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The map label for this gene is prs [H]

Identifier: 167039246

GI number: 167039246

Start: 609183

End: 610133

Strand: Direct

Name: prs [H]

Synonym: Teth514_0587

Alternate gene names: 167039246

Gene position: 609183-610133 (Clockwise)

Preceding gene: 167039245

Following gene: 167039247

Centisome position: 24.79

GC content: 38.7

Gene sequence:

>951_bases
ATGGTAAGATATAATAGTTCTCTAAAAATTTTTTCAGGAAATTCAAATCCTAAGTTAGCCAGTGAAATAGCAGAACATCT
TGGACTTAAACTTTGTGATTCAGAAGTAGGGACTTTTAGTGATGGAGAGATAAGTGTAAGGATTGGAGAAAGTGTAAGAG
GTGCAAGCGTTTTTGTAATACAGTCAACTTGTGCGCCTGTTAACAACAACTTAATGGAATTATTGATAATGATTGATGCT
TTTAAAAGGGCATCTGCGGCTGAAATTAATGCAGTTATACCCTACTATGGTTATGCAAGACAAGACAGAAAAGCAAAGGC
GAGGGACCCAATTACTGCAAAGCTTGTAGCTGACCTTATAACTGCAGCAGGAGCCCATAGAGTTGTTACAATGGACCTTC
ATGCTCCACAAATACAAGGGTATTTTAATATTCCTGTAGACCATCTTTTAGGAGGACCAATACTTGCGAAATATTTTCTT
GACAAGGAATTGGGAAATGATGTAGTAGTTGTTTCCCCTGACCATGGCAGTGTGACAAGAGCGAGGTATTTTGCAGAAAA
ATTGAATGCTCCTCTTGCTATTATTGACAAAAGAAGGCCAAAAGCTAATGTAGCAGAGATAATGAATATAATAGGTGATG
TAAGAGGGAAAAAGGCTATTTTGGTAGATGACCTTATTGATACCGCTGGTACTTTGGTACAAGGGGCGGAGGCTCTTCTT
GACAGTGGTGCTACTGAAGTTTATGCTTGCGCGACTCATGGGGTGTTGTCAGGCCCTGCGATTGAAAGGCTTAAGGAATC
ACCAATAAAAGAATTGGTTATAACCGATACAATCCCTCTTCCCGAAGAGAAAAAAATTGACAAAATTAAAGTGAGGTCTG
TAGCTCCTTTATTTGCAGAAGCGATTTTGAGAATCCATGAAGGAATGTCTGTAAGTAAATTGTTTGTATAG

Upstream 100 bases:

>100_bases
AGAATGTTCCTGAAGGAGCCCTTGCCATAGCCAGAAATAGGCAAACTAATAAAGAGGGCTGGGTACAGGAAAGAATAAAA
AAAGGGAGGCTTTAAATTAA

Downstream 100 bases:

>100_bases
GCACTTTATGTGCCTTTTTTATATTATTTAAAATTTTATTATGATATAATTTAAGCAAGGAAACTTGAAGTAGAGGGTGA
TTTTGTGGGAGATAACCGAA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MVRYNSSLKIFSGNSNPKLASEIAEHLGLKLCDSEVGTFSDGEISVRIGESVRGASVFVIQSTCAPVNNNLMELLIMIDA
FKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLITAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFL
DKELGNDVVVVSPDHGSVTRARYFAEKLNAPLAIIDKRRPKANVAEIMNIIGDVRGKKAILVDDLIDTAGTLVQGAEALL
DSGATEVYACATHGVLSGPAIERLKESPIKELVITDTIPLPEEKKIDKIKVRSVAPLFAEAILRIHEGMSVSKLFV

Sequences:

>Translated_316_residues
MVRYNSSLKIFSGNSNPKLASEIAEHLGLKLCDSEVGTFSDGEISVRIGESVRGASVFVIQSTCAPVNNNLMELLIMIDA
FKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLITAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFL
DKELGNDVVVVSPDHGSVTRARYFAEKLNAPLAIIDKRRPKANVAEIMNIIGDVRGKKAILVDDLIDTAGTLVQGAEALL
DSGATEVYACATHGVLSGPAIERLKESPIKELVITDTIPLPEEKKIDKIKVRSVAPLFAEAILRIHEGMSVSKLFV
>Mature_316_residues
MVRYNSSLKIFSGNSNPKLASEIAEHLGLKLCDSEVGTFSDGEISVRIGESVRGASVFVIQSTCAPVNNNLMELLIMIDA
FKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLITAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFL
DKELGNDVVVVSPDHGSVTRARYFAEKLNAPLAIIDKRRPKANVAEIMNIIGDVRGKKAILVDDLIDTAGTLVQGAEALL
DSGATEVYACATHGVLSGPAIERLKESPIKELVITDTIPLPEEKKIDKIKVRSVAPLFAEAILRIHEGMSVSKLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=48.8745980707396, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=48.8673139158576, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=48.3974358974359, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI28557709, Length=312, Percent_Identity=48.3974358974359, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=38.2608695652174, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=37.5722543352601, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=35, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=35, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=35, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=35, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=54.3408360128617, Blast_Score=337, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=48.3974358974359, Blast_Score=294, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=48.3974358974359, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=48.5436893203884, Blast_Score=291, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=48.3974358974359, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17570245, Length=344, Percent_Identity=35.7558139534884, Blast_Score=201, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=47.1153846153846, Blast_Score=275, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6319403, Length=317, Percent_Identity=47.0031545741325, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=45.8333333333333, Blast_Score=266, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=44.3877551020408, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=45.8715596330275, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=48.7179487179487, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=45.3731343283582, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=37.3595505617978, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=37.3595505617978, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=37.3595505617978, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=37.3595505617978, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24651462, Length=204, Percent_Identity=38.7254901960784, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24651464, Length=204, Percent_Identity=38.7254901960784, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI45552010, Length=204, Percent_Identity=38.7254901960784, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34166; Mature: 34166

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRYNSSLKIFSGNSNPKLASEIAEHLGLKLCDSEVGTFSDGEISVRIGESVRGASVFVI
CEEECCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
QSTCAPVNNNLMELLIMIDAFKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLI
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
TAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFLDKELGNDVVVVSPDHGSVTR
HHCCCCEEEEEECCCCCCCCEECCCHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCHHH
ARYFAEKLNAPLAIIDKRRPKANVAEIMNIIGDVRGKKAILVDDLIDTAGTLVQGAEALL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
DSGATEVYACATHGVLSGPAIERLKESPIKELVITDTIPLPEEKKIDKIKVRSVAPLFAE
HCCCCEEEEEECCCCCCCHHHHHHHHCCHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHH
AILRIHEGMSVSKLFV
HHHHHHCCCCHHHHCC
>Mature Secondary Structure
MVRYNSSLKIFSGNSNPKLASEIAEHLGLKLCDSEVGTFSDGEISVRIGESVRGASVFVI
CEEECCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
QSTCAPVNNNLMELLIMIDAFKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLI
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
TAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFLDKELGNDVVVVSPDHGSVTR
HHCCCCEEEEEECCCCCCCCEECCCHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCHHH
ARYFAEKLNAPLAIIDKRRPKANVAEIMNIIGDVRGKKAILVDDLIDTAGTLVQGAEALL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
DSGATEVYACATHGVLSGPAIERLKESPIKELVITDTIPLPEEKKIDKIKVRSVAPLFAE
HCCCCEEEEEECCCCCCCHHHHHHHHCCHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHH
AILRIHEGMSVSKLFV
HHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]