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The map label for this gene is pth [H]

Identifier: 167039250

GI number: 167039250

Start: 614039

End: 614593

Strand: Direct

Name: pth [H]

Synonym: Teth514_0591

Alternate gene names: 167039250

Gene position: 614039-614593 (Clockwise)

Preceding gene: 167039249

Following gene: 167039251

Centisome position: 24.99

GC content: 31.71

Gene sequence:

>555_bases
ATGTACGTAATTGCAGGTTTAGGAAATCCTGGTAGAGAATATGAAGGAACGAGACATAATGTAGGATTTATGGTAATAGA
TGAATTGGCAAAAAAATTAGGTATGAATGTCACAAAATTAAAATTTAAATCCCTTGTGGGTGAAGGGAATTTTAAAGGAG
AGAAAATAATTCTTTTAAAGCCTCAGACATTTATGAATTCAAGTGGTGAAGCTTTATACGATGCTGTAAATTTTTATAAA
ATTCCACTTGAAAATGTAATTGTGATTTATGACGATAAAGACTTGGATTTGGGCAAAATAAGGATAAGAAAAAAAGGAAG
TTCAGGCGGTCACAATGGAATGAATTCTATCATATATCTTTTAAATAGCGAAGAATTTCCACGAGTTAGAATAGGAATTG
GAAAACCGCAAAAGGATTTAGTAAGTCATGTATTAGGAAAGTTTGAAGAGTCAGAGAAAAAACTAATTGATGAAGCTGTT
ATAAAAGCAGCAGATGCGGTGATAGATATTATAGAAAATGGGATAGAACATGCTATGAGCAAATTTAACGGTTGA

Upstream 100 bases:

>100_bases
ATAAAACCGGCCAGTGATTTTACTGGTCGGTATTTTGTGTACTCTATAGCTTTTTTTTGTTTAATTATGTATAATTAATT
TGATAAGGAAGGGTGGTCGT

Downstream 100 bases:

>100_bases
TAAAAAGGCAATAAAGGAGAAAAATGAATACATGTGGCTATTATCTGGAATTGGTGGTGTAATTTTAGCATATTTTCTAA
ATAGGATGGCAGTAACTAAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MYVIAGLGNPGREYEGTRHNVGFMVIDELAKKLGMNVTKLKFKSLVGEGNFKGEKIILLKPQTFMNSSGEALYDAVNFYK
IPLENVIVIYDDKDLDLGKIRIRKKGSSGGHNGMNSIIYLLNSEEFPRVRIGIGKPQKDLVSHVLGKFEESEKKLIDEAV
IKAADAVIDIIENGIEHAMSKFNG

Sequences:

>Translated_184_residues
MYVIAGLGNPGREYEGTRHNVGFMVIDELAKKLGMNVTKLKFKSLVGEGNFKGEKIILLKPQTFMNSSGEALYDAVNFYK
IPLENVIVIYDDKDLDLGKIRIRKKGSSGGHNGMNSIIYLLNSEEFPRVRIGIGKPQKDLVSHVLGKFEESEKKLIDEAV
IKAADAVIDIIENGIEHAMSKFNG
>Mature_184_residues
MYVIAGLGNPGREYEGTRHNVGFMVIDELAKKLGMNVTKLKFKSLVGEGNFKGEKIILLKPQTFMNSSGEALYDAVNFYK
IPLENVIVIYDDKDLDLGKIRIRKKGSSGGHNGMNSIIYLLNSEEFPRVRIGIGKPQKDLVSHVLGKFEESEKKLIDEAV
IKAADAVIDIIENGIEHAMSKFNG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=176, Percent_Identity=34.0909090909091, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI1787455, Length=186, Percent_Identity=39.247311827957, Blast_Score=105, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321983, Length=183, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20414; Mature: 20414

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVIAGLGNPGREYEGTRHNVGFMVIDELAKKLGMNVTKLKFKSLVGEGNFKGEKIILLK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEC
PQTFMNSSGEALYDAVNFYKIPLENVIVIYDDKDLDLGKIRIRKKGSSGGHNGMNSIIYL
CHHHHCCCCHHHHHHHHHEEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEEE
LNSEEFPRVRIGIGKPQKDLVSHVLGKFEESEKKLIDEAVIKAADAVIDIIENGIEHAMS
ECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFNG
HCCC
>Mature Secondary Structure
MYVIAGLGNPGREYEGTRHNVGFMVIDELAKKLGMNVTKLKFKSLVGEGNFKGEKIILLK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEC
PQTFMNSSGEALYDAVNFYKIPLENVIVIYDDKDLDLGKIRIRKKGSSGGHNGMNSIIYL
CHHHHCCCCHHHHHHHHHEEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEEE
LNSEEFPRVRIGIGKPQKDLVSHVLGKFEESEKKLIDEAVIKAADAVIDIIENGIEHAMS
ECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFNG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA