start: 876734

End: 877417

Strand: Direct

Name: ispD [H]

Synonym: Teth514_0839

Alternate gene names: 167039493

Gene position: 876734-877417 (Clockwise)

Preceding gene: 167039492

Following gene: 167039494

Centisome position: 35.68

GC content: 33.04

Gene sequence:

>684_bases
ATGAATGTAAGTGCGGTAATAGTGGCGGCAGGTAAGGGCATTAGAATGGGTCACACAGTAAATAAAGTATACCTTCCTAT
AGCAGGTAAACCAGTTTTGTATTATTCTCTCAAAGCCTTTGATGAAATTGATTGGATTAAGGAAATTGTTGTTGTTGTAT
CAAAGGAAGAAATGGAATATTGCCAAGAAAATGTAGTAAAAAAGTATTTTTTCAAAAAACCAATTAAATTAGTAGAAGGA
GGTAGTGAAAGGCAGTATTCTGTTTATAATGGAATTATAAATACAGAGGGAGATTGCGAAATTATAGCAATTCATGATGG
AGCAAGGCCTTTAATTGAGAAAGAAATAGTTATAAAAGCTTTAAAAGAAGCTTATTTGCATAAAGCAGTAGCATTGGGAG
TGCCTGTCAAAGACACTATAAAAGTAGTTGATGGGAAAAATTTTATTTTAAATACCCCTGATAGAAAATATTTATGGGCA
ATTCAAACCCCTCAGGTATTTGAAAGGAATTTGATTATTAAAGCTCATCAAAGGGCACTGGAGGATGGTTTTTTAGGGAC
AGATGACACAGTATTAGTGGAGAGATTGGGTTATAAAGTGAAAGTAGTTGAAGGAGACTATAGAAATATAAAGATTACTA
CGCCAGAGGATTTGATTGTGGCAGAAGCTTTTTTAAAAAAATAA

Upstream 100 bases:

>100_bases
ACAAGAAAAGGCTATATGAAAAACGCAGGGAAACCTGTGTTTTTTTATGTGGAAATGATATAATTGGAGTGTGCATTATT
TTACTTGTGAGGTAGAGAAA

Downstream 100 bases:

>100_bases
CGTTTTTTGCGAATCCTCATATAATTTAATAGAGAATTCTCTATTAAGTTATATGAGGGTGATTTTATGGATAACCCTGT
AGTTTTTGTACACGGGATAT

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MNVSAVIVAAGKGIRMGHTVNKVYLPIAGKPVLYYSLKAFDEIDWIKEIVVVVSKEEMEYCQENVVKKYFFKKPIKLVEG
GSERQYSVYNGIINTEGDCEIIAIHDGARPLIEKEIVIKALKEAYLHKAVALGVPVKDTIKVVDGKNFILNTPDRKYLWA
IQTPQVFERNLIIKAHQRALEDGFLGTDDTVLVERLGYKVKVVEGDYRNIKITTPEDLIVAEAFLKK

Sequences:

>Translated_227_residues
MNVSAVIVAAGKGIRMGHTVNKVYLPIAGKPVLYYSLKAFDEIDWIKEIVVVVSKEEMEYCQENVVKKYFFKKPIKLVEG
GSERQYSVYNGIINTEGDCEIIAIHDGARPLIEKEIVIKALKEAYLHKAVALGVPVKDTIKVVDGKNFILNTPDRKYLWA
IQTPQVFERNLIIKAHQRALEDGFLGTDDTVLVERLGYKVKVVEGDYRNIKITTPEDLIVAEAFLKK
>Mature_227_residues
MNVSAVIVAAGKGIRMGHTVNKVYLPIAGKPVLYYSLKAFDEIDWIKEIVVVVSKEEMEYCQENVVKKYFFKKPIKLVEG
GSERQYSVYNGIINTEGDCEIIAIHDGARPLIEKEIVIKALKEAYLHKAVALGVPVKDTIKVVDGKNFILNTPDRKYLWA
IQTPQVFERNLIIKAHQRALEDGFLGTDDTVLVERLGYKVKVVEGDYRNIKITTPEDLIVAEAFLKK

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=235, Percent_Identity=32.7659574468085, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI157671913, Length=133, Percent_Identity=37.593984962406, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1789104, Length=230, Percent_Identity=35.6521739130435, Blast_Score=132, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25638; Mature: 25638

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSAVIVAAGKGIRMGHTVNKVYLPIAGKPVLYYSLKAFDEIDWIKEIVVVVSKEEMEY
CCCEEEEEECCCCEEECCEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHCHHHHHH
CQENVVKKYFFKKPIKLVEGGSERQYSVYNGIINTEGDCEIIAIHDGARPLIEKEIVIKA
HHHHHHHHHHHHCCHHHHCCCCCCEEEEECCEECCCCCEEEEEEECCCCCHHHHHHHHHH
LKEAYLHKAVALGVPVKDTIKVVDGKNFILNTPDRKYLWAIQTPQVFERNLIIKAHQRAL
HHHHHHHHHHHCCCCCHHHEEEECCCEEEEECCCCEEEEEECCCHHHHCCEEEHHHHHHH
EDGFLGTDDTVLVERLGYKVKVVEGDYRNIKITTPEDLIVAEAFLKK
HCCCCCCCCHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MNVSAVIVAAGKGIRMGHTVNKVYLPIAGKPVLYYSLKAFDEIDWIKEIVVVVSKEEMEY
CCCEEEEEECCCCEEECCEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHCHHHHHH
CQENVVKKYFFKKPIKLVEGGSERQYSVYNGIINTEGDCEIIAIHDGARPLIEKEIVIKA
HHHHHHHHHHHHCCHHHHCCCCCCEEEEECCEECCCCCEEEEEEECCCCCHHHHHHHHHH
LKEAYLHKAVALGVPVKDTIKVVDGKNFILNTPDRKYLWAIQTPQVFERNLIIKAHQRAL
HHHHHHHHHHHCCCCCHHHEEEECCCEEEEECCCCEEEEEECCCHHHHCCEEEHHHHHHH
EDGFLGTDDTVLVERLGYKVKVVEGDYRNIKITTPEDLIVAEAFLKK
HCCCCCCCCHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]